PL1896439T3 - Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base - Google Patents
Crystalline base of escitalopram and orodispersible tablets comprising escitalopram baseInfo
- Publication number
- PL1896439T3 PL1896439T3 PL06742481T PL06742481T PL1896439T3 PL 1896439 T3 PL1896439 T3 PL 1896439T3 PL 06742481 T PL06742481 T PL 06742481T PL 06742481 T PL06742481 T PL 06742481T PL 1896439 T3 PL1896439 T3 PL 1896439T3
- Authority
- PL
- Poland
- Prior art keywords
- escitalopram
- base
- crystalline
- orodispersible tablets
- orodispersible
- Prior art date
Links
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 title 2
- 229960004341 escitalopram Drugs 0.000 title 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200500912 | 2005-06-22 | ||
| PCT/DK2006/000366 WO2006136169A2 (en) | 2005-06-22 | 2006-06-22 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| EP06742481.2A EP1896439B2 (en) | 2005-06-22 | 2006-06-22 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL1896439T3 true PL1896439T3 (en) | 2011-04-29 |
| PL1896439T5 PL1896439T5 (en) | 2016-01-29 |
Family
ID=37546630
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL384185A PL384185A1 (en) | 2005-06-22 | 2006-06-22 | Crystalline scitalopram ase and orodispersible tablets containing scitalopram base |
| PL06742481T PL1896439T5 (en) | 2005-06-22 | 2006-06-22 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL384185A PL384185A1 (en) | 2005-06-22 | 2006-06-22 | Crystalline scitalopram ase and orodispersible tablets containing scitalopram base |
Country Status (39)
| Country | Link |
|---|---|
| EP (3) | EP2385044A1 (en) |
| JP (5) | JP4906852B2 (en) |
| KR (5) | KR20080018191A (en) |
| CN (2) | CN101928269A (en) |
| AR (2) | AR055062A1 (en) |
| AT (3) | AT10983U1 (en) |
| AU (2) | AU2006261452B2 (en) |
| BG (1) | BG66086B1 (en) |
| BR (1) | BRPI0612295A2 (en) |
| CA (2) | CA2646780A1 (en) |
| CY (1) | CY1112392T1 (en) |
| CZ (3) | CZ301286B6 (en) |
| DE (2) | DE602006019961D1 (en) |
| DK (3) | DK1896439T4 (en) |
| EA (2) | EA201001108A1 (en) |
| EE (1) | EE00773U1 (en) |
| ES (2) | ES2319073B1 (en) |
| FI (2) | FI20080548L (en) |
| GB (2) | GB2442160B (en) |
| HR (1) | HRP20110093T4 (en) |
| HU (1) | HUP0800135A3 (en) |
| IL (1) | IL187454A0 (en) |
| IS (1) | IS8705A (en) |
| LT (1) | LT5550B (en) |
| LV (1) | LV13677B (en) |
| MX (1) | MX2007015328A (en) |
| MY (2) | MY143239A (en) |
| NO (2) | NO20080359L (en) |
| PL (2) | PL384185A1 (en) |
| PT (1) | PT1896439E (en) |
| RS (1) | RS51575B2 (en) |
| SG (1) | SG169358A1 (en) |
| SI (1) | SI1896439T2 (en) |
| SK (1) | SK500402007A3 (en) |
| TR (2) | TR200708792T1 (en) |
| TW (2) | TWI347942B (en) |
| UA (1) | UA86536C2 (en) |
| WO (1) | WO2006136169A2 (en) |
| ZA (2) | ZA200711066B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
| WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
| EP2134325A2 (en) * | 2007-03-01 | 2009-12-23 | Aurobindo Pharma Limited | Stable solid dosage forms of an antidepressant |
| DK2595979T3 (en) | 2010-07-23 | 2016-05-17 | Lundbeck & Co As H | A process for the purification of pharmaceutically acceptable salts of escitalopram |
| CN103360353A (en) * | 2013-08-07 | 2013-10-23 | 中国药科大学 | Preparation methods for impurities of escitalopram oxalate |
| JP2018016569A (en) * | 2016-07-26 | 2018-02-01 | 株式会社トクヤマ | (1S) -1- [3- (Dimethylamino) propyl] -1- (4-fluorophenyl) -1,3-dihydroisobenzofuran-5-carbonitrile oxalate production method |
| WO2018190294A1 (en) * | 2017-04-10 | 2018-10-18 | 東和薬品株式会社 | Medicinal composition comprising escitalopram |
| CN110711198B (en) * | 2018-07-12 | 2022-03-15 | 山东大学 | Application of D-mannose in preparation of antidepressant |
| KR102331187B1 (en) | 2019-04-09 | 2021-11-26 | 주식회사 라이트팜텍 | Oral solution composition containing escitalopram with good stability and the method for preparing the same |
| WO2022153262A1 (en) * | 2021-01-18 | 2022-07-21 | Anton Frenkel | Pharmaceutical dosage form |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8814057D0 (en) | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| JPH05222041A (en) * | 1992-02-13 | 1993-08-31 | Mitsubishi Gas Chem Co Inc | Purification method of adenine derivative |
| FI962989A0 (en) * | 1994-01-27 | 1996-07-26 | Univ Oklahoma | Quickly soluble oral dosage form |
| US5607697A (en) * | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
| EP0993524B1 (en) | 1997-06-30 | 2002-11-20 | Beloit Technologies, Inc. | Method and apparatus for the high speed application of coating to a traveling paper web |
| TR200000066T2 (en) | 1997-07-08 | 2000-11-21 | H. Lundbeck A/S | Method for the preparation of citalopram. |
| ES2149734T3 (en) | 1997-11-11 | 2003-02-16 | Lundbeck & Co As H | METHOD FOR THE PREPARATION OF CITALOPRAM. |
| FR2785538B1 (en) * | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | PERFECTED QUICK DELIVERY TABLET |
| US20020071864A1 (en) * | 1999-03-25 | 2002-06-13 | Yuhan Corporation | Rapidly disintegrable tablet for oral administration |
| ITMI991579A1 (en) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | METHOD FOR THE PREPARATION OF CITALOPRAM |
| ITMI991581A1 (en) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | METHOD FOR THE PREPARATION OF CITALOPRAM |
| JP2001226372A (en) * | 1999-12-06 | 2001-08-21 | Sumika Fine Chemicals Co Ltd | Crystalline and crystallizing or crystallized rosartan acid adduct and method of purification of rosartan |
| GB2357762B (en) * | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
| US7510728B2 (en) * | 2000-10-06 | 2009-03-31 | Takeda Pharmaceutical Company Limited | Solid preparations |
| CN1469737A (en) * | 2000-10-16 | 2004-01-21 | ��һ��������ҩ��ʽ���� | Oral rapidly disintegrating pharmaceutical composition and preparation method thereof |
| US7799342B2 (en) | 2000-12-06 | 2010-09-21 | Wyeth Llc | Fast dissolving tablet |
| JP3798982B2 (en) * | 2000-12-22 | 2006-07-19 | ハー・ルンドベック・アクチエゼルスカベット | Method for producing pure citalopram |
| CA2359810C (en) * | 2000-12-28 | 2002-11-05 | H. Lundbeck A/S | Process for the preparation of pure citalopram |
| EA200301195A1 (en) * | 2001-05-01 | 2004-04-29 | Х. Лундбекк А/С | APPLICATION OF ENANTIOMERALLY CLEAN ESCYTAL PREMA |
| US6872405B2 (en) * | 2001-05-10 | 2005-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Quick-disintegrating tablet in buccal cavity and manufacturing method thereof |
| GB0113842D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
| AR034612A1 (en) * | 2001-06-25 | 2004-03-03 | Lundbeck & Co As H | PROCESS FOR THE PREPARATION OF RACEMIC CITALOPRAM AND / OR OF THE S- OR R-CITALOPRAM THROUGH THE SEPARATION OF A MIXING OF R- AND S-CITALOPRAM |
| AR034759A1 (en) | 2001-07-13 | 2004-03-17 | Lundbeck & Co As H | METHOD FOR THE PREPARATION OF ESCITALOPRAM |
| HRP20031073A2 (en) * | 2001-07-31 | 2004-04-30 | Lundbeck & Co As H | Crystalline composition containing escitalopram |
| IS7239A (en) | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Process for the production of acitalopram |
| WO2003057132A2 (en) * | 2002-01-07 | 2003-07-17 | Sun Pharmaceutical Industries Limited | Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile |
| FR2834889B1 (en) * | 2002-01-18 | 2004-04-02 | Roquette Freres | SOLID ORODISPERSIBLE PHARMACEUTICAL FORM |
| GB0204607D0 (en) * | 2002-02-27 | 2002-04-10 | Matrix Lab Ltd | Process |
| EP1517676A1 (en) * | 2002-05-03 | 2005-03-30 | Skyepharma Canada Inc. | Oral dosage forms comprising fenofibrate |
| CN100349885C (en) | 2002-12-23 | 2007-11-21 | H·隆德贝克有限公司 | Crystalline escitalopram hydrobromide and methods for preparing the same |
| CN1510024A (en) * | 2002-12-24 | 2004-07-07 | 北京德众万全药物技术开发有限公司 | Compound for preparing citalopram enantiomer and its production |
| DE10305984A1 (en) * | 2003-02-13 | 2004-09-02 | Helm Ag | Salts of organic acids with clopidogrel and their use in the manufacture of pharmaceutical formulations |
| CN1819819B (en) * | 2003-05-07 | 2011-03-09 | 株式会社三养社 | Highly plastic granules for the preparation of fast-melting tablets |
| KR101159617B1 (en) * | 2003-10-15 | 2012-06-27 | 후지카가쿠고교가부시키가이샤 | Tablet quickly disintegrating in oral cavity |
| AU2003282383A1 (en) * | 2003-11-20 | 2005-06-08 | Natco Pharma Limited | A process for the preparation of high purity escitalopram |
| HU227491B1 (en) * | 2003-11-25 | 2011-07-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Tablet containing citalopram hydrogen bromide |
| BRPI0508266A (en) * | 2004-03-05 | 2007-07-31 | Lundbeck & Co As H | escitalopram oxalate crystalline particles, solid single dosage form, and methods for the manufacture of escitalopram oxalate crystalline particles and for reducing the amount of hydroxyl containing impurities in citalopram, escitalopram or a non-racemic mixture of r- and s -citalopram |
| EP1877394A1 (en) * | 2005-04-04 | 2008-01-16 | Jubilant Organosys Limited | Process for the preparation of escitalopram or its acid addition salts |
-
2006
- 2006-06-15 TW TW095121358A patent/TWI347942B/en not_active IP Right Cessation
- 2006-06-15 TW TW100102601A patent/TWI358407B/en not_active IP Right Cessation
- 2006-06-21 MY MYPI2010000618A patent/MY143239A/en unknown
- 2006-06-21 MY MYPI20062933A patent/MY143252A/en unknown
- 2006-06-21 AR ARP060102654A patent/AR055062A1/en not_active Application Discontinuation
- 2006-06-22 HU HU0800135A patent/HUP0800135A3/en unknown
- 2006-06-22 WO PCT/DK2006/000366 patent/WO2006136169A2/en not_active Ceased
- 2006-06-22 DK DK06742481.2T patent/DK1896439T4/en active
- 2006-06-22 TR TR2007/08792T patent/TR200708792T1/en unknown
- 2006-06-22 CN CN201010286088XA patent/CN101928269A/en active Pending
- 2006-06-22 PL PL384185A patent/PL384185A1/en unknown
- 2006-06-22 KR KR1020077028918A patent/KR20080018191A/en not_active Ceased
- 2006-06-22 CA CA002646780A patent/CA2646780A1/en not_active Abandoned
- 2006-06-22 BR BRPI0612295-7A patent/BRPI0612295A2/en not_active IP Right Cessation
- 2006-06-22 EP EP10179318A patent/EP2385044A1/en not_active Withdrawn
- 2006-06-22 CA CA2612827A patent/CA2612827C/en not_active Expired - Fee Related
- 2006-06-22 GB GB0724557A patent/GB2442160B/en not_active Expired - Fee Related
- 2006-06-22 PT PT06742481T patent/PT1896439E/en unknown
- 2006-06-22 CZ CZ20080429A patent/CZ301286B6/en not_active IP Right Cessation
- 2006-06-22 CZ CZ20070898A patent/CZ299906B6/en not_active IP Right Cessation
- 2006-06-22 AT AT0900506U patent/AT10983U1/en not_active IP Right Cessation
- 2006-06-22 DE DE602006019961T patent/DE602006019961D1/en active Active
- 2006-06-22 GB GB0811164A patent/GB2448834B/en not_active Expired - Fee Related
- 2006-06-22 KR KR1020117015711A patent/KR20110084341A/en not_active Ceased
- 2006-06-22 ES ES200750085A patent/ES2319073B1/en not_active Expired - Fee Related
- 2006-06-22 RS RS20110057A patent/RS51575B2/en unknown
- 2006-06-22 KR KR1020107026804A patent/KR20100133023A/en not_active Ceased
- 2006-06-22 FI FI20080548A patent/FI20080548L/en unknown
- 2006-06-22 AT AT06742481T patent/ATE497500T1/en active
- 2006-06-22 HR HRP20110093TT patent/HRP20110093T4/en unknown
- 2006-06-22 EA EA201001108A patent/EA201001108A1/en unknown
- 2006-06-22 SI SI200630923T patent/SI1896439T2/en unknown
- 2006-06-22 CZ CZ20080430A patent/CZ300686B6/en not_active IP Right Cessation
- 2006-06-22 EP EP10179395A patent/EP2325177A1/en not_active Withdrawn
- 2006-06-22 UA UAA200800362A patent/UA86536C2/en unknown
- 2006-06-22 FI FI20077133A patent/FI20077133A7/en unknown
- 2006-06-22 EA EA200800102A patent/EA019239B1/en not_active IP Right Cessation
- 2006-06-22 PL PL06742481T patent/PL1896439T5/en unknown
- 2006-06-22 CN CNA2006800200393A patent/CN101189220A/en active Pending
- 2006-06-22 KR KR1020127014205A patent/KR20120064140A/en not_active Ceased
- 2006-06-22 MX MX2007015328A patent/MX2007015328A/en active IP Right Grant
- 2006-06-22 ES ES06742481.2T patent/ES2356838T5/en active Active
- 2006-06-22 TR TR2010/00625T patent/TR201000625T1/en unknown
- 2006-06-22 SG SG201100648-3A patent/SG169358A1/en unknown
- 2006-06-22 EE EEU200800003U patent/EE00773U1/en not_active IP Right Cessation
- 2006-06-22 KR KR1020117005777A patent/KR101340815B1/en active Active
- 2006-06-22 AU AU2006261452A patent/AU2006261452B2/en not_active Withdrawn - After Issue
- 2006-06-22 JP JP2008517323A patent/JP4906852B2/en active Active
- 2006-06-22 EP EP06742481.2A patent/EP1896439B2/en active Active
- 2006-06-22 ZA ZA200711066A patent/ZA200711066B/en unknown
- 2006-06-22 DE DE112006001619T patent/DE112006001619T5/en not_active Withdrawn
- 2006-06-22 SK SK50040-2007A patent/SK500402007A3/en unknown
-
2007
- 2007-11-18 IL IL187454A patent/IL187454A0/en unknown
- 2007-12-19 BG BG10110024A patent/BG66086B1/en unknown
- 2007-12-21 LV LVP-07-157A patent/LV13677B/en unknown
-
2008
- 2008-01-14 IS IS8705A patent/IS8705A/en unknown
- 2008-01-18 NO NO20080359A patent/NO20080359L/en unknown
- 2008-01-21 DK DK200800075A patent/DK200800075A/en not_active Application Discontinuation
- 2008-01-21 LT LT2008005A patent/LT5550B/en not_active IP Right Cessation
- 2008-10-07 JP JP2008260742A patent/JP4415056B2/en active Active
-
2009
- 2009-02-27 DK DKPA200900284A patent/DK200900284A/en not_active Application Discontinuation
- 2009-03-10 ZA ZA200901698A patent/ZA200901698B/en unknown
- 2009-05-12 JP JP2009115279A patent/JP2009179634A/en active Pending
- 2009-05-12 JP JP2009115280A patent/JP2009179635A/en active Pending
- 2009-07-07 AT AT0041709U patent/AT11883U1/en not_active IP Right Cessation
-
2010
- 2010-03-05 AU AU2010200844A patent/AU2010200844A1/en not_active Withdrawn
- 2010-12-20 NO NO20101777A patent/NO20101777L/en not_active Application Discontinuation
- 2010-12-27 AR ARP100104958A patent/AR079750A2/en not_active Application Discontinuation
-
2011
- 2011-02-03 CY CY20111100116T patent/CY1112392T1/en unknown
- 2011-11-24 JP JP2011255804A patent/JP5731957B2/en active Active
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