PL1682545T3 - Podstawione imidazopirydyną pochodne tropanu o aktywności antagonisty receptora ccr5 do leczenia hiv i stanu zapalnego - Google Patents

Podstawione imidazopirydyną pochodne tropanu o aktywności antagonisty receptora ccr5 do leczenia hiv i stanu zapalnego

Info

Publication number: PL1682545T3
Authority: PL; Poland
Prior art keywords: hiv; inflammation; treatment; receptor antagonist; antagonist activity
Prior art date: 2003-10-03

Application number

PL04769496T

Other languages

English (en)

Inventor

Paul Anthony Stupple

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-03

Filing date

2004-09-28

Publication date

2008-04-30

2003-10-03 Priority claimed from GBGB0323236.0A external-priority patent/GB0323236D0/en

2003-10-27 Priority claimed from GB0325020A external-priority patent/GB0325020D0/en

2004-08-19 Priority claimed from GB0418566A external-priority patent/GB0418566D0/en

2004-09-28 Application filed by Pfizer filed Critical Pfizer

2008-04-30 Publication of PL1682545T3 publication Critical patent/PL1682545T3/pl

Links

206010061218 Inflammation Diseases 0.000 title 1
239000003067 chemokine receptor CCR5 antagonist Substances 0.000 title 1
125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 title 1
230000004054 inflammatory process Effects 0.000 title 1
150000003813 tropane derivatives Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Diabetes (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Tropical Medicine & Parasitology (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Biotechnology (AREA)
AIDS & HIV (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)

PL04769496T 2003-10-03 2004-09-28 Podstawione imidazopirydyną pochodne tropanu o aktywności antagonisty receptora ccr5 do leczenia hiv i stanu zapalnego PL1682545T3 (pl)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB0323236.0A GB0323236D0 (en)	2003-10-03	2003-10-03	Chemical compounds
GB0325020A GB0325020D0 (en)	2003-10-27	2003-10-27	Chemical compounds
GB0418566A GB0418566D0 (en)	2004-08-19	2004-08-19	Tropane derivatives
EP04769496A EP1682545B1 (en)	2003-10-03	2004-09-28	Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation
PCT/IB2004/003153 WO2005033107A1 (en)	2003-10-03	2004-09-28	Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation

Publications (1)

Publication Number	Publication Date
PL1682545T3 true PL1682545T3 (pl)	2008-04-30

Family

ID=34426592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04769496T PL1682545T3 (pl)	2003-10-03	2004-09-28	Podstawione imidazopirydyną pochodne tropanu o aktywności antagonisty receptora ccr5 do leczenia hiv i stanu zapalnego

Country Status (35)

Country	Link
US (2)	US7309790B2 (pl)
EP (1)	EP1682545B1 (pl)
JP (1)	JP4874107B2 (pl)
KR (1)	KR100777885B1 (pl)
AP (1)	AP2174A (pl)
AR (1)	AR045856A1 (pl)
AT (1)	ATE380813T1 (pl)
AU (1)	AU2004278158B2 (pl)
BR (1)	BRPI0414862A (pl)
CA (1)	CA2540834C (pl)
CY (1)	CY1107281T1 (pl)
DE (1)	DE602004010708T2 (pl)
DK (1)	DK1682545T3 (pl)
EA (1)	EA009941B1 (pl)
EC (1)	ECSP066475A (pl)
ES (1)	ES2295924T3 (pl)
GE (1)	GEP20084417B (pl)
HN (1)	HN2004000383A (pl)
HR (1)	HRP20080052T3 (pl)
IL (1)	IL174208A0 (pl)
MA (1)	MA28080A1 (pl)
MX (1)	MXPA06003749A (pl)
MY (1)	MY137609A (pl)
NO (1)	NO20061978L (pl)
NZ (1)	NZ545837A (pl)
OA (1)	OA13266A (pl)
PA (1)	PA8614301A1 (pl)
PE (1)	PE20050961A1 (pl)
PL (1)	PL1682545T3 (pl)
PT (1)	PT1682545E (pl)
RS (1)	RS20060198A (pl)
SI (1)	SI1682545T1 (pl)
TW (1)	TWI280244B (pl)
UY (1)	UY28546A1 (pl)
WO (1)	WO2005033107A1 (pl)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20030762A1 (es)	2001-12-18	2003-09-05	Schering Corp	Compuestos heterociclicos como antagonistas nk1
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
BRPI0413018B8 (pt)	2003-07-30	2021-05-25	Rigel Pharmaceuticals Inc	composto, e, uso de um composto
US20070203161A1 (en)	2006-02-24	2007-08-30	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
WO2006133426A2 (en)	2005-06-08	2006-12-14	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
CA2642229C (en)	2006-02-24	2015-05-12	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
SG10201500028RA (en)	2006-04-05	2015-02-27	Opko Health Inc	Pharmaceutical formulations: salts of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and treatment methods using the same
US20080108586A1 (en) *	2006-09-06	2008-05-08	Incyte Corporation	Combination therapy for human immunodeficiency virus infection
EP2089369B1 (en)	2006-10-19	2011-02-02	Rigel Pharmaceuticals, Inc.	2,4 -pyrimidinediamine derivatives as inhibitors of jak kinases for the treatment of autoimmune diseases
WO2008085302A1 (en) *	2006-12-20	2008-07-17	Merck & Co., Inc.	Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
AR065802A1 (es) *	2007-03-22	2009-07-01	Schering Corp	Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas
CA2703477C (en) *	2007-10-25	2016-10-11	Exelixis, Inc.	Pyridinyl substituted tropane compounds and uses thereof
US8309566B2 (en)	2008-02-15	2012-11-13	Rigel Pharmaceuticals, Inc.	Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases
US8138339B2 (en)	2008-04-16	2012-03-20	Portola Pharmaceuticals, Inc.	Inhibitors of protein kinases
MX2010011463A (es)	2008-04-16	2011-06-03	Portola Pharm Inc	2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas.
NZ588830A (en)	2008-04-22	2012-11-30	Portola Pharm Inc	Inhibitors of protein kinases
JP2010043063A (ja)	2008-05-09	2010-02-25	Agency For Science Technology & Research	川崎病の診断及び治療
CN102573475B (zh)	2009-08-14	2016-01-20	欧科生医股份有限公司	神经激肽-1拮抗剂的静脉内制剂
EP2552429A1 (en)	2010-04-02	2013-02-06	Phivco-1 LLC	Combination therapy comprising a ccr5 antagonist, a hiv-1 protease inhibitor and a pharmacokinetic enhancer
US9102625B2 (en)	2010-11-01	2015-08-11	Portola Pharmaceuticals, Inc.	Nicotinamides as JAK kinase modulators
EP2741777B1 (en)	2011-08-12	2017-01-18	INSERM - Institut National de la Santé et de la Recherche Médicale	Methods and pharmaceutical compositions for treatment of pulmonary hypertension
CA3094793A1 (en)	2011-11-23	2013-05-30	Portola Pharmaceuticals, Inc.	Pyrazine kinase inhibitors
US9676756B2 (en)	2012-10-08	2017-06-13	Portola Pharmaceuticals, Inc.	Substituted pyrimidinyl kinase inhibitors
PL3049378T3 (pl) *	2013-09-25	2019-06-28	SpecGx LLC	Wytwarzanie radiojodowanego 3-fluoropropylo-nor-beta-CIT
GB201321748D0 (en)	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
WO2023192361A1 (en) *	2022-03-31	2023-10-05	Incelldx, Inc.	Methods of treating a subject for fibromyalgia and compositions for use in the same
WO2023192360A1 (en) *	2022-03-31	2023-10-05	Incelldx, Inc.	Methods of treating a subject for post-treatment lyme disease (ptld) and compositions for use in the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0166088B1 (ko)	1990-01-23	1999-01-15	.	수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en)	1990-01-23	1994-12-27	University Of Kansas	Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
BR9507489A (pt)	1994-04-19	1997-08-12	Neurosearch As	Derivados tropano sua preparacão e uso
GB9518953D0 (en)	1995-09-15	1995-11-15	Pfizer Ltd	Pharmaceutical formulations
JP3238414B2 (ja)	1996-02-22	2001-12-17	ニューロサーチ・アクティーゼルスカブ	トロパン―誘導体、その製造方法及びその使用方法
WO2000035298A1 (en)	1996-11-27	2000-06-22	Wm. Wrigley Jr. Company	Chewing gum containing medicament active agents
GB9711643D0 (en)	1997-06-05	1997-07-30	Janssen Pharmaceutica Nv	Glass thermoplastic systems
PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
RS50904B (sr) *	2000-05-26	2010-08-31	Pfizer Inc.	Derivati tropana i njihova primena
EP1492789B1 (en) *	2002-04-08	2006-06-07	Pfizer Limited	Tropane derivatives as ccr5 modulators
US6855724B2 (en) *	2002-04-08	2005-02-15	Agouron Pharmaceuticals, Inc.	Tropane derivatives useful in therapy

2004
- 2004-09-28 EP EP04769496A patent/EP1682545B1/en not_active Expired - Lifetime
- 2004-09-28 MX MXPA06003749A patent/MXPA06003749A/es active IP Right Grant
- 2004-09-28 JP JP2006530737A patent/JP4874107B2/ja not_active Expired - Fee Related
- 2004-09-28 OA OA1200600114A patent/OA13266A/en unknown
- 2004-09-28 HR HR20080052T patent/HRP20080052T3/xx unknown
- 2004-09-28 DE DE602004010708T patent/DE602004010708T2/de not_active Expired - Lifetime
- 2004-09-28 CA CA2540834A patent/CA2540834C/en not_active Expired - Fee Related
- 2004-09-28 PT PT04769496T patent/PT1682545E/pt unknown
- 2004-09-28 RS YUP-2006/0198A patent/RS20060198A/sr unknown
- 2004-09-28 AT AT04769496T patent/ATE380813T1/de active
- 2004-09-28 EA EA200600480A patent/EA009941B1/ru not_active IP Right Cessation
- 2004-09-28 US US10/953,136 patent/US7309790B2/en not_active Expired - Fee Related
- 2004-09-28 ES ES04769496T patent/ES2295924T3/es not_active Expired - Lifetime
- 2004-09-28 PL PL04769496T patent/PL1682545T3/pl unknown
- 2004-09-28 BR BRPI0414862-2A patent/BRPI0414862A/pt not_active IP Right Cessation
- 2004-09-28 WO PCT/IB2004/003153 patent/WO2005033107A1/en not_active Ceased
- 2004-09-28 SI SI200430564T patent/SI1682545T1/sl unknown
- 2004-09-28 NZ NZ545837A patent/NZ545837A/en not_active IP Right Cessation
- 2004-09-28 GE GEAP20049330A patent/GEP20084417B/en unknown
- 2004-09-28 KR KR1020067006293A patent/KR100777885B1/ko not_active Expired - Fee Related
- 2004-09-28 AP AP2006003580A patent/AP2174A/xx active
- 2004-09-28 DK DK04769496T patent/DK1682545T3/da active
- 2004-09-28 AU AU2004278158A patent/AU2004278158B2/en not_active Ceased
- 2004-09-29 HN HN2004000383A patent/HN2004000383A/es unknown
- 2004-09-29 TW TW093129475A patent/TWI280244B/zh not_active IP Right Cessation
- 2004-10-01 PA PA20048614301A patent/PA8614301A1/es unknown
- 2004-10-01 MY MYPI20044043A patent/MY137609A/en unknown
- 2004-10-01 PE PE2004000965A patent/PE20050961A1/es not_active Application Discontinuation
- 2004-10-01 AR ARP040103581A patent/AR045856A1/es not_active Application Discontinuation
- 2004-10-01 UY UY28546A patent/UY28546A1/es unknown
2006
- 2006-03-09 IL IL174208A patent/IL174208A0/en unknown
- 2006-04-03 MA MA28906A patent/MA28080A1/fr unknown
- 2006-04-03 EC EC2006006475A patent/ECSP066475A/es unknown
- 2006-05-03 NO NO20061978A patent/NO20061978L/no not_active Application Discontinuation
2007
- 2007-08-27 US US11/845,500 patent/US7790740B2/en not_active Expired - Fee Related
2008
- 2008-02-14 CY CY20081100178T patent/CY1107281T1/el unknown

Also Published As

Publication number	Publication date
CY1107281T1 (el)	2012-11-21
EP1682545A1 (en)	2006-07-26
RS20060198A (sr)	2008-09-29
DE602004010708T2 (de)	2008-12-04
NO20061978L (no)	2006-07-03
ECSP066475A (es)	2006-10-10
AU2004278158A1 (en)	2005-04-14
IL174208A0 (en)	2006-08-01
EA009941B1 (ru)	2008-04-28
EA200600480A1 (ru)	2006-08-25
HN2004000383A (es)	2008-10-14
ES2295924T3 (es)	2008-04-16
JP4874107B2 (ja)	2012-02-15
MY137609A (en)	2009-02-27
WO2005033107A1 (en)	2005-04-14
SI1682545T1 (sl)	2008-04-30
TW200519112A (en)	2005-06-16
PT1682545E (pt)	2008-02-11
NZ545837A (en)	2009-12-24
US20050131011A1 (en)	2005-06-16
US7309790B2 (en)	2007-12-18
AU2004278158B2 (en)	2009-08-13
AR045856A1 (es)	2005-11-16
KR20060070571A (ko)	2006-06-23
MA28080A1 (fr)	2006-08-01
KR100777885B1 (ko)	2007-11-28
AP2006003580A0 (en)	2006-04-30
TWI280244B (en)	2007-05-01
AP2174A (en)	2010-11-20
UY28546A1 (es)	2005-05-31
OA13266A (en)	2007-01-31
PE20050961A1 (es)	2005-11-29
US20080045563A1 (en)	2008-02-21
BRPI0414862A (pt)	2006-11-28
US7790740B2 (en)	2010-09-07
ATE380813T1 (de)	2007-12-15
HRP20080052T3 (hr)	2008-02-29
DK1682545T3 (da)	2008-03-17
JP2007507483A (ja)	2007-03-29
EP1682545B1 (en)	2007-12-12
CA2540834C (en)	2010-06-22
MXPA06003749A (es)	2006-06-14
CA2540834A1 (en)	2005-04-14
PA8614301A1 (es)	2005-05-10
GEP20084417B (en)	2008-07-10
DE602004010708D1 (de)	2008-01-24

Publication	Publication Date	Title
IL174208A0 (en)	2006-08-01	Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation
ZA200702772B (en)	2008-08-27	Quinuclidine derivatives and their use as muscarinic M3 receptor antagonists
IL181044A0 (en)	2007-07-04	Antagonizing interleukin-21 receptor activity
ZA200805649B (en)	2009-11-25	Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use
EP1656138A4 (en)	2007-04-18	SUBSTITUTED CYCLOALKYAMINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
HUE039348T2 (hu)	2018-12-28	A2A receptor antagonisták mozgási rendellenességek kezelésében történõ alkalmazásra
IL176574A0 (en)	2006-10-31	Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss
IL174702A0 (en)	2006-08-20	Spirocyclic heterocyclic derivatives and methods of their use
HUP0401735A3 (en)	2005-06-28	Piperazine derivatives with ccr1 receptor antagonist activity and pharmaceutical compositions containing them
AP1789A (en)	2007-10-05	Tropane derivatives useful in therapy.
MY139720A (en)	2009-10-30	Micronized crystalline tiotropium bromide
AU2003267088A1 (en)	2004-04-30	Chemokine receptor antagonists as therapeutic agents
IL183485A0 (en)	2007-10-31	Therapeutic pyrazolo[3,4-b] pyridines and indazoles
IL182385A0 (en)	2007-07-24	Pyridine derivatives and the preparation and the therapeutic use thereof
IL197500A0 (en)	2009-12-24	Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof
IL166075A0 (en)	2006-01-15	Bicyclic piperidine derives as antagonists of the ccr1 chemokine receptor
IL206669A0 (en)	2010-12-30	6-HETEROCYCLIC IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
IL177302A0 (en)	2006-12-10	Tricyclic imidazopyridine derivatives and pharmaceutical compositions containing the same
PL1960387T3 (pl)	2012-03-30	Pochodne izochinoliny i benzo[h]izochinoliny, ich wytwarzanie i ich zastosowanie w leczeniu jako antagonistów receptora histaminowego h3
ZA200701015B (en)	2010-07-28	Antagonizing interleukin-21 receptor activity
PL1644012T3 (pl)	2011-01-31	Czwartorzędowe pochodne chelidoniny i alkaloidów, sposób ich otrzymywania oraz zastosowanie do wytwarzania środków leczniczych
IL206672A0 (en)	2010-12-30	N-HETEROCYCLIC-6-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
AU2003253847A8 (en)	2004-01-23	Alkaloid derivatives and methods of their use
IS8347A (is)	2006-03-09	Imídasópýridín setnar trópan afleiður með CCR5 viðtaka gerandvirkni til meðhöndlunar á HIV og bólgu
GB0428581D0 (en)	2005-02-09	Pyrido(3,2-D) pyrimidine derivatives and pharmaceutical compositions useful as medicines fir the treatment of autoimmune disorders