PL2125824T3 - Ulepszony sposób wytwarzania oksymorfonu z oripawiny - Google Patents

Ulepszony sposób wytwarzania oksymorfonu z oripawiny

Info

Publication number
PL2125824T3
PL2125824T3 PL08732176T PL08732176T PL2125824T3 PL 2125824 T3 PL2125824 T3 PL 2125824T3 PL 08732176 T PL08732176 T PL 08732176T PL 08732176 T PL08732176 T PL 08732176T PL 2125824 T3 PL2125824 T3 PL 2125824T3
Authority
PL
Poland
Prior art keywords
oripavine
oxymorphone
improved preparation
preparation
improved
Prior art date
Application number
PL08732176T
Other languages
English (en)
Other versions
PL2125824T5 (pl
Inventor
Peter X Wang
Tao Jiang
Gary L Cantrell
David Wayne Berberich
Original Assignee
SpecGx LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39477545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2125824(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SpecGx LLC filed Critical SpecGx LLC
Publication of PL2125824T3 publication Critical patent/PL2125824T3/pl
Publication of PL2125824T5 publication Critical patent/PL2125824T5/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL08732176.6T 2007-03-23 2008-03-14 Ulepszony sposób wytwarzania oksymorfonu z oripawiny PL2125824T5 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89653707P 2007-03-23 2007-03-23
EP08732176.6A EP2125824B2 (en) 2007-03-23 2008-03-14 Improved preparation of oxymorphone from oripavine
PCT/US2008/056929 WO2008118654A1 (en) 2007-03-23 2008-03-14 Improved preparation of oxymorphone from oripavine

Publications (2)

Publication Number Publication Date
PL2125824T3 true PL2125824T3 (pl) 2014-05-30
PL2125824T5 PL2125824T5 (pl) 2024-11-04

Family

ID=39477545

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08732176.6T PL2125824T5 (pl) 2007-03-23 2008-03-14 Ulepszony sposób wytwarzania oksymorfonu z oripawiny

Country Status (8)

Country Link
US (1) US8217175B2 (pl)
EP (1) EP2125824B2 (pl)
JP (1) JP2010522189A (pl)
AU (1) AU2008231127B2 (pl)
CA (1) CA2681740A1 (pl)
ES (1) ES2438997T5 (pl)
PL (1) PL2125824T5 (pl)
WO (1) WO2008118654A1 (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101395159A (zh) * 2006-03-02 2009-03-25 马林克罗特公司 制备含有低含量α,β-不饱和酮化合物的吗啡烷-6-酮产物的方法
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
EP2580201B1 (en) 2010-06-11 2017-08-02 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
CA2802294C (en) 2010-06-11 2016-05-10 Rhodes Technologies Process for n-dealkylation of tertiary amines
US8563571B2 (en) 2010-07-22 2013-10-22 Noramco, Inc. Crystalline forms of oxymorphone hydrochloride
EP2420503A1 (en) * 2010-07-27 2012-02-22 Universität Innsbruck Process for the synthesis of 14-oxygenated morphinan-6-ones
CN103619847A (zh) 2011-05-06 2014-03-05 布鲁克大学 通过金属催化n-脱甲基化/官能化以及分子内基团转移制备吗啡类似物的方法
PL2812336T3 (pl) 2012-02-08 2017-07-31 Mallinckrodt Llc Sposób wytwarzania 6-hydroksyIowej pochodnej opiatu nal w jednym naczyniu
EP2872516B1 (en) 2012-07-16 2017-08-30 Rhodes Technologies Process for improved opioid synthesis
KR101946104B1 (ko) 2012-07-16 2019-02-08 로드스 테크놀로지즈 개선된 오피오이드 합성을 위한 방법
CA2919602C (en) * 2013-08-02 2018-03-13 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone
GB201313915D0 (en) 2013-08-02 2013-09-18 Johnson Matthey Plc Process
KR101868723B1 (ko) 2014-01-15 2018-06-18 로드스 테크놀로지즈 개선된 옥시코돈 합성을 위한 방법
EP3094633B1 (en) * 2014-01-15 2018-03-14 Rhodes Technologies Process for improved oxymorphone synthesis
WO2016187522A1 (en) 2015-05-20 2016-11-24 Noramco, Inc. Process for the preparation of oxymorphone freebase
US20160340362A1 (en) * 2015-05-20 2016-11-24 Noramco, Inc. Process For The Preparation Of Oxymorphone Freebase
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2772270A (en) 1954-10-21 1956-11-27 M J Lewenstein 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
BE638369A (pl) 1962-10-10
IL26896A (en) 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
GB1123768A (en) 1966-07-29 1968-08-14 Smith Kline French Lab New thebaine and oripavine derivatives and processes for preparing the same
US3905981A (en) 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines
US4277604A (en) 1980-01-25 1981-07-07 The United States Of America As Represented By The Department Of Health And Human Services Facile synthesis of codeine precursors from thebaine
US4795813A (en) 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4472253A (en) 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en) 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US4639520A (en) 1984-03-27 1987-01-27 Mallinckrodt, Inc. Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone
US5668285A (en) 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
FR2636330B1 (fr) 1988-09-13 1990-11-30 Sanofi Sa Procede de preparation de derives de morphinane
US6067749A (en) 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
AUPQ968300A0 (en) 2000-08-25 2000-09-21 Glaxo Wellcome Australia Ltd Chemical methods
PL368732A1 (pl) 2001-08-23 2005-04-04 Akzo Nobel N.V. Utlenianie pochodnych morfiny przy C-14
US6864370B1 (en) 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
CA2539659C (en) 2003-09-22 2013-03-26 Johnson Matthey Public Limited Company Process for the synthesis of morphinane compounds and intermediates thereof
TW201509943A (zh) 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
SK286087B6 (sk) † 2004-08-18 2008-03-05 Zentiva, A. S. Spôsob prípravy oxykodonu
AU2007313103C1 (en) † 2006-10-17 2014-01-30 Penick Corporation Process for preparing oxymorphone
GB0624880D0 (en) † 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics

Also Published As

Publication number Publication date
PL2125824T5 (pl) 2024-11-04
ES2438997T5 (es) 2024-09-03
ES2438997T3 (es) 2014-01-21
CA2681740A1 (en) 2008-10-02
EP2125824B1 (en) 2013-11-20
AU2008231127A1 (en) 2008-10-02
EP2125824B2 (en) 2023-11-15
JP2010522189A (ja) 2010-07-01
US8217175B2 (en) 2012-07-10
AU2008231127B2 (en) 2013-05-02
US20100113787A1 (en) 2010-05-06
EP2125824A1 (en) 2009-12-02
WO2008118654A1 (en) 2008-10-02

Similar Documents

Publication Publication Date Title
PL2125824T3 (pl) Ulepszony sposób wytwarzania oksymorfonu z oripawiny
EP2435439B8 (en) Preparation of nalmefene hydrochloride from naltrexone
HRP20180615T1 (hr) Tetraciklički spojevi
ZA201102113B (en) Morphinan compounds
EP2227085A4 (en) INGREDIBLE COMPOSITIONS WITH INCREASED BIOLOGICAL AVAILABILITY
EP2252150A4 (en) SELECTIVE OPIOID COMPOUNDS
SI1981859T1 (sl) Pripravek delmopinola
GB0712783D0 (en) Preparation of oxycodone
IL215553A0 (en) Processes for the preparation of morphinane and morphinone compounds
EP2212251A4 (en) PROCESS FOR THE PRODUCTION OF CLUSTERBOR
ZA201003241B (en) Method for the preparation of morphine compounds
TWI320362B (en) Enhanced imaging of features
HUE063526T2 (hu) Morfinvegyületek
EP2205524A4 (en) METHODS OF MANUFACTURING CLUSTER BORON
EP2205525A4 (en) PROCESS FOR THE PREPARATION OF CLUSTERBORON
PL2062897T3 (pl) Demetylacja 14-hydroksy-podstawionych pochodnych alkaloidów
IL210106A0 (en) Methods of synthesis of morphinans
GB0922023D0 (en) Preparation of n-monofluoroalkyl compounds
EP2331490A4 (en) PREPARATION OF DIBUTOXYMETHANE
GB0515430D0 (en) Preparation of cabergoline
GB0623548D0 (en) Preparation of tiotropium
ZA200707895B (en) Preparation of cabergoline
IL198836A0 (en) Processes for preparation of 9-haloacetamidomidominocyclines
AU327636S (en) Mixing bowl
TWM311768U (en) Improved structure of A-ladder