PL2082045T3 - Sposób zmniejszania ekspresji genów poprzez modyfikację częstości występowania kodonów - Google Patents

Sposób zmniejszania ekspresji genów poprzez modyfikację częstości występowania kodonów

Info

Publication number
PL2082045T3
PL2082045T3 PL07821516T PL07821516T PL2082045T3 PL 2082045 T3 PL2082045 T3 PL 2082045T3 PL 07821516 T PL07821516 T PL 07821516T PL 07821516 T PL07821516 T PL 07821516T PL 2082045 T3 PL2082045 T3 PL 2082045T3
Authority
PL
Poland
Prior art keywords
gene expression
codon usage
reducing gene
modified codon
modified
Prior art date
Application number
PL07821516T
Other languages
English (en)
Inventor
Andrea Herold
Corinna Klopprogge
Hartwig Schröder
Oskar Zelder
Weol Kyu Jeong
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of PL2082045T3 publication Critical patent/PL2082045T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL07821516T 2006-10-24 2007-10-18 Sposób zmniejszania ekspresji genów poprzez modyfikację częstości występowania kodonów PL2082045T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06122882 2006-10-24
PCT/EP2007/061151 WO2008049781A1 (en) 2006-10-24 2007-10-18 Method of reducing gene expression using modified codon usage
EP07821516.7A EP2082045B1 (en) 2006-10-24 2007-10-18 Method of reducing gene expression using modified codon usage

Publications (1)

Publication Number Publication Date
PL2082045T3 true PL2082045T3 (pl) 2015-07-31

Family

ID=38969443

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07821516T PL2082045T3 (pl) 2006-10-24 2007-10-18 Sposób zmniejszania ekspresji genów poprzez modyfikację częstości występowania kodonów

Country Status (6)

Country Link
US (1) US20100041107A1 (pl)
EP (1) EP2082045B1 (pl)
ES (1) ES2539280T3 (pl)
HU (1) HUE025440T2 (pl)
PL (1) PL2082045T3 (pl)
WO (1) WO2008049781A1 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103476425B (zh) 2007-03-30 2015-07-15 纽约州州立大学研究基金会 用于疫苗的减毒病毒
EP2235194B1 (de) * 2008-01-23 2011-07-20 Basf Se Verfahren zur fermentativen Herstellung von 1,5-Diaminopentan
KR101498753B1 (ko) * 2008-04-30 2015-03-09 바스프 에스이 이소시트레이트 데히드로게나제 활성이 감소된 미생물을 사용한 정밀 화학물질의 생산 방법
CN102159720A (zh) * 2008-04-30 2011-08-17 赢创德固赛有限公司 使用具有降低的异柠檬酸脱氢酶活性的微生物生产甲硫氨酸的方法
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US20160186188A1 (en) * 2010-02-09 2016-06-30 Rutgers, The State University Of New Jersey Methods for altering polypeptide expression and solubility
DE102010003419B4 (de) 2010-03-30 2019-09-12 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von L-Ornithin
JP5719434B2 (ja) * 2010-06-15 2015-05-20 パク グアン インダストリアル カンパニー リミテッドＰａｉｋ Ｋｗａｎｇ Ｉｎｄｕｓｔｒｉａｌ Ｃｏ．， Ｌｔｄ． 微生物を用いたアスパラギン酸系アミノ酸の生産方法
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
KR102013741B1 (ko) * 2017-02-24 2019-08-23 한국과학기술원 메티오닌 생합성능이 향상된 변이세포
WO2019203368A1 (ja) * 2018-04-20 2019-10-24 味の素株式会社 タンパク質の分泌生産法
WO2024077283A2 (en) * 2022-10-07 2024-04-11 Sens Research Foundation Allotopic expression of mtdna genes

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835197A (ja) 1981-08-26 1983-03-01 Kyowa Hakko Kogyo Co Ltd プラスミドｐｃｇ２
GB2165546B (en) 1984-08-21 1989-05-17 Asahi Chemical Ind A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom
DE4120867A1 (de) 1991-06-25 1993-01-07 Agfa Gevaert Ag Fotografisches verarbeitungsverfahren und vorrichtung dafuer
DE19924365A1 (de) * 1999-05-27 2000-11-30 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren und für das accDA Gen codierende Nukleotidsequenzen
US6780405B1 (en) * 2000-04-28 2004-08-24 Avant Immunotherapeutics, Inc. Regulated antigen delivery system (RADS)
EP1307475A1 (en) 2000-08-02 2003-05-07 Degussa AG Nucleotide sequences which code for the meth gene
EP1307563B1 (en) * 2000-08-10 2004-08-18 Degussa AG Nucleotide sequences which code for the lysr2 gene
DE10046870A1 (de) 2000-09-20 2002-03-28 Basf Ag Verfahren zur Veränderung des Genoms von Corynebakterien
DE60234247D1 (de) * 2001-03-30 2009-12-17 Ajinomoto Kk Verfahren zur sekretion und produktion von protein
AU2003275776B2 (en) 2002-11-08 2009-06-18 Jingang Medicine (Australia) Pty Ltd A method for optimising gene expression using synonymous codon optimisation
DE10359594A1 (de) 2003-12-18 2005-07-28 Basf Ag PEF-TU-Expressionseinheiten
DE10359595A1 (de) * 2003-12-18 2005-07-28 Basf Ag Pgro-Expressionseinheiten
DE102004035065A1 (de) 2004-07-20 2006-02-16 Basf Ag P-ET-TS-Expressionseinheiten
CA2611513A1 (en) * 2005-06-17 2006-12-28 Microbia, Inc. Improved amino acid and metabolite biosynthesis
WO2007005053A1 (en) * 2005-06-30 2007-01-11 Codon Devices, Inc. Hierarchical assembly methods for genome engineering
US20070212711A1 (en) * 2005-07-16 2007-09-13 Basf Aktiengesellschaft P1-34 Expression Units
MX2008000480A (es) 2005-07-18 2008-03-07 Basf Ag Microorganismos recombinantes que producen metionina.
EP1931784A2 (en) 2005-08-18 2008-06-18 Basf Se Microorganisms with increased efficiency for methionine synthesis
US20080051317A1 (en) * 2005-12-15 2008-02-28 George Church Polypeptides comprising unnatural amino acids, methods for their production and uses therefor

Also Published As

Publication number Publication date
US20100041107A1 (en) 2010-02-18
HUE025440T2 (en) 2016-04-28
EP2082045A1 (en) 2009-07-29
EP2082045B1 (en) 2015-03-18
ES2539280T3 (es) 2015-06-29
WO2008049781A1 (en) 2008-05-02

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