PL2073842T3 - Zastosowanie ludzkich komórek pochodzących z białaczki szpikowej do ekspresji przeciwciał - Google Patents
Zastosowanie ludzkich komórek pochodzących z białaczki szpikowej do ekspresji przeciwciałInfo
- Publication number
- PL2073842T3 PL2073842T3 PL07818090T PL07818090T PL2073842T3 PL 2073842 T3 PL2073842 T3 PL 2073842T3 PL 07818090 T PL07818090 T PL 07818090T PL 07818090 T PL07818090 T PL 07818090T PL 2073842 T3 PL2073842 T3 PL 2073842T3
- Authority
- PL
- Poland
- Prior art keywords
- antibodies
- expression
- human cells
- myeloid leukaemia
- leukaemia origin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1735—Mucins, e.g. human intestinal mucin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Marine Sciences & Fisheries (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06090162 | 2006-09-10 | ||
| EP06090171A EP1900750A1 (en) | 2006-09-18 | 2006-09-18 | Fully human high yield production system for improved antibodies |
| EP06090190A EP1911766A1 (en) | 2006-10-13 | 2006-10-13 | Use of human cells of myeloid leukaemia origin for expression of antibodies |
| EP07090094 | 2007-05-04 | ||
| EP07818090.8A EP2073842B2 (en) | 2006-09-10 | 2007-09-10 | Use of human cells of myeloid leukaemia origin for expression of antibodies |
| PCT/EP2007/007877 WO2008028686A2 (en) | 2006-09-10 | 2007-09-10 | Use of human cells of myeloid leukaemia origin for expression of antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL2073842T3 true PL2073842T3 (pl) | 2015-06-30 |
| PL2073842T5 PL2073842T5 (pl) | 2024-12-02 |
Family
ID=39157600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07818090.8T PL2073842T5 (pl) | 2006-09-10 | 2007-09-10 | Zastosowanie ludzkich komórek pochodzących z białaczki szpikowej do ekspresji przeciwciał |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US9051356B2 (pl) |
| EP (5) | EP3539981A1 (pl) |
| JP (3) | JP5767779B2 (pl) |
| KR (3) | KR20150126730A (pl) |
| CN (1) | CN103436574B (pl) |
| AU (1) | AU2007294122B2 (pl) |
| BR (1) | BRPI0716997B8 (pl) |
| CA (1) | CA2662226C (pl) |
| CU (1) | CU23791A3 (pl) |
| CY (1) | CY1116279T1 (pl) |
| DK (2) | DK2428224T3 (pl) |
| EA (1) | EA017622B1 (pl) |
| ES (2) | ES2620261T3 (pl) |
| FI (1) | FI2073842T4 (pl) |
| HR (1) | HRP20150307T1 (pl) |
| IL (1) | IL197459A (pl) |
| MX (1) | MX2009002388A (pl) |
| NZ (1) | NZ575974A (pl) |
| PL (1) | PL2073842T5 (pl) |
| PT (1) | PT2073842E (pl) |
| RS (1) | RS53861B1 (pl) |
| SG (1) | SG174792A1 (pl) |
| SI (1) | SI2073842T1 (pl) |
| WO (1) | WO2008028686A2 (pl) |
| ZA (1) | ZA201001903B (pl) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3528611B2 (ja) * | 1998-07-16 | 2004-05-17 | Jfeスチール株式会社 | 結束材の切断方法及びその装置 |
| EP3539981A1 (en) | 2006-09-10 | 2019-09-18 | Glycotope GmbH | Use of human cells of myeloid leukaemia origin for expression of antibodies |
| PL1920781T3 (pl) | 2006-11-10 | 2015-06-30 | Glycotope Gmbh | Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów |
| WO2008135259A2 (en) * | 2007-05-04 | 2008-11-13 | Glycotope Gmbh | Antibody molecule composition |
| GB0812277D0 (en) * | 2008-07-04 | 2008-08-13 | Fusion Antibodies Ltd | Antibody and uses thereof |
| KR20110119702A (ko) | 2009-01-22 | 2011-11-02 | 모멘타 파머슈티컬스 인코포레이티드 | Cho 세포에서 유도된 글리코단백질 생성물에서의 갈락토오스-알파-1,3-갈락토오스-함유 n-글리칸 |
| US20120100576A1 (en) | 2009-07-08 | 2012-04-26 | Glycotope Gmbh | Perfusion bioreactor |
| EP2281844A1 (en) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
| WO2012016576A1 (en) | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| US9051370B2 (en) | 2010-08-10 | 2015-06-09 | Glycotope Gmbh | Humanized EGFR antibodies |
| PT2603528T (pt) * | 2010-08-10 | 2016-12-01 | Glycotope Gmbh | Anticorpos glicosilados em fab |
| EP2603527A1 (en) | 2010-08-10 | 2013-06-19 | Glycotope GmbH | Humanized egfr antibodies |
| ES2624479T3 (es) | 2010-12-21 | 2017-07-14 | Glycotope Gmbh | Métodos para cultivar células de leucemia mieloide humana y células derivadas de esta |
| BR112013027119A8 (pt) | 2011-04-21 | 2018-03-06 | Seattle Genetics Inc | novos conjugados ligante-droga (adcs) e uso dos mesmos |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| CN104168913A (zh) * | 2011-08-10 | 2014-11-26 | 法国化学与生物科技实验室 | 高半乳糖基化抗体 |
| ES2686313T3 (es) | 2011-08-22 | 2018-10-17 | Glycotope Gmbh | Microorganismos que portan un antígeno tumoral |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| BR112014032169A2 (pt) * | 2012-07-18 | 2017-08-01 | Glycotope Gmbh | tratamentos terapêuticos com anticorpos anti-her2 tendo uma fucosilação baixa |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| CA2897505A1 (en) | 2013-01-18 | 2014-07-24 | Glycotope Gmbh | Peptides for enhancing protein expression |
| EP3594230A1 (en) * | 2013-02-13 | 2020-01-15 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
| CN105358577A (zh) * | 2013-02-13 | 2016-02-24 | 法国化学与生物科技实验室 | 具有经修饰的糖基化的西妥昔单抗及其用途 |
| US10034921B2 (en) | 2013-02-13 | 2018-07-31 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
| WO2014125377A2 (en) * | 2013-02-13 | 2014-08-21 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Highly galactosylated anti-her2 antibodies and uses thereof |
| HK1207960A1 (en) | 2013-03-12 | 2016-02-19 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| WO2014143343A1 (en) | 2013-03-14 | 2014-09-18 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| JP2016512241A (ja) | 2013-03-14 | 2016-04-25 | アボット・ラボラトリーズAbbott Laboratories | 改良された抗体検出のためのhcvns3組換え抗原およびこの突然変異体 |
| MX362075B (es) | 2013-03-14 | 2019-01-07 | Abbott Lab | Ensayo de combinación de antígeno-anticuerpo del virus de la hepatitis c (vhc) y métodos y composiciones para usarlo. |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| TWI670279B (zh) | 2013-03-15 | 2019-09-01 | Alder Biopharmaceuticals, Inc. | 抗體純化及純度監測 |
| CA2908819A1 (en) | 2013-04-22 | 2014-10-30 | Glycotope Gmbh | Anti-cancer treatments with anti-egfr antibodies having a low fucosylation |
| US10208125B2 (en) * | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) * | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| RU2698697C2 (ru) | 2013-12-23 | 2019-08-29 | Байер Фарма Акциенгезельшафт | Конъюгаты связующего (ADC) с ингибиторами KSP |
| BR112016019893B1 (pt) * | 2014-03-05 | 2023-02-14 | Ultragenyx Pharmaceutical Inc | Composição |
| US20150307546A1 (en) * | 2014-04-29 | 2015-10-29 | Georgia Tech Research Corporation | Thermo-responsive lectin-elp fusion binding ligands for glycoprotein purification by affinity precipitation |
| CN105820248A (zh) * | 2015-01-07 | 2016-08-03 | 上海张江生物技术有限公司 | 一种新型抗egfr单克隆抗体的制备方法及应用 |
| LU92659B1 (en) * | 2015-02-23 | 2016-08-24 | Glycotope Gmbh | Glycooptimized antibody drug conjugates |
| LT3277807T (lt) | 2015-03-31 | 2020-01-10 | Glycotope Gmbh | Eukariotiniai ekspresijos vektoriai, apimantys globino genų klasterių reguliavimo elementus |
| FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
| WO2016198499A1 (en) | 2015-06-09 | 2016-12-15 | Glycotope Gmbh | IMPROVED METHOD FOR PRODUCTION OF γ-CARBOXYLATED POLYPEPTIDES |
| JP6971858B2 (ja) | 2015-06-22 | 2021-11-24 | バイエル ファーマ アクチエンゲゼルシャフト | 酵素開裂性基を有する抗体薬物複合体(adc)および抗体プロドラッグ複合体(apdc) |
| EP3313523A2 (en) | 2015-06-23 | 2018-05-02 | Bayer Pharma Aktiengesellschaft | Targeted conjugates of ksp inhibitors |
| WO2016207328A1 (en) | 2015-06-24 | 2016-12-29 | Glycotope Gmbh | PROCESS FOR THE PURIFICATION OF γ-CARBOXYLATED POLYPEPTIDES |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| EP3347380B1 (en) * | 2015-09-11 | 2024-09-25 | Nascent Biotech, Inc. | Enhanced delivery of drugs to the brain |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| US20170114127A1 (en) | 2015-10-22 | 2017-04-27 | Massachusetts Institute Of Technology | Vegf-a-binding proteins and her2-binding proteins with enhanced stability against aggregation |
| WO2017162733A1 (en) * | 2016-03-22 | 2017-09-28 | Glycotope Gmbh | Iga antibodies with enhanced stability |
| JP7251981B2 (ja) | 2016-03-24 | 2023-04-04 | バイエル ファーマ アクチエンゲゼルシャフト | 酵素開裂基を有する細胞毒性活性剤のプロドラッグ |
| EP3919518A1 (en) | 2016-06-15 | 2021-12-08 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| EP3472338B1 (en) | 2016-06-20 | 2024-05-22 | Octapharma AG | Means and methods for modifying multiple alleles |
| FR3060395B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-her2 |
| FR3060394B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-amhrii |
| CN110312534B (zh) | 2016-12-21 | 2023-04-04 | 拜耳制药股份公司 | 具有酶促可裂解基团的抗体-药物-缀合物(adc) |
| CN110072556B (zh) | 2016-12-21 | 2023-05-02 | 拜耳制药股份公司 | 具有ksp抑制剂的特异性抗体药物缀合物(adc) |
| US12059472B2 (en) | 2016-12-21 | 2024-08-13 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| US20190343953A1 (en) | 2017-01-27 | 2019-11-14 | Glycotope Gmbh | Anti-cancer treatments with an anti-muc1 antibody and an erbb inhibitor |
| JP6829357B2 (ja) * | 2017-03-17 | 2021-02-10 | 住友ベークライト株式会社 | 抗体の糖鎖検出法 |
| WO2018178047A1 (en) | 2017-03-29 | 2018-10-04 | Glycotope Gmbh | Multispecific antibody constructs binding to muc1 and cd3 |
| US20200148785A1 (en) * | 2017-03-29 | 2020-05-14 | Glycotope (GmbH) | Pd-l1 and ta-muc1 antibodies |
| WO2018178046A1 (en) | 2017-03-29 | 2018-10-04 | Glycotope Gmbh | Humanized anti-cd40 antibodies |
| EP3679066A4 (en) | 2017-09-06 | 2021-06-09 | Airway Therapeutics, Inc. | METHOD AND COMPOSITIONS FOR MANUFACTURING SURFACTANT PROTEIN D (SP-D) |
| CN112040967A (zh) * | 2017-09-06 | 2020-12-04 | 气道治疗公司 | 用于制备表面活性蛋白d(sp-d)的方法、组合物和细胞 |
| CA3090407A1 (en) | 2018-03-01 | 2019-09-06 | Glycotope Gmbh | Fusion protein constructs comprising an anti-muc1 antibody and il-15 |
| SG11202010496WA (en) | 2018-05-18 | 2020-12-30 | Daiichi Sankyo Co Ltd | Anti-muc1 antibody-drug conjugate |
| CN114450306B (zh) * | 2019-07-26 | 2024-04-05 | Abl生物公司 | 抗egfr/抗4-1bb双特异性抗体及其用途 |
| SG11202110968VA (en) | 2019-12-06 | 2021-10-28 | Regeneron Pharma | Anti-vegf protein compositions and methods for producing the same |
| AU2021268026A1 (en) | 2020-05-08 | 2023-01-19 | Regeneron Pharmaceuticals, Inc. | VEGF traps and mini-traps and methods for treating ocular disorders and cancer |
| AU2021298824A1 (en) | 2020-06-30 | 2023-01-19 | Pentixapharm Ag | Humanized antibodies against lewis Y |
| CA3253998A1 (en) | 2022-03-16 | 2023-09-21 | Pentixapharm Ag | ANTIBODIES DIRECTED AGAINST LYPD3 |
| WO2025099324A1 (en) | 2023-11-10 | 2025-05-15 | Tixapharm Ag | Antibodies against cd44 |
| WO2025132836A1 (en) | 2023-12-19 | 2025-06-26 | Pentixapharm Ag | Antibodies against cd24 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4966843A (en) * | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
| AU2353384A (en) * | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
| KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| US4931275A (en) * | 1985-12-02 | 1990-06-05 | Yeda Research & Development Co., Ltd. | Anti-tumor vaccines and their preparation |
| US5683674A (en) * | 1987-01-07 | 1997-11-04 | Imperial Cancer Research Technology Ltd. | Antibody against human mucin core protein and method of preparing and using same |
| CA2100671C (en) | 1991-02-27 | 1999-02-02 | James S. Huston | Serine rich peptide linkers |
| JP3698370B2 (ja) | 1992-04-13 | 2005-09-21 | ダナ−ファーバー キャンサー インスティチュート インク | 癌腫抗原用抗体 |
| US5804187A (en) * | 1992-11-16 | 1998-09-08 | Cancer Research Fund Of Contra Costa | Modified antibodies with human milk fat globule specificity |
| JP3626187B2 (ja) | 1993-06-07 | 2005-03-02 | バイカル インコーポレイテッド | 遺伝子治療に適するプラスミド |
| DE4329004A1 (de) | 1993-08-28 | 1995-03-09 | Max Delbrueck Centrum | Monoklonale Antikörper gegen das Thomsen-Friedenreich-Antigen, ihre Herstellung und ihre Verwendung zum Tumornachweis |
| AU7965694A (en) * | 1993-10-15 | 1995-05-04 | Curators Of The University Of Missouri, The | Dna encoding the human p2u receptor and null cells expressing p2u receptors |
| US5997873A (en) * | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| US5888773A (en) * | 1994-08-17 | 1999-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Method of producing single-chain Fv molecules |
| US5739277A (en) * | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| CA2225460A1 (en) | 1995-06-23 | 1997-01-09 | Winston Campbell Patterson | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
| GB9603256D0 (en) * | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| EP0906444A1 (de) | 1996-04-19 | 1999-04-07 | Gabriele Pecher | Gentransfizierte humane dendritische zellen, ihre herstellung und ihre verwendung, bevorzugt als vakzine |
| ATE550042T1 (de) * | 1997-11-20 | 2012-04-15 | Vical Inc | Behandlung von krebs mithilfe cytokin- exprimierender polynukleotide und zusammensetzungen dafür |
| US5948646A (en) * | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
| DK1071700T3 (da) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet |
| AUPP816899A0 (en) | 1999-01-14 | 1999-02-11 | Food Technology Innovations Pty Limited | Improved microbial products |
| EP1399538A4 (en) | 1999-03-02 | 2004-03-24 | Human Genome Sciences Inc | TECHOLOGICAL MANIPULATION OF INTRACELLULAR SIALIZATION PATHS |
| CA2368734C (en) | 1999-03-30 | 2005-08-23 | Japan Tobacco Inc. | Method for preparing monoclonal antibody |
| JP4488579B2 (ja) * | 1999-03-30 | 2010-06-23 | 日本たばこ産業株式会社 | モノクローナル抗体の製造方法 |
| CA2704600C (en) | 1999-04-09 | 2016-10-25 | Kyowa Kirin Co., Ltd. | A method for producing antibodies with increased adcc activity |
| ATE290879T1 (de) | 1999-08-18 | 2005-04-15 | Altarex Medical Corp | Therapeutische antikörper gegen das muc-1 antigen und verfahren zu deren verwendung |
| US7147850B2 (en) * | 1999-08-18 | 2006-12-12 | Altarex Medical Corp. | Therapeutic binding agents against MUC-1 antigen and methods for their use |
| AU7743100A (en) * | 1999-09-30 | 2001-04-30 | Corixa Corporation | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| FR2809312B1 (fr) | 2000-05-25 | 2002-07-12 | Gervais Danone Sa | Utilisation de l. casei dans des compositions immunostimulantes |
| CA2424977C (en) * | 2000-10-06 | 2008-03-18 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| GB0029360D0 (en) | 2000-12-01 | 2001-01-17 | Univ Nottingham | Humanised antibodies and uses thereof |
| JPWO2002061118A1 (ja) | 2001-02-01 | 2004-06-03 | 株式会社ヤクルト本社 | 発酵乳飲食品中のビフィドバクテリウム属細菌の腸内到達度評価方法 |
| DE10139428A1 (de) | 2001-08-17 | 2003-03-27 | Nemod Immuntherapie Ag | Herstellung und Verwendung von humanen CD124 und CD116 positiven Tumorzelllinien zur Herstellung von allogenen oder semi-allogenen Immuntherapeutika |
| AU2002336981A1 (en) * | 2001-08-17 | 2003-03-03 | Charite | Glycoconjugates of sialic acid derivates, methods for their production and use thereof |
| MEP38608A (en) * | 2001-10-22 | 2011-02-10 | Merck Serono Sa | Gonadotrophins for folliculogenesis |
| GB0125473D0 (en) | 2001-10-24 | 2001-12-12 | Syngenta Ltd | Chemical process |
| EP1451217A4 (en) * | 2001-11-20 | 2005-10-12 | Atgen Co Ltd | NEW PEPTIDES PROVIDING ENVIRONMENTAL RESISTANCE, AND FUSION PROTEINS CONTAINING THOSE PEPTIDES |
| ES2524442T3 (es) * | 2002-07-22 | 2014-12-09 | Glycotope Gmbh | Procedimiento para la producción de una mucina (MUC1) inmunoestimulante |
| DK1530628T3 (da) * | 2002-08-16 | 2011-01-10 | Glycotope Gmbh | Fremgangsmåde til fremstilling af temperaturinducerede tumorcellelysater til anvendelse som immunogene forbindelser |
| DE10256900A1 (de) | 2002-11-29 | 2004-06-24 | Nemod Immuntherapie Ag | Tumorspezifische Erkennungsmoleküle |
| DE10303664A1 (de) | 2003-01-23 | 2004-08-12 | Nemod Immuntherapie Ag | Erkennungsmoleküle zur Behandlung und Detektion von Tumoren |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| SI1654353T1 (sl) | 2003-08-18 | 2013-09-30 | Glycotope Gmbh | Tumorski celični liniji NM-F9 (DSM ACC2606) in NM-D4 (DSM ACC2605), njihove uporabe |
| FR2861080B1 (fr) * | 2003-10-20 | 2006-02-17 | Lab Francais Du Fractionnement | Anticorps presentant un taux de fucose et de galactose optimise |
| US20050203010A1 (en) * | 2003-11-14 | 2005-09-15 | Atgen Co., Ltd. | Novel peptides conferring environmental stress resistance and fusion proteins including said peptides |
| CN103627670B (zh) * | 2004-02-13 | 2016-12-21 | 格莱克托普有限公司 | 高活性糖蛋白加工条件及其有效生产方法 |
| JP4904266B2 (ja) | 2004-07-26 | 2012-03-28 | ザ リサーチ ファウンデイション オブ ステイト ユニバーシティー オブ ニューヨーク | 抗−tf−抗原抗体の治療的使用 |
| KR20080104143A (ko) | 2006-02-14 | 2008-12-01 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 광 디스크 판독용 비트 검출 |
| WO2007124992A1 (en) | 2006-04-28 | 2007-11-08 | Unilever N.V. | Method of manufacturing a cultured edible product comprising omega-3 polyunsaturated fatty acids |
| EP3539981A1 (en) | 2006-09-10 | 2019-09-18 | Glycotope GmbH | Use of human cells of myeloid leukaemia origin for expression of antibodies |
| EP1900750A1 (en) | 2006-09-18 | 2008-03-19 | Glycotope Gmbh | Fully human high yield production system for improved antibodies |
| EP1911766A1 (en) | 2006-10-13 | 2008-04-16 | Glycotope Gmbh | Use of human cells of myeloid leukaemia origin for expression of antibodies |
| PL1920781T3 (pl) * | 2006-11-10 | 2015-06-30 | Glycotope Gmbh | Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów |
| JP2011520435A (ja) | 2008-05-13 | 2011-07-21 | グリコトープ ゲーエムベーハー | 発酵プロセス |
| US9079957B2 (en) | 2009-04-16 | 2015-07-14 | The University Of Tokyo | Diagnosis and treatment of cancer using anti-TMPRSS11E antibody |
| EP2281844A1 (en) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
| CA2897505A1 (en) | 2013-01-18 | 2014-07-24 | Glycotope Gmbh | Peptides for enhancing protein expression |
| JP2015138634A (ja) | 2014-01-22 | 2015-07-30 | 株式会社オートネットワーク技術研究所 | 端子金具付き電線及びその製造方法 |
-
2007
- 2007-09-10 EP EP18188122.8A patent/EP3539981A1/en not_active Withdrawn
- 2007-09-10 AU AU2007294122A patent/AU2007294122B2/en active Active
- 2007-09-10 NZ NZ575974A patent/NZ575974A/en not_active IP Right Cessation
- 2007-09-10 ES ES11176197.9T patent/ES2620261T3/es active Active
- 2007-09-10 CA CA2662226A patent/CA2662226C/en active Active
- 2007-09-10 DK DK11176197.9T patent/DK2428224T3/en active
- 2007-09-10 RS RS20150158A patent/RS53861B1/sr unknown
- 2007-09-10 PL PL07818090.8T patent/PL2073842T5/pl unknown
- 2007-09-10 ES ES07818090T patent/ES2533964T5/es active Active
- 2007-09-10 CN CN201310176217.3A patent/CN103436574B/zh active Active
- 2007-09-10 EP EP20110176200 patent/EP2428225A3/en not_active Ceased
- 2007-09-10 EA EA200970263A patent/EA017622B1/ru not_active IP Right Cessation
- 2007-09-10 DK DK07818090.8T patent/DK2073842T4/da active
- 2007-09-10 HR HRP20150307TT patent/HRP20150307T1/hr unknown
- 2007-09-10 FI FIEP07818090.8T patent/FI2073842T4/fi active
- 2007-09-10 EP EP11176193A patent/EP2428223A3/en not_active Withdrawn
- 2007-09-10 KR KR1020157031066A patent/KR20150126730A/ko not_active Ceased
- 2007-09-10 SI SI200731634T patent/SI2073842T1/sl unknown
- 2007-09-10 KR KR1020097007469A patent/KR101603632B1/ko active Active
- 2007-09-10 EP EP11176197.9A patent/EP2428224B1/en active Active
- 2007-09-10 SG SG2011064987A patent/SG174792A1/en unknown
- 2007-09-10 WO PCT/EP2007/007877 patent/WO2008028686A2/en not_active Ceased
- 2007-09-10 BR BRPI0716997A patent/BRPI0716997B8/pt active IP Right Grant
- 2007-09-10 US US12/440,562 patent/US9051356B2/en active Active
- 2007-09-10 MX MX2009002388A patent/MX2009002388A/es active IP Right Grant
- 2007-09-10 EP EP07818090.8A patent/EP2073842B2/en active Active
- 2007-09-10 KR KR1020177004543A patent/KR20170021375A/ko not_active Ceased
- 2007-09-10 PT PT78180908T patent/PT2073842E/pt unknown
- 2007-09-10 JP JP2009527066A patent/JP5767779B2/ja active Active
-
2009
- 2009-03-08 IL IL197459A patent/IL197459A/en active IP Right Grant
- 2009-03-10 CU CU20090033A patent/CU23791A3/es active IP Right Grant
-
2010
- 2010-03-17 ZA ZA2010/01903A patent/ZA201001903B/en unknown
-
2015
- 2015-03-27 CY CY20151100305T patent/CY1116279T1/el unknown
- 2015-04-23 JP JP2015088247A patent/JP6166303B2/ja active Active
- 2015-05-04 US US14/703,498 patent/US10280230B2/en active Active
-
2017
- 2017-04-26 JP JP2017087053A patent/JP2017123879A/ja not_active Withdrawn
-
2019
- 2019-04-05 US US16/376,174 patent/US20190359731A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL2073842T5 (pl) | Zastosowanie ludzkich komórek pochodzących z białaczki szpikowej do ekspresji przeciwciał | |
| HRP20181616T1 (hr) | Potpuno ljudska anti-vap-1 monoklonska antitijela | |
| IL193604A0 (en) | Methods of using antibodies against human il-22 | |
| ZA201008952B (en) | Compositions and methods of use for therapeutic antibodies | |
| SI2949666T1 (sl) | Človeška anti alfa-sinukleinska protitelesa | |
| IL196701A0 (en) | HUMAN ANTIBODIES TO ErbB2 | |
| PT3002298T (pt) | Anticorpos monoclonais anti-fator xi e métodos de utilização dos mesmos | |
| IL200610A0 (en) | Human monoclonal anti-ip-10 antibodies and uses thereof | |
| ZA201103723B (en) | Human antibodies against human tissue factor | |
| PL2631241T3 (pl) | Sposób generowania białka i jego zastosowanie | |
| PL2037950T3 (pl) | Dodatkowe zastosowania medyczne białka antysekrecyjnego | |
| IL212795A0 (en) | Fully human antibodies against n-cadherin | |
| ZA200901912B (en) | Use of human cells of myeloid leukaemia origin for expression of antibodies | |
| GB0605950D0 (en) | Device for prediction of human or other mammalian labour onset | |
| HRP20190159T1 (hr) | Antitijela humanog anti-alfa-sinukleina | |
| HU3177U (en) | Electro-optical device for screening of skin diseases | |
| HU0700076V0 (en) | Device for covered introduction of scalpels | |
| TWM300387U (en) | Improved structure of cupulate holder | |
| SG10202006468XA (en) | Human antibodies against human tissue factor | |
| HU0600626D0 (en) | New medical use of mononucleosides |