PL2054050T3 - Leczenie zaburzeń chrząstki z zastosowaniem FGF-18 - Google Patents

Leczenie zaburzeń chrząstki z zastosowaniem FGF-18

Info

Publication number
PL2054050T3
PL2054050T3 PL07802876T PL07802876T PL2054050T3 PL 2054050 T3 PL2054050 T3 PL 2054050T3 PL 07802876 T PL07802876 T PL 07802876T PL 07802876 T PL07802876 T PL 07802876T PL 2054050 T3 PL2054050 T3 PL 2054050T3
Authority
PL
Poland
Prior art keywords
fgf
treatment
cartilage disorders
cartilage
disorders
Prior art date
Application number
PL07802876T
Other languages
English (en)
Inventor
Alberto Gimona
Christoph H Ladel
Baur Elmar Vom
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of PL2054050T3 publication Critical patent/PL2054050T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL07802876T 2006-08-25 2007-08-24 Leczenie zaburzeń chrząstki z zastosowaniem FGF-18 PL2054050T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP06119557 2006-08-25
US84060006P 2006-08-28 2006-08-28
EP07802876A EP2054050B1 (en) 2006-08-25 2007-08-24 Treatment of cartilage disorders with fgf-18
PCT/EP2007/058830 WO2008023063A2 (en) 2006-08-25 2007-08-24 Treatment of cartilage disorders with fgf-18

Publications (1)

Publication Number Publication Date
PL2054050T3 true PL2054050T3 (pl) 2013-01-31

Family

ID=38984134

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07802876T PL2054050T3 (pl) 2006-08-25 2007-08-24 Leczenie zaburzeń chrząstki z zastosowaniem FGF-18

Country Status (14)

Country Link
US (1) US8207115B2 (pl)
EP (1) EP2054050B1 (pl)
JP (2) JP5815206B2 (pl)
KR (1) KR101419961B1 (pl)
AR (1) AR062522A1 (pl)
AU (1) AU2007287510B2 (pl)
CA (1) CA2658511C (pl)
CY (1) CY1113136T1 (pl)
EA (1) EA015644B1 (pl)
HR (1) HRP20120643T1 (pl)
IL (1) IL197169A (pl)
MX (1) MX2009002063A (pl)
PL (1) PL2054050T3 (pl)
WO (1) WO2008023063A2 (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012038953A2 (en) 2010-09-21 2012-03-29 Hepacore Ltd. Fgf-18 truncated variants having increased receptor specificity and uses thereof
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
TWI527590B (zh) 2011-06-17 2016-04-01 艾瑞斯貿易公司 Ｆｇｆ－１８之凍乾調配物
US9790264B2 (en) 2012-06-25 2017-10-17 The Brigham And Women's Hospital, Inc. Compounds and methods for modulating pharmacokinetics
CN104619727B (zh) * 2012-06-25 2019-04-05 布里格姆及妇女医院股份有限公司 靶向治疗
CN104736723B (zh) * 2012-08-06 2017-10-31 默克专利有限公司 用于预测对fgf‑18化合物的响应性的遗传标记
AU2013301607B2 (en) * 2012-08-06 2018-10-18 Merck Patent Gmbh Prognosis biomarkers in cartilage disorders
KR102622290B1 (ko) 2013-12-24 2024-01-05 아레스 트레이딩 에스.아. 크실로글루칸 겔 중의 fgf-18 제형물
MX2016010873A (es) * 2014-02-20 2016-11-17 Merck Patent Gmbh Factor de crecimiento de fibroblastos 18 en los procedimientos para el trasplante de injertos y para ingenieria de tejidos.
HUE040350T2 (hu) * 2014-02-20 2019-03-28 Merck Patent Gmbh FGF-18 vegyületadagoló étrend
ES3055185T3 (en) 2014-03-28 2026-02-10 Univ Duke Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator
AU2016211950A1 (en) 2015-01-29 2017-07-13 Ares Trading S.A. Immunoassays for high positively charged proteins
CA2977812A1 (en) * 2015-03-03 2016-09-09 Radius Health, Inc. Uses of pthrp analogue in reducing fracture risk
KR20250152679A (ko) 2015-04-29 2025-10-23 래디어스 파마슈티컬스, 인코포레이티드 암을 치료하는 방법
WO2017008758A1 (en) * 2015-07-15 2017-01-19 Prosit Sole Biotechnology (Beijing) Co., Ltd Fusion polypeptides and methods of use
JP7140677B2 (ja) * 2015-08-13 2022-09-21 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｆｇｆ－１８化合物を含む組み合わせ組成物
EP3318563A1 (en) 2016-11-07 2018-05-09 Sanofi Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders
JP7481115B2 (ja) 2017-01-05 2024-05-10 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形性形態
CN107338218B (zh) * 2017-07-28 2020-11-24 中国人民解放军总医院第一附属医院 一种诱导脂肪干细胞向软骨细胞分化的诱导分化培养基和方法
EP3684791A1 (en) * 2017-09-21 2020-07-29 Merck Patent GmbH Fusion protein comprising an fgf-18 moiety
SI3688468T1 (sl) 2017-09-29 2022-08-31 Merck Patent Gmbh Vnetni biomarkerji za predvidevanje odzivov na spojino FGF-18
IL273613B2 (en) * 2017-09-29 2026-02-01 Merck Patent Gmbh Metabolic biomarkers for predicting response to FGF-18 compound
MX2020013713A (es) 2018-07-04 2021-03-02 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
IL281333B2 (en) 2018-09-10 2025-11-01 Merck Patent Gmbh A method for reducing risk in a clinical trial
WO2020104833A1 (en) * 2018-11-19 2020-05-28 4P-Pharma Composition and methods for regulating chondrocyte proliferation and increasing of cartilage matrix production
JP7671249B2 (ja) * 2019-02-08 2025-05-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 変形性関節症が急速に進行するリスクがある患者の治療
EP3924328A1 (en) 2019-02-12 2021-12-22 Radius Pharmaceuticals, Inc. Processes and compounds
CN109836487B (zh) * 2019-03-01 2022-06-17 重庆派金生物科技有限公司 一种人成纤维细胞生长因子18及其可溶性重组表达方法、制备方法、制剂和应用
CN117721115A (zh) * 2022-09-06 2024-03-19 深圳瑞吉生物科技有限公司 用于治疗骨关节炎的mRNA及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2225840T3 (es) * 1994-03-08 2005-03-16 Osteosa Liquidation Trust Utilizacion de factores de crecimiento de fibroblasto para estimular el crecimiento oseo.
US20050043234A1 (en) * 1996-10-16 2005-02-24 Deisher Theresa A. Novel FGF homologs
JPH11332570A (ja) * 1998-05-27 1999-12-07 Shionogi & Co Ltd 新規な線維芽細胞成長因子及びそれをコードする遺伝子
AU1804201A (en) * 1999-12-02 2001-06-12 Zymogenetics Inc. Methods for targeting cells that express fibroblast growth receptor-3 or-2
JP2004536575A (ja) * 2001-02-28 2004-12-09 コンドロジーン・インコーポレイテッド 変形性関節症に関連する組成物および方法
ES2493840T3 (es) * 2002-10-07 2014-09-12 Zymogenetics, Inc. Procedimiento de administración de FGF-18
ES2706848T3 (es) * 2004-07-06 2019-04-01 Zymogenetics Inc Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso
AU2005314438B2 (en) * 2004-12-10 2012-03-29 Zymogenetics, Inc. FGF18 production in prokaryotic hosts

Also Published As

Publication number Publication date
US20100016223A1 (en) 2010-01-21
CY1113136T1 (el) 2016-04-13
JP5815206B2 (ja) 2015-11-17
AU2007287510B2 (en) 2012-08-30
IL197169A (en) 2013-08-29
KR20090051100A (ko) 2009-05-20
CA2658511A1 (en) 2008-02-28
MX2009002063A (es) 2009-03-06
US8207115B2 (en) 2012-06-26
JP2010501531A (ja) 2010-01-21
CA2658511C (en) 2019-02-19
HRP20120643T1 (hr) 2012-08-31
EA015644B1 (ru) 2011-10-31
EP2054050A2 (en) 2009-05-06
EP2054050B1 (en) 2012-08-08
EA200970224A1 (ru) 2009-08-28
JP2014088429A (ja) 2014-05-15
IL197169A0 (en) 2009-12-24
AU2007287510A1 (en) 2008-02-28
KR101419961B1 (ko) 2014-07-30
WO2008023063A2 (en) 2008-02-28
AR062522A1 (es) 2008-11-12
WO2008023063A3 (en) 2008-05-02

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