PL1689751T3 - 5,7-diaminopirazolo[4,3-d]pirymidyny z działaniem hamującym PDE-5 - Google Patents

5,7-diaminopirazolo[4,3-d]pirymidyny z działaniem hamującym PDE-5

Info

Publication number: PL1689751T3
Authority: PL; Poland
Prior art keywords: diaminopyrazolo; pde; pyrimidines; inhibiting activity; inhibiting
Prior art date: 2003-11-24

Application number

PL04798876T

Other languages

English (en)

Inventor

Andrew Simon Bell

David Graham Brown

Kevin Neil Dack

David Nathan A Fox

Ian Roger Marsh

Andrew Ian Morrell

Michael John Palmer

Carol Ann Winslow

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-24

Filing date

2004-11-12

Publication date

2011-03-31

2004-11-12 Application filed by Pfizer filed Critical Pfizer

2011-03-31 Publication of PL1689751T3 publication Critical patent/PL1689751T3/pl

Links

ZTAWTRPFJHKMRU-UHFFFAOYSA-N 7-deaza-8-aza-2,6-diaminopurine Chemical class NC1=NC(N)=C2NN=CC2=N1 ZTAWTRPFJHKMRU-UHFFFAOYSA-N 0.000 title 1
101100296726 Caenorhabditis elegans pde-5 gene Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL04798876T 2003-11-24 2004-11-12 5,7-diaminopirazolo[4,3-d]pirymidyny z działaniem hamującym PDE-5 PL1689751T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0327319.0A GB0327319D0 (en)	2003-11-24	2003-11-24	Novel pharmaceuticals
PCT/IB2004/003747 WO2005049616A1 (en)	2003-11-24	2004-11-12	5,7-DIAMINOPYRAZOLO [4,3-d] PYRIMIDINES WITH PDE-5 INHIBITING ACTIVITY
EP04798876A EP1689751B1 (en)	2003-11-24	2004-11-12	5,7-diaminopyrazolo[4,3-d]pyrimidines with pde-5 inhibiting activity

Publications (1)

Publication Number	Publication Date
PL1689751T3 true PL1689751T3 (pl)	2011-03-31

Family

ID=29764364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04798876T PL1689751T3 (pl)	2003-11-24	2004-11-12	5,7-diaminopirazolo[4,3-d]pirymidyny z działaniem hamującym PDE-5

Country Status (43)

Country	Link
EP (1)	EP1689751B1 (pl)
JP (1)	JP4056015B2 (pl)
KR (2)	KR100848216B1 (pl)
CN (4)	CN101647802A (pl)
AP (1)	AP2227A (pl)
AR (1)	AR046711A1 (pl)
AT (1)	ATE485297T1 (pl)
AU (1)	AU2004290643B2 (pl)
BR (1)	BRPI0416869A (pl)
CA (1)	CA2546987C (pl)
CR (1)	CR8416A (pl)
CY (1)	CY1110933T1 (pl)
DE (1)	DE602004029705D1 (pl)
DK (1)	DK1689751T3 (pl)
EA (1)	EA011772B1 (pl)
EC (1)	ECSP066580A (pl)
ES (1)	ES2351622T3 (pl)
GB (1)	GB0327319D0 (pl)
GE (1)	GEP20084528B (pl)
HR (1)	HRP20100651T1 (pl)
IL (1)	IL175433A (pl)
IS (1)	IS8406A (pl)
MA (1)	MA28172A1 (pl)
ME (1)	ME01216B (pl)
MX (1)	MXPA06005914A (pl)
MY (1)	MY140872A (pl)
NL (1)	NL1027568C2 (pl)
NO (1)	NO336526B1 (pl)
NZ (1)	NZ548097A (pl)
OA (1)	OA13289A (pl)
PA (1)	PA8617701A1 (pl)
PE (1)	PE20051061A1 (pl)
PL (1)	PL1689751T3 (pl)
PT (1)	PT1689751E (pl)
RS (1)	RS51556B (pl)
SG (1)	SG133614A1 (pl)
SI (1)	SI1689751T1 (pl)
TN (1)	TNSN06154A1 (pl)
TW (1)	TWI265031B (pl)
UA (1)	UA81994C2 (pl)
UY (1)	UY28625A1 (pl)
WO (1)	WO2005049616A1 (pl)
ZA (1)	ZA200602899B (pl)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0515482A (pt)	2004-09-20	2008-07-22	Xenon Pharmaceuticals Inc	derivados heterocìclicos e seus usos como agentes terapêuticos
CA2580855A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AR051026A1 (es)	2004-09-20	2006-12-13	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
MX2007003327A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
US8071603B2 (en)	2004-09-20	2011-12-06	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
TW200626138A (en)	2004-09-20	2006-08-01	Xenon Pharmaceuticals Inc	Heterocyclic derivatives and their use as therapeutic agents
WO2006034341A2 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
JP2008517994A (ja) *	2004-10-28	2008-05-29	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	新規医薬品
EP1881985B1 (en)	2005-05-12	2010-12-29	Pfizer, Inc.	Anhydrous crystalline forms of n-ý1-(2-ethoxyethyl)-5-(n-ethyl-n-methylamino)-7-(4-methylpyridin-2-yl-amino)-1h-pyrazolo[4,3-d]pyrimidine-3-carbonyl¨methanesulfonamide
US8541457B2 (en)	2005-06-03	2013-09-24	Xenon Pharmaceuticals Inc.	Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
NL1029244C2 (nl) *	2005-06-10	2006-12-12	Ronald Silfried Marlin	Middel ter vergroting van het mannelijk geslachtsorgaan.
DE102005050377A1 (de) *	2005-10-21	2007-04-26	Bayer Healthcare Ag	Heterocyclische Verbindungen und ihre Verwendung
NL2000291C2 (nl) *	2005-11-10	2009-02-17	Pfizer Prod Inc	1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2007070872A1 (en)	2005-12-15	2007-06-21	Rigel Pharmaceuticals, Inc.	Kinase inhibitors and their uses
EP1820502A1 (en) *	2006-02-10	2007-08-22	Laboratorios Del Dr. Esteve, S.A.	Active substance combination comprising azolylcarbinol compounds
WO2007113243A2 (en) *	2006-03-31	2007-10-11	Investigación Y Clínica Andrológicas S.L.	Use of pde 5 inhibitors for the treatment of overactive bladder
WO2008132589A1 (en) *	2007-05-01	2008-11-06	Pfizer Limited	Combinations comprising pregabalin
WO2009050554A2 (en) *	2007-10-19	2009-04-23	Pfizer Inc.	Treatment of central nervous system disorders
DE102008063992A1 (de) *	2008-12-19	2010-09-02	Lerner, Zinoviy, Dipl.-Ing.	Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
JP5767393B2 (ja)	2011-03-31	2015-08-19	ファイザー・インク	新規二環式ピリジノン
WO2012172449A1 (en)	2011-06-13	2012-12-20	Pfizer Inc.	Lactams as beta secretase inhibitors
WO2013030713A1 (en)	2011-08-31	2013-03-07	Pfizer Inc.	Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds
JP6110937B2 (ja)	2012-05-04	2017-04-05	ファイザー・インク	ＡＰＰ、ＢＡＣＥ１、およびＢＡＣＥ２の阻害剤としての複素環式置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
CA2882389A1 (en)	2012-09-20	2014-03-27	Pfizer Inc.	Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (uk)	2012-09-21	2016-01-25	Пфайзер Інк.	Біциклічні піридинони
JP2016502978A (ja)	2012-12-11	2016-02-01	ファイザー・インク	ＢＡＣＥ１の阻害剤としてのヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
CA2893333C (en)	2012-12-19	2017-10-24	Pfizer Inc.	Carbocyclic-and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CA2897678A1 (en)	2013-02-13	2014-08-21	Pfizer Inc.	Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en)	2013-02-15	2016-01-12	Pfizer Inc.	Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CA2900302C (en)	2013-02-19	2018-07-03	Pfizer Inc.	Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders
JP6425717B2 (ja)	2013-10-04	2018-11-21	ファイザー・インク	ガンマセクレターゼモジュレーターとしての新規二環式ピリジノン
JP2017500333A (ja) *	2013-12-20	2017-01-05	バイエル・ファルマ・アクティエンゲゼルシャフト	グルコース輸送阻害剤
EP3126361B1 (en)	2014-04-01	2019-11-06	Pfizer Inc	Chromene and 1,1a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators
CA2943011A1 (en) *	2014-04-04	2015-10-08	H. Lundbeck A/S	Halogenated quinazolin-thf-amines as pde1 inhibitors
AU2015245260A1 (en)	2014-04-10	2016-10-06	Pfizer Inc.	2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
WO2016012896A1 (en)	2014-07-24	2016-01-28	Pfizer Inc.	Pyrazolopyrimidine compounds
CR20170035A (es)	2014-08-06	2017-04-28	Pfizer	Compuestos de imidazopiridazina
ES2704740T3 (es) *	2014-12-08	2019-03-19	Janssen Sciences Ireland Uc	Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicación del virus sincicial respiratorio (vsr)
JP6628805B2 (ja)	2015-02-03	2020-01-15	ファイザー・インク	新規シクロプロパベンゾフラニルピリドピラジンジオン
BR112017026191B1 (pt)	2015-06-17	2023-10-10	Pfizer Inc	Compostos tricíclicos inibidores de fosfodiesterase, sua composição farmacêutica e uso dos mesmos
WO2017051294A1 (en)	2015-09-24	2017-03-30	Pfizer Inc.	N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
AU2016325665A1 (en)	2015-09-24	2018-03-08	Pfizer Inc.	N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3] thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl] amides
JP2018531924A (ja)	2015-09-24	2018-11-01	ファイザー・インク	テトラヒドロピラノ［３，４−ｄ］［１，３］オキサジン誘導体、およびｂａｃｅ阻害剤としてのその使用
US10323042B2 (en)	2016-02-23	2019-06-18	Pfizer Inc.	6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
MX386258B (es)	2016-07-01	2025-03-18	Pfizer	Derivados de 5,7-dihidro-pirrolo-piridina para tratar enfermedades neurologicas y neurodegenerativas
PL3642202T3 (pl)	2017-06-22	2023-03-13	Pfizer Inc.	Pochodne dihydropirolopirydyny
CA3094366A1 (en)	2018-03-23	2019-09-26	Pfizer Inc.	Piperazine azaspiro derivatives
CN118834214A (zh)	2018-06-04	2024-10-25	爱克思科技有限公司	作为腺苷受体拮抗剂的吡唑并嘧啶化合物
US10800767B2 (en) *	2018-08-24	2020-10-13	Terns, Inc.	Thyroid hormone receptor beta agonist compounds
CN121081472A (zh)	2018-12-13	2025-12-09	拓臻股份有限公司	一种THRβ受体激动剂化合物及其制备方法和用途
EP4017875A4 (en)	2019-08-23	2023-05-03	Terns Pharmaceuticals, Inc.	THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS
AU2020346057A1 (en)	2019-09-12	2022-04-21	Terns Pharmaceuticals, Inc.	Thyroid hormone receptor beta agonist compounds
WO2021154668A1 (en) *	2020-01-27	2021-08-05	Bristol-Myers Squibb Company	1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
WO2022182658A1 (en)	2021-02-23	2022-09-01	Hoth Therapeutics, Inc.	Use of aprepitant for treating alzheimer's disease
KR20240163659A (ko) *	2022-03-10	2024-11-19	세키스이가가쿠 고교가부시키가이샤	바이러스 감염 저지제, 바이러스 감염 저지 제품, 바이러스 감염 저지 도료 및 수지 조성물
WO2024118524A1 (en)	2022-11-28	2024-06-06	Cerevel Therapeutics, Llc	Azaindole compounds and their use as phosphodiesterase inhibitors
WO2024211898A1 (en)	2023-04-07	2024-10-10	Terns Pharmaceuticals, Inc.	Combination comprising a thrbeta agonist anda glp-1r agonist for use in treating a liver disorder or a cardiometabolic disease
WO2025145091A1 (en)	2023-12-29	2025-07-03	Pfizer Inc.	Crystalline forms of a muscarinic m4 receptor modulator and methods of treating diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW444018B (en) *	1992-12-17	2001-07-01	Pfizer	Pyrazolopyrimidines
EP1123296B1 (en) *	1998-10-23	2003-09-17	Pfizer Limited	PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
GB9823102D0 (en) *	1998-10-23	1998-12-16	Pfizer Ltd	Pharmaceutically active compounds
DE10031236A1 (de) *	2000-06-27	2002-01-10	Qiagen Gmbh	Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien
DE10031584A1 (de) *	2000-06-29	2002-01-10	Merck Patent Gmbh	5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
EP1348707B1 (en) *	2002-03-28	2010-08-25	Ustav Experimentalni Botaniky AV CR, v.v.i. (Institute of Experimental Botany Academy of Sciences of the Czech Republic, PRO)	Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy
EP1620437B1 (en) *	2003-04-29	2009-06-17	Pfizer Limited	5,7-diaminopyrazolo¬4,3-d pyrimidines useful in the traetment of hypertension

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Publication number	Publication date
WO2005049616A8 (en)	2006-06-01
NZ548097A (en)	2008-12-24
AP2227A (en)	2011-03-29
CN101362765A (zh)	2009-02-11
PA8617701A1 (es)	2005-08-04
IS8406A (is)	2006-04-10
CA2546987A1 (en)	2005-06-02
NL1027568A1 (nl)	2005-05-26
HK1099286A1 (en)	2007-08-10
JP2007512314A (ja)	2007-05-17
IL175433A (en)	2011-08-31
HK1128917A1 (en)	2009-11-13
SG133614A1 (en)	2007-07-30
NO336526B1 (no)	2015-09-21
CN101362764A (zh)	2009-02-11
TWI265031B (en)	2006-11-01
MXPA06005914A (es)	2006-06-27
NL1027568C2 (nl)	2005-11-30
CN1882591B (zh)	2011-08-10
DE602004029705D1 (de)	2010-12-02
EA200600677A1 (ru)	2006-12-29
ATE485297T1 (de)	2010-11-15
CN101362764B (zh)	2011-04-20
PE20051061A1 (es)	2005-12-12
UY28625A1 (es)	2005-06-30
GEP20084528B (en)	2008-11-10
SI1689751T1 (sl)	2011-01-31
CR8416A (es)	2006-11-15
WO2005049616A1 (en)	2005-06-02
BRPI0416869A (pt)	2007-03-27
CN101362765B (zh)	2011-02-02
KR100848216B1 (ko)	2008-07-24
AU2004290643A1 (en)	2005-06-02
GB0327319D0 (en)	2003-12-24
CN101647802A (zh)	2010-02-17
CA2546987C (en)	2009-05-12
JP4056015B2 (ja)	2008-03-05
HRP20100651T1 (hr)	2011-01-31
MA28172A1 (fr)	2006-09-01
KR20070026334A (ko)	2007-03-08
AR046711A1 (es)	2005-12-21
OA13289A (en)	2007-01-31
NO20062950L (no)	2006-08-23
ECSP066580A (es)	2006-12-20
EP1689751A1 (en)	2006-08-16
TW200520758A (en)	2005-07-01
AU2004290643B2 (en)	2008-08-07
ME01216B (me)	2013-03-20
RS51556B (sr)	2011-06-30
CN1882591A (zh)	2006-12-20
AP2006003591A0 (en)	2006-04-30
ES2351622T3 (es)	2011-02-08
MY140872A (en)	2010-01-29
DK1689751T3 (da)	2011-01-17
ZA200602899B (en)	2007-07-25
PT1689751E (pt)	2010-11-29
CY1110933T1 (el)	2015-06-10
KR20080052666A (ko)	2008-06-11
IL175433A0 (en)	2006-09-05
EP1689751B1 (en)	2010-10-20
EA011772B1 (ru)	2009-06-30
UA81994C2 (en)	2008-02-25
KR100893999B1 (ko)	2009-04-20
TNSN06154A1 (fr)	2007-11-15

Publication	Publication Date	Title
IL175433A0 (en)	2006-09-05	5,7 diaminopyrazolo [4,3-d] pyrimidines with pde-5 inhibiting activity
IL182099A0 (en)	2007-07-24	Piperidinylamino-thieno[2,3-d] pyrimidine compounds
EP1599482A4 (en)	2008-10-01	PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
PL376916A1 (pl)	2006-01-09	Pochodne pirymido [4,5-d] pirymidyny o działaniu przeciwrakowym
TWI365189B (en)	2012-06-01	Novel pyrrolo[3,2-d]pyrimidin-4-one derivatives
EG24843A (en)	2010-10-13	Herbicidal pyrimidines
IL159832A0 (en)	2004-06-20	4-amino-6-phenyl-pyrrolo[2,3-d] pyrimidine derivatives
ZA200604960B (en)	2007-11-28	Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-A]pyrimidin-6-onederivatives
EP1653969A4 (en)	2006-12-20	PYRROLO 1,2-B PYRIDAZINE DERIVATIVES
AP2002002543A0 (en)	2002-06-30	Pyrrolo Ä2,3-dÜ pyrimidine compounds
IL170680A0 (en)	2009-02-11	8 - SUBSTITUTED - 6,7,8,9 -TETRAHYDROPYRIMIDO [1,2-a] PYRIMIDIN - 4 - ONE DERIVATIVES
ZA200507192B (en)	2007-03-28	Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido [1,2-A] pyrimidin-4-one derivatives
PL353366A1 (pl)	2003-11-17	Pirozolo[4,3-d]pirymidyny
IL172098A0 (en)	2009-02-11	Triazolopyrimidines
PL358551A1 (pl)	2004-08-09	5-Aminoalkilopirazolo [4,3-D] pirymidyny
AP2157A (en)	2010-09-13	2-substituted pyrimidines.
PL372989A1 (pl)	2005-08-08	Triazolopirymidyny
IL172359A0 (en)	2009-02-11	Triazolopyrimidines
MXPA03004498A (es)	2003-09-05	Uso de pirazolo (4,3-d)pirimidinas.
GB0323137D0 (en)	2003-11-05	2,4,6- Trisubstituted pyrimidines and their different uses
IL172845A0 (en)	2006-06-11	2-substituted pyrimidines
TWI372760B (en)	2012-09-21	A pyrazolo[1,5-a]pyrimidine compound
ZA200600471B (en)	2007-04-25	7-substituted 3-nitro-pyrazolo[1,5-A] pyrimidines
TJ431B (en)	2007-06-05	2-Brom-7-methil-5-oxo-5h-1,3,4-thyodyazol-(3,2-a)pyrimidin, has antibacterial activity
HK1083692A (en)	2006-07-07	7-substituted 3-nitro-pyrazolo [1,5-a] pyrimidines