PL1708998T3 - Pochodne indolo-alaninowe jako selektywni agoniści S1P4 - Google Patents

Pochodne indolo-alaninowe jako selektywni agoniści S1P4

Info

Publication number: PL1708998T3
Authority: PL; Poland
Prior art keywords: agonists; selective; indol; 6alkyl; alanine derivatives
Prior art date: 2004-01-21

Application number

PL05706935T

Other languages

English (en)

Inventor

Kamal Azzaoui

Rochdi Bouhelal

Peter Buehlmayer

Danilo Guerini

Manuel Koller

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-21

Filing date

2005-01-20

Publication date

2009-04-30

2005-01-20 Application filed by Novartis Ag filed Critical Novartis Ag

2009-04-30 Publication of PL1708998T3 publication Critical patent/PL1708998T3/pl

Links

239000000556 agonist Substances 0.000 title abstract 2
102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 6
108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 6
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Oncology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Neurology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Virology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)

PL05706935T 2004-01-21 2005-01-20 Pochodne indolo-alaninowe jako selektywni agoniści S1P4 PL1708998T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0401332.2A GB0401332D0 (en)	2004-01-21	2004-01-21	Organic compounds
EP05706935A EP1708998B1 (en)	2004-01-21	2005-01-20	Indol-alanine derivatives as selective s1p4-agonists
PCT/EP2005/000541 WO2005070886A1 (en)	2004-01-21	2005-01-20	Indol-alanine derivatives as selective s1p4-agonists

Publications (1)

Publication Number	Publication Date
PL1708998T3 true PL1708998T3 (pl)	2009-04-30

Family

ID=31971237

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL05706935T PL1708998T3 (pl)	2004-01-21	2005-01-20	Pochodne indolo-alaninowe jako selektywni agoniści S1P4

Country Status (16)

Country	Link
US (1)	US7754896B2 (pl)
EP (1)	EP1708998B1 (pl)
JP (1)	JP2007518766A (pl)
KR (1)	KR20060130122A (pl)
CN (1)	CN1910148A (pl)
AT (1)	ATE411289T1 (pl)
AU (1)	AU2005206289B2 (pl)
BR (1)	BRPI0506974A (pl)
CA (1)	CA2552781A1 (pl)
DE (1)	DE602005010388D1 (pl)
ES (1)	ES2315838T3 (pl)
GB (1)	GB0401332D0 (pl)
PL (1)	PL1708998T3 (pl)
PT (1)	PT1708998E (pl)
RU (1)	RU2373195C2 (pl)
WO (1)	WO2005070886A1 (pl)

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Publication number	Priority date	Publication date	Assignee	Title
ATE502630T1 (de)	2004-07-16	2011-04-15	Kyorin Seiyaku Kk	Verfahren zur effektiven anwendung eines medikaments und verfahren zur prävention von nebenwirkungen
AU2005292984B2 (en)	2004-10-12	2011-01-20	Kyorin Pharmaceutical Co., Ltd.	Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride or hydrate thereof and intermediate for the same
RU2421214C2 (ru) *	2005-10-07	2011-06-20	Киорин Фармасьютикал Ко., Лтд.	Терапевтическое средство для лечения гепатита и способ лечения гепатита
TWI389683B (zh) *	2006-02-06	2013-03-21	Kyorin Seiyaku Kk	A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
US8232319B2 (en)	2006-08-08	2012-07-31	Kyorin Pharmaceutical Co., Ltd.	Amino phosphate derivative and S1P receptor modulator having same as an active ingredient
JP5140593B2 (ja) *	2006-08-08	2013-02-06	杏林製薬株式会社	アミノアルコール誘導体及びそれらを有効成分とする免疫抑制剤
TW200946105A (en)	2008-02-07	2009-11-16	Kyorin Seiyaku Kk	Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
JP2011514385A (ja) *	2008-03-17	2011-05-06	アラーガン、インコーポレイテッド	炎症を処置するためのｓ１ｐ３受容体阻害剤
HRP20161133T1 (hr)	2008-07-23	2016-12-02	Arena Pharmaceuticals, Inc.	DERIVATI SUSPSTITUIRANE 1,2,3,4-TETRAHIDROCIKLOPENTA[b]INDOL-3-IL-OCTENE KISELINE KORISNI U LIJEČENJU AUTOIMUNIH I UPALNIH POREMEĆAJA
CN105816453B (zh)	2008-08-27	2021-03-05	艾尼纳制药公司	用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物
UA107360C2 (en)	2009-08-05	2014-12-25	Biogen Idec Inc	Bicyclic aryl sphingosine 1-phosphate analogs
CA2786994C (en) *	2010-01-27	2018-01-16	Arena Pharmaceuticals, Inc.	Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
CN105503882B (zh)	2010-03-03	2019-07-05	艾尼纳制药公司	制备s1p1受体调节剂及其晶体形式的方法
TW201643169A (zh)	2010-07-09	2016-12-16	艾伯維股份有限公司	作為s1p調節劑的螺-哌啶衍生物
TWI522361B (zh)	2010-07-09	2016-02-21	艾伯維公司	作為s1p調節劑的稠合雜環衍生物
USRE48301E1 (en)	2010-07-09	2020-11-10	Abbvie B.V.	Fused heterocyclic derivatives as S1P modulators
TW201206893A (en)	2010-07-09	2012-02-16	Abbott Healthcare Products Bv	Bisaryl (thio) morpholine derivatives as S1P modulators
PT2672823T (pt) *	2011-02-07	2016-11-21	Biogen Ma Inc	Agentes que modulam s1p
AU2016205361C1 (en)	2015-01-06	2021-04-08	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the S1P1 receptor
PL3310760T3 (pl)	2015-06-22	2023-03-06	Arena Pharmaceuticals, Inc.	Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
JP2020507610A (ja)	2017-02-16	2020-03-12	アリーナファーマシューティカルズ，インコーポレイテッド	腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法
KR20190116416A (ko)	2017-02-16	2019-10-14	아레나 파마슈티칼스, 인크.	원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
AU2019280822A1 (en)	2018-06-06	2021-01-07	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the S1P1 receptor
EP3847158A1 (en)	2018-09-06	2021-07-14	Arena Pharmaceuticals, Inc.	Compounds useful in the treatment of autoimmune and inflammatory disorders
US11466027B2 (en)	2019-07-03	2022-10-11	H. Lundbeck A/S	Modulators of the NMDA receptor
US11358971B2 (en)	2019-07-03	2022-06-14	H. Lundbeck A/S	Prodrugs of modulators of the NMDA receptor
US11535632B2 (en)	2019-10-31	2022-12-27	ESCAPE Bio, Inc.	Solid forms of an S1P-receptor modulator

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Publication number	Priority date	Publication date	Assignee	Title
PT708085E (pt) *	1994-10-19	2002-11-29	Novartis Ag	Eteres antivirais de isosteros de substrato de aspartato protease
EP1383778B1 (en) *	2001-01-30	2009-10-21	University Of Virginia Patent Foundation	Agonists and antagonists of sphingosine-1-phosphate receptors
ATE441654T1 (de) *	2002-01-18	2009-09-15	Merck & Co Inc	Edg-rezeptoragonisten
US20050070506A1 (en) *	2002-01-18	2005-03-31	Doherty George A.	Selective s1p1/edg1 receptor agonists

2004
- 2004-01-21 GB GBGB0401332.2A patent/GB0401332D0/en not_active Ceased
2005
- 2005-01-20 DE DE602005010388T patent/DE602005010388D1/de not_active Expired - Fee Related
- 2005-01-20 JP JP2006550040A patent/JP2007518766A/ja active Pending
- 2005-01-20 AU AU2005206289A patent/AU2005206289B2/en not_active Ceased
- 2005-01-20 EP EP05706935A patent/EP1708998B1/en not_active Expired - Lifetime
- 2005-01-20 CN CNA2005800026852A patent/CN1910148A/zh active Pending
- 2005-01-20 KR KR1020067014641A patent/KR20060130122A/ko not_active Withdrawn
- 2005-01-20 US US10/586,422 patent/US7754896B2/en not_active Expired - Fee Related
- 2005-01-20 CA CA002552781A patent/CA2552781A1/en not_active Abandoned
- 2005-01-20 WO PCT/EP2005/000541 patent/WO2005070886A1/en not_active Ceased
- 2005-01-20 PL PL05706935T patent/PL1708998T3/pl unknown
- 2005-01-20 BR BRPI0506974-2A patent/BRPI0506974A/pt not_active IP Right Cessation
- 2005-01-20 AT AT05706935T patent/ATE411289T1/de not_active IP Right Cessation
- 2005-01-20 PT PT05706935T patent/PT1708998E/pt unknown
- 2005-01-20 RU RU2006130001/04A patent/RU2373195C2/ru not_active IP Right Cessation
- 2005-01-20 ES ES05706935T patent/ES2315838T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
BRPI0506974A (pt)	2007-07-03
RU2373195C2 (ru)	2009-11-20
ATE411289T1 (de)	2008-10-15
ES2315838T3 (es)	2009-04-01
WO2005070886A1 (en)	2005-08-04
EP1708998A1 (en)	2006-10-11
RU2006130001A (ru)	2008-02-27
GB0401332D0 (en)	2004-02-25
DE602005010388D1 (de)	2008-11-27
CN1910148A (zh)	2007-02-07
KR20060130122A (ko)	2006-12-18
US7754896B2 (en)	2010-07-13
PT1708998E (pt)	2009-01-14
EP1708998B1 (en)	2008-10-15
AU2005206289A1 (en)	2005-08-04
JP2007518766A (ja)	2007-07-12
US20090023797A1 (en)	2009-01-22
CA2552781A1 (en)	2005-08-04
AU2005206289B2 (en)	2008-12-04

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