PL1940818T3 - Pochodne aminokwasów zawierające grupę disulfanylową jako mieszane inhibitory neprylizyny i aminopeptydazy n - Google Patents

Pochodne aminokwasów zawierające grupę disulfanylową jako mieszane inhibitory neprylizyny i aminopeptydazy n

Info

Publication number
PL1940818T3
PL1940818T3 PL06807506T PL06807506T PL1940818T3 PL 1940818 T3 PL1940818 T3 PL 1940818T3 PL 06807506 T PL06807506 T PL 06807506T PL 06807506 T PL06807506 T PL 06807506T PL 1940818 T3 PL1940818 T3 PL 1940818T3
Authority
PL
Poland
Prior art keywords
disulfanyl
aminopeptidase
inhibitors
mixed
derivatives containing
Prior art date
Application number
PL06807506T
Other languages
English (en)
Inventor
Bernard Roques
Marie-Claude Fournie-Zaluski
Original Assignee
Pharmaleads
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0510862A external-priority patent/FR2892413B1/fr
Application filed by Pharmaleads filed Critical Pharmaleads
Publication of PL1940818T3 publication Critical patent/PL1940818T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL06807506T 2005-10-25 2006-10-24 Pochodne aminokwasów zawierające grupę disulfanylową jako mieszane inhibitory neprylizyny i aminopeptydazy n PL1940818T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0510862A FR2892413B1 (fr) 2005-10-25 2005-10-25 Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
FR0604030A FR2892414B1 (fr) 2005-10-25 2006-05-05 Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
PCT/EP2006/067711 WO2007048787A1 (fr) 2005-10-25 2006-10-24 Derives d'amino-acides contenant un groupement disulfanyle comme inhibiteurs mixtes de la neprilysine et de l 'aminopeptidase n
EP06807506A EP1940818B1 (fr) 2005-10-25 2006-10-24 Derives d'amino-acides contenant un groupement disulfanyle comme inhibiteurs mixtes de la neprilysine et de l 'aminopeptidase n

Publications (1)

Publication Number Publication Date
PL1940818T3 true PL1940818T3 (pl) 2012-01-31

Family

ID=37491764

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06807506T PL1940818T3 (pl) 2005-10-25 2006-10-24 Pochodne aminokwasów zawierające grupę disulfanylową jako mieszane inhibitory neprylizyny i aminopeptydazy n

Country Status (4)

Country Link
EP (1) EP1940818B1 (pl)
AU (1) AU2006307938B2 (pl)
PL (1) PL1940818T3 (pl)
WO (1) WO2007048787A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2931151A1 (fr) * 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
US20150018566A1 (en) 2011-08-25 2015-01-15 The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy Tubulin binding agents
FR2997081B1 (fr) 2012-10-23 2015-11-27 Pharmaleads Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine
TWI712582B (zh) 2015-10-14 2020-12-11 法商領先藥物公司 用來製備(5s,10s)-10-苄基-16-甲基-11,14,18-三側氧基-15,17,19-三氧雜-2,7,8-三噻基-12-氮二十一烷基-5-銨基(e)-3-羧基丙烯酸鹽的工業方法
FR3077201B1 (fr) 2018-01-26 2020-01-17 Pharmaleads Derives aminoacides contenant un groupement disulfanyle sous forme d'un inhibiteur de nep et d'apn pour la prevention et le traitement des douleurs relatives au nerf trijumeau

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2651229B1 (fr) * 1989-08-24 1991-12-13 Inst Nat Sante Rech Med Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique.

Also Published As

Publication number Publication date
AU2006307938B2 (en) 2012-04-19
AU2006307938A1 (en) 2007-05-03
EP1940818A1 (fr) 2008-07-09
EP1940818B1 (fr) 2011-08-24
WO2007048787A1 (fr) 2007-05-03

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