PL1919466T3 - Formulacje do leczenia nieprawidłowości lipoproteinowych obejmujące statynę i pochodną metylonikotynoamidu - Google Patents
Formulacje do leczenia nieprawidłowości lipoproteinowych obejmujące statynę i pochodną metylonikotynoamiduInfo
- Publication number
- PL1919466T3 PL1919466T3 PL06848969T PL06848969T PL1919466T3 PL 1919466 T3 PL1919466 T3 PL 1919466T3 PL 06848969 T PL06848969 T PL 06848969T PL 06848969 T PL06848969 T PL 06848969T PL 1919466 T3 PL1919466 T3 PL 1919466T3
- Authority
- PL
- Poland
- Prior art keywords
- statin
- methylnicotinamide
- formulations
- derivative
- treatment
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 2
- 102000004895 Lipoproteins Human genes 0.000 title abstract 2
- 108090001030 Lipoproteins Proteins 0.000 title abstract 2
- 230000005856 abnormality Effects 0.000 title abstract 2
- JRYYVMDEUJQWRO-UHFFFAOYSA-N 2-methylnicotinamide Chemical class CC1=NC=CC=C1C(N)=O JRYYVMDEUJQWRO-UHFFFAOYSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000005480 nicotinamides Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69829205P | 2005-07-11 | 2005-07-11 | |
| EP06848969A EP1919466B9 (en) | 2005-07-11 | 2006-07-11 | Formulations for treatment of lipoprotein abnormalities comprising a statin and a methylnicotinamide derivative |
| PCT/IB2006/004013 WO2007074406A2 (en) | 2005-07-11 | 2006-07-11 | Formulations for treatment of lipoprotein abnormalities comprising a statin a statin and a methylnicotinamide derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1919466T3 true PL1919466T3 (pl) | 2012-05-31 |
Family
ID=38218362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06848969T PL1919466T3 (pl) | 2005-07-11 | 2006-07-11 | Formulacje do leczenia nieprawidłowości lipoproteinowych obejmujące statynę i pochodną metylonikotynoamidu |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20070021379A1 (pl) |
| EP (1) | EP1919466B9 (pl) |
| JP (1) | JP5490409B2 (pl) |
| AT (1) | ATE548035T1 (pl) |
| AU (1) | AU2006329564A1 (pl) |
| CA (1) | CA2614885C (pl) |
| DK (1) | DK1919466T3 (pl) |
| ES (1) | ES2383822T3 (pl) |
| PL (1) | PL1919466T3 (pl) |
| PT (1) | PT1919466E (pl) |
| WO (1) | WO2007074406A2 (pl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL364348A1 (pl) | 2004-01-12 | 2005-07-25 | PHARMENA Sp.z o.o. | Zastosowanie czwartorzędowych soli pirydyniowych jako środka naczynioprotekcyjnego |
| DK2026651T3 (da) * | 2006-03-08 | 2013-07-08 | Cortria Corp | Kombinationsterapi med ikke-selektive COX-inhibitorer til forebyggelse af COX-relaterede maveskader |
| CA2700585A1 (en) * | 2006-10-18 | 2008-08-14 | Dermena North America, Inc. | Food extracts for treatment of lipoprotein abnormalities and skin diseases and skin disorders |
| WO2009042440A1 (en) * | 2007-09-28 | 2009-04-02 | Cortria Corporation | 1-methyl nicotinamide and derivatives for treatment of gastric injury |
| US8304439B1 (en) | 2007-10-12 | 2012-11-06 | Politechnika Lodzka | Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage |
| PL2211857T3 (pl) * | 2007-10-12 | 2012-11-30 | Politechnika Lodzka | Zastosowanie czwartorzędowych soli pirydyniowych do radioprotekcji |
| MX2010012106A (es) * | 2008-05-06 | 2011-03-21 | Cortria Corp | Analogos de 1-metilnicotinamida. |
| ES2385686B1 (es) | 2010-08-18 | 2013-06-12 | Telefónica, S.A. | Elemento de mejora de la privacidad multimedia. |
| CA2889035A1 (en) * | 2012-10-24 | 2014-05-01 | Biocopea Limited | Drug combinations and uses |
| PL3484475T3 (pl) * | 2016-07-18 | 2024-03-11 | Pharmena S.A. | 1-Metylonikotynamid do leczenia choroby układu krążenia |
| WO2018015862A1 (en) * | 2016-07-18 | 2018-01-25 | Pharmena S.A. | 1-methylnicotinamide salts for use in raising the blood levels of adiponectin |
| CN108478573A (zh) * | 2018-03-30 | 2018-09-04 | 浙江中医药大学 | 一种1-甲基烟酰胺在制备预防或治疗酒精性脂肪肝药物中的应用 |
| CN111138427B (zh) | 2018-12-05 | 2021-09-17 | 江西富祥药业股份有限公司 | 黄连素及其类似物的非诺贝特酸盐、晶型、制备方法及应用 |
| WO2020115765A1 (en) | 2018-12-05 | 2020-06-11 | Celagenex Research (India) Pvt. Ltd. | Novel synergistic composition comprising sirt1 and ampk activators for treating metabolic syndrome |
| US10864207B2 (en) * | 2019-01-02 | 2020-12-15 | Celagenex Research (India) Pvt. Ltd. | Method of treating endothelial dysfunction |
| WO2021205341A1 (en) | 2020-04-07 | 2021-10-14 | Pharmena S.A. | 1-methylnicotinamide for the prevention/treatment of inflammatory airway diseases |
| CN115837023B (zh) * | 2023-02-20 | 2023-05-16 | 中山大学附属第八医院(深圳福田) | 1-甲基烟酰胺在制备抗血管钙化药物中的应用 |
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| DE840698C (de) | 1949-07-12 | 1952-06-05 | Cilag Aktiengesellschaft | Verfahren zur herstellung neuer derivate des nicotinsaureamids |
| US5354772A (en) | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
| US4681893A (en) | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US5260305A (en) * | 1988-12-12 | 1993-11-09 | E. R. Squibb & Sons, Inc. | Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination |
| US5007790A (en) | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| HU217629B (hu) | 1991-12-12 | 2000-03-28 | Novartis Ag. | Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására |
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| ATE173159T1 (de) | 1992-03-25 | 1998-11-15 | Depomed Systems Inc | Auf hydroxyethylzellulose basierende oralen arzneidosisformen mit verzoegerter wirkstoffabgabe |
| JP3254219B2 (ja) | 1993-01-19 | 2002-02-04 | ワーナー−ランバート・コンパニー | 安定な経口用のci−981製剤およびその製法 |
| WO1995006470A1 (en) | 1993-08-30 | 1995-03-09 | Merck & Co., Inc. | Prevention and treatment of alzheimer's disease |
| US6818229B1 (en) * | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
| US6129930A (en) * | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6406715B1 (en) * | 1993-09-20 | 2002-06-18 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique urinary metabolite profiles |
| US20060263428A1 (en) * | 1993-09-20 | 2006-11-23 | Eugenio Cefali | Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics |
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-
2006
- 2006-07-11 WO PCT/IB2006/004013 patent/WO2007074406A2/en not_active Ceased
- 2006-07-11 JP JP2008520987A patent/JP5490409B2/ja not_active Expired - Fee Related
- 2006-07-11 ES ES06848969T patent/ES2383822T3/es active Active
- 2006-07-11 PL PL06848969T patent/PL1919466T3/pl unknown
- 2006-07-11 EP EP06848969A patent/EP1919466B9/en active Active
- 2006-07-11 CA CA2614885A patent/CA2614885C/en not_active Expired - Fee Related
- 2006-07-11 AT AT06848969T patent/ATE548035T1/de active
- 2006-07-11 PT PT06848969T patent/PT1919466E/pt unknown
- 2006-07-11 DK DK06848969.9T patent/DK1919466T3/da active
- 2006-07-11 AU AU2006329564A patent/AU2006329564A1/en not_active Abandoned
- 2006-07-11 US US11/484,892 patent/US20070021379A1/en not_active Abandoned
-
2010
- 2010-01-20 US US12/690,797 patent/US8211922B2/en active Active
-
2012
- 2012-06-11 US US13/493,703 patent/US8481570B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20100120726A1 (en) | 2010-05-13 |
| ES2383822T3 (es) | 2012-06-26 |
| PT1919466E (pt) | 2012-05-21 |
| WO2007074406A2 (en) | 2007-07-05 |
| US20120245115A1 (en) | 2012-09-27 |
| CA2614885A1 (en) | 2007-07-05 |
| EP1919466A2 (en) | 2008-05-14 |
| US8481570B2 (en) | 2013-07-09 |
| CA2614885C (en) | 2015-03-17 |
| EP1919466B9 (en) | 2012-05-16 |
| US20070021379A1 (en) | 2007-01-25 |
| AU2006329564A1 (en) | 2007-07-05 |
| EP1919466B1 (en) | 2012-03-07 |
| DK1919466T3 (da) | 2012-07-02 |
| US8211922B2 (en) | 2012-07-03 |
| JP5490409B2 (ja) | 2014-05-14 |
| WO2007074406A3 (en) | 2007-11-08 |
| ATE548035T1 (de) | 2012-03-15 |
| JP2009500445A (ja) | 2009-01-08 |
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