PL2024375T3 - Skondensowane z cyklopropylem indolobenzoazepinowe inhibitory NS5B HCV - Google Patents

Skondensowane z cyklopropylem indolobenzoazepinowe inhibitory NS5B HCV

Info

Publication number: PL2024375T3
Authority: PL; Poland
Prior art keywords: hcv ns5b; ns5b inhibitors; cyclopropyl fused; fused indolobenzazepine; indolobenzazepine hcv
Prior art date: 2006-05-17

Application number

PL07761873T

Other languages

English (en)

Inventor

John A Bender

Min Ding

Robert G Gentles

Piyasena Hewawasam

Original Assignee

Bristol Myers Squibb Holdings Ireland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-17

Filing date

2007-05-04

Publication date

2011-07-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38512732&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2024375(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-05-04 Application filed by Bristol Myers Squibb Holdings Ireland filed Critical Bristol Myers Squibb Holdings Ireland

2011-07-29 Publication of PL2024375T3 publication Critical patent/PL2024375T3/pl

Links

JYGUARFTLQSWDG-UHFFFAOYSA-N 3,12-diazatetracyclo[9.7.0.02,8.013,18]octadeca-1,3,5,7,9,11,13,15,17-nonaene Chemical compound C1=CC=NC2=C3C4=CC=CC=C4N=C3C=CC2=C1 JYGUARFTLQSWDG-UHFFFAOYSA-N 0.000 title 1
101710112514 Host translation inhibitor 5b Proteins 0.000 title 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL07761873T 2006-05-17 2007-05-04 Skondensowane z cyklopropylem indolobenzoazepinowe inhibitory NS5B HCV PL2024375T3 (pl)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US80112506P	2006-05-17	2006-05-17
US80200506P	2006-05-19	2006-05-19
US85208406P	2006-10-16	2006-10-16
US89475707P	2007-03-14	2007-03-14
PCT/US2007/068209 WO2007136982A1 (en)	2006-05-17	2007-05-04	Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors
EP07761873A EP2024375B1 (en)	2006-05-17	2007-05-04	Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors

Publications (1)

Publication Number	Publication Date
PL2024375T3 true PL2024375T3 (pl)	2011-07-29

Family

ID=38512732

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07761873T PL2024375T3 (pl)	2006-05-17	2007-05-04	Skondensowane z cyklopropylem indolobenzoazepinowe inhibitory NS5B HCV

Country Status (24)

Country	Link
US (1)	US7456166B2 (pl)
EP (1)	EP2024375B1 (pl)
JP (1)	JP5284952B2 (pl)
KR (1)	KR101417145B1 (pl)
AR (1)	AR061008A1 (pl)
AT (1)	ATE501156T1 (pl)
AU (1)	AU2007253998B2 (pl)
BR (1)	BRPI0711821A2 (pl)
CA (1)	CA2651690C (pl)
CY (1)	CY1111526T1 (pl)
DE (1)	DE602007013036D1 (pl)
DK (1)	DK2024375T3 (pl)
EA (1)	EA015286B1 (pl)
HR (1)	HRP20110194T1 (pl)
IL (1)	IL195025A (pl)
MX (1)	MX2008014435A (pl)
NO (1)	NO341663B1 (pl)
NZ (1)	NZ572555A (pl)
PE (1)	PE20080070A1 (pl)
PL (1)	PL2024375T3 (pl)
SI (1)	SI2024375T1 (pl)
TW (1)	TWI401244B (pl)
WO (1)	WO2007136982A1 (pl)
ZA (1)	ZA200809548B (pl)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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WO2005049622A1 (ja) *	2003-11-19	2005-06-02	Japan Tobacco Inc.	５－５員縮合複素環化合物及びそのｈｃｖポリメラーゼ阻害剤としての用途
US20070049593A1 (en)	2004-02-24	2007-03-01	Japan Tobacco Inc.	Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
US7659263B2 (en)	2004-11-12	2010-02-09	Japan Tobacco Inc.	Thienopyrrole compound and use thereof as HCV polymerase inhibitor
US7521443B2 (en) *	2006-05-17	2009-04-21	Bristol-Myers Squibb Company	Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
DE602007006796D1 (de) *	2006-05-25	2010-07-08	Bristol Myers Squibb Co	Cyclopropyl-fusionierte indolbenzazepin-hcv-ns5b-hemmer
US7541351B2 (en) *	2007-01-11	2009-06-02	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
US7541352B2 (en) *	2007-02-02	2009-06-02	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
US7517872B2 (en) *	2007-02-22	2009-04-14	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
US7998951B2 (en) *	2007-03-05	2011-08-16	Bristol-Myers Squibb Company	HCV NS5B inhibitors
CN101679437B (zh)	2007-03-13	2013-04-17	百时美施贵宝公司	环丙基稠合的吲哚并苯并氮杂*hcv ns5b抑制剂
US7521444B2 (en) *	2007-03-14	2009-04-21	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
US7538102B2 (en) *	2007-03-14	2009-05-26	Bristol-Myers Squibb Company	Compounds for the treatment of Hepatitis C
US7547690B2 (en) *	2007-03-14	2009-06-16	Bristol-Myers Squibb Company	Compounds for the treatment of Hepatitis C
US7541353B2 (en) *	2007-03-14	2009-06-02	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
US7538103B2 (en) *	2007-03-15	2009-05-26	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
MX2009011930A (es)	2007-05-04	2009-11-18	Vertex Pharma	Terapia de combinacion para el tratamiento de infeccion de virus de hepatitis c.
US7642251B2 (en) *	2007-08-09	2010-01-05	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
US8143243B2 (en) *	2007-08-09	2012-03-27	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
US7652004B2 (en) *	2007-08-09	2010-01-26	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
EP2209789B1 (en) *	2007-11-20	2011-11-16	Bristol-Myers Squibb Company	Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors
US8124601B2 (en) *	2007-11-21	2012-02-28	Bristol-Myers Squibb Company	Compounds for the treatment of Hepatitis C
US8129367B2 (en) *	2007-11-21	2012-03-06	Bristol-Myers Squibb Company	Compounds for the treatment of Hepatitis C
EP2234977A4 (en)	2007-12-19	2011-04-13	Boehringer Ingelheim Int	VIRAL POLYMERASE INHIBITORS
CN101910177B (zh)	2007-12-24	2013-08-28	泰博特克药品公司	作为丙型肝炎病毒抑制剂的大环吲哚
US8178523B2 (en) *	2008-03-27	2012-05-15	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
US8138171B2 (en) *	2008-03-27	2012-03-20	Bristol-Myers Squibb Company	Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors
KR20100126560A (ko) *	2008-03-27	2010-12-01	브리스톨-마이어스 스큅 컴퍼니	피롤리딘 융합된 인돌로벤자디아제핀 ｈｃｖｎｓ5ｂ 억제제
US8133884B2 (en) *	2008-05-06	2012-03-13	Bristol-Myers Squibb Company	Compounds for the treatment of hepatitis C
TWI454476B (zh) *	2008-07-08	2014-10-01	Tibotec Pharm Ltd	用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
UY32099A (es)	2008-09-11	2010-04-30	Enanta Pharm Inc	Inhibidores macrocíclicos de serina proteasas de hepatitis c
KR20110116136A (ko)	2009-01-07	2011-10-25	싸이넥시스, 인크.	Ｈｃｖ 및 ｈｉｖ 감염의 치료에 사용하기 위한 사이클로스포린 유도체
US8143244B2 (en) *	2009-02-26	2012-03-27	Bristol-Myers Squibb Company	Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
EP2585438B1 (en)	2010-06-24	2014-08-20	Janssen R&D Ireland	PREPARATION OF 13-CYCLOHEXYL-3-METHOXY-6-[METHYL-(2-{2-[METHYL-(SULPHAMOYL)-AMINO]-ETHOXY}-ETHYL)-CARBAMOYL]-7H-INDOLO-[2,1-a]-[2]-BENZAZEPINE-10-CARBOXYLIC ACID
US20120196794A1 (en) *	2010-08-06	2012-08-02	Bristol-Myers Squibb Company	Combinations of Hepatitis C Virus Inhibitors
WO2012087833A1 (en)	2010-12-22	2012-06-28	Abbott Laboratories	Hepatitis c inhibitors and uses thereof
CN103534256B (zh)	2010-12-30	2016-08-10	益安药业	大环丙型肝炎丝氨酸蛋白酶抑制剂
KR20140003521A (ko)	2010-12-30	2014-01-09	이난타 파마슈티칼스, 인코포레이티드	페난트리딘 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제
US10201584B1 (en)	2011-05-17	2019-02-12	Abbvie Inc.	Compositions and methods for treating HCV
US8716275B2 (en) *	2011-10-20	2014-05-06	Bristol-Myers Squibb Company	Compound for the treatment of hepatitis C
EP3091022A3 (en)	2012-07-18	2016-12-14	Bristol-Myers Squibb Holdings Ireland	Methods and intermediates for the preparation of (4bs,5ar)-12-cyclohexyl-n-(n,n-dimethylsulfamoyl)-3- methoxy-5a-((1r,5s)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo [3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide
WO2015103490A1 (en)	2014-01-03	2015-07-09	Abbvie, Inc.	Solid antiviral dosage forms
US12083099B2 (en)	2020-10-28	2024-09-10	Accencio LLC	Methods of treating symptoms of coronavirus infection with viral protease inhibitors
US12274700B1 (en)	2020-10-30	2025-04-15	Accencio LLC	Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors

Family Cites Families (13)

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US752354A (en) *		1904-02-16		Composition post
US753137A (en) *		1904-02-23		Dust-pan
US756203A (en) *	1903-11-14	1904-04-05	Oliver E Barthel	Muffler.
WO2005080399A1 (ja)	2004-02-24	2005-09-01	Japan Tobacco Inc.	４環縮合複素環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用
US7348425B2 (en) *	2004-08-09	2008-03-25	Bristol-Myers Squibb Company	Inhibitors of HCV replication
US7153848B2 (en) *	2004-08-09	2006-12-26	Bristol-Myers Squibb Company	Inhibitors of HCV replication
JP5065034B2 (ja)	2004-10-13	2012-10-31	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	キナーゼ阻害剤として適しているｎ，ｎ’−ジフェニル尿素誘導体
RU2007119562A (ru)	2004-10-26	2008-12-10	Институто Ди Ричерке Ди Биолоджиа Молеколаре П Анджелетти Спа (It)	Тетрациклические производные индолов в качестве противовирусных агентов
GB0518390D0 (en)	2005-09-09	2005-10-19	Angeletti P Ist Richerche Bio	Therapeutic compounds
US7399758B2 (en) *	2005-09-12	2008-07-15	Meanwell Nicholas A	Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7473688B2 (en) *	2005-09-13	2009-01-06	Bristol-Myers Squibb Company	Indolobenzazepine HCV NS5B inhibitors
US7456165B2 (en) *	2006-02-08	2008-11-25	Bristol-Myers Squibb Company	HCV NS5B inhibitors
GB0608928D0 (en) *	2006-05-08	2006-06-14	Angeletti P Ist Richerche Bio	Therapeutic agents

2007
- 2007-05-03 US US11/743,921 patent/US7456166B2/en not_active Expired - Fee Related
- 2007-05-04 AT AT07761873T patent/ATE501156T1/de active
- 2007-05-04 CA CA2651690A patent/CA2651690C/en not_active Expired - Fee Related
- 2007-05-04 HR HR20110194T patent/HRP20110194T1/hr unknown
- 2007-05-04 BR BRPI0711821-0A patent/BRPI0711821A2/pt not_active IP Right Cessation
- 2007-05-04 PL PL07761873T patent/PL2024375T3/pl unknown
- 2007-05-04 WO PCT/US2007/068209 patent/WO2007136982A1/en not_active Ceased
- 2007-05-04 DK DK07761873.4T patent/DK2024375T3/da active
- 2007-05-04 NZ NZ572555A patent/NZ572555A/en unknown
- 2007-05-04 SI SI200730612T patent/SI2024375T1/sl unknown
- 2007-05-04 EP EP07761873A patent/EP2024375B1/en not_active Not-in-force
- 2007-05-04 EA EA200802346A patent/EA015286B1/ru not_active IP Right Cessation
- 2007-05-04 DE DE602007013036T patent/DE602007013036D1/de active Active
- 2007-05-04 KR KR1020087027866A patent/KR101417145B1/ko not_active Expired - Fee Related
- 2007-05-04 JP JP2009511151A patent/JP5284952B2/ja active Active
- 2007-05-04 MX MX2008014435A patent/MX2008014435A/es active IP Right Grant
- 2007-05-04 AU AU2007253998A patent/AU2007253998B2/en not_active Ceased
- 2007-05-15 PE PE2007000585A patent/PE20080070A1/es active IP Right Grant
- 2007-05-17 AR ARP070102138A patent/AR061008A1/es active IP Right Grant
- 2007-05-17 TW TW096117512A patent/TWI401244B/zh not_active IP Right Cessation
2008
- 2008-10-30 IL IL195025A patent/IL195025A/en not_active IP Right Cessation
- 2008-11-04 NO NO20084637A patent/NO341663B1/no not_active IP Right Cessation
- 2008-11-07 ZA ZA2008/09548A patent/ZA200809548B/en unknown
2011
- 2011-06-03 CY CY20111100539T patent/CY1111526T1/el unknown

Also Published As

Publication number	Publication date
AR061008A1 (es)	2008-07-30
HRP20110194T1 (hr)	2011-04-30
WO2007136982A1 (en)	2007-11-29
CA2651690A1 (en)	2007-11-29
NO20084637L (no)	2008-12-15
EP2024375B1 (en)	2011-03-09
IL195025A (en)	2013-09-30
EA015286B1 (ru)	2011-06-30
JP5284952B2 (ja)	2013-09-11
DK2024375T3 (da)	2011-06-27
EA200802346A1 (ru)	2009-06-30
TWI401244B (zh)	2013-07-11
KR20090008344A (ko)	2009-01-21
AU2007253998B2 (en)	2012-03-15
HK1122814A1 (en)	2009-05-29
DE602007013036D1 (de)	2011-04-21
CA2651690C (en)	2014-11-04
EP2024375A1 (en)	2009-02-18
NZ572555A (en)	2010-11-26
ATE501156T1 (de)	2011-03-15
JP2009537557A (ja)	2009-10-29
KR101417145B1 (ko)	2014-07-08
CY1111526T1 (el)	2016-02-10
MX2008014435A (es)	2008-11-27
US20070270405A1 (en)	2007-11-22
SI2024375T1 (sl)	2011-10-28
PE20080070A1 (es)	2008-03-10
BRPI0711821A2 (pt)	2012-01-17
AU2007253998A1 (en)	2007-11-29
NO341663B1 (no)	2017-12-18
TW200804282A (en)	2008-01-16
ZA200809548B (en)	2009-12-30
IL195025A0 (en)	2009-08-03
US7456166B2 (en)	2008-11-25

Publication	Publication Date	Title
ZA200809548B (en)	2009-12-30	Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
IL198401A0 (en)	2010-02-17	Hcv ns3 protease inhibitors
IL197907A0 (en)	2009-12-24	Hcv nucleoside inhibitor
HRP20160410T8 (hr)	2019-04-19	Inhibitori hepatitis c virusa
IL233818A0 (en)	2014-09-30	Inhibitors to ns5a hcv
IL213278A0 (en)	2011-07-31	Inhibitors of hcv ns5a
ZA201008988B (en)	2012-01-25	Hcv protease inhibitors
IL195515A0 (en)	2011-08-01	Macrocyclic oximyl hepatitis c protease inhibitors
EP2410841A4 (en)	2012-10-24	SUBSTITUTED BICYCLIC HCV INHIBITORS
SI2094702T1 (sl)	2016-03-31	Virusni inhibitorji
IL189626A0 (en)	2008-08-07	Benzodiazepines as hcv inhibitors
EP2432318A4 (en)	2012-11-21	NS3 PROTEASE INHIBITORS OF BIPACROCYCLIC HEPATITIS C VIRUS
GB2439606B (en)	2011-08-17	An oscillator
ZA200902475B (en)	2010-03-31	HCV NS3 Protease Inhibitors
ZA200711069B (en)	2009-03-25	HCV inhibitors
ZA200903379B (en)	2010-07-28	Hepatitis C virus inhibitors
GB0611451D0 (en)	2006-07-19	Cellular antagonist
HUS1500008I1 (hu)	2016-10-28	Hepatitis C vírus inhibitorok
AU313339S (en)	2007-03-20	Chiller bottle
AU313340S (en)	2007-03-20	Chiller bottle
ZA200903014B (en)	2010-07-28	Hepatitis C virus inhibitors
ZA200810235B (en)	2009-10-28	Macrocyclic oximyl hepatitis C protease inhibitors