PL1863448T3 - Nowe kompozycje liposomowe - Google Patents
Nowe kompozycje liposomoweInfo
- Publication number
- PL1863448T3 PL1863448T3 PL06737793T PL06737793T PL1863448T3 PL 1863448 T3 PL1863448 T3 PL 1863448T3 PL 06737793 T PL06737793 T PL 06737793T PL 06737793 T PL06737793 T PL 06737793T PL 1863448 T3 PL1863448 T3 PL 1863448T3
- Authority
- PL
- Poland
- Prior art keywords
- liposome compositions
- novel liposome
- novel
- compositions
- liposome
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005067469A JP2006248978A (ja) | 2005-03-10 | 2005-03-10 | 新規なリポソーム製剤 |
| EP06737793.7A EP1863448B1 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| PCT/US2006/008650 WO2006099169A2 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1863448T3 true PL1863448T3 (pl) | 2015-05-29 |
Family
ID=36992280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06737793T PL1863448T3 (pl) | 2005-03-10 | 2006-03-08 | Nowe kompozycje liposomowe |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7829113B2 (pl) |
| EP (1) | EP1863448B1 (pl) |
| JP (2) | JP2006248978A (pl) |
| KR (1) | KR101352490B1 (pl) |
| CN (1) | CN101170995B (pl) |
| AU (1) | AU2006223329B2 (pl) |
| BR (1) | BRPI0608297A2 (pl) |
| CA (1) | CA2600446A1 (pl) |
| CY (1) | CY1116075T1 (pl) |
| DK (1) | DK1863448T3 (pl) |
| ES (1) | ES2529453T3 (pl) |
| HU (1) | HUE024290T2 (pl) |
| MX (1) | MX2007010996A (pl) |
| NO (1) | NO20075136L (pl) |
| NZ (1) | NZ561569A (pl) |
| PL (1) | PL1863448T3 (pl) |
| PT (1) | PT1863448E (pl) |
| RU (1) | RU2454229C2 (pl) |
| SI (1) | SI1863448T1 (pl) |
| WO (1) | WO2006099169A2 (pl) |
| ZA (1) | ZA200708600B (pl) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2566007C (en) | 2004-05-03 | 2013-09-24 | Hermes Biosciences, Inc. | Drug delivery liposomes containing anionic polyols or anionic sugars |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| CN101209243B (zh) * | 2006-12-29 | 2010-12-08 | 石药集团中奇制药技术(石家庄)有限公司 | 一种脂质体药物及其制备方法 |
| ES2550759T3 (es) * | 2007-08-17 | 2015-11-12 | Celator Pharmaceuticals, Inc. | Formulaciones farmacológicas de platino mejoradas |
| DK2200431T3 (en) * | 2007-09-10 | 2016-08-15 | Boston Biomedical Inc | UNKNOWN COMPOSITIONS AND PROCEDURES FOR CANCER TREATMENT |
| TWI468188B (zh) * | 2008-01-30 | 2015-01-11 | Univ Tokushima | Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation |
| EP2451950B9 (en) * | 2009-07-06 | 2016-11-23 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
| US8956600B2 (en) | 2009-08-10 | 2015-02-17 | Taiwan Liposome Co. Ltd. | Ophthalmic drug delivery system containing phospholipid and cholesterol |
| CA2781527C (en) * | 2009-09-23 | 2017-10-24 | Indu Javeri | Methods for the preparation of liposomes |
| US10143652B2 (en) * | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
| WO2011102904A1 (en) * | 2010-02-19 | 2011-08-25 | Robert Shorr | Imageable lipid-oil-water nanoemulsion therapeutic delivery system |
| DK2544663T3 (en) * | 2010-03-12 | 2018-04-16 | Berg Llc | INTRAVENOUS FORMULATIONS OF COENZYM Q10 (CoQ10) AND PROCEDURES FOR USING IT |
| BR112012023660B8 (pt) | 2010-03-19 | 2021-05-25 | Boston Biomedical Inc | usos de uma quantidade terapeuticamente eficaz de um composto, ou de um sal, solvato, hidrato ou pró-fármaco farmaceuticamente aceitável do mesmo para o tratamento de câncer |
| US9492480B2 (en) * | 2010-04-12 | 2016-11-15 | Ramot At Tel Aviv University Ltd. | Iron oxide nanoparticles for use in treating non-infectious inflammatory disorders |
| CA2817755C (en) | 2010-11-12 | 2021-07-06 | Rachael Terry | Modified immune-modulating particles |
| WO2012153616A1 (ja) * | 2011-05-10 | 2012-11-15 | 国立大学法人北海道大学 | 標的細胞移行能を有する脂質膜構造体、その製造方法および標的細胞において効果を示す物質のスクリーニング方法 |
| WO2013011598A1 (ja) * | 2011-07-15 | 2013-01-24 | コニカミノルタホールディングス株式会社 | 溶解助剤を利用したリポソーム含有製剤およびその製造方法 |
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| JP2015509085A (ja) * | 2012-01-01 | 2015-03-26 | キュービーアイ エンタープライゼズ リミテッドQbi Enterprises Ltd. | 治療剤および診断剤の選択的送達のためのendo180を標的とする粒子 |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| EP2863942B1 (en) | 2012-06-21 | 2019-04-10 | Northwestern University | Peptide conjugated particles |
| WO2014025042A1 (ja) | 2012-08-10 | 2014-02-13 | 大鵬薬品工業株式会社 | 安定なオキサリプラチン封入リポソーム水分散液及びその安定化方法 |
| AU2013360302C1 (en) | 2012-12-12 | 2019-01-24 | Temple University - Of The Commonwealth System Of Higher Education | Compositions and methods for treatment of cancer |
| CN103083239B (zh) * | 2012-12-26 | 2015-11-25 | 中国人民解放军第四军医大学 | 一种蟾毒灵脂质体及其制备方法和应用 |
| TW201427681A (zh) | 2013-01-07 | 2014-07-16 | Superlab Far East Ltd | 用空間構象改變的重組干擾素治療腫瘤的方法 |
| US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
| BR112015022476A2 (pt) * | 2013-03-13 | 2017-07-18 | Mallinckrodt Llc | composições de oxaliplatina de lipossoma para terapia de câncer |
| CN116966162A (zh) | 2013-03-13 | 2023-10-31 | onCOUR制药股份有限公司 | 用于治疗炎症的免疫修饰性颗粒 |
| JP6077710B2 (ja) * | 2013-03-13 | 2017-02-08 | マリンクロッド エルエルシー | がん療法のためのリポソームシスプラチン組成物 |
| WO2014169078A2 (en) | 2013-04-09 | 2014-10-16 | Boston Biomedical, Inc. | Methods for treating cancer |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| PT3033102T (pt) | 2013-08-13 | 2019-12-19 | Univ Northwestern | Partículas conjugadas com péptidos |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| WO2016070129A1 (en) | 2014-10-30 | 2016-05-06 | President And Fellows Of Harvard College | Delivery of negatively charged proteins using cationic lipids |
| EP4372090A3 (en) | 2013-11-07 | 2024-08-07 | Editas Medicine, Inc. | Crispr-related methods and compositions with governing grnas |
| US20150166985A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting von willebrand factor point mutations |
| US20170007700A1 (en) * | 2014-02-21 | 2017-01-12 | The Curators Of The University Of Missouri | Compositions and methods for boron neutron capture therapy |
| CA2956224A1 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US10098813B2 (en) * | 2014-09-03 | 2018-10-16 | Sun Pharmaceutical Industries Limited | Perfusion dosage form |
| US9816080B2 (en) | 2014-10-31 | 2017-11-14 | President And Fellows Of Harvard College | Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs) |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| EP3315487B1 (en) | 2015-06-24 | 2020-10-28 | Nippon Kayaku Kabushiki Kaisha | Novel platinum (iv) complex |
| PL3337467T3 (pl) | 2015-08-20 | 2021-06-14 | Ipsen Biopharm Ltd. | Terapia skojarzona z zastosowaniem liposomalnego irynotekanu i inhibitora parp do leczenia nowotworu |
| BR112018002941B1 (pt) | 2015-08-21 | 2023-12-05 | Ipsen Biopharm Ltd | Uso de irinotecano lipossomal, oxaliplatina, leucovorina e 5- fluorouracil no tratamento de primeira linha de adenocarcinoma metastático do pâncreas |
| EP3351580B1 (en) | 2015-09-14 | 2021-02-24 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of hexa-coordinated platinum complex |
| ES3036518T3 (en) | 2015-10-16 | 2025-09-19 | Ipsen Biopharm Ltd | Stabilizing camptothecin pharmaceutical compositions |
| IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| EP3377043A4 (en) * | 2015-11-20 | 2019-06-26 | The Regents of The University of California | DEVICABLE NANOSCAL CARRIER (DNVS) FOR ADMINISTRATION THROUGH THE BLOOD-BRAIN-BARRIER, MICE AND SKIN |
| US10946028B2 (en) | 2015-12-22 | 2021-03-16 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of sulfoxide derivative-coordinated platinum(II) complex |
| CN110590855B (zh) * | 2016-01-25 | 2023-05-12 | 沈阳药科大学 | 铂类配合物的制备方法及其含有该铂类配合物的脂质体与制备方法 |
| CN117757794A (zh) * | 2016-03-07 | 2024-03-26 | 美国政府(由卫生和人类服务部的部长所代表) | 微小rna及其使用方法 |
| CN109069817B (zh) * | 2016-04-15 | 2021-07-13 | 富士胶片株式会社 | 微针阵列 |
| AU2017284499A1 (en) * | 2016-06-17 | 2019-01-31 | Osaka University | Intratumoral vein formation promoter |
| WO2018026794A1 (en) * | 2016-08-02 | 2018-02-08 | Curirx Inc. | Methods for the preparation of liposomes |
| SG11201900907YA (en) | 2016-08-03 | 2019-02-27 | Harvard College | Adenosine nucleobase editors and uses thereof |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| WO2018031967A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Polyglutamated antifolates and uses thereof |
| KR102708209B1 (ko) | 2016-08-12 | 2024-09-20 | 엘.이.에이.에프. 홀딩스 그룹 엘엘씨. | 알파 및 감마-d 폴리글루타메이트화 항엽산 및 이의 용도 |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018083470A1 (en) | 2016-11-02 | 2018-05-11 | Ipsen Biopharm Ltd. | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
| WO2018087720A1 (en) | 2016-11-14 | 2018-05-17 | Novartis Ag | Compositions, methods, and therapeutic uses related to fusogenic protein minion |
| CA3045306A1 (en) | 2016-11-29 | 2018-06-07 | Boston Biomedical, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| IL269458B2 (en) | 2017-03-23 | 2024-02-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| CN110662532A (zh) | 2017-04-03 | 2020-01-07 | 加利福尼亚大学董事会 | 用于跨血脑屏障、透粘膜和经皮药物递送的可变形的纳米级媒介物(dnvs) |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN110869006A (zh) * | 2017-05-12 | 2020-03-06 | 库里纳尔克斯有限公司 | 制备含药脂质体的方法 |
| CA3062656A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| AU2018352592C1 (en) | 2017-10-16 | 2025-09-25 | Beam Therapeutics, Inc. | Uses of adenosine base editors |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND PROCEDURES FOR PREDICTING REPAIR RESULTS IN GENE ENGINEERING |
| WO2019157138A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pemetrexed and uses thereof |
| CA3090483A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pemetrexed and uses thereof |
| CA3090387A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
| CN111954529A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | α聚谷氨酸化氨甲蝶呤及其用途 |
| JP7514533B2 (ja) | 2018-02-07 | 2024-07-11 | エル.イー.エー.エフ. ホールディングス グループ エルエルシー | アルファポリグルタミン酸化テトラヒドロ葉酸およびその使用 |
| CA3090389A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated raltitrexed and uses thereof |
| CN111867593A (zh) | 2018-02-07 | 2020-10-30 | L.E.A.F.控股集团公司 | α聚谷氨酸化抗叶酸剂及其用途 |
| US12246019B2 (en) | 2018-02-07 | 2025-03-11 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated lometrexol and uses thereof |
| WO2019157140A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated raltitrexed and uses thereof |
| US12310966B2 (en) | 2018-02-07 | 2025-05-27 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated aminopterin and uses thereof |
| WO2019160733A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated methotrexate and uses thereof |
| WO2019160734A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| EP3755335A4 (en) | 2018-02-14 | 2022-06-22 | L.E.A.F Holdings Group LLC | GAMMA POLYGLUTAMIC TETRAHYDROFOLATES AND THEIR USES |
| EP3752156A4 (en) | 2018-02-14 | 2021-10-27 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMIZED PRALATREXATE AND USES THEREOF |
| EP3752158A4 (en) | 2018-02-14 | 2022-03-09 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMATED AMINOPTERINE AND USES THEREOF |
| JP2021521279A (ja) * | 2018-04-11 | 2021-08-26 | ニュー メキシコ テック ユニバーシティ リサーチ パーク コーポレーション | 薬物送達における使用のための脂質プロドラッグ |
| CN108524450A (zh) * | 2018-04-16 | 2018-09-14 | 温州医科大学 | 基于磁性热敏阳离子脂质体的奥沙利铂和mdc1-as共传递药物载体的制备及应用 |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| JP7483193B2 (ja) | 2018-06-13 | 2024-05-15 | カリフォルニア・インスティテュート・オブ・テクノロジー | 血脳バリアを越えるためのナノ粒子とそれを用いた治療法 |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| AU2019347666B2 (en) | 2018-09-28 | 2025-10-02 | President And Fellows Of Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| US11980673B2 (en) | 2018-10-09 | 2024-05-14 | The University Of British Columbia | Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| GB2601618B (en) | 2019-03-19 | 2024-11-06 | Broad Inst Inc | Methods and compositions for editing nucleotide sequences |
| CN111721841B (zh) * | 2019-03-19 | 2022-07-12 | 海南长安国际制药有限公司 | 与洛铂有关物质的检测 |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN110292563B (zh) * | 2019-06-12 | 2021-07-16 | 兰州大学 | 基于叶酸热敏脂质体的阴离子载体诱导癌细胞凋亡的方法 |
| WO2021072328A1 (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna |
| CN115135774A (zh) * | 2020-03-04 | 2022-09-30 | 美国西门子医学诊断股份有限公司 | 使用修饰的脂质体的组合物和方法 |
| EP4127175A4 (en) | 2020-04-02 | 2025-01-22 | Mirecule, Inc. | Targeted inhibition using engineered oligonucleotides |
| JP2023525304A (ja) | 2020-05-08 | 2023-06-15 | ザ ブロード インスティテュート,インコーポレーテッド | 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物 |
| CN112129871B (zh) * | 2020-09-04 | 2021-06-15 | 斯微(上海)生物科技有限公司 | 复合磷脂脂质体中dope和m5两种磷脂含量的检测方法 |
| CN112870164B (zh) * | 2021-01-25 | 2021-12-17 | 山东大学 | 一种双靶向载药脂质体及其制备方法和应用 |
| WO2023196851A1 (en) | 2022-04-06 | 2023-10-12 | President And Fellows Of Harvard College | Reversing aging of the central nervous system |
| KR20250146635A (ko) | 2024-04-01 | 2025-10-13 | 고려대학교 산학협력단 | 리포좀 폴록사머 복합체를 포함하는 통증 질환 치료 조성물 |
Family Cites Families (156)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041077B2 (ja) | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | 1,2‐ジアミノシクロヘキサン異性体のシス白金(2)錯体 |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| GR75598B (pl) | 1980-04-29 | 1984-08-01 | Sanofi Sa | |
| US4534899A (en) * | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US4565696A (en) * | 1983-08-03 | 1986-01-21 | The Regents Of The University Of California | Production of immunogens by antigen conjugation to liposomes |
| US4789633A (en) | 1984-04-19 | 1988-12-06 | University Of Tennessee Research Corporation | Fused liposome and acid induced method for liposome fusion |
| US4925661A (en) * | 1984-04-19 | 1990-05-15 | Leaf Huang | Target-specific cytotoxic liposomes |
| US5736155A (en) * | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4762915A (en) * | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
| EP0211042A1 (en) * | 1985-01-18 | 1987-02-25 | Cooper-Lipotech, Inc. | Liposome composition and method |
| US5026651A (en) * | 1985-04-25 | 1991-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of human transferrin |
| PH26160A (en) * | 1985-08-19 | 1992-03-18 | Univ Texas | Pharmaceutical compositions consisting of acylated phospholipids |
| US4983397A (en) * | 1985-08-19 | 1991-01-08 | Board Of Regents, University Of Texas System | Pharmaceutical compositions consisting of acylated phospholipids |
| US5384127A (en) * | 1985-10-18 | 1995-01-24 | Board Of Regents, The University Of Texas System | Stable liposomal formulations of lipophilic platinum compounds |
| JPH0714865B2 (ja) * | 1986-10-28 | 1995-02-22 | 武田薬品工業株式会社 | リポソ−ム製剤およびその製造法 |
| US5049390A (en) * | 1987-09-02 | 1991-09-17 | Allergy Immuno Technologies, Inc. | Liposome containing immunotherapy agents for treating IgE mediated allergies |
| US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| FR2631826B1 (fr) * | 1988-05-27 | 1992-06-19 | Centre Nat Rech Scient | Vecteur particulaire utile notamment pour le transport de molecules a activite biologique et procede pour sa preparation |
| JPH0720857B2 (ja) | 1988-08-11 | 1995-03-08 | テルモ株式会社 | リポソームおよびその製法 |
| DK0436717T3 (da) * | 1989-08-02 | 2003-05-05 | Mitra Medical Technology Ab | System til anvendelse ved en fremgangsmåde til terapeutisk eller diagnostisk behandling |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| AU646520B2 (en) * | 1990-10-09 | 1994-02-24 | Nexstar Pharmaceuticals, Inc. | Phospholipid analogue vesicle with a succinimidyl moiety |
| US5554728A (en) * | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
| US6509032B1 (en) | 1991-08-28 | 2003-01-21 | Mcmaster University | Cationic amphiphiles |
| US5292524A (en) * | 1991-09-06 | 1994-03-08 | California Institute Of Technology | Blood platelet loaded with diagnostic or therapeutic-containing liposome or reconstituted Sendai virus |
| JPH0776230B2 (ja) | 1992-01-13 | 1995-08-16 | 田中貴金属工業株式会社 | 白金化合物の製造方法 |
| JP2673331B2 (ja) * | 1993-01-12 | 1997-11-05 | 田中貴金属工業 株式会社 | 光学的に高純度なシス―オキザラート(トランス―1―1,2―シクロヘキサンジアミン)白金(▲ii▼) |
| JPH06287021A (ja) * | 1992-04-22 | 1994-10-11 | Tanaka Kikinzoku Kogyo Kk | 光学活性な白金錯化合物の光学的分割方法 |
| US20030190638A1 (en) | 1992-05-13 | 2003-10-09 | Board Of Regents, The University Of Texas System | Methods of screening for compounds that derepress or increase telomerase activity |
| US5962316A (en) * | 1992-10-16 | 1999-10-05 | Cold Spring Harbor Laboratory | Cell-cycle regulatory proteins, and uses related thereto |
| US20030100489A1 (en) * | 1992-10-16 | 2003-05-29 | Beach David H. | Cell-cycle regulatory proteins, and uses related thereto |
| AU6833994A (en) | 1993-05-17 | 1994-12-12 | Liposome Company, Inc., The | Incorporation of taxol into liposomes and gels |
| JP3025602B2 (ja) * | 1993-05-21 | 2000-03-27 | デビオファーム エス.アー. | 光学的に高純度なシス−オキザラート(トランス−l−1,2−シクロヘキサンジアミン)白金(II)錯体の製造方法 |
| US5534241A (en) * | 1993-07-23 | 1996-07-09 | Torchilin; Vladimir P. | Amphipathic polychelating compounds and methods of use |
| PT671905E (pt) * | 1993-10-06 | 2002-12-31 | Amgen Inc | Composicoes estaveis de proteinas: fosfolipidos e respectivos metodos |
| AU1552995A (en) * | 1993-12-17 | 1995-07-03 | Spinal Cord Society | Method for inducing dna synthesis in neurons |
| US6057299A (en) * | 1994-01-13 | 2000-05-02 | Calydon, Inc. | Tissue-specific enhancer active in prostate |
| US5830686A (en) * | 1994-01-13 | 1998-11-03 | Calydon | Tissue-specific enhancer active in prostate |
| ATE219688T1 (de) | 1994-03-28 | 2002-07-15 | Nycomed Imaging As | Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel |
| CA2192836A1 (en) | 1994-07-29 | 1996-02-15 | Anthony R. Haight | Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane |
| ES2152412T3 (es) * | 1994-08-08 | 2001-02-01 | Debiopharm Sa | Preparacion farmaceuticamente estable de oxaliplatino. |
| KR100381449B1 (ko) * | 1994-10-14 | 2003-07-18 | 더 리포좀 컴퍼니, 인코퍼레이티드 | 에테르지질리포좀과이들의제약학적용도 |
| DE69531722T2 (de) | 1994-11-11 | 2004-07-01 | Debiopharm S.A. | Karzinostatische Zusammensetzungen, welche Cis-Oxaliplatin und eine oder mehrere andere verträgliche Karzinostatika enthalten |
| US5786214A (en) * | 1994-12-15 | 1998-07-28 | Spinal Cord Society | pH-sensitive immunoliposomes and method of gene delivery to the mammalian central nervous system |
| US5580899A (en) * | 1995-01-09 | 1996-12-03 | The Liposome Company, Inc. | Hydrophobic taxane derivatives |
| US6008202A (en) | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| TW319763B (pl) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US5780052A (en) * | 1995-04-24 | 1998-07-14 | Northeastern University | Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell |
| US5834012A (en) * | 1995-05-03 | 1998-11-10 | Roman Perez-Soler | Lipid complexed topoisomerase I inhibitors |
| US20020022264A1 (en) | 1995-05-26 | 2002-02-21 | Sullivan Sean M. | Delivery vehicles comprising stable lipid/nucleic acid complexes |
| US6825174B2 (en) * | 1995-06-07 | 2004-11-30 | East Carolina University | Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation |
| JPH09278785A (ja) | 1996-04-10 | 1997-10-28 | Tanaka Kikinzoku Kogyo Kk | 白金化合物の製造方法 |
| JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス.アー. | 白金化合物の製造方法 |
| FR2740686B1 (fr) | 1995-11-03 | 1998-01-16 | Sanofi Sa | Formulation pharmaceutique lyophilisee stable |
| US6428977B1 (en) | 1995-12-20 | 2002-08-06 | Curis, Inc. | Signalin family of TGFβ signal transduction proteins, and uses related thereto |
| JP3735921B2 (ja) * | 1996-02-07 | 2006-01-18 | 三菱ウェルファーマ株式会社 | GPIb・脂質複合体およびその用途 |
| DE69736385T2 (de) * | 1996-02-09 | 2007-08-23 | Pi-Wan Cheng | Kationisches lipid und rezeptorligand erleichterte gabe von biologisch aktiven molekuelen |
| US6153646A (en) | 1996-03-11 | 2000-11-28 | Yoshinori Kidani | Binuclear platinum complexes, method for preparing same and pharmaceutical compositions containing said complexes |
| CA2250219C (en) * | 1996-03-28 | 2008-10-07 | Hayat Onyuksel | Materials and methods for making improved liposome compositions |
| JP3919227B2 (ja) * | 1996-05-02 | 2007-05-23 | テルモ株式会社 | アミジン誘導体及びそれを構成成分とする薬物担体 |
| CA2263455C (en) | 1996-08-23 | 2002-10-29 | Sequus Pharmaceuticals, Inc. | Liposomes containing a cisplatin compound |
| TW520297B (en) * | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| CA2276267C (en) * | 1996-10-15 | 2009-12-22 | The Liposome Company, Inc. | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
| IL130822A (en) | 1996-10-15 | 2005-12-18 | Elan Pharm Inc | N-acyl phosphatidylethanolamine-mediated liposomaldrug delivery |
| WO1998027209A1 (en) | 1996-12-18 | 1998-06-25 | Emory University | Polycationic oligomers |
| EP1014990B1 (en) * | 1997-03-07 | 2006-09-06 | Sanofi-Aventis U.S. LLC | Antitumor combination of 3-amino-1,2,4-benzotriazine 1,4-dioxide/paclitaxel/platinum |
| JPH10253632A (ja) * | 1997-03-10 | 1998-09-25 | Nissui Pharm Co Ltd | 分析方法、キット及び装置 |
| DE19709704C2 (de) * | 1997-03-10 | 1999-11-04 | Michael Georgieff | Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie |
| US6120751A (en) * | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6060082A (en) * | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| US6524613B1 (en) * | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| US6272370B1 (en) * | 1998-08-07 | 2001-08-07 | The Regents Of University Of Minnesota | MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging |
| WO1998059035A2 (en) | 1997-06-25 | 1998-12-30 | The Goverment Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services, National Institutes Of Health | Serum-free cell growth medium |
| WO1999003889A1 (en) * | 1997-07-15 | 1999-01-28 | The Regents Of The University Of California | Isolated dna encoding human calcium activated potassium channel |
| ATE376062T1 (de) | 1997-08-04 | 2007-11-15 | Cell Genesys Inc | Enhancer des menschlichen glandulären kallikreingens, vektoren die ihn enthalten und methoden für seine verwendung |
| WO1999017809A2 (en) * | 1997-10-02 | 1999-04-15 | Epix Medical, Inc. | Contrast-enhanced diagnostic imaging method for monitoring interventional therapies |
| US6749863B1 (en) * | 1997-11-19 | 2004-06-15 | Georgetown University | Targeted liposome gene delivery |
| US6320017B1 (en) * | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| US6573101B1 (en) * | 1998-02-12 | 2003-06-03 | The Regents Of The University Of California | Compositions for receptor/liposome mediated transfection and methods of using same |
| GB9804013D0 (en) | 1998-02-25 | 1998-04-22 | Sanofi Sa | Formulations |
| US6245427B1 (en) * | 1998-07-06 | 2001-06-12 | DüZGüNES NEJAT | Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles |
| BRPI9914508B8 (pt) * | 1998-10-14 | 2021-05-25 | Debiopharm Sa | bolsa flexível impermeável para uso médico contendo uma preparação farmacêutica de oxaliplatina sob a forma líquida |
| US7311924B2 (en) * | 1999-04-01 | 2007-12-25 | Hana Biosciences, Inc. | Compositions and methods for treating cancer |
| US6723338B1 (en) * | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
| JP2003502025A (ja) | 1999-05-17 | 2003-01-21 | エイブイアイ バイオファーマ, インコーポレイテッド | hcGワクチンを用いた癌の処置のための併用アプローチ |
| JP2001002592A (ja) | 1999-06-18 | 2001-01-09 | Dai Ichi Seiyaku Co Ltd | 遺伝子導入用組成物 |
| US6280054B1 (en) * | 1999-07-02 | 2001-08-28 | Zight Corporation | Image generator having an improved illumination system |
| US6242188B1 (en) * | 1999-07-30 | 2001-06-05 | Applied Gene Technologies, Inc. | Sample processing to release nucleic acids for direct detection |
| WO2001011826A1 (en) * | 1999-08-09 | 2001-02-15 | Fujitsu Limited | Package control device and method |
| JP4890711B2 (ja) | 1999-08-30 | 2012-03-07 | デビオファーム ソシエテ アノニム | 非経口投与のための医薬として安定なオキザリプラチナム製剤 |
| AP2002002546A0 (en) | 1999-12-30 | 2002-06-30 | Judith K Gwathmey | Iron chelator delivery system. |
| EP1242609A2 (en) | 1999-12-30 | 2002-09-25 | Novartis AG | Novel colloid synthetic vectors for gene therapy |
| CA2397016C (en) * | 2000-01-10 | 2011-03-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of disease |
| US6530944B2 (en) * | 2000-02-08 | 2003-03-11 | Rice University | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
| US7001735B2 (en) * | 2000-03-01 | 2006-02-21 | Albert Einstein College Of Medicine Of Yeshiva University | Glucose transporter/sensor protein and uses thereof |
| DE60130741T2 (de) * | 2000-03-02 | 2008-07-03 | Mitsubishi Pharma Corp. | GPib-GEBUNDENES KONSTRUKT UND VERWENDUNGEN DAVON |
| JP4449147B2 (ja) | 2000-03-22 | 2010-04-14 | 日油株式会社 | ホスファチジルエタノールアミン誘導体の製造方法 |
| FR2806727A1 (fr) | 2000-03-23 | 2001-09-28 | Pf Medicament | Molecule d'interet pharmaceutique comprotant en son extremite n-terminale un acide glutamique ou une glutamine sous forme de sel d'addition d'acide fort physiologiquement acceptable |
| JP2003530362A (ja) | 2000-04-12 | 2003-10-14 | リプラサム ファーマ アー/エス | 診断剤をターゲッティングするための脂質ベースの系 |
| CZ20023913A3 (cs) * | 2000-05-03 | 2003-09-17 | Munich Biotech Ag | Kationtová diagnostická, zobrazovací a terapeutická činidla spojená s aktivovanými cévními místy |
| US20030059461A1 (en) * | 2000-06-06 | 2003-03-27 | Sibtech, Inc. | Molecular delivery vehicle for delivery of selected compounds to targets |
| US20030072794A1 (en) * | 2000-06-09 | 2003-04-17 | Teni Boulikas | Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes |
| AU2002215004A1 (en) * | 2000-09-11 | 2002-03-22 | Centre National De La Recherche Scientifique | Mitochondrial membrane permeabilization bv hiv-1 vpr and methods of screening |
| US20040234588A1 (en) | 2000-09-21 | 2004-11-25 | University Of Georgia Research Foundation, Inc. | Artificial lipoprotein carrier system for bioactive materials |
| EP1324758B1 (fr) | 2000-10-03 | 2005-01-12 | Debiopharm S.A. | Microspheres de polymere de type plga/pla encapsulant des substances solubles dans l'eau, et leur procede de preparation |
| US20030129223A1 (en) * | 2000-10-11 | 2003-07-10 | Targesome, Inc. | Targeted multivalent macromolecules |
| EP1209469A1 (en) * | 2000-11-22 | 2002-05-29 | Vectron Therapeutics AG | Production and use of a targeted diagnostic system |
| EP1342063A4 (en) * | 2000-12-12 | 2004-07-14 | Australian Inst Marine Science | Assay for paralytic shellfish toxin |
| EP1341555A2 (fr) | 2000-12-12 | 2003-09-10 | Debiopharm S.A. | Preparation pharmaceutique d'oxaliplatine pour administration par voie parenterale et procede d'obtention de ladite preparation |
| US6897196B1 (en) * | 2001-02-07 | 2005-05-24 | The Regents Of The University Of California | pH sensitive lipids based on ortho ester linkers, composition and method |
| US6703524B2 (en) * | 2001-02-20 | 2004-03-09 | Lkt Laboratories, Inc. | Organoselenium compounds for cancer chemoprevention |
| US20040220078A1 (en) | 2001-03-02 | 2004-11-04 | Houssam Ibrahim | Device for packaging an oxaliplatinum solution |
| FI113840B (fi) | 2001-03-26 | 2004-06-30 | Ctt Cancer Targeting Tech Oy | Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa |
| US20040049022A1 (en) * | 2001-04-24 | 2004-03-11 | Nyce Jonathan W. | Composition & methods for treatment and screening |
| US20030203865A1 (en) | 2001-04-30 | 2003-10-30 | Pierrot Harvie | Lipid-comprising drug delivery complexes and methods for their production |
| US20030082228A1 (en) * | 2001-05-09 | 2003-05-01 | Inex Pharmaceuticals Corporation | Anti-angiogenic therapy using liposome-encapsulated chemotherapeutic agents |
| US20030108986A1 (en) * | 2001-06-21 | 2003-06-12 | Euroscreen, S.A. | Compositions and methods comprising G-protein coupled receptors |
| US20040186172A1 (en) | 2001-07-02 | 2004-09-23 | Houssam Ibrahim | Oxaliplatin active substance with a very low content of oxalic acid |
| US20030096299A1 (en) * | 2001-07-09 | 2003-05-22 | Valerie Wittamer | Natural ligand of G protein coupled receptor ChemR23 and uses thereof |
| US6793912B2 (en) * | 2001-08-20 | 2004-09-21 | Transave Inc. | Treatment of cancers by inhalation of stable platinum-containing formulations |
| DE10144252A1 (de) | 2001-08-31 | 2003-03-27 | Fraunhofer Ges Forschung | Nanopartikel mit daran immobilisiertem biologisch aktivem TNF |
| US7402392B2 (en) * | 2001-10-03 | 2008-07-22 | Vanderbilt University | In vivo panning for ligands to radiation-induced molecules |
| US7101985B2 (en) | 2001-11-20 | 2006-09-05 | Baylor College Of Medicine | Methods and compositions in checkpoint signaling |
| JP4468617B2 (ja) | 2001-12-04 | 2010-05-26 | デビオファーム エス.アー. | 抗癌剤の併用投与方法及び併用可能な抗癌剤 |
| US6476068B1 (en) | 2001-12-06 | 2002-11-05 | Pharmacia Italia, S.P.A. | Platinum derivative pharmaceutical formulations |
| WO2003057730A1 (en) | 2002-01-07 | 2003-07-17 | Euroscreen S.A. | Ligand for g-protein coupled receptor gpr43 and uses thereof |
| US20030220284A1 (en) | 2002-02-22 | 2003-11-27 | Patricia Yotnda | Delivery of adenoviral DNA in a liposomal formulation for treatment of disease |
| EP2308898B1 (en) * | 2002-03-01 | 2016-06-08 | Immunomedics, Inc. | Internalizing anti-CD74 antibodies and methods of use |
| US20050100963A1 (en) * | 2002-03-01 | 2005-05-12 | Dyax Corporation | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| AU2003221533A1 (en) | 2002-03-29 | 2003-10-13 | Euroscreen Sa | Ligands for g protein coupled receptor gpr7 and uses thereof |
| CA2391438A1 (en) * | 2002-05-01 | 2003-11-01 | Procyon Biopharma Inc. | Psp94 diagnostic reagents and assays |
| US20030228285A1 (en) | 2002-05-03 | 2003-12-11 | Mien-Chie Hung | Bipartite T-cell factor (Tcf)-responsive promoter |
| US7460960B2 (en) | 2002-05-10 | 2008-12-02 | Epitome Biosystems, Inc. | Proteome epitope tags and methods of use thereof in protein modification analysis |
| US20040022842A1 (en) * | 2002-06-03 | 2004-02-05 | Mebiopharm Co., Ltd. | Liposome preparations containing oxaliplatin |
| JP3415131B1 (ja) * | 2002-06-03 | 2003-06-09 | メビオファーム株式会社 | リポソーム製剤 |
| FR2840236B1 (fr) | 2002-06-03 | 2005-02-04 | Inst Francais Du Petrole | Membrane zeolithique de faible epaisseur, sa preparation et son utilisation en separation |
| EP1511518A2 (en) * | 2002-06-07 | 2005-03-09 | Immunomedics, Inc. | Neutrophil imaging methods in cystic fibrosis |
| KR101143035B1 (ko) * | 2002-06-14 | 2012-05-08 | 이뮤노메딕스, 인코오포레이티드 | 단클론 항체 hPAM4 |
| EP1521775B1 (en) * | 2002-06-14 | 2015-09-09 | Immunomedics, Inc. | Monoclonal antibody pam4 and its use for diagnosis and therapy of pancreatic cancer |
| US6790632B2 (en) | 2002-06-17 | 2004-09-14 | Stephen Eliot Zweig | Membrane receptor reagent and assay |
| DE60334618D1 (de) * | 2002-06-28 | 2010-12-02 | Protiva Biotherapeutics Inc | Verfahren und vorrichtung zur herstellung von liposomen |
| EP1546203B1 (en) | 2002-08-01 | 2012-06-20 | Immunomedics, Inc. | Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof |
| US20040132652A1 (en) * | 2002-08-30 | 2004-07-08 | Shire Biochem Inc. | Pharmaceutical compositions |
| US20040197770A1 (en) | 2002-11-14 | 2004-10-07 | Mount Sinai School Of Medicine | Induction of apoptosis by HIV-1 infected monocytic cells |
| JP4848637B2 (ja) | 2002-11-15 | 2011-12-28 | ニプロ株式会社 | リポソーム |
| WO2004071518A1 (ja) | 2003-02-17 | 2004-08-26 | Mebiopharm Co., Ltd. | 癌治療薬 |
| US20050003403A1 (en) * | 2003-04-22 | 2005-01-06 | Rossi Edmund A. | Polyvalent protein complex |
| EP1633773A4 (en) * | 2003-06-13 | 2010-10-20 | Immunomedics Inc | PEPTIDES OF AMINO ACIDS D |
| EP2216342B1 (en) * | 2003-07-31 | 2015-04-22 | Immunomedics, Inc. | Anti-CD19 antibodies |
| JP2005154282A (ja) | 2003-11-20 | 2005-06-16 | Mebiopharm Co Ltd | ガス封入リポソームの製造法 |
| US7582430B2 (en) * | 2004-01-20 | 2009-09-01 | United States Of America As Represented By The Secretary Of The Army | Immunoliposome-nucleic acid amplification (ILNAA) assay |
| US7212869B2 (en) * | 2004-02-04 | 2007-05-01 | Medtronic, Inc. | Lead retention means |
| EP1579850A3 (en) | 2004-03-15 | 2009-12-16 | Nipro Corporation | A pharmaceutical composition containing liposomes for treating a cancer |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| WO2008030818A2 (en) | 2006-09-05 | 2008-03-13 | Mebiopharm Co., Ltd. | Novel liposome compositions |
-
2005
- 2005-03-10 JP JP2005067469A patent/JP2006248978A/ja active Pending
-
2006
- 2006-03-08 BR BRPI0608297-1A patent/BRPI0608297A2/pt not_active IP Right Cessation
- 2006-03-08 MX MX2007010996A patent/MX2007010996A/es active IP Right Grant
- 2006-03-08 EP EP06737793.7A patent/EP1863448B1/en not_active Expired - Lifetime
- 2006-03-08 NZ NZ561569A patent/NZ561569A/en not_active IP Right Cessation
- 2006-03-08 JP JP2008500977A patent/JP5438317B2/ja not_active Expired - Fee Related
- 2006-03-08 HU HUE06737793A patent/HUE024290T2/en unknown
- 2006-03-08 DK DK06737793.7T patent/DK1863448T3/en active
- 2006-03-08 SI SI200631892T patent/SI1863448T1/sl unknown
- 2006-03-08 PT PT67377937T patent/PT1863448E/pt unknown
- 2006-03-08 ES ES06737793.7T patent/ES2529453T3/es not_active Expired - Lifetime
- 2006-03-08 RU RU2007137492/15A patent/RU2454229C2/ru not_active IP Right Cessation
- 2006-03-08 AU AU2006223329A patent/AU2006223329B2/en not_active Ceased
- 2006-03-08 WO PCT/US2006/008650 patent/WO2006099169A2/en not_active Ceased
- 2006-03-08 CN CN2006800159670A patent/CN101170995B/zh not_active Expired - Fee Related
- 2006-03-08 PL PL06737793T patent/PL1863448T3/pl unknown
- 2006-03-08 US US11/371,586 patent/US7829113B2/en not_active Expired - Fee Related
- 2006-03-08 CA CA002600446A patent/CA2600446A1/en not_active Abandoned
- 2006-03-08 KR KR1020077023219A patent/KR101352490B1/ko not_active Expired - Fee Related
- 2006-03-08 ZA ZA200708600A patent/ZA200708600B/xx unknown
-
2007
- 2007-10-09 NO NO20075136A patent/NO20075136L/no not_active Application Discontinuation
-
2010
- 2010-09-27 US US12/891,568 patent/US8758810B2/en not_active Expired - Fee Related
-
2014
- 2014-05-09 US US14/274,377 patent/US20140363491A1/en not_active Abandoned
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2015
- 2015-02-06 CY CY20151100123T patent/CY1116075T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1863448E (pt) | 2015-02-10 |
| WO2006099169A3 (en) | 2007-02-22 |
| AU2006223329B2 (en) | 2011-11-17 |
| ZA200708600B (en) | 2009-01-28 |
| WO2006099169A2 (en) | 2006-09-21 |
| CA2600446A1 (en) | 2006-09-21 |
| JP5438317B2 (ja) | 2014-03-12 |
| CN101170995B (zh) | 2013-01-16 |
| US8758810B2 (en) | 2014-06-24 |
| HK1111625A1 (en) | 2008-08-15 |
| SI1863448T1 (sl) | 2015-03-31 |
| CY1116075T1 (el) | 2017-02-08 |
| US20110081404A1 (en) | 2011-04-07 |
| US20060222696A1 (en) | 2006-10-05 |
| ES2529453T3 (es) | 2015-02-20 |
| EP1863448A2 (en) | 2007-12-12 |
| US7829113B2 (en) | 2010-11-09 |
| BRPI0608297A2 (pt) | 2009-12-08 |
| DK1863448T3 (en) | 2015-02-16 |
| JP2008538105A (ja) | 2008-10-09 |
| AU2006223329A1 (en) | 2006-09-21 |
| NO20075136L (no) | 2007-12-07 |
| MX2007010996A (es) | 2007-11-07 |
| NZ561569A (en) | 2011-03-31 |
| EP1863448B1 (en) | 2014-11-26 |
| KR101352490B1 (ko) | 2014-02-04 |
| RU2454229C2 (ru) | 2012-06-27 |
| KR20080002819A (ko) | 2008-01-04 |
| CN101170995A (zh) | 2008-04-30 |
| JP2006248978A (ja) | 2006-09-21 |
| HUE024290T2 (en) | 2016-01-28 |
| US20140363491A1 (en) | 2014-12-11 |
| RU2007137492A (ru) | 2009-04-20 |
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