PL204599B1 - Enzymy uzyskane z orzęsków i ich zastosowanie - Google Patents

Enzymy uzyskane z orzęsków i ich zastosowanie

Info

Publication number: PL204599B1
Authority: PL; Poland
Prior art keywords: enzymes; ciliates; pancreatic; pharmaceuticals; group
Prior art date: 2000-11-02

Application number

PL361630A

Other languages

English (en)

Polish (pl)

Other versions

PL361630A1 (en

Inventor

Marcus Hartmann

Original Assignee

Cilian Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-02

Filing date

2001-11-02

Publication date

2010-01-29

2001-11-02 Application filed by Cilian Ag filed Critical Cilian Ag

2004-10-04 Publication of PL361630A1 publication Critical patent/PL361630A1/xx

2010-01-29 Publication of PL204599B1 publication Critical patent/PL204599B1/pl

Links

102000004190 Enzymes Human genes 0.000 title claims abstract description 81
108090000790 Enzymes Proteins 0.000 title claims abstract description 81
241000223782 Ciliophora Species 0.000 title claims abstract description 26
239000003814 drug Substances 0.000 title claims abstract description 15
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229940088598 enzyme Drugs 0.000 claims abstract description 80
102000004882 Lipase Human genes 0.000 claims abstract description 17
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239000004367 Lipase Substances 0.000 claims abstract description 17
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102000013563 Acid Phosphatase Human genes 0.000 description 1
108010051457 Acid Phosphatase Proteins 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nutrition Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

PL361630A 2000-11-02 2001-11-02 Enzymy uzyskane z orzęsków i ich zastosowanie PL204599B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10054239		2000-11-02
PCT/EP2001/012740 WO2002036156A1 (de)	2000-11-02	2001-11-02	Verwendung von aus ciliaten gewonnenen enzymen als verdauungsfördernde arzneimittel

Publications (2)

Publication Number	Publication Date
PL361630A1 PL361630A1 (en)	2004-10-04
PL204599B1 true PL204599B1 (pl)	2010-01-29

Family

ID=7661849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL361630A PL204599B1 (pl)	2000-11-02	2001-11-02	Enzymy uzyskane z orzęsków i ich zastosowanie

Country Status (16)

Country	Link
US (2)	US20040033220A1 (de)
EP (1)	EP1330262B1 (de)
JP (1)	JP4139215B2 (de)
CN (1)	CN1262308C (de)
AT (1)	ATE295737T1 (de)
AU (2)	AU2366602A (de)
CA (1)	CA2427537A1 (de)
DE (1)	DE50106273D1 (de)
DK (1)	DK1330262T3 (de)
ES (1)	ES2239686T3 (de)
IL (2)	IL155515A0 (de)
NO (1)	NO20031979L (de)
PL (1)	PL204599B1 (de)
PT (1)	PT1330262E (de)
RU (1)	RU2299074C2 (de)
WO (1)	WO2002036156A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20060127857A (ko) *	2003-10-29	2006-12-13	알투스 파마슈티컬스 인코포레이티드	혈장 콜레시스토키닌(ｃｃｋ) 농도 조절 및 통증 치료를위한 비-췌장 프로테아제
CA2560613C (en) *	2004-03-22	2015-11-24	Solvay Pharmaceuticals Gmbh	Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
WO2005098427A2 (en) *	2004-04-05	2005-10-20	Arbab Saccharides Science & Technology Co. Ltd	Method, composition and device for treating starch related diseases
WO2005099748A1 (de) *	2004-04-13	2005-10-27	Cilian Ag	Rekombinante lysosomale enzyme mit ciliaten-typischem glykosylierungsmuster für die therapie
HUE031042T2 (en) *	2005-07-29	2017-06-28	Abbott Laboratories Gmbh	Methods for producing pancreatin powder with low viral content
US9198871B2 (en)	2005-08-15	2015-12-01	Abbott Products Gmbh	Delayed release pancreatin compositions
US11266607B2 (en)	2005-08-15	2022-03-08	AbbVie Pharmaceuticals GmbH	Process for the manufacture and use of pancreatin micropellet cores
WO2007053619A2 (en) *	2005-11-01	2007-05-10	Bio-Cat, Inc.	A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency
US10072256B2 (en) *	2006-05-22	2018-09-11	Abbott Products Gmbh	Process for separating and determining the viral load in a pancreatin sample
RU2385158C2 (ru) *	2007-07-03	2010-03-27	Государственное научное учреждение Всероссийский научно-исследовательский институт мясной промышленности им. В.М. Горбатова Российской академии сельскохозяйственных наук	Средство для лечения диареи у поросят "колимак", способ его получения и способ лечения диареи у поросят
US20090130063A1 (en) *	2007-11-15	2009-05-21	Solvay Pharmaceuticals Gmbh	Process for separating and determining the viral load in a pancreatin sample
EP2328566A1 (de) *	2008-09-30	2011-06-08	DSM IP Assets B.V.	Enzymzusammensetzung und deren anwendung bei der behandlung von pankreasinsuffizienz
GB201501081D0 (en)	2015-01-22	2015-03-11	Cilian Ag	Use of enzymes with a wide pH activity range as medicaments for promoting digestion
CN115803083A (zh) *	2020-06-24	2023-03-14	基利安股份公司	新脂肪酶
US20240191275A1 (en) *	2021-04-09	2024-06-13	Cilian Ag	Purification of proteins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE454566B (sv) *	1984-04-24	1988-05-16	Lars G I Hellgren	Farmaceutisk komposition innehallande en verksam mengd av vattenlosliga proteinaser som extraherats fran ett vattenlevande djur valt av ordningen euphausiaceae eller slektet mallotus
CA2110497C (en) *	1991-07-01	2005-04-19	Reinhard Braatz	Use of bacterial lipases for producing drugs for maldigestion therapy
DE4238842A1 (de) *	1992-11-17	1994-05-19	Arno Prof Dr Tiedtke	Hochzelldichte Fermentation von Ciliaten zur Gewinnung von Naturstoffen
DE19524307A1 (de) *	1995-07-07	1997-01-09	Hoechst Ag	Verfahren zur Massenkultivierung von Ciliaten
DE19724845A1 (de) *	1996-08-28	1998-03-05	Solvay Pharm Gmbh	Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen
US6846481B1 (en) *	1999-02-04	2005-01-25	University Of Georgia Research Foundation, Inc.	Recombinant expression of heterologous nucleic acids in protozoa
US6539128B1 (en) *	1999-04-16	2003-03-25	Macronix International Co., Ltd.	Method and apparatus for interpolation
US6543100B1 (en) *	2001-09-24	2003-04-08	Christopher J. Finley	Test tube retention system

2001
- 2001-11-02 AT AT01992585T patent/ATE295737T1/de not_active IP Right Cessation
- 2001-11-02 IL IL15551501A patent/IL155515A0/xx active IP Right Grant
- 2001-11-02 EP EP01992585A patent/EP1330262B1/de not_active Expired - Lifetime
- 2001-11-02 US US10/399,551 patent/US20040033220A1/en not_active Abandoned
- 2001-11-02 WO PCT/EP2001/012740 patent/WO2002036156A1/de not_active Ceased
- 2001-11-02 DE DE50106273T patent/DE50106273D1/de not_active Expired - Lifetime
- 2001-11-02 PT PT01992585T patent/PT1330262E/pt unknown
- 2001-11-02 CN CNB018217109A patent/CN1262308C/zh not_active Expired - Lifetime
- 2001-11-02 PL PL361630A patent/PL204599B1/pl unknown
- 2001-11-02 AU AU2366602A patent/AU2366602A/xx active Pending
- 2001-11-02 CA CA002427537A patent/CA2427537A1/en not_active Abandoned
- 2001-11-02 ES ES01992585T patent/ES2239686T3/es not_active Expired - Lifetime
- 2001-11-02 JP JP2002538965A patent/JP4139215B2/ja not_active Expired - Fee Related
- 2001-11-02 DK DK01992585T patent/DK1330262T3/da active
- 2001-11-02 AU AU2002223666A patent/AU2002223666B2/en not_active Ceased
- 2001-11-02 RU RU2003116131/15A patent/RU2299074C2/ru not_active IP Right Cessation
2003
- 2003-04-20 IL IL155515A patent/IL155515A/en not_active IP Right Cessation
- 2003-04-30 NO NO20031979A patent/NO20031979L/no not_active Application Discontinuation
2007
- 2007-07-25 US US11/878,618 patent/US20080292610A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1330262B1 (de)	2005-05-18
HK1057861A1 (en)	2004-04-23
DK1330262T3 (da)	2005-09-19
WO2002036156A1 (de)	2002-05-10
JP4139215B2 (ja)	2008-08-27
IL155515A (en)	2009-02-11
DE50106273D1 (de)	2005-06-23
AU2002223666B2 (en)	2006-08-24
NO20031979D0 (no)	2003-04-30
RU2299074C2 (ru)	2007-05-20
CN1262308C (zh)	2006-07-05
ATE295737T1 (de)	2005-06-15
ES2239686T3 (es)	2005-10-01
AU2366602A (en)	2002-05-15
PT1330262E (pt)	2005-07-29
US20080292610A1 (en)	2008-11-27
EP1330262A1 (de)	2003-07-30
IL155515A0 (en)	2003-11-23
JP2004512375A (ja)	2004-04-22
CA2427537A1 (en)	2002-05-10
PL361630A1 (en)	2004-10-04
NO20031979L (no)	2003-06-30
US20040033220A1 (en)	2004-02-19
CN1484530A (zh)	2004-03-24

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US20080292610A1 (en)	2008-11-27	Medicaments containing enzymes from ciliates for promoting digestion in digestive disorders
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US6051220A (en)	2000-04-18	Composition to improve digestibility and utilization of nutrients
RU2389504C2 (ru)	2010-05-20	Ферменты для фармацевтического применения
US10596235B2 (en)	2020-03-24	Pharmaceutical preparation
US20080279839A1 (en)	2008-11-13	Composition With a Fungal (Yeast) Lipase and Method For Treating Lipid Malabsorption in Cystic Fibrous as Well as People Suffering From Pancreatic Lipase Insufficiency
KR20080031868A (ko)	2008-04-11	약학적 용도를 위한 아밀라제
CA2367355A1 (en)	2000-09-21	Medicinal product for the treatment of diabetes
MX2007004534A (es)	2007-11-08	Composiciones que contienen lipasa, proteasa y amilasa para tratar la insuficiencia pancreatica.
EP0600868A1 (de)	1994-06-15	Gentechnologisch hergestellte lipasen für die therapeutische behandlung
EP0177605B1 (de)	1992-04-15	Eine enzymzusammensetzung als verdauungsbeschleuniger bei verschiedenen spiegeln im verdauungskanal und deren herstellungsverfahren
US8455235B2 (en)	2013-06-04	Protease variants for pharmaceutical use
KR102601352B1 (ko)	2023-11-10	소화 촉진을 위한 약제로서 광범위한 pH 활성 범위를 갖는 효소의 용도
HK1057861B (en)	2005-08-26	Use of enzymes obtained from ciliates as medicaments for promoting digestion
ES2349086T3 (es)	2010-12-27	Enzimas para uso farmacéutico.
KR20030067752A (ko)	2003-08-14	미생물 효소의 신규 혼합물
KR20120021590A (ko)	2012-03-09	틸라피아 비늘의 효소적 가수분해물을 유효성분으로 포함하는 고혈압의 예방 또는 치료용 약학적 조성물
JPH02240028A (ja)	1990-09-25	血圧降下剤
WO2001030373A1 (en)	2001-05-03	Polypeptide composition
HK1063150A (en)	2004-12-17	Novel mixtures of microbial enzymes
HK1145697A (en)	2011-04-29	Protease variants for pharmaceutical use