PL1951882T3 - Nucleic acids encoding vaccines against the porcine reproductive and respiratory syndrome virus (prrsv) - Google Patents

Nucleic acids encoding vaccines against the porcine reproductive and respiratory syndrome virus (prrsv)

Info

Publication number: PL1951882T3
Authority: PL; Poland
Prior art keywords: prrsv; nucleic acids; acids encoding; respiratory syndrome; syndrome virus
Prior art date: 2005-12-01

Application number

PL06829221T

Other languages

Polish (pl)

Inventor

Sanches Luis Enjuanes

Lucas Sonia Zuniga

Durán Joan Plana

Gurpegui Isabel Sola

Original Assignee

Consejo Superior Investigacion

Fort Dodge Veterinaria S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-01

Filing date

2006-11-30

Publication date

2011-05-31

2006-11-30 Application filed by Consejo Superior Investigacion, Fort Dodge Veterinaria S A filed Critical Consejo Superior Investigacion

2011-05-31 Publication of PL1951882T3 publication Critical patent/PL1951882T3/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—RNA viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20041—Use of virus, viral particle or viral elements as a vector
- C12N2770/20043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Plant Pathology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL06829221T 2005-12-01 2006-11-30 Nucleic acids encoding vaccines against the porcine reproductive and respiratory syndrome virus (prrsv) PL1951882T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP05026255A EP1792996A1 (en)	2005-12-01	2005-12-01	Nucleic acid sequences encoding vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV)
PCT/EP2006/011529 WO2007062851A2 (en)	2005-12-01	2006-11-30	Nucleic acids encoding tgev and prrsv sequences for improved expression of prrsv sequences
EP06829221A EP1951882B1 (en)	2005-12-01	2006-11-30	Nucleic acids encoding vaccines against the porcine reproductive and respiratory syndrome virus (prrsv)

Publications (1)

Publication Number	Publication Date
PL1951882T3 true PL1951882T3 (en)	2011-05-31

Family

ID=36084331

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06829221T PL1951882T3 (en)	2005-12-01	2006-11-30	Nucleic acids encoding vaccines against the porcine reproductive and respiratory syndrome virus (prrsv)

Country Status (13)

Country	Link
US (2)	US20120114683A1 (en)
EP (5)	EP1792996A1 (en)
AR (1)	AR057213A1 (en)
AT (1)	ATE485383T1 (en)
CA (1)	CA2631382A1 (en)
CL (1)	CL2010000883A1 (en)
DE (1)	DE602006017725D1 (en)
DK (1)	DK1951882T3 (en)
ES (1)	ES2353952T3 (en)
PL (1)	PL1951882T3 (en)
PT (1)	PT1951882E (en)
TW (2)	TWI358455B (en)
WO (1)	WO2007062851A2 (en)

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EP1792996A1 (en) *	2005-12-01	2007-06-06	Consejo Superior de Investigaciones Cientificas	Nucleic acid sequences encoding vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV)
WO2011075379A1 (en) *	2009-12-18	2011-06-23	Boehringer Ingelheim Vetmedica, Inc.	Multivalent vaccine against porcine teschovirus and other disease causing organisms in swine
CN102115755A (en) *	2010-10-11	2011-07-06	洛阳普莱柯生物工程有限公司	Pichia expression PCV2 (porcine circovirus 2) ORF2 (open reading frame 2) protein and subunit vaccine
EP2457583A1 (en)	2010-11-26	2012-05-30	Consejo Superior De Investigaciones Cientificas	Nucleic acids encoding PRRSV GP5-ecto and M protein
BR112013030321A2 (en)	2011-05-27	2017-07-11	Sinovet Beijing Biotechnology Co Ltd	vaccine composition, method for preparing the vaccine composition, use of the vaccine composition, method for immunizing a pig, csfv vaccine strain, and use of a cell in cultivating a csfv vaccine strain.
CN102727883B (en) *	2011-05-27	2014-05-14	华威特（北京）生物科技有限公司	Combined live vaccine against porcine reproductive and respiratory syndrome and swine fever, and application thereof
CN102727882B (en) *	2011-10-27	2014-05-14	华威特（北京）生物科技有限公司	Combined live vaccine against porcine reproductive and respiratory syndrome, swine fever and pseudorabies, and preparation method thereof
CN102727884B (en) *	2011-10-27	2014-05-14	华威特（北京）生物科技有限公司	Combined live vaccine against porcine reproductive and respiratory syndrome and pseudorabies, and preparation method thereof
CN105327344B (en) *	2011-08-01	2019-03-05	普莱柯生物工程股份有限公司	Vaccine composition and the preparation method and application thereof containing porcine circovirus 2 type antigen Yu haemophilus parasuis antigen
CN103157100B (en) *	2011-12-08	2014-09-24	普莱柯生物工程股份有限公司	hemophilus parasuis disease, swine streptococcosis bivalent inactivated vaccine and preparation method thereof
UA114503C2 (en)	2012-04-04	2017-06-26	Зоетіс Сервісіз Ллс	PCV AND MYCOPLASMA HYOPNEUMONIA COMBINED VACCINE
UA114504C2 (en)	2012-04-04	2017-06-26	Зоетіс Сервісіз Ллс	PCV, MYCOPLASMA HYOPNEUMONIA AND PRRS COMBINED VACCINE
US9120859B2 (en)	2012-04-04	2015-09-01	Zoetis Services Llc	Mycoplasma hyopneumoniae vaccine
CN102715132A (en) *	2012-05-04	2012-10-10	吉林大学	Porcine reproductive and respiratory syndrome virus receptor CD163 knock-out swine and cultivation method thereof
KR101641865B1 (en) *	2013-12-13	2016-07-22	한남대학교 산학협력단	Real-time PCR assays for quantitative detection of transmissible gastroenteritis virus
WO2016007955A1 (en) *	2014-07-11	2016-01-14	Merial, Inc.	Inactivated vaccine for porcine epidemic diarrhea virus (pedv)
CN104745578A (en) *	2015-04-21	2015-07-01	天津出入境检验检疫局动植物与食品检测中心	Duplex fluorescent RT-PCR (Reverse Transcription-Polymerase Chain Reaction) detection reagent for Nipah virus and porcine reproductive and respiratory syndrome virus (PRRSV) as well as preparation method and application of duplex fluorescent RT-PCR detection reagent
CN106929480B (en) *	2015-12-29	2021-04-27	普莱柯生物工程股份有限公司	Porcine reproductive and respiratory syndrome virus strain and application thereof
JP7250520B2 (en)	2016-04-13	2023-04-03	ヤンセンファーマシューティカルズ，インコーポレーテッド	Recombinant arterivirus replicon system and uses thereof
CA3045650A1 (en) *	2016-12-05	2018-06-14	Janssen Pharmaceuticals, Inc.	Compositions and methods for enhancing gene expression
CN106755576A (en) *	2016-12-27	2017-05-31	湖南新南方养殖服务有限公司	A kind of real-time fluorescence RT PCR kits for detecting porcine rotavirus in piglet Cord blood and application thereof
CN107266581B (en) *	2017-06-13	2021-07-09	四川大学	Preparation method and application of Tibetan pig IL-12 recombinant plasmid to enhance PCV2 vaccine immune adjuvant
CN109232736B (en) *	2017-07-10	2021-11-09	洛阳普泰生物技术有限公司	Monoclonal antibody specifically binding to porcine transmissible gastroenteritis virus, pharmaceutical composition, kit and application thereof
CN107880120B (en) *	2017-11-06	2018-10-12	陕西诺威利华生物科技有限公司	A kind of transmissible gastro-enteritis virus Yolk antibody and preparation method thereof
CN110616201A (en) *	2018-06-19	2019-12-27	中国动物疫病预防控制中心（农业部屠宰技术中心）	Porcine reproductive and respiratory syndrome virus American classical strain nucleic acid standard substance and preparation method thereof
CN109735551A (en) *	2018-12-26	2019-05-10	河南农业大学	A kind of porcine reproductive and respiratory syndrome virus recombinant plasmid and its construction method
CN110055251B (en) *	2019-04-25	2022-05-27	山东省农业科学院畜牧兽医研究所	Sequence for regulating and controlling PCV2 virus proliferation and application thereof
CN111996213A (en) *	2020-02-06	2020-11-27	广西大学	Construction method of porcine reproductive and respiratory syndrome virus double fluorescent marker gene recombinant strain
CN112812177B (en) *	2020-08-18	2022-12-09	安徽九川生物科技有限公司	Mouse-derived single-chain antibody for resisting transmissible gastroenteritis virus of swine and preparation method thereof
CN112089804A (en) *	2020-09-17	2020-12-18	楚雄彝族自治州动物疫病预防控制中心	Medicine for resisting porcine reproductive and respiratory syndrome infection and detection method thereof
CN116445454B (en) *	2023-05-23	2023-11-17	中农种源(深圳)科技有限公司	Complete system for breeding pig breeds resistant to TGEV infection and application thereof
CN119258209B (en) *	2024-12-10	2025-03-28	山东仙普爱瑞科技股份有限公司	A vaccine highly expressing porcine interferon-alpha and PRRSV GP5 protein, preparation method and application thereof
CN120865395B (en) *	2025-09-29	2025-12-02	北京溯本源和生物科技有限公司	A monoclonal antibody combination for detecting porcine reproductive and respiratory syndrome virus (PRRSV) N protein and its application
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CA2620667A1 (en) *	2005-08-30	2007-04-12	Board Of Regents Of The University Of Nebraska	Methods and compositions for vaccination of animals with prrsv antigens with improved immunogenicity
EP1792996A1 (en) *	2005-12-01	2007-06-06	Consejo Superior de Investigaciones Cientificas	Nucleic acid sequences encoding vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV)

2005
- 2005-12-01 EP EP05026255A patent/EP1792996A1/en not_active Withdrawn
2006
- 2006-11-30 EP EP10013126A patent/EP2327787A1/en not_active Ceased
- 2006-11-30 CA CA002631382A patent/CA2631382A1/en not_active Abandoned
- 2006-11-30 WO PCT/EP2006/011529 patent/WO2007062851A2/en not_active Ceased
- 2006-11-30 EP EP06829221A patent/EP1951882B1/en not_active Not-in-force
- 2006-11-30 EP EP10013125A patent/EP2316960A1/en not_active Ceased
- 2006-11-30 PT PT06829221T patent/PT1951882E/en unknown
- 2006-11-30 US US12/085,924 patent/US20120114683A1/en not_active Abandoned
- 2006-11-30 TW TW095144370A patent/TWI358455B/en not_active IP Right Cessation
- 2006-11-30 PL PL06829221T patent/PL1951882T3/en unknown
- 2006-11-30 ES ES06829221T patent/ES2353952T3/en active Active
- 2006-11-30 US US11/606,237 patent/US20090202588A1/en not_active Abandoned
- 2006-11-30 DK DK06829221.8T patent/DK1951882T3/en active
- 2006-11-30 EP EP10013128A patent/EP2275565A3/en not_active Ceased
- 2006-11-30 TW TW100107364A patent/TWI382089B/en not_active IP Right Cessation
- 2006-11-30 AT AT06829221T patent/ATE485383T1/en active
- 2006-11-30 DE DE602006017725T patent/DE602006017725D1/en active Active
- 2006-12-01 AR ARP060105309A patent/AR057213A1/en not_active Application Discontinuation
2010
- 2010-08-19 CL CL2010000883A patent/CL2010000883A1/en unknown

Also Published As

Publication number	Publication date
EP2327787A1 (en)	2011-06-01
US20120114683A1 (en)	2012-05-10
TW201124536A (en)	2011-07-16
EP2316960A1 (en)	2011-05-04
DE602006017725D1 (en)	2010-12-02
ES2353952T3 (en)	2011-03-08
EP1951882B1 (en)	2010-10-20
EP1951882A2 (en)	2008-08-06
DK1951882T3 (en)	2011-02-07
WO2007062851A2 (en)	2007-06-07
CL2010000883A1 (en)	2010-12-10
TW200738880A (en)	2007-10-16
WO2007062851A3 (en)	2007-10-11
AR057213A1 (en)	2007-11-21
TWI382089B (en)	2013-01-11
CA2631382A1 (en)	2007-06-07
EP2275565A2 (en)	2011-01-19
EP1792996A1 (en)	2007-06-06
US20090202588A1 (en)	2009-08-13
EP2275565A3 (en)	2011-04-27
PT1951882E (en)	2010-12-31
ATE485383T1 (en)	2010-11-15
TWI358455B (en)	2012-02-21

Publication	Publication Date	Title
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