PL1819729T3 - Sposób wytwarzania karboksy-terminalnych amidowanych peptydów - Google Patents

Sposób wytwarzania karboksy-terminalnych amidowanych peptydów

Info

Publication number: PL1819729T3
Authority: PL; Poland
Prior art keywords: terminal; amidified; peptides; carboxy; producing carboxy
Prior art date: 2004-12-01

Application number

PL05850211T

Other languages

English (en)

Inventor

Paul Habermann

Heinrich Decker

Claus Lattemann

Oliver Maneg

Christophe Salagnad

Frank Zocher

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-01

Filing date

2005-11-18

Publication date

2009-09-30

2005-11-18 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2009-09-30 Publication of PL1819729T3 publication Critical patent/PL1819729T3/pl

Links

238000004519 manufacturing process Methods 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
210000004899 c-terminal region Anatomy 0.000 abstract 2
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 1
102400000322 Glucagon-like peptide 1 Human genes 0.000 abstract 1
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
229940127557 pharmaceutical product Drugs 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Toxicology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Vascular Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

PL05850211T 2004-12-01 2005-11-18 Sposób wytwarzania karboksy-terminalnych amidowanych peptydów PL1819729T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102004058306A DE102004058306A1 (de)	2004-12-01	2004-12-01	Verfahren zur Herstellung von Carboxy-terminal amidierten Peptiden
PCT/EP2005/012365 WO2006058620A2 (de)	2004-12-01	2005-11-18	Verfahren zur herstellung von carboxy-terminal amidierten peptiden
EP05850211A EP1819729B8 (de)	2004-12-01	2005-11-18	Verfahren zur herstellung von carboxy-terminal amidierten peptiden

Publications (1)

Publication Number	Publication Date
PL1819729T3 true PL1819729T3 (pl)	2009-09-30

Family

ID=36001270

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL05850211T PL1819729T3 (pl)	2004-12-01	2005-11-18	Sposób wytwarzania karboksy-terminalnych amidowanych peptydów

Country Status (19)

Country	Link
US (1)	US7939293B2 (pl)
EP (1)	EP1819729B8 (pl)
JP (1)	JP4857279B2 (pl)
KR (1)	KR101299417B1 (pl)
CN (1)	CN101068833B (pl)
AT (1)	ATE429445T1 (pl)
AU (1)	AU2005312165B2 (pl)
BR (1)	BRPI0518759A2 (pl)
CA (1)	CA2589951C (pl)
CY (1)	CY1110488T1 (pl)
DE (2)	DE102004058306A1 (pl)
DK (1)	DK1819729T3 (pl)
ES (1)	ES2324951T3 (pl)
IL (1)	IL183467A0 (pl)
MX (1)	MX2007005840A (pl)
PL (1)	PL1819729T3 (pl)
PT (1)	PT1819729E (pl)
SI (1)	SI1819729T1 (pl)
WO (1)	WO2006058620A2 (pl)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102005046113A1 (de) *	2005-09-27	2007-03-29	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen
DE102006031955A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
DE102007002580A1 (de) *	2007-01-11	2008-07-17	C-Lecta Gmbh	Proteolytische Abspaltung von Protein-Tags in der rekombinanten Protein-Herstellung
KR20100111683A (ko)	2008-01-09	2010-10-15	사노피-아벤티스 도이칠란트 게엠베하	극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체
DE102008003566A1 (de)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003568A1 (de)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025007A1 (de)	2008-05-24	2009-11-26	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
RU2524423C2 (ru)	2008-01-09	2014-07-27	Санофи-Авентис Дойчланд Гмбх	Новые производные инсулина с чрезвычайно замедленным профилем время/действие
DE102008025008A1 (de)	2008-05-24	2009-11-26	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
PH12011502708B1 (en)	2009-07-06	2017-11-10	Sanofi Aventis Deutschland	Insulin preparations containing methionine
SG10201500871TA (en)	2009-11-13	2015-04-29	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
JP5832439B2 (ja)	2009-11-13	2015-12-16	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物
JP5198427B2 (ja) *	2009-12-29	2013-05-15	ザインエレクトロニクス株式会社	シグマデルタ変調器
CN103179978A (zh)	2010-08-30	2013-06-26	赛诺菲-安万特德国有限公司	Ave0010用于制造供治疗2型糖尿病用的药物的用途
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
JP6367115B2 (ja)	2011-08-29	2018-08-01	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	２型糖尿病患者の血糖コントロールに使用する組合せ医薬
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
TWI780236B (zh)	2013-02-04	2022-10-11	法商賽諾菲公司	胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
KR20160104726A (ko)	2014-01-09	2016-09-05	사노피	인슐린 유사체 및/또는 인슐린 유도체의 안정화된 무글리세롤 약제학적 제형
JP6641280B2 (ja)	2014-01-09	2020-02-05	サノフイＳａｎｏｆｉ	インスリンアナログおよび／またはインスリン誘導体の安定化された医薬製剤
CA2932873A1 (en)	2014-01-09	2015-07-16	Sanofi	Stabilized pharmaceutical formulations of insulin aspart
CN107206058A (zh)	2014-12-12	2017-09-26	赛诺菲-安万特德国有限公司	甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
CN115786426B (zh) *	2022-10-31	2023-09-08	杭州先为达生物科技有限公司	高特异性肠激酶酶切方法及乙醇在提高肠激酶酶切特异性中的用途
WO2025133045A1 (en) *	2023-12-22	2025-06-26	Novo Nordisk A/S	Fermentation process

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4708934A (en)	1984-09-27	1987-11-24	Unigene Laboratories, Inc.	α-amidation enzyme
US5496924A (en)	1985-11-27	1996-03-05	Hoechst Aktiengesellschaft	Fusion protein comprising an interleukin-2 fragment ballast portion
JP2598050B2 (ja)	1987-07-17	1997-04-09	サントリー株式会社	Ｃ−末端α−アミド化酵素
US5789234A (en)	1987-08-14	1998-08-04	Unigene Laboratories, Inc.	Expression systems for amidating enzyme
US6255067B1 (en)	1987-09-15	2001-07-03	The Johns Hopkins University	cDNA encoding peptidyl-glycine alpha-amidating monooxygenase (PAM)
US6319695B1 (en)	1991-10-15	2001-11-20	The Scripps Research Insitute	Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
US5338833A (en) *	1992-07-23	1994-08-16	The University Of North Carolina At Chapel Hill	Carboxy terminal IL-6 muteins
US5589364A (en) *	1994-07-29	1996-12-31	Magainin Pharmaceuticals Inc.	Recombinant production of biologically active peptides and proteins
JP3291172B2 (ja)	1994-10-04	2002-06-10	キヤノン株式会社	金属製ミラーの製造方法
AU4415796A (en)	1994-12-07	1996-06-26	Bionebraska, Inc.	Production of c-terminal amidated peptides from recombinant protein constructs
US6723530B1 (en) *	1997-02-05	2004-04-20	Amylin Pharmaceuticals, Inc.	Polynucleotides encoding proexendin, and methods and uses thereof
US6461834B1 (en) *	1998-11-06	2002-10-08	Bionebraska, Inc.	Clostripain catalyzed amidation of peptides
US6924264B1 (en) *	1999-04-30	2005-08-02	Amylin Pharmaceuticals, Inc.	Modified exendins and exendin agonists
US6528486B1 (en) *	1999-07-12	2003-03-04	Zealand Pharma A/S	Peptide agonists of GLP-1 activity
EP1076066A1 (en) *	1999-07-12	2001-02-14	Zealand Pharmaceuticals A/S	Peptides for lowering blood glucose levels
US6992172B1 (en) *	1999-11-12	2006-01-31	Fibrogen, Inc.	Recombinant gelatins
DE10123348A1 (de) *	2001-05-14	2002-11-21	Fresenius Kabi De Gmbh	DNS-Konstrukte für die Herstellung von Peptiden
BR0314996A (pt) *	2002-10-02	2005-08-09	Zealand Pharma As	Composição, composição farmaceuticamente aceitável, método para produzir a composição, métodos para estabilizar a exendina-4 (1-39) ou uma sua variante, derivado ou análogo contra a degradação, antes, durante ou após o uso pretendido, para tratar doenças, para tratar de estados de doenças associados com nìveis elevados de glicose do sangue, para a regulação dos nìveis de glicose do sangue, para a regulação do esvaziamento gástrico, para estimular a liberação de insulina em um mamìfero para reduzir o nìvel de glicose do sangue em um mamìfero, para reduzir o nìvel de lipìdeos plasmáticos em um mamìfero, para reduzir a mortalidade e a morbidez após o infarto miocárdico em um mamìfero, para estimular a liberação de insulina em um mamìfero, e para produzir uma exendina (1-39) estabilizada, e, exendina (1-39) estabilizada

2004
- 2004-12-01 DE DE102004058306A patent/DE102004058306A1/de not_active Withdrawn
2005
- 2005-11-18 KR KR1020077012501A patent/KR101299417B1/ko not_active Expired - Fee Related
- 2005-11-18 AT AT05850211T patent/ATE429445T1/de active
- 2005-11-18 EP EP05850211A patent/EP1819729B8/de not_active Expired - Lifetime
- 2005-11-18 WO PCT/EP2005/012365 patent/WO2006058620A2/de not_active Ceased
- 2005-11-18 PT PT05850211T patent/PT1819729E/pt unknown
- 2005-11-18 DE DE502005007161T patent/DE502005007161D1/de not_active Expired - Lifetime
- 2005-11-18 AU AU2005312165A patent/AU2005312165B2/en not_active Ceased
- 2005-11-18 MX MX2007005840A patent/MX2007005840A/es active IP Right Grant
- 2005-11-18 PL PL05850211T patent/PL1819729T3/pl unknown
- 2005-11-18 CN CN2005800412833A patent/CN101068833B/zh not_active Expired - Fee Related
- 2005-11-18 DK DK05850211T patent/DK1819729T3/da active
- 2005-11-18 JP JP2007543728A patent/JP4857279B2/ja not_active Expired - Fee Related
- 2005-11-18 SI SI200530733T patent/SI1819729T1/sl unknown
- 2005-11-18 BR BRPI0518759-1A patent/BRPI0518759A2/pt active Search and Examination
- 2005-11-18 US US11/720,006 patent/US7939293B2/en not_active Expired - Fee Related
- 2005-11-18 ES ES05850211T patent/ES2324951T3/es not_active Expired - Lifetime
- 2005-11-18 CA CA2589951A patent/CA2589951C/en not_active Expired - Fee Related
2007
- 2007-05-28 IL IL183467A patent/IL183467A0/en not_active IP Right Cessation
2009
- 2009-06-30 CY CY20091100691T patent/CY1110488T1/el unknown

Also Published As

Publication number	Publication date
KR20070091131A (ko)	2007-09-07
WO2006058620A2 (de)	2006-06-08
CN101068833B (zh)	2011-04-20
ATE429445T1 (de)	2009-05-15
CY1110488T1 (el)	2015-04-29
IL183467A0 (en)	2007-09-20
US7939293B2 (en)	2011-05-10
AU2005312165A1 (en)	2006-06-08
DE502005007161D1 (de)	2009-06-04
MX2007005840A (es)	2007-07-04
AU2005312165B2 (en)	2011-08-04
BRPI0518759A2 (pt)	2008-12-09
JP4857279B2 (ja)	2012-01-18
DK1819729T3 (da)	2009-08-17
HK1111426A1 (en)	2008-08-08
SI1819729T1 (sl)	2009-10-31
EP1819729A2 (de)	2007-08-22
CA2589951C (en)	2013-10-15
PT1819729E (pt)	2009-06-12
EP1819729B1 (de)	2009-04-22
JP2008521415A (ja)	2008-06-26
DE102004058306A1 (de)	2006-07-27
CA2589951A1 (en)	2006-06-08
US20090005299A1 (en)	2009-01-01
ES2324951T3 (es)	2009-08-20
WO2006058620A3 (de)	2006-08-03
CN101068833A (zh)	2007-11-07
KR101299417B1 (ko)	2013-08-28
EP1819729B8 (de)	2009-08-12

Publication	Publication Date	Title
IL183467A0 (en)	2007-09-20	Method for producing carboxy-terminal amidified peptides
IL160319A0 (en)	2004-07-25	Compositions and method of treating diabetes
TW200734393A (en)	2007-09-16	Odour-binding superabsorbing composition
GB0013488D0 (en)	2000-07-26	Chemical compound
WO2008031045A3 (en)	2008-04-24	Aquaretic and natriuretic polypeptides lacking vasodilatory activity
EP2455461A3 (en)	2013-05-29	Lipase variants for pharmaceutical use
SG135037A1 (en)	2007-09-28	Composite semipermeable membrane, and production process thereof
TNSN07069A1 (en)	2008-06-02	Process for concentration of antibodies and therapeutic products thereof
MX2008012748A (es)	2009-01-07	Un proceso para la concentracion de un polipeptido.
NZ598176A (en)	2013-08-30	Disintegrin variants and pharmaceutical uses thereof
SG158141A1 (en)	2010-01-29	Pancreatic polypeptide family motifs, polypeptides and methods comprising the same
EP1718782A4 (en)	2008-07-02	CLEAN TREATMENT TO IMPROVE THE MECHANICAL, CATALYTIC, CHEMICAL AND BIOLOGICAL ACTIVITY OF ARTICLES AND SURFACES
WO2007001264A3 (en)	2007-02-22	Method of making recombinant human antibodies for use in biosensor technology
MY148447A (en)	2013-04-30	Method for amidating polypeptides with basic aminoacid d-terminals by means of specific endoproteases
ATE483766T1 (de)	2010-10-15	Druckverfahren zur herstellung teilchenförmiger produkte
WO2008110374A3 (de)	2009-06-25	Pellets enthaltend pharmazeutische substanz, verfahren zu deren herstellung und deren verwendung
PL1750700T3 (pl)	2008-06-30	Ciekły preparat dla medycyny weterynaryjnej; sposób jego wytwarzania i zastosowanie
WO2005121328A8 (en)	2007-08-30	Method for ameliorating an inflammatory skin condition
AU2003212213A1 (en)	2003-09-09	Composite membrane, method for the production thereof and the use of the membrane
MY140061A (en)	2009-11-30	Improved method for the production of ramipril
WO2006111372A3 (en)	2006-12-28	Phytase
PL378059A1 (pl)	2006-02-20	Optycznie czynne pochodne bisoksazoliny, sposób ich wytwarzania i zastosowania
PT1763515E (pt)	2008-04-07	Ácidos 4-trifluorometoxifenoxibenzeno-4¿-sulfónicos, processo para a sua preparação e utilização em medicamentos
WO2005017109A3 (en)	2006-01-26	Nucleic acids and polypeptides required for cell survival in the absence of rb
PT102695A (pt)	2003-05-30	Processo para a preparacao de oligossacaridos com actividade anti-ulcerativa e sua utilizacao para apreparacao de medicamentos