PL1699459T3 - Sposób leczenia stwardnienia rozsianego - Google Patents

Sposób leczenia stwardnienia rozsianego

Info

Publication number: PL1699459T3
Authority: PL; Poland
Prior art keywords: multiple sclerosis; meca; treatment; a3rag; apnea
Prior art date: 2003-12-29

Application number

PL04806691T

Other languages

English (en)

Inventor

Pnina Fishman

Yehuda Sara Bar

Lea Madi

Original Assignee

Can Fite Biopharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-29

Filing date

2004-12-23

Publication date

2007-12-31

2004-12-23 Application filed by Can Fite Biopharma Ltd filed Critical Can Fite Biopharma Ltd

2007-12-31 Publication of PL1699459T3 publication Critical patent/PL1699459T3/pl

Links

201000006417 multiple sclerosis Diseases 0.000 title abstract 2
229940122614 Adenosine receptor agonist Drugs 0.000 abstract 3
239000003379 purinergic P1 receptor agonist Substances 0.000 abstract 3
IPSYPUKKXMNCNQ-PFHKOEEOSA-N (2s,3s,4r,5r)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-n-methyloxolane-2-carboxamide Chemical compound O[C@@H]1[C@H](O)[C@@H](C(=O)NC)O[C@H]1N1C2=NC(Cl)=NC(NCC=3C=C(I)C=CC=3)=C2N=C1 IPSYPUKKXMNCNQ-PFHKOEEOSA-N 0.000 abstract 1
LDYMCRRFCMRFKB-MOROJQBDSA-N (2s,3s,4r,5r)-5-[6-[(4-aminophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-n-methyloxolane-2-carboxamide Chemical compound O[C@@H]1[C@H](O)[C@@H](C(=O)NC)O[C@H]1N1C2=NC=NC(NCC=3C=CC(N)=CC=3)=C2N=C1 LDYMCRRFCMRFKB-MOROJQBDSA-N 0.000 abstract 1
HUJXGQILHAUCCV-MOROJQBDSA-N 3-iodobenzyl-5'-N-methylcarboxamidoadenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](C(=O)NC)O[C@H]1N1C2=NC=NC(NCC=3C=C(I)C=CC=3)=C2N=C1 HUJXGQILHAUCCV-MOROJQBDSA-N 0.000 abstract 1
101150046889 ADORA3 gene Proteins 0.000 abstract 1
208000008784 apnea Diseases 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preliminary Treatment Of Fibers (AREA)
Spinning Or Twisting Of Yarns (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Treatment Of Fiber Materials (AREA)
Sewing Machines And Sewing (AREA)
Steroid Compounds (AREA)

PL04806691T 2003-12-29 2004-12-23 Sposób leczenia stwardnienia rozsianego PL1699459T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US53271203P	2003-12-29	2003-12-29
PCT/IL2004/001160 WO2005063246A1 (en)	2003-12-29	2004-12-23	Method for treatment of multiple sclerosis
EP04806691A EP1699459B1 (en)	2003-12-29	2004-12-23	Method for treatment of multiple sclerosis

Publications (1)

Publication Number	Publication Date
PL1699459T3 true PL1699459T3 (pl)	2007-12-31

Family

ID=34738826

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04806691T PL1699459T3 (pl)	2003-12-29	2004-12-23	Sposób leczenia stwardnienia rozsianego

Country Status (10)

Country	Link
US (1)	US7465715B2 (pl)
EP (1)	EP1699459B1 (pl)
JP (1)	JP2007517019A (pl)
CN (1)	CN100423723C (pl)
AT (1)	ATE363907T1 (pl)
DE (1)	DE602004006895T2 (pl)
DK (1)	DK1699459T3 (pl)
ES (1)	ES2287804T3 (pl)
PL (1)	PL1699459T3 (pl)
WO (1)	WO2005063246A1 (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GT200500281A (es) *	2004-10-22	2006-04-24	Novartis Ag	Compuestos organicos.
WO2006059327A1 (en)	2004-12-02	2006-06-08	Can-Fite Biopharma Ltd.	A biological marker for inflammation
GB0500785D0 (en)	2005-01-14	2005-02-23	Novartis Ag	Organic compounds
JP5414277B2 (ja)	2006-01-26	2014-02-12	ザ・ガバメント・オブ・ジ・ユナイテッド・ステイツ・オブ・アメリカ・レプリゼンテッド・バイ・ザ・セクレタリー・ディパートメント・オブ・ヘルス・アンド・ヒューマン・サービシーズ	Ａ３アデノシンレセプタ・アロステリックモジュレータ
GB0607944D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607950D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
PE20080361A1 (es)	2006-04-21	2008-06-03	Novartis Ag	Compuestos derivados de purina como activadores del receptor de adenosina a2a
GB0607953D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
EP1889846A1 (en)	2006-07-13	2008-02-20	Novartis AG	Purine derivatives as A2a agonists
EP1903044A1 (en)	2006-09-14	2008-03-26	Novartis AG	Adenosine Derivatives as A2A Receptor Agonists
WO2008055874A1 (en) *	2006-11-10	2008-05-15	Novartis Ag	Cyclopentene diol monoacetate derivatives
US9102698B2 (en)	2007-03-14	2015-08-11	Can-Fite Biopharma Ltd.	Process for the synthesis of IB-MECA
US20090088403A1 (en) *	2007-05-07	2009-04-02	Randy Blakely	A3 adenosine receptors as targets for the modulation of central serotonergic signaling
US9199102B2 (en)	2009-07-21	2015-12-01	Oradin Pharmaceutical Ltd.	A3 adenosine receptor ligands for modulation of pigmentation
IL200753A (en)	2009-09-06	2015-06-30	Can Fite Biopharma Ltd	Pharmaceutical preparation containing ib – meca for the treatment of psoriasis
US20140194308A1 (en) *	2011-04-22	2014-07-10	Kyoto University	Use of myelin basic protein as a novel genetic factor for rheumatoid arthritis
SG10201610936RA (en)	2011-12-22	2017-02-27	Alios Biopharma Inc	Substituted nucleosides, nucleotides and analogs thereof
EP2806878A1 (en) *	2012-01-23	2014-12-03	Can-Fite Biopharma Ltd.	Treatment of liver conditions
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
MX391725B (es)	2016-04-21	2025-03-21	Astrocyte Pharmaceuticals Inc	Compuestos y metodos para tratamiento de afecciones neurologicas y cardiovasculares.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5310732A (en)	1986-02-03	1994-05-10	The Scripps Research Institute	2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
AU7331094A (en) *	1993-07-13	1995-02-13	United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The	A3 adenosine receptor agonists
WO1995011681A1 (en)	1993-10-29	1995-05-04	Merck & Co., Inc.	Human adenosine receptor antagonists
WO1997033879A1 (en) *	1996-03-15	1997-09-18	Merck & Co., Inc.	Compounds and methods for selectively inhibiting activation of the human a3 adenosine receptor
YU44900A (sh) *	1998-01-31	2003-01-31	Glaxo Group Limited	Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
US6117878A (en) *	1998-02-24	2000-09-12	University Of Virginia	8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors
US6303619B1 (en) *	1998-03-12	2001-10-16	University Of Virginia	Meta-substituted acidic 8-phenylxanthine antagonists of A3 human adenosine receptors
US7160890B2 (en)	1999-12-02	2007-01-09	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
CZ294538B6 (cs) *	2002-12-30	2005-01-12	Ústav Experimentální Botaniky Akademie Vědčeské Re	Substituční deriváty N6-benzyladenosinu, způsob jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující

2004
- 2004-12-23 PL PL04806691T patent/PL1699459T3/pl unknown
- 2004-12-23 US US10/521,193 patent/US7465715B2/en not_active Expired - Fee Related
- 2004-12-23 DE DE602004006895T patent/DE602004006895T2/de not_active Expired - Fee Related
- 2004-12-23 DK DK04806691T patent/DK1699459T3/da active
- 2004-12-23 EP EP04806691A patent/EP1699459B1/en not_active Expired - Lifetime
- 2004-12-23 JP JP2006546475A patent/JP2007517019A/ja not_active Withdrawn
- 2004-12-23 AT AT04806691T patent/ATE363907T1/de not_active IP Right Cessation
- 2004-12-23 CN CNB2004800393344A patent/CN100423723C/zh not_active Expired - Fee Related
- 2004-12-23 WO PCT/IL2004/001160 patent/WO2005063246A1/en not_active Ceased
- 2004-12-23 ES ES04806691T patent/ES2287804T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1699459B1 (en)	2007-06-06
CN1901915A (zh)	2007-01-24
EP1699459A1 (en)	2006-09-13
JP2007517019A (ja)	2007-06-28
CN100423723C (zh)	2008-10-08
US7465715B2 (en)	2008-12-16
DE602004006895T2 (de)	2008-01-31
ES2287804T3 (es)	2007-12-16
DE602004006895D1 (de)	2007-07-19
DK1699459T3 (da)	2007-10-08
US20060142237A1 (en)	2006-06-29
WO2005063246A1 (en)	2005-07-14
ATE363907T1 (de)	2007-06-15

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PL1699459T3 (pl)	2007-12-31	Sposób leczenia stwardnienia rozsianego
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