PL204667A1 - METHOD OF MAKING 2-ARYLPROPIONIC ACIDS AND METHOD OF MAKING NEW MAGNESIUM COMPLEX COMPOUNDS AS INTERMEDIATE PRODUCTS - Google Patents
METHOD OF MAKING 2-ARYLPROPIONIC ACIDS AND METHOD OF MAKING NEW MAGNESIUM COMPLEX COMPOUNDS AS INTERMEDIATE PRODUCTSInfo
- Publication number
- PL204667A1 PL204667A1 PL20466778A PL20466778A PL204667A1 PL 204667 A1 PL204667 A1 PL 204667A1 PL 20466778 A PL20466778 A PL 20466778A PL 20466778 A PL20466778 A PL 20466778A PL 204667 A1 PL204667 A1 PL 204667A1
- Authority
- PL
- Poland
- Prior art keywords
- making
- arylpropionic acids
- intermediate products
- complex compounds
- magnesium complex
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 229910052749 magnesium Inorganic materials 0.000 title 1
- 239000011777 magnesium Substances 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- -1 6-methoxy-2-naphthyl Chemical group 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/14—Monocyclic dicarboxylic acids
- C07C63/15—Monocyclic dicarboxylic acids all carboxyl groups bound to carbon atoms of the six-membered aromatic ring
- C07C63/24—1,3 - Benzenedicarboxylic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of the formula aryl CH(CH3)COOMgX, in which aryl denotes 6-methoxy-2-naphthyl, 4-alkylphenyl or 4'-fluoro-4-biphenyl, and X denotes chlorine or bromine, and their etherates, are described. They are prepared by treating a solution of the corresponding arylmagnesium bromide with the solution of a complex of the formula CH3CH(Br)COOMgX in an aprotic solvent containing an ether. The compounds are important intermediates in the synthesis of known 2-arylpropionic acids of therapeutic importance.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76907077A | 1977-02-16 | 1977-02-16 | |
| US05/863,290 US4144397A (en) | 1977-02-16 | 1977-12-19 | Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL204667A1 true PL204667A1 (en) | 1978-12-04 |
| PL108144B1 PL108144B1 (en) | 1980-03-31 |
Family
ID=27118118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1978204667A PL108144B1 (en) | 1977-02-16 | 1978-02-16 | METHOD OF PRODUCING 2-ARYLPROPIONIC ACIDS |
Country Status (18)
| Country | Link |
|---|---|
| CH (3) | CH640499A5 (en) |
| DD (3) | DD137099A5 (en) |
| DK (1) | DK156898C (en) |
| ES (1) | ES467037A1 (en) |
| FI (1) | FI64571C (en) |
| HK (2) | HK25383A (en) |
| HU (2) | HU179309B (en) |
| IE (1) | IE46614B1 (en) |
| IL (1) | IL54019A (en) |
| IT (1) | IT1107880B (en) |
| MY (2) | MY8400039A (en) |
| NO (1) | NO145435C (en) |
| NZ (1) | NZ186472A (en) |
| PL (1) | PL108144B1 (en) |
| PT (1) | PT67654B (en) |
| SE (3) | SE430155B (en) |
| SU (2) | SU1003749A3 (en) |
| YU (3) | YU41427B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8915531D0 (en) * | 1989-07-06 | 1989-08-23 | Ass Octel | Alkaline earth,transition and lanthanide metal inorganic salt complexes |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1459084A (en) * | 1973-05-24 | 1976-12-22 | Boots Co Ltd | Preparation of arylalkanoic acid |
-
1978
- 1978-02-09 HU HU78SI1618A patent/HU179309B/en unknown
- 1978-02-09 HU HU802271A patent/HU183210B/en unknown
- 1978-02-09 FI FI780417A patent/FI64571C/en not_active IP Right Cessation
- 1978-02-10 IL IL54019A patent/IL54019A/en unknown
- 1978-02-10 IT IT67279/78A patent/IT1107880B/en active
- 1978-02-13 SE SE7801648A patent/SE430155B/en not_active IP Right Cessation
- 1978-02-13 YU YU329/78A patent/YU41427B/en unknown
- 1978-02-13 DK DK064578A patent/DK156898C/en not_active IP Right Cessation
- 1978-02-14 PT PT67654A patent/PT67654B/en unknown
- 1978-02-14 IE IE320/78A patent/IE46614B1/en not_active IP Right Cessation
- 1978-02-14 NZ NZ186472A patent/NZ186472A/en unknown
- 1978-02-15 NO NO780524A patent/NO145435C/en unknown
- 1978-02-15 DD DD78203717A patent/DD137099A5/en not_active IP Right Cessation
- 1978-02-15 DD DD78214577A patent/DD145107A5/en not_active IP Right Cessation
- 1978-02-15 CH CH167578A patent/CH640499A5/en not_active IP Right Cessation
- 1978-02-15 DD DD78214578A patent/DD148212A5/en not_active IP Right Cessation
- 1978-02-15 SU SU782580499A patent/SU1003749A3/en active
- 1978-02-16 PL PL1978204667A patent/PL108144B1/en unknown
- 1978-02-16 ES ES467037A patent/ES467037A1/en not_active Expired
- 1978-10-11 SU SU782672198A patent/SU963462A3/en active
-
1982
- 1982-03-09 SE SE8201459A patent/SE453094B/en not_active IP Right Cessation
- 1982-03-09 SE SE8201458A patent/SE453093B/en not_active IP Right Cessation
- 1982-09-07 CH CH531882A patent/CH640500A5/en not_active IP Right Cessation
- 1982-09-07 CH CH531782A patent/CH640498A5/en not_active IP Right Cessation
-
1983
- 1983-03-10 YU YU588/83A patent/YU42843B/en unknown
- 1983-03-10 YU YU587/83A patent/YU43302B/en unknown
- 1983-08-04 HK HK253/83A patent/HK25383A/en not_active IP Right Cessation
- 1983-08-04 HK HK254/83A patent/HK25483A/en not_active IP Right Cessation
-
1984
- 1984-12-30 MY MY39/84A patent/MY8400039A/en unknown
- 1984-12-30 MY MY40/84A patent/MY8400040A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RECP | Rectifications of patent specification |