PL1981863T3 - Sposób wytwarzania pochodnych chinazoliny podstawionych przez ugrupowanie aminokrotonyloaminowe - Google Patents

Sposób wytwarzania pochodnych chinazoliny podstawionych przez ugrupowanie aminokrotonyloaminowe

Info

Publication number
PL1981863T3
PL1981863T3 PL07704145T PL07704145T PL1981863T3 PL 1981863 T3 PL1981863 T3 PL 1981863T3 PL 07704145 T PL07704145 T PL 07704145T PL 07704145 T PL07704145 T PL 07704145T PL 1981863 T3 PL1981863 T3 PL 1981863T3
Authority
PL
Poland
Prior art keywords
quinazoline derivatives
substituted quinazoline
aminocrotonylamino
preparing
preparing aminocrotonylamino
Prior art date
Application number
PL07704145T
Other languages
English (en)
Inventor
Juergen Schroeder
Georg Dziewas
Thomas Fachinger
Burkhard Jaeger
Carsten Reichel
Svenja Renner
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PL1981863T3 publication Critical patent/PL1981863T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/02—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms not condensed with other rings
    • C07D293/04—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL07704145T 2006-01-26 2007-01-25 Sposób wytwarzania pochodnych chinazoliny podstawionych przez ugrupowanie aminokrotonyloaminowe PL1981863T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06100914 2006-01-26
PCT/EP2007/050752 WO2007085638A1 (en) 2006-01-26 2007-01-25 Process for preparing aminocrotonylamino-substituted quinazoline derivatives
EP07704145A EP1981863B1 (en) 2006-01-26 2007-01-25 Process for preparing aminocrotonylamino-substituted quinazoline derivatives

Publications (1)

Publication Number Publication Date
PL1981863T3 true PL1981863T3 (pl) 2013-03-29

Family

ID=38180518

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07704145T PL1981863T3 (pl) 2006-01-26 2007-01-25 Sposób wytwarzania pochodnych chinazoliny podstawionych przez ugrupowanie aminokrotonyloaminowe

Country Status (11)

Country Link
US (3) US7960546B2 (pl)
EP (1) EP1981863B1 (pl)
JP (1) JP5241513B2 (pl)
CA (1) CA2639936C (pl)
CY (1) CY1113778T1 (pl)
DK (1) DK1981863T3 (pl)
ES (1) ES2397181T3 (pl)
PL (1) PL1981863T3 (pl)
PT (1) PT1981863E (pl)
SI (1) SI1981863T1 (pl)
WO (1) WO2007085638A1 (pl)

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US7019012B2 (en) * 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
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DE10349113A1 (de) * 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
PL1948180T3 (pl) * 2005-11-11 2013-09-30 Boehringer Ingelheim Int Terapia skojarzona raka polegająca na podawaniu inhibitorów EGFR/HER2
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UY31867A (es) * 2008-06-06 2010-01-29 Boehringer Ingelheim Int Nuevas formulaciones farmacéuticas sólidas que comprenden bibw 2992
JP5721709B2 (ja) * 2009-07-02 2015-05-20 ニューゲン セラピューティクス， インコーポレイテッド リンを含むキナゾリン化合物および使用方法
PL2451445T3 (pl) 2009-07-06 2019-09-30 Boehringer Ingelheim International Gmbh Sposób suszenia BIBW2992, jego soli i stałych preparatów farmaceutycznych zawierających tę substancję czynną
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EP2951171A1 (en) * 2013-02-01 2015-12-09 Boehringer Ingelheim International GmbH Radiolabeled quinazoline derivatives
TWI609012B (zh) 2013-04-28 2017-12-21 廣東東陽光藥業有限公司 氨基喹唑啉類衍生物及其鹽和使用方法
CN103254183B (zh) * 2013-05-10 2015-11-11 苏州明锐医药科技有限公司 阿法替尼的制备方法
CN103254156B (zh) * 2013-05-10 2015-08-26 苏州明锐医药科技有限公司 阿法替尼中间体的制备方法
WO2014180271A1 (zh) * 2013-05-10 2014-11-13 苏州明锐医药科技有限公司 阿法替尼及其中间体的制备方法
CN103288808B (zh) * 2013-05-16 2015-11-11 苏州明锐医药科技有限公司 一种阿法替尼的制备方法
CN104710413B (zh) * 2013-12-16 2019-05-03 江苏豪森药业集团有限公司 二马来酸阿法替尼的制备方法
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN107141261B (zh) * 2014-07-15 2020-05-05 杭州华东医药集团新药研究院有限公司 喹唑啉类化合物及其制备方法和在制备酪氨酸激酶抑制剂中的应用
CN105315263B (zh) * 2014-07-30 2018-11-27 正大天晴药业集团股份有限公司 阿法替尼中间体的合成方法
CN105439879B (zh) * 2014-08-07 2018-08-10 天津法莫西医药科技有限公司 一种反式-4-二甲胺基巴豆酸盐酸盐的制备方法
CN105330652B (zh) * 2014-08-07 2019-04-05 天津法莫西医药科技有限公司 一种阿法替尼的制备方法
CN104447713B (zh) * 2014-11-18 2019-03-29 江苏奥赛康药业股份有限公司 阿法替尼化合物的制备方法
EP3023421A1 (en) 2014-11-21 2016-05-25 Sandoz Ag Crystalline forms of afatinib dimaleate
CN105777655B (zh) * 2014-12-25 2018-02-02 深圳海王医药科技研究院有限公司 萘普替尼对甲苯磺酸盐的α晶型及制备方法和含有其的药物组合物
CN104592212B (zh) * 2014-12-31 2017-11-10 广东东阳光药业有限公司 一种阿法替尼中间体的制备方法
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US20190112317A1 (en) 2015-10-05 2019-04-18 The Trustees Of Columbia University In The City Of New York Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
CN107216317B (zh) * 2016-03-21 2020-04-07 上海医药工业研究院 一种阿法替尼中间体的制备方法
CN105669658B (zh) * 2016-04-05 2018-06-29 北京民康百草医药科技有限公司 一种阿法替尼的精制方法
CN106045983A (zh) * 2016-06-02 2016-10-26 苏州富士莱医药股份有限公司 阿法替尼的制备方法
CN107488171B (zh) * 2016-06-10 2020-08-28 山东新时代药业有限公司 一种阿法替尼制备方法
CN105968103B (zh) * 2016-07-18 2018-11-27 山东罗欣药业集团恒欣药业有限公司 抗肿瘤药物阿法替尼的合成方法
CN106243092B (zh) * 2016-07-28 2019-02-15 南京臣功制药股份有限公司 一种高选择性制备马来酸阿法替尼的方法
CN106565692A (zh) * 2016-11-03 2017-04-19 常茂生物化学工程股份有限公司 一种阿法替尼合成工艺的改进方法
CN106908531B (zh) * 2017-02-22 2019-08-06 深圳海王医药科技研究院有限公司 一种高效液相色谱梯度法同时测定萘普替尼光降解产物及其它有关物质的方法
CN110693846B (zh) * 2018-07-10 2021-07-27 杭州华东医药集团新药研究院有限公司 迈华替尼药物组合物及其制备方法
CN110590754A (zh) * 2019-09-21 2019-12-20 广东安诺药业股份有限公司 一种马来酸阿法替尼中间体的制备方法
JP7450037B2 (ja) 2020-07-09 2024-03-14 Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 脳転移を有する末期非小細胞肺がん患者を治療するための組み合わせ医薬品
WO2023028056A1 (en) 2021-08-24 2023-03-02 Genentech, Inc. 3-amino piperidyl sodium channel inhibitors
CA3242316A1 (en) 2021-12-30 2023-07-06 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3

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YU90901A (sh) 1999-06-21 2004-07-15 Boehringer Ingelheim Pharma Gmbh. & Co.Kg. Biciklični heterocikli, lekovi koji sadrže ta jedinjenja, njihova primena i postupci za njihovo pripremanje
DE10063435A1 (de) * 2000-12-20 2002-07-04 Boehringer Ingelheim Pharma Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
DE10221018A1 (de) 2002-05-11 2003-11-27 Boehringer Ingelheim Pharma Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie
US20030225079A1 (en) 2002-05-11 2003-12-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of inhibitors of the EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH)/prostatic hypertrophy
DE10307165A1 (de) 2003-02-20 2004-09-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung
US7223749B2 (en) 2003-02-20 2007-05-29 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
DE10349113A1 (de) 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
EP1948179A1 (en) 2005-11-11 2008-07-30 Boehringer Ingelheim International GmbH Quinazoline derivatives for the treatment of cancer diseases
PL1948180T3 (pl) 2005-11-11 2013-09-30 Boehringer Ingelheim Int Terapia skojarzona raka polegająca na podawaniu inhibitorów EGFR/HER2
CA2639936C (en) 2006-01-26 2014-06-17 Boehringer Ingelheim International Gmbh Process for preparing aminocrotonylamino-substituted quinazoline derivatives
BRPI0717586A2 (pt) 2006-09-18 2013-10-29 Boehringer Ingelheim Int Método para tratar câncer apresentando mutações do egfr
UY31867A (es) 2008-06-06 2010-01-29 Boehringer Ingelheim Int Nuevas formulaciones farmacéuticas sólidas que comprenden bibw 2992
WO2010081817A1 (en) 2009-01-14 2010-07-22 Boehringer Ingelheim International Gmbh Method for treating colorectal cancer
PL2451445T3 (pl) 2009-07-06 2019-09-30 Boehringer Ingelheim International Gmbh Sposób suszenia BIBW2992, jego soli i stałych preparatów farmaceutycznych zawierających tę substancję czynną

Also Published As

Publication number Publication date
EP1981863A1 (en) 2008-10-22
PT1981863E (pt) 2012-12-07
ES2397181T3 (es) 2013-03-05
CY1113778T1 (el) 2016-07-27
US8188274B2 (en) 2012-05-29
WO2007085638A1 (en) 2007-08-02
US20090306378A1 (en) 2009-12-10
US20110207932A1 (en) 2011-08-25
US20110207929A1 (en) 2011-08-25
US7960546B2 (en) 2011-06-14
CA2639936C (en) 2014-06-17
JP5241513B2 (ja) 2013-07-17
JP2009528981A (ja) 2009-08-13
CA2639936A1 (en) 2008-08-02
EP1981863B1 (en) 2012-10-10
SI1981863T1 (sl) 2013-01-31
US8067593B2 (en) 2011-11-29
DK1981863T3 (da) 2013-01-02

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