PL1846412T3 - Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny - Google Patents
Sposób wytwarzania 7-etylo-10-hydroksykamptotecynyInfo
- Publication number
- PL1846412T3 PL1846412T3 PL06708893T PL06708893T PL1846412T3 PL 1846412 T3 PL1846412 T3 PL 1846412T3 PL 06708893 T PL06708893 T PL 06708893T PL 06708893 T PL06708893 T PL 06708893T PL 1846412 T3 PL1846412 T3 PL 1846412T3
- Authority
- PL
- Poland
- Prior art keywords
- ethyl
- manufacturing
- hydroxy camptothecin
- hydroxy
- temperature
- Prior art date
Links
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- HHCZNCHGYNRIBP-UHFFFAOYSA-N 1-(2-amino-5-hydroxyphenyl)propan-1-one Chemical compound CCC(=O)C1=CC(O)=CC=C1N HHCZNCHGYNRIBP-UHFFFAOYSA-N 0.000 abstract 1
- IGKWOGMVAOYVSJ-UHFFFAOYSA-N 4-ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10-trione Chemical compound C1=C2C(=O)CCN2C(=O)C2=C1C(CC)(O)C(=O)OC2 IGKWOGMVAOYVSJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65017505P | 2005-02-07 | 2005-02-07 | |
| EP06708893A EP1846412B1 (en) | 2005-02-07 | 2006-02-06 | Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin |
| PCT/FI2006/000034 WO2006082279A1 (en) | 2005-02-07 | 2006-02-06 | Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1846412T3 true PL1846412T3 (pl) | 2010-03-31 |
Family
ID=36588759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06708893T PL1846412T3 (pl) | 2005-02-07 | 2006-02-06 | Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7910737B2 (pl) |
| EP (1) | EP1846412B1 (pl) |
| JP (1) | JP5133705B2 (pl) |
| AT (1) | ATE446299T1 (pl) |
| CA (1) | CA2591081C (pl) |
| DE (1) | DE602006009901D1 (pl) |
| ES (1) | ES2333462T3 (pl) |
| PL (1) | PL1846412T3 (pl) |
| WO (1) | WO2006082279A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006082279A1 (en) | 2005-02-07 | 2006-08-10 | Fermion Oy | Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin |
| CA2591071C (en) * | 2005-02-08 | 2014-04-29 | Fermion Oy | Process for producing [1,4'] bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof |
| PL1928883T3 (pl) * | 2005-02-08 | 2014-03-31 | Fermion Oy | Sposób otrzymywania chlorowodorku irynotekanu |
| TWI375678B (en) | 2005-06-09 | 2012-11-01 | Yakult Honsha Kk | A method of preparation of a tricyclic ketone |
| EP2082741A1 (en) * | 2005-09-20 | 2009-07-29 | Scinopharm Singapore Pte, Ltd. | Novel crystal form of irinotecan hydrochloride |
| JP5860213B2 (ja) * | 2007-06-25 | 2016-02-16 | シノファーム タイワン, リミテッドScinopharm Taiwan, Ltd. | ７−エチル−１０−ヒドロキシカンプトテシンの結晶多形 |
| WO2012032531A1 (en) * | 2010-09-06 | 2012-03-15 | Avra Laboratories Pvt. Ltd. | Process for the manufacture of irinotecan hydrochloride by total synthesis |
| KR101327720B1 (ko) * | 2013-02-15 | 2013-11-11 | 제일약품주식회사 | 이리노테칸의 제조방법 |
| ES2754649T3 (es) * | 2014-10-22 | 2020-04-20 | Vivacitas Oncology Inc | Métodos y sistemas para la síntesis del análogo de camptotecina |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US103309A (en) * | 1870-05-24 | Improvement in machines for burring wool | ||
| US182990A (en) * | 1876-10-10 | Improvement in corner-finish for rooms | ||
| US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
| JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US5053512A (en) * | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
| TW438775B (en) * | 1995-04-07 | 2001-06-07 | Pharmacia & Upjohn Co Llc | Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds |
| HUP0103314A3 (en) * | 1998-08-05 | 2002-07-29 | Aventis Pharma Sa | Use of camptothecin derivatives, with reduced gastrointestinal toxicity |
| AR035684A1 (es) * | 2001-02-21 | 2004-06-23 | Yakult Honsha Kk | Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina |
| JP2005525367A (ja) | 2002-03-01 | 2005-08-25 | フアルマシア・イタリア・エツセ・ピー・アー | 塩酸イリノテカンの結晶多形 |
| WO2003089413A1 (en) | 2002-04-17 | 2003-10-30 | Pharmacia Corporation | Pharmacia corporation |
| US20050267141A1 (en) | 2004-05-28 | 2005-12-01 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives |
| JP2008509211A (ja) | 2004-08-09 | 2008-03-27 | シルパ・メディケア・リミテッド | 塩酸イリノテカン三水和物の改良された製造方法 |
| WO2006082279A1 (en) | 2005-02-07 | 2006-08-10 | Fermion Oy | Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin |
-
2006
- 2006-02-06 WO PCT/FI2006/000034 patent/WO2006082279A1/en not_active Ceased
- 2006-02-06 ES ES06708893T patent/ES2333462T3/es not_active Expired - Lifetime
- 2006-02-06 AT AT06708893T patent/ATE446299T1/de not_active IP Right Cessation
- 2006-02-06 DE DE602006009901T patent/DE602006009901D1/de not_active Expired - Lifetime
- 2006-02-06 US US11/883,576 patent/US7910737B2/en active Active
- 2006-02-06 EP EP06708893A patent/EP1846412B1/en not_active Expired - Lifetime
- 2006-02-06 PL PL06708893T patent/PL1846412T3/pl unknown
- 2006-02-06 JP JP2007553634A patent/JP5133705B2/ja not_active Expired - Fee Related
- 2006-02-06 CA CA2591081A patent/CA2591081C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008529993A (ja) | 2008-08-07 |
| CA2591081C (en) | 2014-10-28 |
| WO2006082279A1 (en) | 2006-08-10 |
| US20080103309A1 (en) | 2008-05-01 |
| ES2333462T3 (es) | 2010-02-22 |
| EP1846412A1 (en) | 2007-10-24 |
| EP1846412B1 (en) | 2009-10-21 |
| JP5133705B2 (ja) | 2013-01-30 |
| US7910737B2 (en) | 2011-03-22 |
| DE602006009901D1 (de) | 2009-12-03 |
| CA2591081A1 (en) | 2006-08-10 |
| ATE446299T1 (de) | 2009-11-15 |
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