PL2083811T3 - Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu - Google Patents

Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu

Info

Publication number
PL2083811T3
PL2083811T3 PL07862184T PL07862184T PL2083811T3 PL 2083811 T3 PL2083811 T3 PL 2083811T3 PL 07862184 T PL07862184 T PL 07862184T PL 07862184 T PL07862184 T PL 07862184T PL 2083811 T3 PL2083811 T3 PL 2083811T3
Authority
PL
Poland
Prior art keywords
syndrome
autism
fragile
methods
treating down
Prior art date
Application number
PL07862184T
Other languages
English (en)
Inventor
Randall L. Carpenter
Kathryn Roberts
Mark F. Bear
Original Assignee
Clinical Research Associates, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinical Research Associates, Llc filed Critical Clinical Research Associates, Llc
Publication of PL2083811T3 publication Critical patent/PL2083811T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
  • Surgical Instruments (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL07862184T 2006-11-22 2007-11-21 Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu PL2083811T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86073306P 2006-11-22 2006-11-22
US156707P 2007-11-02 2007-11-02
PCT/US2007/024311 WO2008066750A1 (en) 2006-11-22 2007-11-21 Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism

Publications (1)

Publication Number Publication Date
PL2083811T3 true PL2083811T3 (pl) 2017-05-31

Family

ID=39272866

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07862184T PL2083811T3 (pl) 2006-11-22 2007-11-21 Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu

Country Status (16)

Country Link
US (6) US8143311B2 (pl)
EP (3) EP2567696A1 (pl)
JP (1) JP2010510314A (pl)
AU (1) AU2007325836B2 (pl)
CA (1) CA2670116C (pl)
CY (1) CY1118406T1 (pl)
DK (1) DK2083811T3 (pl)
ES (1) ES2610508T3 (pl)
HR (1) HRP20170027T1 (pl)
HU (1) HUE032743T2 (pl)
LT (1) LT2083811T (pl)
PL (1) PL2083811T3 (pl)
PT (1) PT2083811T (pl)
RS (1) RS55585B1 (pl)
SI (1) SI2083811T1 (pl)
WO (1) WO2008066750A1 (pl)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2201950B1 (en) * 2008-12-08 2016-11-16 Biocodex Compounds and methods for treating autism spectrum disorders
PT2395990E (pt) 2009-02-12 2015-02-09 Univ Indiana Res & Tech Corp Material e métodos de tratamento de transtornos do desenvolvimento incluindo autismo comórbido e idiopático
US8334287B2 (en) 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
WO2011053636A1 (en) * 2009-10-27 2011-05-05 Mount Sinai School Of Medicine Methods of treating psychiatric or neurological disorders with mglur antagonists
US20130058915A1 (en) * 2010-03-02 2013-03-07 Children's Medica Center Corporation Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
US20120016021A1 (en) * 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders
US8946206B2 (en) 2010-12-17 2015-02-03 The Board Of Trustees Of The Leland Stanford Junior University Methods for improving cognitive function
CA2874737A1 (en) 2012-06-01 2013-12-05 Lynn Health Science Institute, Inc. Use of baclofen to treat insomnia
EP2928300A4 (en) * 2012-11-28 2016-07-13 Neuren Pharmaceuticals Ltd TREATMENT OF AUTISTIC DISEASES WITH GLYCYL-L-2-METHYLPROLYL-L-GLUTAMINE ACID
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
WO2014128882A1 (ja) * 2013-02-21 2014-08-28 医療法人 和楽会 不安うつ病の治療薬
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
WO2015057736A1 (en) * 2013-10-14 2015-04-23 Indiana University Research And Technology Corporation Use of acamprosate to modulate erk 1-2 activation in animal models for fxs and asd and individuals diagnosed with fxs and asd
MX2017009313A (es) 2015-01-15 2018-02-09 Allaysis Llc Formulaciones intravenosas de baclofeno y metodos de tratamiento.
US10987328B2 (en) 2015-02-20 2021-04-27 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form
US10172800B2 (en) 2015-02-20 2019-01-08 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form with enhanced pharmacokinetics
US10300032B2 (en) 2015-02-20 2019-05-28 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form
WO2016132220A1 (en) 2015-02-20 2016-08-25 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release oral dosage form of gaba receptor agonist
KR20180031721A (ko) 2015-07-17 2018-03-28 오비드 테라퓨틱스 인크. 가복사돌로 발달장애들을 치료하는 방법들
EP4233861A3 (en) 2016-08-11 2023-10-11 Ovid Therapeutics, Inc. Compositions for treatment of essential tremor
US10535243B2 (en) * 2016-10-28 2020-01-14 HBH Development LLC Target behavior monitoring system
US10071083B2 (en) 2017-02-03 2018-09-11 Ovid Therapeutics Inc Use of gaboxadol in the treatment of tinnitus
AU2018309049A1 (en) 2017-08-04 2020-02-27 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of diabetes and related conditions
US20210057078A1 (en) * 2018-01-18 2021-02-25 Cureapp, Inc. System, device, method, and program for treating disorder treatable by behavior modification
MD3746126T2 (ro) 2018-01-30 2024-12-31 Apnimed Inc Delaware Metode și compoziții pentru tratamentul apneei în somn sau sforăitului simplu
WO2020061410A1 (en) 2018-09-20 2020-03-26 Ovid Therapeutics Inc. Use of gaboxadol for the treatment of tourette syndrome, tics and stuttering
US12558327B2 (en) 2019-02-08 2026-02-24 The Brigham And Women's Hospital, Inc. Methods and compositions for treating sleep apnea
US11186909B2 (en) * 2019-08-26 2021-11-30 Applied Materials, Inc. Methods of depositing low-K films
USD970544S1 (en) * 2021-02-26 2022-11-22 Oracle International Corporation Display screen or portion thereof with icon or paper product with surface ornamentation
USD967184S1 (en) * 2021-02-26 2022-10-18 Oracle International Corporation Display screen or portion thereof with icon, or paper product with surface ornamentation
USD1059370S1 (en) * 2021-09-15 2025-01-28 Capital Preferences NZ Limited Display screen or portion thereof with an animated graphical user interface for a sustainability simulator
US11523984B1 (en) 2021-11-12 2022-12-13 Amneal Pharmaceuticals Llc Compositions and methods of administering baclofen
WO2023178183A1 (en) * 2022-03-16 2023-09-21 University Of Florida Research Foundation, Incorporated Combinatorial activation of gaba(b) and alpha-2 adrenergic receptors for treatment of stress induced depression
US20240408042A1 (en) * 2023-06-08 2024-12-12 Clinical Research Associates LLC Orally disintegrating baclofen compositions and methods of making same
USD1103182S1 (en) * 2023-07-07 2025-11-25 Illumina, Inc. Display screen or portion thereof with graphical user interface

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539573A (en) 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
NO129043B (pl) 1968-02-16 1974-02-18 Fujisawa Pharmaceutical Co
FR2492258A1 (fr) 1980-10-17 1982-04-23 Pharmindustrie Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
US4411901A (en) 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
JPH0625181B2 (ja) 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
IE58370B1 (en) 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8607684D0 (en) 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
US4831031A (en) 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
ATE107922T1 (de) 1989-03-03 1994-07-15 Dainippon Pharmaceutical Co 2-(1-piperazinyl)-4-phenylcycloalkanpyridin- derivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
GB8908085D0 (en) 1989-04-11 1989-05-24 Lundbeck & Co As H New therapeutic use
US5238945A (en) 1989-04-11 1993-08-24 H. Lundbeck A/S Method of treating psychoses
EP0402644B1 (en) 1989-05-19 1995-08-16 Hoechst-Roussel Pharmaceuticals Incorporated N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US6107025A (en) 1991-05-24 2000-08-22 Baylor College Of Medicine Diagnosis of the fragile X syndrome
US6180337B1 (en) 1991-05-24 2001-01-30 Baylor College Of Medicine Diagnosis of the fragile X syndrome
DE4243287A1 (de) 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4339702A1 (de) 1993-11-22 1995-05-24 Bayer Ag Verfahren zur Herstellung von harten Polyurethanschaumstoffen
MX9604023A (es) 1994-03-14 1997-09-30 Novo Nordisk As Compuestos heterociclicos, su preparacion y su uso.
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
AU1106195A (en) 1994-11-09 1996-06-06 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
US6011021A (en) 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
AU6514196A (en) 1995-07-31 1997-02-26 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
EP0843660A1 (en) 1995-07-31 1998-05-27 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
GB9609976D0 (en) 1996-05-13 1996-07-17 Lilly Industries Ltd Pharmaceutical compounds
US5795877A (en) 1996-12-31 1998-08-18 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5902817A (en) 1997-04-09 1999-05-11 Guilford Pharmaceuticals Inc. Certain sulfoxide and sulfone derivatives
US5672592A (en) 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
US6025344A (en) 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US6046180A (en) 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
US5863536A (en) 1996-12-31 1999-01-26 Guilford Pharmaceuticals Inc. Phosphoramidate derivatives
WO1998006724A1 (en) 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists
FR2759366B1 (fr) 1997-02-11 1999-04-16 Centre Nat Rech Scient Composes constituant notamment des effecteurs de recepteurs du systeme nerveux central sensibles aux amino acides neuroexcitateurs, leur preparation et leurs applications biologiques
EA199900912A1 (ru) 1997-04-07 2000-04-24 Эли Лилли Энд Компани Фармацевтические средства
EP0994707A4 (en) 1997-05-27 2001-11-14 Guilford Pharm Inc INHIBITORS OF NAALADASE ENZYME ACTIVITY
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
HUP0004412A3 (en) 1997-08-14 2003-06-30 Hoffmann La Roche Use of heterocyclic vinylethers for the preparation of pharmaceutical compositions treating neurological disorders
SI20270A (sl) * 1997-08-25 2000-12-31 Neurogen Corporation Substituirani 4-okso-naftiridin-3-karboksamidi kot ligandi možganskih GABA receptorjev
JP2001524468A (ja) 1997-11-21 2001-12-04 エヌピーエス ファーマシューティカルズ インコーポレーテッド 中枢神経系疾患を治療するための代謝調節型グルタミン酸受容体アンタゴニスト
WO1999044639A1 (en) 1998-03-03 1999-09-10 Yamanouchi Pharmaceutical Co., Ltd. Remedies for brain infarction
CN1367775A (zh) 1998-04-17 2002-09-04 肯尼思·柯里 用作亲代谢型谷氨酸受体对抗剂的立方烷衍生物及其制备方法
SE511005C2 (sv) 1998-07-07 1999-07-19 Laekartjaenster I Vaestsverige Användning av komposition omfattande minst ett ämne inom gruppen GnRH-analoger för framställning av ett läkemedel för behandling av tvångstanke-tvångshandlingssjukdom
US20030216293A1 (en) 1998-07-07 2003-11-20 Tomas Eriksson Use of composition comprising at least one substance within the group GnRH-analogues for treatment of obsessive -compulsive disorder (OCD)
DK1117403T3 (da) 1998-10-02 2004-04-13 Sibia Neurosciences Inc MGLUR5-antagonister til behandling af smerte og angst
GB9823845D0 (en) 1998-11-02 1998-12-23 Lilly Co Eli Pharmaceutical compounds
GB9823847D0 (en) 1998-11-02 1998-12-23 Lilly Co Eli Pharmaceutical compounds
TW593241B (en) 1999-04-20 2004-06-21 Hoffmann La Roche Carbamic acid derivatives
EP1183238A1 (en) 1999-05-17 2002-03-06 Eli Lilly And Company Metabotropic glutamate receptor antagonists
AU778063C (en) 1999-06-02 2005-12-15 Astrazeneca Ab Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
WO2001002342A1 (en) 1999-06-30 2001-01-11 Igt Pharma Inc. 2-aminoindane analogs
WO2001002340A2 (en) 1999-07-02 2001-01-11 Igt Pharma Inc. Novel aminoindanes
ES2198323T3 (es) 1999-07-06 2004-02-01 Eli Lilly And Company Profarmacos de diesteres de un acido decahidroisoquinolin-3-carboxilico.
WO2001005963A2 (en) 1999-07-15 2001-01-25 Mcgill University ANTISENSE OLIGONUCLEOTIDES FOR METABOTROPIC GLUTAMATE RECEPTOR TYPE 1 (mGluR1)
AU6182000A (en) 1999-08-02 2001-02-19 Yamanouchi Pharmaceutical Co., Ltd. Remedies for neurogenic pains
ATE254614T1 (de) 1999-08-06 2003-12-15 Hoffmann La Roche Tetrahydro-benzo(d)azepine und deren verwendung als metabotrope glutamatrezeptor-antagonisten
JP2003506407A (ja) * 1999-08-10 2003-02-18 ユーエイビー リサーチ ファンデーション 痙性障害、痙攣、及び癲癇の治療のためのγ−アミノ酪酸アゴニストの使用
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
AU1071301A (en) 1999-11-01 2001-05-14 Eli Lilly And Company Pharmaceutical compounds
GB0005700D0 (en) 2000-03-09 2000-05-03 Glaxo Group Ltd Therapy
US20030008897A1 (en) 2000-03-17 2003-01-09 Mendel Carl M. Method of controlling weight gain associated with therapeutic drugs
US6455553B1 (en) * 2000-10-03 2002-09-24 Albert Einstein College Of Medicine Of Yeshiva University Method for treating a demyelinating condition
US20020123490A1 (en) 2001-03-01 2002-09-05 Pfizer Inc. Combination treatment for anxiety, depression, obsessive compulsive disorder and psychosis
US6916821B2 (en) 2001-04-02 2005-07-12 Brown University Methods of treating disorders with Group I mGluR antagonists
JP2005500260A (ja) * 2001-04-02 2005-01-06 ブラウン ユニバーシティ リサーチ ファウンデイション ｍＧｌｕＲ５アンタゴニストの組成物および使用方法
US6831077B2 (en) 2002-07-25 2004-12-14 Comprehensive Neuroscience, Inc. Augmentation of atypical antipsychotic agent pharmacotherapy with chromium supplementation
US6656172B1 (en) * 2002-09-27 2003-12-02 Medtronic, Inc. Method for treating severe tinnitus
CA2778309C (en) 2003-06-24 2014-12-02 University Of Connecticut Methods of inhibiting vascular permeability and apoptosis
BRPI0413756A (pt) * 2003-08-20 2006-10-31 Xenoport Inc composto, métodos para tratar ou evitar espasticidade ou um sintoma de espasticidade, doença de refluxo gastro-esofágico, vìcio em droga, vìcio em ou abuso de álcool, ou vìcio em ou abuso de nicotina, e tosse ou êmese em um paciente, e, composição farmacêutica
US20050090554A1 (en) * 2003-09-12 2005-04-28 John Devane Treatment of gastroparesis and nonulcer dyspepsia with GABAB agonists
WO2006012403A1 (en) * 2004-07-20 2006-02-02 Massachusetts Institute Of Technology Methods of treatment: cell signaling and glutamate release
US20060058271A1 (en) 2004-09-16 2006-03-16 Geier Mark R Methods for screening, studying, and treating dissorders with a component of mercurial toxicity
US20070254314A1 (en) 2004-09-16 2007-11-01 Geier Mark R Methods of treating autism and autism spectrum disorders
US9095713B2 (en) * 2004-12-21 2015-08-04 Allison M. Foster Methods and systems for treating autism by decreasing neural activity within the brain
WO2006121919A2 (en) * 2005-05-05 2006-11-16 Massachusetts Institute Of Technology Methods of treating obsessive compulsive disorder
WO2007029063A2 (en) * 2005-07-29 2007-03-15 Ecole Polytechnique Federale De Lausanne (Epfl) Treatment and/or prevention of pervasive developmental disorders
US20080312279A1 (en) * 2005-10-26 2008-12-18 Warren Stephen T Compositions for Treating Fragile X and Other Disorders Methods of Use Thereof, and Screening for Compounds for Fragile X and Other Disorders
EP1942879A1 (en) * 2005-10-31 2008-07-16 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20070191440A1 (en) * 2006-01-25 2007-08-16 Solomon Michael E Methods of treating autism and fragile X syndrome
CA2780205A1 (en) 2009-11-05 2011-05-12 Brown University Methods of treating elevations in mtor signaling

Also Published As

Publication number Publication date
EP2083811B1 (en) 2016-10-26
AU2007325836B2 (en) 2011-07-21
US20120129940A1 (en) 2012-05-24
US8278276B2 (en) 2012-10-02
AU2007325836A1 (en) 2008-06-05
SI2083811T1 (sl) 2017-02-28
US8143311B2 (en) 2012-03-27
RS55585B1 (sr) 2017-06-30
US20100029770A1 (en) 2010-02-04
HRP20170027T1 (hr) 2017-03-10
DK2083811T3 (en) 2017-01-30
WO2008066750A1 (en) 2008-06-05
ES2610508T3 (es) 2017-04-27
JP2010510314A (ja) 2010-04-02
US20130012587A1 (en) 2013-01-10
US20120122986A1 (en) 2012-05-17
CA2670116A1 (en) 2008-06-05
EP2567696A1 (en) 2013-03-13
LT2083811T (lt) 2017-01-25
US20130261186A1 (en) 2013-10-03
US9044443B2 (en) 2015-06-02
US20130012586A1 (en) 2013-01-10
EP2083811A1 (en) 2009-08-05
HUE032743T2 (en) 2017-10-30
PT2083811T (pt) 2017-01-23
CA2670116C (en) 2015-03-10
EP2578216A1 (en) 2013-04-10
US8273715B2 (en) 2012-09-25
CY1118406T1 (el) 2017-06-28

Similar Documents

Publication Publication Date Title
SI2083811T1 (sl) Postopki zdravljenja Downovega sindroma, sindroma krhkega X in avtizma
GB2434604B (en) Porous composites containing hydrocarbon-soluble well treatment agents and methods for using the same
EP1951263A4 (en) MULTITARGETING DISTURBING RNAS WITH TWO ACTIVE STRANDS AND DESIGN AND APPLICATION METHODS
IL183963A0 (en) 1 - aminocyclohexane - derivatives for the treatment of multiple sclerosis, emotional liability and pseudobulbar affect
EG26217A (en) Activated carbon impregnated with acid and a way to form
EP2078051A4 (en) PROCESS FOR PRODUCTION OF POLYSILOXANES AND USE THEREOF
SI2079760T1 (sl) Sestavki in metode za zdravljenje okužb
ZA200704677B (en) Compositions and methods for the treatment of autism
EP1845915A4 (en) SYSTEMS AND METHOD FOR TARGET HEAT TREATMENT
EP2012972A4 (en) ABRASIVE ARTICLE STRUCTURE AND METHOD OF MANUFACTURING AND USING THE SAME
ZA200709727B (en) Compounds and methods for the treatment of prevention of flavivirus infections
EP2087865A4 (en) ABSORBENT ARTICLE AND PRODUCTION METHOD THEREOF
EP2087866A4 (en) ABSORBENT ARTICLE AND PRODUCTION METHOD THEREOF
EP2098200A4 (en) ABSORBENT ARTICLE AND ITS MANUFACTURING PROCESS
IL190097A0 (en) Method and means of preventing and treating sleep disordered breathing
ZA200904519B (en) Emission treatment systems and methods
IL195272A0 (en) Methods and compositions for the treatment of viral infections
ZA200902385B (en) Fabric treatment method and composition
IL188728A0 (en) Methods of treating epileptogenesis
EP1931601A4 (en) DENITRIFICATION PROCESS AND SYSTEM
GB0417263D0 (en) Process and system
TWI369732B (en) Semiconductor process and chamber used
GB0619684D0 (en) Method and articles
ZA200805224B (en) Geopolymeric particles, fibers, shaped articles and methods of manufacture
EP1737445A4 (en) METHOD FOR TREATING DOWN SYNDROME