PL1689391T3 - Pochodne 5-fenylo-4-metylo-tiazol-2-ilo-aminy jako inhibitory enzymów - kinaz fosfatydyloinozytolu 3 (PI3) do leczenia zapalnych chorób dróg oddechowych - Google Patents

Pochodne 5-fenylo-4-metylo-tiazol-2-ilo-aminy jako inhibitory enzymów - kinaz fosfatydyloinozytolu 3 (PI3) do leczenia zapalnych chorób dróg oddechowych

Info

Publication number: PL1689391T3
Authority: PL; Poland
Prior art keywords: phosphatidylinositol; thiazol; inhibitors; phenyl; methyl
Prior art date: 2003-08-28

Application number

PL04764560T

Other languages

English (en)

Inventor

G C Bloomfield

Ian Bruce

Judy Fox Hayler

C Leblanc

Grand D M Le

Clive Mccarthy

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-28

Filing date

2004-08-27

Publication date

2009-09-30

2004-08-27 Application filed by Novartis Ag filed Critical Novartis Ag

2009-09-30 Publication of PL1689391T3 publication Critical patent/PL1689391T3/pl

Links

XSTQXTKOICQHDC-UHFFFAOYSA-N 4-methyl-5-phenyl-1,3-thiazol-2-amine Chemical class N1=C(N)SC(C=2C=CC=CC=2)=C1C XSTQXTKOICQHDC-UHFFFAOYSA-N 0.000 title 1
108091007960 PI3Ks Proteins 0.000 title 1
102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 title 1
108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 title 1
230000002757 inflammatory effect Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
208000023504 respiratory system disease Diseases 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL04764560T 2003-08-28 2004-08-27 Pochodne 5-fenylo-4-metylo-tiazol-2-ilo-aminy jako inhibitory enzymów - kinaz fosfatydyloinozytolu 3 (PI3) do leczenia zapalnych chorób dróg oddechowych PL1689391T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0320197.7A GB0320197D0 (en)	2003-08-28	2003-08-28	Organic compounds
PCT/EP2004/009586 WO2005021519A2 (en)	2003-08-28	2004-08-27	5-phenyl-4-methyl-thiazol-2-yl-amine derivatives as inhibitors of phosphatidylinositol 3 kinase enzymes (pi3) for the treatment of inflammatory airway diseases
EP04764560A EP1689391B1 (en)	2003-08-28	2004-08-27	5-phenyl-4-methyl-thiazol-2-yl-amine derivatives as inhibitors of phosphatidylinositol 3 kinase enzymes (pi3) for the treatment of inflammatory airway diseases

Publications (1)

Publication Number	Publication Date
PL1689391T3 true PL1689391T3 (pl)	2009-09-30

Family

ID=28686509

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04764560T PL1689391T3 (pl)	2003-08-28	2004-08-27	Pochodne 5-fenylo-4-metylo-tiazol-2-ilo-aminy jako inhibitory enzymów - kinaz fosfatydyloinozytolu 3 (PI3) do leczenia zapalnych chorób dróg oddechowych

Country Status (33)

Country	Link
US (3)	US7902375B2 (pl)
EP (1)	EP1689391B1 (pl)
JP (1)	JP4574618B2 (pl)
KR (1)	KR100774038B1 (pl)
CN (1)	CN1838953B (pl)
AR (1)	AR045510A1 (pl)
AT (1)	ATE429225T1 (pl)
AU (1)	AU2004268050B2 (pl)
BR (1)	BRPI0413934A (pl)
CA (1)	CA2533175A1 (pl)
CY (1)	CY1109227T1 (pl)
DE (1)	DE602004020793D1 (pl)
DK (1)	DK1689391T3 (pl)
EC (1)	ECSP066383A (pl)
ES (1)	ES2323000T3 (pl)
GB (1)	GB0320197D0 (pl)
HR (1)	HRP20090340T1 (pl)
IL (1)	IL173035A0 (pl)
IS (1)	IS2690B (pl)
MA (1)	MA28007A1 (pl)
MX (1)	MXPA06002217A (pl)
MY (1)	MY135050A (pl)
NO (1)	NO20061406L (pl)
NZ (1)	NZ545139A (pl)
PE (1)	PE20050872A1 (pl)
PL (1)	PL1689391T3 (pl)
PT (1)	PT1689391E (pl)
RU (1)	RU2382783C2 (pl)
SI (1)	SI1689391T1 (pl)
TN (1)	TNSN06064A1 (pl)
TW (1)	TWI347941B (pl)
WO (1)	WO2005021519A2 (pl)
ZA (1)	ZA200600415B (pl)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR044519A1 (es)	2003-05-02	2005-09-14	Novartis Ag	Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
WO2005118543A1 (ja) *	2004-06-03	2005-12-15	Ono Pharmaceutical Co., Ltd.	キナーゼ阻害薬およびその用途
WO2006037468A1 (en) *	2004-09-30	2006-04-13	Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa	Hiv reverse transcriptase inhibitors
WO2006125807A1 (en)	2005-05-24	2006-11-30	Laboratoires Serono S.A.	Thiazole derivatives and use thereof
CN101248054B (zh)	2005-05-24	2012-05-09	默克雪兰诺有限公司	噻唑衍生物及其应用
US8071597B2 (en)	2005-08-26	2011-12-06	Merck Serono Sa	Pyrazine compounds and uses as PI3K inhibitors
GB0525671D0 (en) *	2005-12-16	2006-01-25	Novartis Ag	Organic compounds
WO2007098826A2 (en) *	2006-01-18	2007-09-07	Siena Biotech S.P.A.	Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof
GB0608854D0 (en) *	2006-05-04	2006-06-14	Chroma Therapeutics Ltd	P13 kinase inhibitors
GB0608823D0 (en) *	2006-05-04	2006-06-14	Chroma Therapeutics Ltd	Inhibitors of P13 kinase
GB0610243D0 (en) *	2006-05-23	2006-07-05	Novartis Ag	Organic compounds
GB0612630D0 (en) *	2006-06-26	2006-08-02	Novartis Ag	Organic compounds
JP5508027B2 (ja)	2007-02-22	2014-05-28	メルクセローノソシエテアノニム	キノキサリン化合物及びその使用
EP2581081A3 (en)	2007-06-01	2013-07-31	The Trustees Of Princeton University	Treatment of viral infections by modulation of host cell metabolic pathways
JP2011506563A (ja) *	2007-12-20	2011-03-03	ノバルティスアーゲー	ビスチアゾール誘導体、その製造方法および医薬品としてのその使用
EP2240475B1 (en) *	2007-12-20	2013-09-25	Novartis AG	Thiazole derivatives used as pi 3 kinase inhibitors
UA104147C2 (uk) *	2008-09-10	2014-01-10	Новартис Аг	Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
CN101684106B (zh) *	2008-09-22	2013-06-12	北京摩力克科技有限公司	噻唑鎓盐类化合物及其治疗蛋白老化相关疾病的用途
CN102388041B (zh)	2009-02-12	2014-12-24	默克雪兰诺有限公司	2-吗啉代-吡啶并[3,2-d]嘧啶
LT2899191T (lt) *	2009-04-30	2017-10-25	Glaxo Group Limited	Oksazolo pakeistieji indazolai kaip pi3-kinazės inhibitoriai
EP2440556A1 (en) *	2009-06-10	2012-04-18	Vertex Pharmaceuticals Incorporated	Inhibitors of phosphatidylinositol 3-kinase
AU2010268058A1 (en)	2009-07-02	2012-01-19	Novartis Ag	2-carboxamide cycloamino ureas useful as PI3K inhibitors
US8293753B2 (en) *	2009-07-02	2012-10-23	Novartis Ag	Substituted 2-carboxamide cycloamino ureas
EP2492269A4 (en)	2009-10-19	2013-08-07	Taisho Pharmaceutical Co Ltd	aminothiazole
EA201290305A1 (ru)	2009-11-13	2012-12-28	Мерк Сероно С.А.	Производные трициклического пиразоламина
CA2788678C (en)	2010-02-03	2019-02-26	Signal Pharmaceuticals, Llc	Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors
GB201018124D0 (en)	2010-10-27	2010-12-08	Glaxo Group Ltd	Polymorphs and salts
EP2727920B1 (en) *	2011-07-29	2016-11-02	FUJIFILM Corporation	1,5-naphthyridine derivative or salt thereof
HK1199068A1 (en)	2011-08-03	2015-06-19	西格诺药品有限公司	Identification of gene expression profile as a predictive biomarker for lkb1 status
US9926309B2 (en)	2011-10-05	2018-03-27	The Board Of Trustees Of The Leland Stanford Junior University	Pi-kinase inhibitors with anti-infective activity
WO2013052845A1 (en)	2011-10-05	2013-04-11	The Board Of Trustees Of The Leland Stanford Junior University	Pi-kinase inhibitors with broad spectrum anti-infective activity
AU2013203714B2 (en)	2012-10-18	2015-12-03	Signal Pharmaceuticals, Llc	Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
CA2909579A1 (en)	2013-04-17	2014-10-23	Signal Pharmaceuticals, Llc	Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
US9630966B2 (en)	2013-04-17	2017-04-25	Signal Pharmaceuticals, Llc	Treatment of cancer with dihydropyrazino-pyrazines
CN105377299B (zh)	2013-04-17	2018-06-12	西格诺药品有限公司	用于治疗前列腺癌的包含二氢吡嗪并-吡嗪化合物和雄激素受体拮抗剂的组合疗法
WO2014172436A1 (en)	2013-04-17	2014-10-23	Signal Pharmaceuticals, Llc	Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
US9505764B2 (en)	2013-04-17	2016-11-29	Signal Pharmaceuticals, Llc	Treatment of cancer with dihydropyrazino-pyrazines
CA2909629C (en)	2013-04-17	2022-12-13	Signal Pharmaceuticals, Llc	Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
CA2908742C (en)	2013-04-17	2021-06-01	Signal Pharmaceuticals, Llc	Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer
NZ629486A (en)	2013-05-29	2017-11-24	Signal Pharm Llc	Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
NZ714742A (en)	2014-04-16	2017-04-28	Signal Pharm Llc	Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
US9512129B2 (en)	2014-04-16	2016-12-06	Signal Pharmaceuticals, Llc	Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer
WO2016149756A1 (en) *	2015-03-23	2016-09-29	The University Of Melbourne	Treatment of respiratory diseases
JP6845165B2 (ja) *	2015-06-30	2021-03-17	デイナファーバーキャンサーインスティチュート，インコーポレイテッド	Ｅｇｆｒ阻害剤およびその使用方法
WO2017147526A1 (en)	2016-02-26	2017-08-31	The Board Of Trustees Of The Leland Stanford Junior University	Pi-kinase inhibitors with anti-infective activity
MA46268B1 (fr) *	2016-09-22	2020-08-31	Astrazeneca Ab	Dérivés de 5-[2-(pyridin-2-ylamino)-1 ,3-thiazol-5-yl]-2,3-dihydro-1h-isoindol-1-one et leur utilisation en tant qu'inhibiteurs doubles de phosphatidylinositol 3-kinase delta & gamma
TWI787284B (zh)	2017-06-22	2022-12-21	美商西建公司	以b型肝炎病毒感染表徵之肝細胞癌之治療
US12415788B2 (en)	2019-03-21	2025-09-16	The Board Of Trustees Of The Leland Stanford Junior University	PI4-kinase inhibitors and methods of using the same
TW202146393A (zh)	2020-03-03	2021-12-16	美商皮克醫療公司	Eif4e抑制劑及其用途
US12157732B2 (en)	2021-08-25	2024-12-03	PIC Therapeutics, Inc.	eIF4E inhibitors and uses thereof
CA3229560A1 (en)	2021-08-25	2023-03-02	Christopher L. Vandeusen	Eif4e inhibitors and uses thereof
CN116874442B (zh) *	2023-07-27	2025-10-24	武汉呈瑞生物医药科技有限公司	一种有机化合物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU1279531A3 (ru) *	1983-02-14	1986-12-23	Ниппон Сода Компани Лимитед (Фирма)	Способ получени производных тиазолинотриазина
WO1993000342A1 (en) *	1991-06-21	1993-01-07	Boehringer Mannheim Italia S.P.A.	2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract
GB9823873D0 (en) *	1998-10-30	1998-12-30	Pharmacia & Upjohn Spa	2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
AU779908B2 (en)	1999-09-10	2005-02-17	Merck & Co., Inc.	Tyrosine kinase inhibitors
US6667300B2 (en) *	2000-04-25	2003-12-23	Icos Corporation	Inhibitors of human phosphatidylinositol 3-kinase delta
JP2004516238A (ja) *	2000-06-21	2004-06-03	ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー	ケモカイン受容体活性調節剤としてのｎ−ウレイドアルキル−ピペリジン
CA2417254A1 (en)	2000-07-26	2002-02-07	Bristol Myers Squibb Company	N-¢5-¢¢¢5-alkyl-2-oxazolyl!methyl!thio!-2-thiazolyl! carboxamide inhibitors of cyclin dependent kinases
WO2003015778A1 (en) *	2001-08-17	2003-02-27	Merck & Co., Inc.	Tyrosine kinase inhibitors
AR038703A1 (es) *	2002-02-28	2005-01-26	Novartis Ag	Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3

2003
- 2003-08-28 GB GBGB0320197.7A patent/GB0320197D0/en not_active Ceased
2004
- 2004-08-26 PE PE2004000820A patent/PE20050872A1/es not_active Application Discontinuation
- 2004-08-26 AR ARP040103072A patent/AR045510A1/es not_active Application Discontinuation
- 2004-08-26 TW TW093125599A patent/TWI347941B/zh not_active IP Right Cessation
- 2004-08-27 AU AU2004268050A patent/AU2004268050B2/en not_active Ceased
- 2004-08-27 KR KR1020067004006A patent/KR100774038B1/ko not_active Expired - Fee Related
- 2004-08-27 BR BRPI0413934-8A patent/BRPI0413934A/pt not_active IP Right Cessation
- 2004-08-27 SI SI200431138T patent/SI1689391T1/sl unknown
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- 2004-08-27 DK DK04764560T patent/DK1689391T3/da active
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- 2004-08-27 CA CA002533175A patent/CA2533175A1/en not_active Abandoned
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- 2004-08-27 MX MXPA06002217A patent/MXPA06002217A/es active IP Right Grant
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- 2004-08-27 AT AT04764560T patent/ATE429225T1/de active
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- 2004-08-27 WO PCT/EP2004/009586 patent/WO2005021519A2/en not_active Ceased
- 2004-08-27 PT PT04764560T patent/PT1689391E/pt unknown
2006
- 2006-01-09 IL IL173035A patent/IL173035A0/en unknown
- 2006-01-16 ZA ZA200600415A patent/ZA200600415B/en unknown
- 2006-02-17 EC EC2006006383A patent/ECSP066383A/es unknown
- 2006-02-27 MA MA28835A patent/MA28007A1/fr unknown
- 2006-02-27 TN TNP2006000064A patent/TNSN06064A1/en unknown
- 2006-03-24 IS IS8372A patent/IS2690B/is unknown
- 2006-03-28 NO NO20061406A patent/NO20061406L/no not_active Application Discontinuation
2009
- 2009-07-14 CY CY20091100743T patent/CY1109227T1/el unknown
2011
- 2011-02-03 US US13/020,247 patent/US20110124624A1/en not_active Abandoned
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Also Published As

Publication number	Publication date
US20080280871A1 (en)	2008-11-13
TNSN06064A1 (en)	2007-10-03
MY135050A (en)	2008-01-31
ES2323000T3 (es)	2009-07-03
TW200517386A (en)	2005-06-01
JP2007504109A (ja)	2007-03-01
BRPI0413934A (pt)	2006-10-24
DE602004020793D1 (de)	2009-06-04
MXPA06002217A (es)	2006-04-27
PT1689391E (pt)	2009-06-19
RU2006109545A (ru)	2007-10-10
CA2533175A1 (en)	2005-03-10
CY1109227T1 (el)	2014-07-02
EP1689391B1 (en)	2009-04-22
AU2004268050A1 (en)	2005-03-10
KR100774038B1 (ko)	2007-11-06
MA28007A1 (fr)	2006-07-03
NO20061406L (no)	2006-08-25
AR045510A1 (es)	2005-11-02
ZA200600415B (en)	2007-12-27
GB0320197D0 (en)	2003-10-01
SI1689391T1 (sl)	2009-08-31
CN1838953B (zh)	2011-02-02
HK1093688A1 (en)	2007-03-09
WO2005021519A2 (en)	2005-03-10
HRP20090340T1 (hr)	2009-07-31
TWI347941B (en)	2011-09-01
WO2005021519A3 (en)	2005-05-12
US20110124624A1 (en)	2011-05-26
EP1689391A2 (en)	2006-08-16
IS2690B (is)	2010-10-15
ECSP066383A (es)	2006-08-30
IL173035A0 (en)	2006-06-11
CN1838953A (zh)	2006-09-27
NZ545139A (en)	2009-11-27
PE20050872A1 (es)	2005-11-22
JP4574618B2 (ja)	2010-11-04
DK1689391T3 (da)	2009-07-27
US7902375B2 (en)	2011-03-08
ATE429225T1 (de)	2009-05-15
IS8372A (is)	2006-03-24
US20110124693A1 (en)	2011-05-26
RU2382783C2 (ru)	2010-02-27
AU2004268050B2 (en)	2006-11-16
KR20060060704A (ko)	2006-06-05

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