PL1891446T3 - Sposób identyfikacji nowych związków oddziałujących z enzymami - Google Patents

Sposób identyfikacji nowych związków oddziałujących z enzymami

Info

Publication number
PL1891446T3
PL1891446T3 PL06763568T PL06763568T PL1891446T3 PL 1891446 T3 PL1891446 T3 PL 1891446T3 PL 06763568 T PL06763568 T PL 06763568T PL 06763568 T PL06763568 T PL 06763568T PL 1891446 T3 PL1891446 T3 PL 1891446T3
Authority
PL
Poland
Prior art keywords
identification
novel enzyme
interacting compounds
enzyme interacting
compounds
Prior art date
Application number
PL06763568T
Other languages
English (en)
Inventor
Gerard Drewes
Bernhard Kuester
Ulrich Kruse
Carsten Hopf
Dirk Eberhard
Marcus Bantscheff
Valerie Reader
David Middlemiss
Manfred Raida
Original Assignee
Cellzome Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05012722A external-priority patent/EP1734367A1/en
Application filed by Cellzome Gmbh filed Critical Cellzome Gmbh
Publication of PL1891446T3 publication Critical patent/PL1891446T3/pl

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL06763568T 2005-06-14 2006-06-07 Sposób identyfikacji nowych związków oddziałujących z enzymami PL1891446T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05012722A EP1734367A1 (en) 2005-06-14 2005-06-14 Process for the identification of novel enzyme interacting compounds
US71139905P 2005-08-25 2005-08-25
US78217006P 2006-03-14 2006-03-14
EP06763568.0A EP1891446B1 (en) 2005-06-14 2006-06-07 Process for the identification of novel enzyme interacting compounds
PCT/EP2006/062984 WO2006134056A1 (en) 2005-06-14 2006-06-07 Process for the identification of novel enzyme interacting compounds

Publications (1)

Publication Number Publication Date
PL1891446T3 true PL1891446T3 (pl) 2013-08-30

Family

ID=37038265

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06763568T PL1891446T3 (pl) 2005-06-14 2006-06-07 Sposób identyfikacji nowych związków oddziałujących z enzymami

Country Status (6)

Country Link
US (1) US20090238808A1 (pl)
EP (1) EP1891446B1 (pl)
AU (1) AU2006259153B2 (pl)
CA (1) CA2611365C (pl)
PL (1) PL1891446T3 (pl)
WO (1) WO2006134056A1 (pl)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1866433T3 (da) * 2006-03-14 2009-08-17 Cellzome Ag Fremgangsmåde til identifikation af LRRK-2interagerende molekyler og til rensning af LRRK2
ES2318616T3 (es) * 2006-06-01 2009-05-01 Cellzome Ag Metodos para la identificacion de moleculas que interactuan con zap-70 y para la purificacion de zap-70.
DK1887359T3 (da) 2006-08-03 2009-03-02 Cellzome Ag Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K
SG174086A1 (en) 2006-08-30 2011-09-29 Cellzome Ltd Triazole derivatives as kinase inhibitors
JP5279063B2 (ja) * 2007-05-25 2013-09-04 国立大学法人愛媛大学 Ｈｌａ−ａ２拘束性抗原ペプチドおよびその用途
EP2045332B1 (en) * 2007-10-05 2010-07-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Proteome-wide quantification of small molecule binding to cellular target proteins
EP2058307A1 (en) 2007-11-12 2009-05-13 Cellzome Ag Methods for the identification of JAK kinase interacting molecules and for the purification of JAK kinases
SG186040A1 (en) 2007-11-27 2012-12-28 Cellzome Ltd Amino triazoles as pi3k inhibitors
US20110111972A1 (en) 2008-02-04 2011-05-12 Cellzome Ag Selectivity profiling of pi3k interacting molecules against multiple targets
US8148677B2 (en) * 2008-02-05 2012-04-03 Thermo Finnigan Llc Peptide identification and quantitation by merging MS/MS spectra
US8703438B2 (en) * 2008-11-18 2014-04-22 The Regents Of The University Of California Ligand binding stabilization method for drug target identification
EP2406258B1 (en) 2009-03-13 2014-12-03 Cellzome Limited PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
WO2010112210A1 (en) 2009-04-03 2010-10-07 Cellzome Ag Methods for the identification of kinase interacting molecules and for the purification of kinase proteins
EP2419423A1 (en) 2009-04-14 2012-02-22 Cellzome Limited Fluoro substituted pyrimidine compounds as jak3 inhibitors
US8367830B2 (en) 2009-05-20 2013-02-05 Cellzome Ag Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins
US20100304998A1 (en) * 2009-06-02 2010-12-02 Marquette University Chemical Proteomic Assay for Optimizing Drug Binding to Target Proteins
US20130071854A1 (en) * 2009-08-14 2013-03-21 Gerard Drewes Methods for the identification and characterization of hdac interacting compounds
CA2771675A1 (en) 2009-09-11 2011-03-17 Cellzome Limited Ortho substituted pyrimidine compounds as jak inhibitors
AU2010309882B2 (en) 2009-10-20 2016-01-28 Cellzome Limited Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors
KR101028875B1 (ko) 2010-02-12 2011-04-12 메디스커브 주식회사 세포 내에서 세포내 물질의 생리활성 기능을 조절하는 조절물질을 검출하는 방법
EP2542536B1 (en) 2010-03-04 2015-01-21 Cellzome Limited Morpholino substituted urea derivatives as mtor inhibitors
EP2566867A1 (en) 2010-04-30 2013-03-13 Cellzome Limited Pyrazole compounds as jak inhibitors
US20130143915A1 (en) 2010-07-01 2013-06-06 Cellzome Limited Triazolopyridines as tyk2 inhibitors
US20130210030A1 (en) 2010-07-19 2013-08-15 Cellzome Ag In vivo method for the evaluation of a compound-target interaction
WO2012016704A1 (en) 2010-08-05 2012-02-09 Cellzome Ag Methods for the identification of methyltransferase interacting molecules and for the purification of methyltransferase proteins
JP2013534233A (ja) 2010-08-20 2013-09-02 セルゾーム リミティッド 選択的ｊａｋ阻害剤としてのヘテロシクリルピラゾロピリミジン類似体
CN103298794A (zh) 2010-11-09 2013-09-11 塞尔卓姆有限公司 作为tyk2抑制剂的吡啶化合物及其氮杂类似物
WO2012084244A1 (en) * 2010-12-22 2012-06-28 Cellzome Ag A method for the evaluation of compound-target interactions across species
EP2665829A1 (en) 2011-01-21 2013-11-27 Cellzome GmbH Compounds and methods for the identification and characterization of hdac interacting compounds
WO2012123119A1 (en) 2011-03-17 2012-09-20 Cellzome Ag Methods for the identification and characterization of proteins interacting with histone tails and of compounds interacting with said proteins
JP2012197258A (ja) * 2011-03-23 2012-10-18 Tohoku Univ 個別化治療診断のためのマーカータンパク質絶対量の定量方法
EP2505659A1 (en) 2011-03-31 2012-10-03 Cellzome Ag Methods for the identification of dioxygenase interacting molecules and for the purification of dioxygenase proteins
WO2012143320A1 (en) 2011-04-18 2012-10-26 Cellzome Limited (7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
WO2012150042A1 (en) 2011-05-04 2012-11-08 Cellzome Ag Compounds and methods for the identification of histone demethylase interacting molecules and for the purification of histone demethylase proteins
WO2012175201A1 (en) 2011-06-20 2012-12-27 Cellzome Ag Methods for the characterization of antibodies
CN103781780B (zh) 2011-07-28 2015-11-25 赛尔佐姆有限公司 作为jak抑制剂的杂环基嘧啶类似物
WO2013017479A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
WO2013017480A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
EP2760863A1 (en) 2011-09-20 2014-08-06 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as kinase inhibitors
EP2758379B1 (en) 2011-09-21 2016-10-19 Cellzome Limited Urea and carbamate derivatives of 2-morpholino-1,3,5-triazine as mTOR inhibitors for the treatment of immunological or proliferative diseases
AU2012318590B2 (en) 2011-10-04 2017-05-18 Expression Pathology, Inc. SRM/MRM assay for the ephrin type-A receptor 2 protein
AU2012320465B2 (en) 2011-10-07 2016-03-03 Cellzome Limited Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors
EP2592154A1 (en) 2011-11-09 2013-05-15 Cellzome Ag Immobilization products and methods for the identification of histone demethylase interacting molecules and for the purification of histone demethylase proteins
US20150005281A1 (en) 2011-12-23 2015-01-01 Cellzome Limited Pyrimidine-2,4-diamine derivatives as kinase inhibitors
JP6197031B2 (ja) 2012-05-24 2017-09-13 セルゾーム リミティッド Ｔｙｋ２阻害剤としてのヘテロシクリルピリミジン類似体
WO2014168721A2 (en) * 2013-04-12 2014-10-16 Tufts Medical Center Methods and systems for designing and/or characterizing soluble lipidated ligand agents
WO2017118997A2 (en) * 2016-01-08 2017-07-13 Saxena Chaitanya Methods for determining protein targets of a ligand without ligand derivatization
WO2017127827A1 (en) 2016-01-22 2017-07-27 Tufts Medical Center Compounds and methods for treating inflammation
US11561226B2 (en) 2016-03-14 2023-01-24 Pierce Biotechnology Inc. Detection and quantification of AKT-mTOR pathway proteins
KR20190017928A (ko) 2016-06-10 2019-02-20 순-쳉 리 변이체 sh2 도메인에 의한 단백질 티로신 인산화 프로파일링 방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536822A (en) 1994-03-09 1996-07-16 University Of Virginia Alumni Patents Foundation γ-phosphate linked adenosine 5' triphosphate sepharose
SE9602545L (sv) * 1996-06-25 1997-12-26 Michael Mecklenburg Metod för att diskriminera komplexa biologiska prover
US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US7300753B2 (en) * 1998-09-04 2007-11-27 John Rush Immunoaffinity isolation of modified peptides from complex mixtures
AU2196200A (en) * 1998-12-17 2000-07-03 Johns Hopkins University School Of Medicine, The Olfactory receptor expression libraries and methods of making and using them
GB9923146D0 (en) * 1999-09-30 1999-12-01 Imperial College Detector array
JP2003534533A (ja) * 2000-02-08 2003-11-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン タンパク質のディファレンシャルディスプレイのマッピング
EP1275006A2 (en) 2000-04-10 2003-01-15 The Scripps Research Institute Proteomic analysis using activity-based probe libraries
EP1461621A4 (en) 2001-11-29 2005-11-23 Scripps Research Inst ENZYME ACTIVITY PROFILE
WO2003052120A2 (en) * 2001-12-14 2003-06-26 President And Fellows Of Harvard College Dual inhibition of sister chromatide separation at metaphase
US20030186221A1 (en) 2002-04-02 2003-10-02 Lockhart David J. Phage display affinity filter and forward screen
US20060105445A1 (en) * 2002-07-29 2006-05-18 Klaus Godl Medium and method for enriching, purifying or depleting atp binding proteins from a pool of proteins
DK1644513T3 (da) * 2003-06-20 2011-10-17 Discoverx Corp Assay til detektion af proteinbinding

Also Published As

Publication number Publication date
CA2611365A1 (en) 2006-12-21
HK1115631A1 (en) 2008-12-05
WO2006134056A1 (en) 2006-12-21
AU2006259153B2 (en) 2012-04-12
EP1891446B1 (en) 2013-04-10
US20090238808A1 (en) 2009-09-24
EP1891446A1 (en) 2008-02-27
CA2611365C (en) 2014-02-11
AU2006259153A1 (en) 2006-12-21

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