PL1828151T3 - Pochodne malonoamidów jako inhibitory gama-sekretazy do leczenia choroby alzheimera - Google Patents
Pochodne malonoamidów jako inhibitory gama-sekretazy do leczenia choroby alzheimeraInfo
- Publication number
- PL1828151T3 PL1828151T3 PL05811672T PL05811672T PL1828151T3 PL 1828151 T3 PL1828151 T3 PL 1828151T3 PL 05811672 T PL05811672 T PL 05811672T PL 05811672 T PL05811672 T PL 05811672T PL 1828151 T3 PL1828151 T3 PL 1828151T3
- Authority
- PL
- Poland
- Prior art keywords
- secretase
- alzheimer
- gamma
- inhibitors
- disease
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- WRIRWRKPLXCTFD-UHFFFAOYSA-N malonamide Chemical class NC(=O)CC(N)=O WRIRWRKPLXCTFD-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 | ||
| EP05811672A EP1828151B1 (en) | 2004-12-08 | 2005-12-01 | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of alzheimer's disease |
| PCT/EP2005/012834 WO2006061136A2 (en) | 2004-12-08 | 2005-12-01 | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1828151T3 true PL1828151T3 (pl) | 2011-09-30 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05811672T PL1828151T3 (pl) | 2004-12-08 | 2005-12-01 | Pochodne malonoamidów jako inhibitory gama-sekretazy do leczenia choroby alzheimera |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (pl) |
| EP (1) | EP1828151B1 (pl) |
| JP (1) | JP4979590B2 (pl) |
| KR (1) | KR100890678B1 (pl) |
| CN (1) | CN101072760B (pl) |
| AR (1) | AR053987A1 (pl) |
| AT (1) | ATE504580T1 (pl) |
| AU (1) | AU2005313582B8 (pl) |
| BR (1) | BRPI0518615A2 (pl) |
| CA (1) | CA2589196A1 (pl) |
| DE (1) | DE602005027388D1 (pl) |
| DK (1) | DK1828151T3 (pl) |
| IL (1) | IL183293A0 (pl) |
| MX (1) | MX2007006504A (pl) |
| NO (1) | NO20072609L (pl) |
| NZ (1) | NZ555184A (pl) |
| PL (1) | PL1828151T3 (pl) |
| PT (1) | PT1828151E (pl) |
| RU (1) | RU2402538C2 (pl) |
| TW (1) | TWI349005B (pl) |
| WO (1) | WO2006061136A2 (pl) |
| ZA (1) | ZA200705018B (pl) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2663240A1 (en) * | 2006-09-20 | 2008-03-27 | F. Hoffmann-La Roche Ag | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives |
| WO2008092786A1 (en) | 2007-02-02 | 2008-08-07 | F. Hoffmann-La Roche Ag | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| KR20100101624A (ko) * | 2008-01-11 | 2010-09-17 | 에프. 호프만-라 로슈 아게 | 암 치료를 위한 감마-세크레타제 저해제의 용도 |
| CN107438599B (zh) * | 2015-06-11 | 2021-12-10 | 豪夫迈·罗氏有限公司 | 靶向Notch通路抑制剂 |
| US11339157B1 (en) | 2017-10-24 | 2022-05-24 | Bayer Aktiengesellschaft | 4H-pyrrolo[3,2-c]pyridin-4-one derivatives |
| KR102841441B1 (ko) | 2018-11-07 | 2025-07-31 | 추가이 세이야쿠 가부시키가이샤 | O-치환 세린 유도체의 제조 방법 |
| EP3958865B1 (en) | 2019-04-24 | 2025-12-10 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| US20220298157A1 (en) | 2019-04-24 | 2022-09-22 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| US20240307362A1 (en) | 2019-04-24 | 2024-09-19 | Bayer Aktiengesellschaft | 4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| CA3177214A1 (en) | 2020-03-31 | 2021-10-07 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| CN116940549B (zh) | 2021-03-09 | 2026-02-03 | 巴斯夫欧洲公司 | 丙二酰胺类及其作为除草剂的用途 |
| CR20240097A (es) * | 2021-08-25 | 2024-05-20 | Basf Se | Malonamidas herbicidas |
| AU2022339008A1 (en) * | 2021-08-31 | 2024-03-14 | Basf Se | Herbicidal malonamides containing a condensed ring system |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL72523A (en) * | 1983-08-12 | 1988-06-30 | Takeda Chemical Industries Ltd | 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them |
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| JP2002518481A (ja) * | 1998-06-22 | 2002-06-25 | エラン ファーマシューティカルズ，インコーポレイテッド | β−アミロイドペプチドの放出および／またはその合成を阻害するための化合物 |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| ES2324214T3 (es) * | 2002-05-29 | 2009-08-03 | F. Hoffmann-La Roche Ag | Derivados de n-acilaminobenceno como inhibidores de la monoamina oxidasa b selectiva. |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| HRP20050663A2 (en) | 2003-02-04 | 2006-12-31 | F. Hoffmann - La Roche Ag | Malonamide derivatives as gamma-secretase inhibitors |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| AU2004270361B2 (en) | 2003-09-09 | 2009-06-25 | F. Hoffmann-La Roche Ag | Malonamide derivatives blocking the activity of gama-secretase |
| WO2005040126A1 (en) | 2003-10-06 | 2005-05-06 | F. Hoffman-La Roche Ag | Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active Expired - Fee Related
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en not_active Expired - Lifetime
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en not_active Ceased
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de not_active Expired - Lifetime
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101072760B (zh) | 2011-12-28 |
| IL183293A0 (en) | 2007-09-20 |
| DK1828151T3 (da) | 2011-05-16 |
| AR053987A1 (es) | 2007-05-30 |
| WO2006061136A3 (en) | 2006-08-03 |
| ATE504580T1 (de) | 2011-04-15 |
| CN101072760A (zh) | 2007-11-14 |
| TW200626568A (en) | 2006-08-01 |
| NZ555184A (en) | 2010-01-29 |
| EP1828151A2 (en) | 2007-09-05 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| TWI349005B (en) | 2011-09-21 |
| JP4979590B2 (ja) | 2012-07-18 |
| KR100890678B1 (ko) | 2009-03-26 |
| JP2008522994A (ja) | 2008-07-03 |
| EP1828151B1 (en) | 2011-04-06 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| RU2402538C2 (ru) | 2010-10-27 |
| MX2007006504A (es) | 2007-06-22 |
| AU2005313582A1 (en) | 2006-06-15 |
| HK1114840A1 (en) | 2008-11-14 |
| AU2005313582B2 (en) | 2011-06-02 |
| AU2005313582A8 (en) | 2011-06-16 |
| RU2007120211A (ru) | 2009-01-20 |
| PT1828151E (pt) | 2011-06-16 |
| AU2005313582B8 (en) | 2011-06-16 |
| KR20070086979A (ko) | 2007-08-27 |
| DE602005027388D1 (de) | 2011-05-19 |
| NO20072609L (no) | 2007-06-19 |
| US7211573B2 (en) | 2007-05-01 |
| CA2589196A1 (en) | 2006-06-15 |
| US20060122168A1 (en) | 2006-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200705018B (en) | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of Alzheimer's disease | |
| ZA200809857B (en) | Terphenyl derivatives for treatment of alzheimer's disease | |
| CY2015025I1 (el) | Μεθοδοι για την αντιμετωπιση της νοσου παρκινσον | |
| MXPA05008172A (es) | Derivados de malonamida como inhibidores gamma-secretasa. | |
| PT2527315E (pt) | Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson | |
| IL185546A0 (en) | N - (n - sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain | |
| EP1940373B8 (en) | 1-fluoro-1-deoxy-scyllo-inositol for the treatment of alzheimer's disease | |
| WO2005065195A3 (en) | Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease | |
| WO2005051914A8 (en) | Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease | |
| GB0329874D0 (en) | Compounds useful for the treatment of diseases | |
| EP1807396A4 (en) | 2-AMINOPYRIDINE COMPOSITIONS AS A BETA SEKRETASE INHIBITOR FOR THE TREATMENT OF MORBUS ALZHEIMER | |
| IL185300A0 (en) | New pharmaceutical compositions useful in the treatment of parkinson's disease | |
| PL1631296T3 (pl) | Pochodne amidu kwasu 2,3,4,5,-tetrahydrobenzo[f][1,4]oksazepino-5-karboksylowego jako inhibitory gamma-sekretazy do leczenia choroby Alzheimera | |
| IL186022A0 (en) | Dermatological compositions and salts for the treatment of dermatological diseases | |
| WO2008036316A3 (en) | Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease | |
| AU2003238046A1 (en) | Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer's disease | |
| IL184849A0 (en) | Organic compounds useful for the treatment of alzheimer's disease, their use and method of preparation | |
| WO2007058862A3 (en) | Imidazolidinone compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease | |
| IL188449A0 (en) | Compositions to improve the bioavailability of polymethoxyflavones and tocotrienols for the treatment of cardiovascular disease | |
| GB0521716D0 (en) | Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases | |
| IL172018A0 (en) | Enalapril-nitroxyderivatives derivatives and related compounds as ace inhibitors for the treatment of cardiovascular diseases | |
| AU2008339005A8 (en) | 3,4-substituted pyrrolidine beta-secretase inhibitors for the treatment of Alzheimer's disease | |
| EP2099476A4 (en) | METHODS OF TREATING ALZHEIMER'S DISEASE | |
| ZA200708279B (en) | Dermatological compositions and salts for the treatment of dermatological diseases | |
| AU2004907196A0 (en) | Use of Naltrexone for Treating Alzheimer's Disease |