PL2061749T3 - Dodatnio naładowane, rozpuszczalne w wodzie proleki acetaminofenu i związków pokrewnych o bardzo dużej szybkości przenikania przez skórę - Google Patents
Dodatnio naładowane, rozpuszczalne w wodzie proleki acetaminofenu i związków pokrewnych o bardzo dużej szybkości przenikania przez skóręInfo
- Publication number
- PL2061749T3 PL2061749T3 PL06795894T PL06795894T PL2061749T3 PL 2061749 T3 PL2061749 T3 PL 2061749T3 PL 06795894 T PL06795894 T PL 06795894T PL 06795894 T PL06795894 T PL 06795894T PL 2061749 T3 PL2061749 T3 PL 2061749T3
- Authority
- PL
- Poland
- Prior art keywords
- acetaminophen
- positively charged
- related compounds
- skin penetration
- penetration rate
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- 229960005489 paracetamol Drugs 0.000 title 1
- 230000035515 penetration Effects 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06795894.2A EP2061749B1 (en) | 2006-09-03 | 2006-09-03 | Positively charged water-soluble prodrugs of acetaminophen and related compounds with very fast skin penetration rate |
| PCT/IB2006/053091 WO2008029200A1 (en) | 2006-09-03 | 2006-09-03 | Positively charged water-soluble prodrugs of acetaminophen and related compounds with very fast skin penetration rate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2061749T3 true PL2061749T3 (pl) | 2018-11-30 |
Family
ID=39156869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06795894T PL2061749T3 (pl) | 2006-09-03 | 2006-09-03 | Dodatnio naładowane, rozpuszczalne w wodzie proleki acetaminofenu i związków pokrewnych o bardzo dużej szybkości przenikania przez skórę |
Country Status (7)
| Country | Link |
|---|---|
| EP (3) | EP3388417A1 (pl) |
| JP (1) | JP5466006B2 (pl) |
| CN (1) | CN101506143B (pl) |
| CA (1) | CA2661649C (pl) |
| ES (1) | ES2670407T3 (pl) |
| PL (1) | PL2061749T3 (pl) |
| WO (1) | WO2008029200A1 (pl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| PL2084124T3 (pl) | 2006-10-02 | 2014-08-29 | Techfields Biochem Co Ltd | Dodatnio naładowane rozpuszczalne w wodzie proleki prostaglandyn i związków pokrewnych o bardzo dużych szybkościach przenikania przez skórę |
| AU2006350707A1 (en) | 2006-11-08 | 2008-05-15 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| CN101547898B (zh) | 2006-12-10 | 2014-09-24 | 于崇曦 | β-内酰胺类抗生素的透皮给药系统 |
| HUE031712T2 (en) | 2007-01-15 | 2017-08-28 | Chongxi Yu | Retinoids and retinoid-like compounds with positively charged water-soluble prodrugs having very high skin penetration rates |
| WO2008093173A1 (en) | 2007-01-31 | 2008-08-07 | Chongxi Yu | Positively charged water-soluble prodrugs of 1h-imidazo[4, 5-c]quinolin-4-amines and related compounds with very high skin penetration rates |
| KR20150058566A (ko) * | 2007-06-04 | 2015-05-28 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 ｎｓａｉａ 약물전구체 및 이들의 새로운 의약적 용도 |
| BR122021011394B1 (pt) * | 2008-12-04 | 2021-09-28 | Chongxi Yu | Composição de alta penetração de um fármaco principal, e uso de uma hpc |
| JP2012520342A (ja) * | 2009-03-16 | 2012-09-06 | ジェンメディカ・セラピューティックス・ソシエダッド・リミターダ | 代謝障害を処置するのに有用な抗炎症剤および抗酸化剤のコンジュゲート |
| PL2427475T3 (pl) | 2009-05-08 | 2021-07-19 | Techfields Biochem Co., Ltd. | Kompozycje proleku o wysokim przenikaniu peptydów i związków powiązanych z peptydami |
| US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
| WO2013102142A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation |
| HK1203412A1 (en) | 2011-12-28 | 2015-10-30 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| CN111012914A (zh) | 2012-01-18 | 2020-04-17 | 苏州泰飞尔医药有限公司 | 治疗肺部疾病的高穿透力前药组合物和医药组合物 |
| CN102786431A (zh) * | 2012-07-27 | 2012-11-21 | 蚌埠丰原涂山制药有限公司 | 一种盐酸丙帕他莫的制备方法 |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US20140274961A1 (en) * | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| AP2015008718A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| EP3919056B1 (en) | 2013-03-15 | 2024-08-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| SG10201802911RA (en) | 2013-03-15 | 2018-05-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| CN112521305B (zh) * | 2013-03-15 | 2023-04-25 | 苏州泰飞尔医药有限公司 | 治疗帕金森疾病的新型高穿透力药物及其药物组合物 |
| JP5855599B2 (ja) * | 2013-04-30 | 2016-02-09 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ |
| EA202092627A1 (ru) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| ES2860648T5 (es) | 2014-02-07 | 2024-11-27 | Global Blood Therapeutics Inc | Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehído |
| US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
| US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
| JP6165816B2 (ja) * | 2015-10-01 | 2017-07-19 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ |
| US11020382B2 (en) | 2015-12-04 | 2021-06-01 | Global Blood Therapeutics, Inc. | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| TWI825524B (zh) | 2016-05-12 | 2023-12-11 | 美商全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| CN112020354A (zh) | 2018-04-26 | 2020-12-01 | Adt制药有限责任公司 | 抗癌茚类、茚满类、氮杂茚类、氮杂茚满类、药物组合物和用途 |
| EP3860975B1 (en) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
| US11389409B2 (en) | 2019-08-30 | 2022-07-19 | Remedy Diagnostics LLC | Transdermal device comprising acetaminophen prodrug |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR4672E (fr) * | 1903-05-05 | 1905-09-16 | Cesar Vuarchex | Valve perfectionnée pour bandages pneumatiques |
| FR467219A (fr) * | 1914-01-12 | 1914-06-06 | Robert Dubois | Appareil réfrigérant à air sec |
| FR4672M (pl) * | 1965-02-22 | 1965-12-19 | ||
| FR2348701A1 (fr) * | 1976-04-22 | 1977-11-18 | Hexachimie | Nouveau derive du p-acetamidophenol,sa preparation et son utilisation en therapeutique |
| JPS53144537A (en) * | 1977-05-18 | 1978-12-15 | Hexachimie | Novel derivative of ppacetoamtde phenol process for preparing same and application to medical treatment thereof |
| US5109011A (en) * | 1990-07-30 | 1992-04-28 | Hoechst-Roussel Pharmaceuticals Incorporated | P-acylaminophenoxycarbamates and derivatives |
| US5654337A (en) | 1995-03-24 | 1997-08-05 | II William Scott Snyder | Topical formulation for local delivery of a pharmaceutically active agent |
| AUPN531195A0 (en) | 1995-09-11 | 1995-10-05 | J.W. Broadbent Nominees Pty. Ltd. | Lipid extract having anti-inflamatory activity |
| IT1282736B1 (it) * | 1996-05-21 | 1998-03-31 | Angelini Ricerche Spa | Uso di derivati del p-amminofenolo per preparare composizioni farmaceutiche utili nel trattamento di malattie neurodegenerative |
| KR100213465B1 (ko) | 1996-11-01 | 1999-08-02 | 최좌진 | 케토프로펜 패취 조성물 |
| US5888523A (en) * | 1997-09-22 | 1999-03-30 | Biocontrol, Inc. | Topical non-steroidal anti-inflammatory drug composition |
| US5885597A (en) | 1997-10-01 | 1999-03-23 | Medical Research Industries,Inc. | Topical composition for the relief of pain |
| AU4972599A (en) | 1998-07-07 | 2000-01-24 | Transdermal Technologies, Inc. | Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof |
| AU3104301A (en) * | 2000-01-20 | 2001-07-31 | Noven Pharmaceuticals, Inc. | Compositions and methods to effect the release profile in the transdermal administration of active agents |
| US6416772B1 (en) | 2001-01-12 | 2002-07-09 | H. Wayne Van Engelen | Topical dermal anaesthetic |
| US6528040B1 (en) | 2001-01-18 | 2003-03-04 | Maurine Pearson | EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic |
| PE20021017A1 (es) * | 2001-04-03 | 2002-11-24 | Pharmacia Corp | Composicion parenteral reconstituible |
| US7052715B2 (en) | 2003-04-11 | 2006-05-30 | All Natural Fmg, Inc. | Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof |
| JP2007531784A (ja) * | 2004-04-05 | 2007-11-08 | ラボラトリオス・デル・デエレ・エステベ・エセ・ア | 活性物質組合せ物 |
| TWI351284B (en) * | 2004-04-09 | 2011-11-01 | Chugai Pharmaceutical Co Ltd | Novel water-soluble prodrugs |
| CN100379422C (zh) * | 2005-03-24 | 2008-04-09 | 重庆医药工业研究院有限责任公司 | 一种丙帕他莫与丁螺环酮的组合物 |
-
2006
- 2006-09-03 ES ES06795894.2T patent/ES2670407T3/es active Active
- 2006-09-03 PL PL06795894T patent/PL2061749T3/pl unknown
- 2006-09-03 WO PCT/IB2006/053091 patent/WO2008029200A1/en not_active Ceased
- 2006-09-03 JP JP2009526183A patent/JP5466006B2/ja not_active Expired - Fee Related
- 2006-09-03 EP EP18157598.6A patent/EP3388417A1/en active Pending
- 2006-09-03 CN CN2006800557470A patent/CN101506143B/zh not_active Expired - Fee Related
- 2006-09-03 CA CA2661649A patent/CA2661649C/en active Active
- 2006-09-03 EP EP06795894.2A patent/EP2061749B1/en not_active Not-in-force
- 2006-09-03 EP EP14153622.7A patent/EP2746251A3/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2661649A1 (en) | 2008-03-13 |
| AU2006347925A1 (en) | 2008-03-13 |
| EP2061749B1 (en) | 2018-02-21 |
| EP3388417A1 (en) | 2018-10-17 |
| EP2746251A2 (en) | 2014-06-25 |
| CN101506143B (zh) | 2013-06-05 |
| CA2661649C (en) | 2014-12-30 |
| ES2670407T3 (es) | 2018-05-30 |
| JP2010502583A (ja) | 2010-01-28 |
| WO2008029200A1 (en) | 2008-03-13 |
| EP2061749A1 (en) | 2009-05-27 |
| JP5466006B2 (ja) | 2014-04-09 |
| EP2061749A4 (en) | 2010-12-29 |
| EP2746251A3 (en) | 2014-07-02 |
| CN101506143A (zh) | 2009-08-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2061749A4 (en) | POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF ACETAMINOPHEN AND COMPOUNDS ASSOCIATED WITH VERY HIGH SKIN PENETRATION SPEED | |
| PL2046727T3 (pl) | Dodatnio naładowane rozpuszczalne w wodzie proleki diklofenaku o bardzo szybkim stopniu przenikania przez skórę | |
| PT2041068T (pt) | Pró-fármacos solúveis em água positivamente carregados de ibuprofeno com taxa de penetração de pele muito rápida | |
| IL205977A0 (en) | 5-anilinoimidazopyridines and methods of use | |
| EP2125697A4 (en) | POSITIVELY LOADED WATER-SOLUBLE PRODRUGS OF RETINOIDS AND RETINOIDARY COMPOUNDS WITH VERY HIGH SKIN PENETRATION RATES | |
| IL209383A0 (en) | Carbonate prodrugs and methods of using the same | |
| EP2126589A4 (en) | METABOLISM AND DIABETIC SUFFERING AND METHOD OF USE THEREOF | |
| ZA201104463B (en) | Compounds and methods of use | |
| ZA201008483B (en) | Diazacarbazoles and methods of use | |
| IL196462A0 (en) | Substituted acylanilides and methods of use thereof | |
| IL197185A0 (en) | Substituted acylanilides and methods of use thereof | |
| IL206125A0 (en) | Azaindolizines and methods of use | |
| SI2152256T1 (sl) | Aktivirne spojine telomeraze in postopki za njihovo uporabo | |
| IL209548A0 (en) | Diazacarbazoles and methods of use | |
| PL2623495T3 (pl) | Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę | |
| ZA200905741B (en) | Indenoisoquinolinone analogs and methods of use thereof | |
| PL2084124T3 (pl) | Dodatnio naładowane rozpuszczalne w wodzie proleki prostaglandyn i związków pokrewnych o bardzo dużych szybkościach przenikania przez skórę | |
| EP2084165A4 (en) | PRO-DRUGS OF WATER-SOLUBLE OXICAMS POSITIVE AND RELATED COMPOUNDS WITH VERY HIGH SKIN PENETRATION SPEED | |
| PT2049482E (pt) | Profármacos solúveis em água carregados positivamente de ácidos aril- e heteroarilacéticos com velocidade de penetração na pele muito rápida | |
| EP2077991A4 (en) | POSITIVELY LOADED, WATER-SOLUBLE PRODRUGS OF LOTS AND RELATED COMPOUNDS WITH VERY HIGH SKIN PENETRATION RATES | |
| ZA201004894B (en) | Nuctraceutical composition and methods of use | |
| ZA201004893B (en) | Nuctraceutical composition and methods of use | |
| GB0814583D0 (en) | Herbicidal composition and method of use thereof | |
| GB0814582D0 (en) | Herbicidal composition and method of use thereof | |
| GB0814580D0 (en) | herbicidal composition and method of use thereof |