PL1696904T3 - Zastosowanie rotygotyny do leczenia lub do prewencji dopaminergicznej utraty neuronów - Google Patents
Zastosowanie rotygotyny do leczenia lub do prewencji dopaminergicznej utraty neuronówInfo
- Publication number
- PL1696904T3 PL1696904T3 PL04804249T PL04804249T PL1696904T3 PL 1696904 T3 PL1696904 T3 PL 1696904T3 PL 04804249 T PL04804249 T PL 04804249T PL 04804249 T PL04804249 T PL 04804249T PL 1696904 T3 PL1696904 T3 PL 1696904T3
- Authority
- PL
- Poland
- Prior art keywords
- rotigotine
- treatment
- prevention
- neurone loss
- dopaminergic neurone
- Prior art date
Links
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 title abstract 3
- 229960003179 rotigotine Drugs 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 2
- 230000003291 dopaminomimetic effect Effects 0.000 title 1
- 230000004770 neurodegeneration Effects 0.000 title 1
- 230000006378 damage Effects 0.000 abstract 2
- 210000004002 dopaminergic cell Anatomy 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10361259A DE10361259A1 (de) | 2003-12-24 | 2003-12-24 | Verwendung von Rotigotine in einem Frühstadium von Morbus Parkinson zur Prävention des weiteren Neuronenverlustes |
| PCT/EP2004/014655 WO2005063237A1 (de) | 2003-12-24 | 2004-12-23 | Verwendung von rotigotin zur behandlung oder zur prävention des dopaminergen neuronenverlustes |
| EP04804249A EP1696904B1 (de) | 2003-12-24 | 2004-12-23 | Verwendung von rotigotin zur behandlung oder zur prävention des dopaminergen neuronenverlustes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1696904T3 true PL1696904T3 (pl) | 2012-04-30 |
Family
ID=34706587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04804249T PL1696904T3 (pl) | 2003-12-24 | 2004-12-23 | Zastosowanie rotygotyny do leczenia lub do prewencji dopaminergicznej utraty neuronów |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1696904B1 (pl) |
| JP (1) | JP5032125B2 (pl) |
| KR (1) | KR101296561B1 (pl) |
| CN (1) | CN1897935B (pl) |
| AT (1) | ATE533484T1 (pl) |
| AU (1) | AU2004308648B2 (pl) |
| BR (1) | BRPI0418195A (pl) |
| CA (1) | CA2547645C (pl) |
| DE (1) | DE10361259A1 (pl) |
| DK (1) | DK1696904T3 (pl) |
| EA (1) | EA014418B1 (pl) |
| ES (1) | ES2376881T3 (pl) |
| IL (1) | IL175891A0 (pl) |
| IS (1) | IS8493A (pl) |
| NO (1) | NO20063276L (pl) |
| NZ (1) | NZ547841A (pl) |
| PL (1) | PL1696904T3 (pl) |
| UA (1) | UA85858C2 (pl) |
| WO (1) | WO2005063237A1 (pl) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10361258A1 (de) * | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
| DE102004014841B4 (de) * | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
| CN103278641A (zh) * | 2005-10-21 | 2013-09-04 | 株式会社芳珂 | 特应性皮炎标记物及其利用技术 |
| CN101147739B (zh) | 2007-07-06 | 2010-12-08 | 北京康倍得医药技术开发有限公司 | 含罗替戈汀的组合物及其制药用途以及含该组合物的透皮贴剂 |
| PL2215072T3 (pl) | 2007-11-28 | 2015-12-31 | Ucb Pharma Gmbh | Polimorficzna postać rotygotyny |
| EP2201941A1 (de) | 2008-12-29 | 2010-06-30 | UCB Pharma GmbH | Pflaster-Herstellungstechnologie |
| EP2281559A1 (en) | 2009-06-26 | 2011-02-09 | UCB Pharma GmbH | Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis |
| WO2011076879A1 (en) | 2009-12-22 | 2011-06-30 | Ucb Pharma Gmbh | Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine |
| EP2531486B1 (en) | 2010-02-05 | 2017-06-21 | UCB Biopharma SPRL | Novel process for the preparation of nitrogen substituted aminotetralins derivatives |
| CA2798815C (en) | 2010-06-25 | 2017-01-03 | Ucb Pharma Gmbh | Novel process for the preparation of nitrogen substituted aminotetralins derivatives |
| CN102379873B (zh) * | 2010-09-06 | 2013-10-30 | 四川大学华西医院 | 一种急性全身性猴帕金森病模型及其药物筛选方法 |
| EP2559435A1 (en) | 2011-08-19 | 2013-02-20 | UCB Pharma GmbH | Rotigotine in the treatment of hemispatial neglect, stroke and deficits following stroke |
| US9303038B2 (en) | 2011-09-06 | 2016-04-05 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological diseases |
| WO2013075822A1 (en) | 2011-11-22 | 2013-05-30 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermal therapeutic system (tts) with rotigotine |
| DE102012013421A1 (de) | 2012-07-03 | 2014-01-09 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System (TTS) mit Rotigotin |
| DE102012013439A1 (de) | 2012-07-03 | 2014-01-23 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System umfassend Rotigotin und Kristallisationsinhibitor |
| JP2015522531A (ja) | 2012-05-07 | 2015-08-06 | セリックスビオ プライヴェート リミテッド | 神経筋疾患及び神経変性疾患の治療のための組成物及び方法 |
| WO2013167990A1 (en) | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of depression |
| US9738631B2 (en) | 2012-05-07 | 2017-08-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological disorders |
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| US9522884B2 (en) | 2012-05-08 | 2016-12-20 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic disorders |
| US9266823B2 (en) | 2012-05-08 | 2016-02-23 | Cellix Bio Private Limited | Compositions and methods for the treatment of parkinson's disease |
| US9434704B2 (en) | 2012-05-08 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological degenerative disorders |
| US9315461B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurologic diseases |
| US9499527B2 (en) | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
| US9321775B2 (en) | 2012-05-10 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of moderate to severe pain |
| SG11201407318UA (en) | 2012-05-10 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of metabolic syndrome |
| WO2013168011A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of chronic pain |
| US9242939B2 (en) | 2012-05-10 | 2016-01-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of respiratory disorders |
| WO2013168004A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of fibromyalgia pain |
| WO2013168002A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurological conditions |
| US9339484B2 (en) | 2012-05-10 | 2016-05-17 | Cellix Bio Private Limited | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
| US9499526B2 (en) | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurologic diseases |
| WO2013167997A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic syndrome |
| WO2013168000A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of severe pain |
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| US9498461B2 (en) | 2012-05-23 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
| WO2013175344A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of periodontitis and rheumatoid arthritis |
| AU2013264820A1 (en) | 2012-05-23 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for treatment of mucositis |
| AU2013264896A1 (en) | 2012-05-23 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
| WO2013175347A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of respiratory disorders |
| WO2013175376A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of local pain |
| US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
| WO2014020480A2 (en) | 2012-08-03 | 2014-02-06 | Mahesh Kandula | Compositions and methods for the treatment migraine and neurologic diseases |
| US9624168B2 (en) | 2012-09-06 | 2017-04-18 | Cellix Bio Private Limited | Compositions and methods for the treatment inflammation and lipid disorders |
| CA2873029A1 (en) | 2012-09-08 | 2014-03-13 | Cellixbio Private Limited | Compositions and methods for the treatment of inflammation and lipid disorders |
| TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀(Rotigotine)之多天式貼片 |
| US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
| SG11201509782TA (en) | 2013-06-04 | 2015-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of diabetes and pre-diabetes |
| CN105358139B (zh) | 2013-07-03 | 2020-10-16 | Lts罗曼治疗方法有限公司 | 具有电子元件的经皮治疗系统 |
| US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
| ES2954087T3 (es) | 2014-05-20 | 2023-11-20 | Lts Lohmann Therapie Systeme Ag | Sistema de administración transdérmica que incluye un mediador de interfase |
| CN106456567A (zh) | 2014-05-20 | 2017-02-22 | Lts勒曼治疗系统股份公司 | 在经皮递送系统中调节活性剂释放的方法 |
| JP6573913B2 (ja) | 2014-05-20 | 2019-09-11 | エルテーエス ローマン テラピー−ジステーメ アーゲー | ロチゴチンを含む経皮送達システム |
| EP3240779B1 (en) | 2014-09-26 | 2020-10-28 | Cellixbio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
| ES2799309T3 (es) | 2014-09-29 | 2020-12-16 | Cellix Bio Private Ltd | Compuestos y composiciones para el tratamiento de esclerosis múltiple |
| CA2965449C (en) | 2014-10-27 | 2020-11-10 | Cellix Bio Private Limited | Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis |
| US9175008B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Prodrugs of anti-platelet agents |
| US9284287B1 (en) | 2014-11-05 | 2016-03-15 | Cellix Bio Private Limited | Compositions and methods for the suppression of carbonic anhydrase activity |
| US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
| US10208014B2 (en) | 2014-11-05 | 2019-02-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological disorders |
| US9150557B1 (en) | 2014-11-05 | 2015-10-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of hyperglycemia |
| US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
| US9321716B1 (en) | 2014-11-05 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| CN107207411A (zh) | 2014-12-01 | 2017-09-26 | 塞尔利克斯生物私人有限公司 | 用于治疗多发性硬化的组合物和方法 |
| US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
| ES2905771T3 (es) | 2015-01-06 | 2022-04-12 | Cellix Bio Private Ltd | Composiciones y procedimientos para el tratamiento de la inflamación y del dolor |
| AU2016415408B2 (en) * | 2016-07-21 | 2019-04-11 | Geneora Pharma (Shijiazhuang) Co., Ltd. | Rotigotine behenate, and preparation method and use thereof |
| DK3854388T3 (da) | 2020-01-24 | 2023-11-27 | Luye Pharma Switzerland Ag | Transdermalt terapeutisk system omfattende rotigotin og mindst et ikke-aminresistent silikoneklæbestof |
| CN112014193B (zh) * | 2020-07-24 | 2021-06-15 | 武汉大学中南医院 | 一种新的fj染色方法和装置 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4564628A (en) * | 1983-01-03 | 1986-01-14 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
| CO5111024A1 (es) * | 1998-12-29 | 2001-12-26 | Kimberly Clark Co | Composiciones de recubrimientos de polimero disparado por ion sobre peliculas de polimero sensibles al agua |
| SE9904723D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| WO2002031499A1 (en) * | 2000-10-09 | 2002-04-18 | Unisearch Limited | Detection of neurodegenerative disorders |
| PT1256340E (pt) * | 2001-05-08 | 2003-12-31 | Sanol Arznei Schwarz Gmbh | Sistema terapeutico transdermico aperfeicoado para o tratamento da doenca de parkinson |
| ES2204780T3 (es) * | 2001-05-08 | 2004-05-01 | Schwarz Pharma Ag | Sistema terapeutico transdermico para la enfermedad de parkinson que induce altos niveles de rotigotina en plasma. |
| FR2828212B1 (fr) * | 2001-08-03 | 2003-10-31 | Aventis Pharma Sa | Methodes de diagnostic et de pronostic de la maladie de parkinson |
| EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
| DE10361258A1 (de) * | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
| DE102004014841B4 (de) * | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
-
2003
- 2003-12-24 DE DE10361259A patent/DE10361259A1/de not_active Withdrawn
-
2004
- 2004-12-23 WO PCT/EP2004/014655 patent/WO2005063237A1/de not_active Ceased
- 2004-12-23 NZ NZ547841A patent/NZ547841A/en not_active IP Right Cessation
- 2004-12-23 AT AT04804249T patent/ATE533484T1/de active
- 2004-12-23 CA CA2547645A patent/CA2547645C/en not_active Expired - Fee Related
- 2004-12-23 PL PL04804249T patent/PL1696904T3/pl unknown
- 2004-12-23 CN CN2004800386660A patent/CN1897935B/zh not_active Expired - Fee Related
- 2004-12-23 AU AU2004308648A patent/AU2004308648B2/en not_active Ceased
- 2004-12-23 ES ES04804249T patent/ES2376881T3/es not_active Expired - Lifetime
- 2004-12-23 KR KR1020067012204A patent/KR101296561B1/ko not_active Expired - Fee Related
- 2004-12-23 UA UAA200606332A patent/UA85858C2/uk unknown
- 2004-12-23 DK DK04804249.3T patent/DK1696904T3/da active
- 2004-12-23 JP JP2006546071A patent/JP5032125B2/ja not_active Expired - Fee Related
- 2004-12-23 EP EP04804249A patent/EP1696904B1/de not_active Revoked
- 2004-12-23 BR BRPI0418195-6A patent/BRPI0418195A/pt not_active IP Right Cessation
- 2004-12-23 EA EA200601227A patent/EA014418B1/ru not_active IP Right Cessation
-
2006
- 2006-05-24 IL IL175891A patent/IL175891A0/en unknown
- 2006-05-31 IS IS8493A patent/IS8493A/is unknown
- 2006-07-14 NO NO20063276A patent/NO20063276L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1696904B1 (de) | 2011-11-16 |
| JP2007516996A (ja) | 2007-06-28 |
| NZ547841A (en) | 2011-02-25 |
| IS8493A (is) | 2006-05-31 |
| HK1094538A1 (en) | 2007-04-04 |
| JP5032125B2 (ja) | 2012-09-26 |
| ATE533484T1 (de) | 2011-12-15 |
| ES2376881T3 (es) | 2012-03-20 |
| CN1897935B (zh) | 2010-05-26 |
| KR101296561B1 (ko) | 2013-08-13 |
| EA014418B1 (ru) | 2010-12-30 |
| DE10361259A1 (de) | 2005-07-28 |
| UA85858C2 (uk) | 2009-03-10 |
| IL175891A0 (en) | 2006-10-05 |
| KR20060109952A (ko) | 2006-10-23 |
| WO2005063237A1 (de) | 2005-07-14 |
| AU2004308648A1 (en) | 2005-07-14 |
| CA2547645C (en) | 2013-07-16 |
| EA200601227A1 (ru) | 2006-12-29 |
| CA2547645A1 (en) | 2005-07-14 |
| DK1696904T3 (da) | 2012-02-13 |
| BRPI0418195A (pt) | 2007-06-19 |
| EP1696904A1 (de) | 2006-09-06 |
| AU2004308648B2 (en) | 2010-12-16 |
| NO20063276L (no) | 2006-08-30 |
| CN1897935A (zh) | 2007-01-17 |
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