PL2133091T3 - Kompozycje zawierające supramolekularne układy insuliny użyteczne do leczenia cukrzycy - Google Patents

Kompozycje zawierające supramolekularne układy insuliny użyteczne do leczenia cukrzycy

Info

Publication number: PL2133091T3
Authority: PL; Poland
Prior art keywords: diabetes; compositions; treatment; supramolecular insulin; assemblies useful
Prior art date: 2008-04-07

Application number

PL09155775T

Other languages

English (en)

Inventor

Avadhesha Suriola

Sarika Gupta

Mahendra Pal Singh

Tandrika Chattopadhyay

Original Assignee

Nat Institute Of Immunology

Indian Inst Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-07

Filing date

2009-03-20

Publication date

2014-03-31

2009-03-20 Application filed by Nat Institute Of Immunology, Indian Inst Scient filed Critical Nat Institute Of Immunology

2014-03-31 Publication of PL2133091T3 publication Critical patent/PL2133091T3/pl

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
230000000712 assembly Effects 0.000 title 1
238000000429 assembly Methods 0.000 title 1
206010012601 diabetes mellitus Diseases 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
239000000203 mixture Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL09155775T 2008-04-07 2009-03-20 Kompozycje zawierające supramolekularne układy insuliny użyteczne do leczenia cukrzycy PL2133091T3 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN914DE2008		2008-04-07
EP09155775.1A EP2133091B1 (en)	2008-04-07	2009-03-20	Compositions comprising supramolecular insulin assemblies useful for the treatment of diabetes

Publications (1)

Publication Number	Publication Date
PL2133091T3 true PL2133091T3 (pl)	2014-03-31

Family

ID=40841040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL09155775T PL2133091T3 (pl)	2008-04-07	2009-03-20	Kompozycje zawierające supramolekularne układy insuliny użyteczne do leczenia cukrzycy

Country Status (12)

Country	Link
US (3)	US20110034385A1 (pl)
EP (2)	EP2282763B1 (pl)
JP (3)	JP2011516541A (pl)
CN (1)	CN102088997A (pl)
AU (2)	AU2008354530B2 (pl)
CA (1)	CA2720864C (pl)
ES (1)	ES2425491T3 (pl)
HR (1)	HRP20130772T1 (pl)
PL (1)	PL2133091T3 (pl)
PT (1)	PT2133091E (pl)
WO (1)	WO2009125423A2 (pl)
ZA (2)	ZA200902374B (pl)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1808438T3 (da)	1999-06-29	2014-10-27	Mannkind Corp	Rensning og stabilisering af peptid og proteiner i lægemidler
US9006175B2 (en)	1999-06-29	2015-04-14	Mannkind Corporation	Potentiation of glucose elimination
WO2003080149A2 (en)	2002-03-20	2003-10-02	Mannkind Corporation	Inhalation apparatus
PL1786784T3 (pl)	2004-08-20	2011-04-29	Mannkind Corp	Kataliza syntezy diketopiperazyn
KR101644250B1 (ko)	2004-08-23	2016-07-29	맨카인드 코포레이션	약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
CN104324362B (zh)	2005-09-14	2018-04-24	曼金德公司	以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
IN2015DN00888A (pl)	2006-02-22	2015-07-10	Mannkind Corp
DE102006033167A1 (de) *	2006-07-10	2008-01-24	Gelita Ag	Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers
US8785396B2 (en)	2007-10-24	2014-07-22	Mannkind Corporation	Method and composition for treating migraines
WO2009055742A2 (en) *	2007-10-24	2009-04-30	Mannkind Corporation	Delivery of active agents
ES2929343T3 (es)	2008-06-13	2022-11-28	Mannkind Corp	Inhalador de polvo seco accionado por aspiración para la administración de fármacos
US8485180B2 (en)	2008-06-13	2013-07-16	Mannkind Corporation	Dry powder drug delivery system
KR101628410B1 (ko)	2008-06-20	2016-06-08	맨카인드 코포레이션	흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
TWI614024B (zh)	2008-08-11	2018-02-11	曼凱公司	超快起作用胰島素之用途
US8314106B2 (en)	2008-12-29	2012-11-20	Mannkind Corporation	Substituted diketopiperazine analogs for use as drug delivery agents
DK2405963T3 (da)	2009-03-11	2013-12-16	Mannkind Corp	Apparat, system og fremgangsmåde til at måle modstand i en inhalator
CN104721825B (zh)	2009-06-12	2019-04-12	曼金德公司	具有确定比表面积的二酮哌嗪颗粒
WO2011056889A1 (en)	2009-11-03	2011-05-12	Mannkind Corporation	An apparatus and method for simulating inhalation efforts
IL223742A (en)	2010-06-21	2016-06-30	Mannkind Corp	A dry powder inhaler and preparation for it
AU2012236150B2 (en)	2011-04-01	2016-03-31	Mannkind Corporation	Blister package for pharmaceutical cartridges
WO2012156811A2 (en) *	2011-05-19	2012-11-22	National Institute Of Immunology	Compositions useful for the treatment of inflammatory disease or disorders
WO2012174472A1 (en)	2011-06-17	2012-12-20	Mannkind Corporation	High capacity diketopiperazine microparticles
BR112014009686A2 (pt)	2011-10-24	2018-08-07	Mannkind Corp	composição analgésica inalável, pó seco e método para tratar dor
WO2013102921A2 (en) *	2011-11-17	2013-07-11	Sanzyme Limited	Hcg - newer treatment modality for type 2 diabetes mellitus (t2dm)
CN104619369B (zh)	2012-07-12	2018-01-30	曼金德公司	干粉药物输送系统和方法
WO2014054046A1 (en) *	2012-10-04	2014-04-10	Gavish-Galilee Bio Applications Ltd	Ordered reversible fibrils, aggregates and multimers of proteins and uses thereof
UA116217C2 (uk)	2012-10-09	2018-02-26	Санофі	Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
US10159644B2 (en)	2012-10-26	2018-12-25	Mannkind Corporation	Inhalable vaccine compositions and methods
US9707276B2 (en)	2012-12-03	2017-07-18	Merck Sharp & Dohme Corp.	O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
AU2013366692B2 (en)	2012-12-21	2017-11-23	Sanofi	Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists
AU2014228415B2 (en)	2013-03-15	2018-08-09	Mannkind Corporation	Microcrystalline diketopiperazine compositions and methods
MX375448B (es)	2013-07-18	2025-03-06	Mannkind Corp	Composiciones farmacéuticas en polvo seco estables al calor y métodos.
US11446127B2 (en)	2013-08-05	2022-09-20	Mannkind Corporation	Insufflation apparatus and methods
EP3080154B1 (en)	2013-12-13	2018-02-07	Sanofi	Dual glp-1/gip receptor agonists
EP3080152A1 (en)	2013-12-13	2016-10-19	Sanofi	Non-acylated exendin-4 peptide analogues
WO2015086733A1 (en)	2013-12-13	2015-06-18	Sanofi	Dual glp-1/glucagon receptor agonists
WO2015086728A1 (en)	2013-12-13	2015-06-18	Sanofi	Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
US10307464B2 (en)	2014-03-28	2019-06-04	Mannkind Corporation	Use of ultrarapid acting insulin
TW201625668A (zh)	2014-04-07	2016-07-16	賽諾菲公司	作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625670A (zh)	2014-04-07	2016-07-16	賽諾菲公司	衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625669A (zh)	2014-04-07	2016-07-16	賽諾菲公司	衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
US9932381B2 (en)	2014-06-18	2018-04-03	Sanofi	Exendin-4 derivatives as selective glucagon receptor agonists
US10561806B2 (en)	2014-10-02	2020-02-18	Mannkind Corporation	Mouthpiece cover for an inhaler
AR105319A1 (es)	2015-06-05	2017-09-27	Sanofi Sa	Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
TW201706291A (zh)	2015-07-10	2017-02-16	賽諾菲公司	作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
CN106977609B (zh) *	2017-04-19	2020-07-28	刘崇东	一种融合蛋白、制备方法及其应用
CN111714643A (zh) *	2019-03-22	2020-09-29	约翰霍普金斯大学	一种单宁酸/Fe3+纳米颗粒体系、药物递送方法
US10799564B1 (en)	2019-05-06	2020-10-13	Baxter International Inc.	Insulin premix formulation and product, methods of preparing same, and methods of using same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5714167A (en) *	1992-06-15	1998-02-03	Emisphere Technologies, Inc.	Active agent transport systems
GB9108634D0 (en) *	1991-04-23	1991-06-12	Ciba Geigy	Pharmaceutical compositions
US6531448B1 (en) *	1997-12-23	2003-03-11	Eli Lilly And Company	Insoluble compositions for controlling blood glucose
FR2786098B1 (fr) *	1998-11-20	2003-05-30	Flamel Tech Sa	Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication
US6506724B1 (en)	1999-06-01	2003-01-14	Amylin Pharmaceuticals, Inc.	Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus
US20020099013A1 (en) *	2000-11-14	2002-07-25	Thomas Piccariello	Active agent delivery systems and methods for protecting and administering active agents
WO2002067969A2 (en) *	2001-02-21	2002-09-06	Medtronic Minimed, Inc.	Stabilized insulin formulations
FR2822834B1 (fr) *	2001-04-02	2005-02-25	Flamel Tech Sa	Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
US20070021345A1 (en) *	2003-06-30	2007-01-25	Ehud Gazit	Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
US7655618B2 (en) *	2002-12-27	2010-02-02	Diobex, Inc.	Compositions and methods for the prevention and control of insulin-induced hypoglycemia
KR101308912B1 (ko) *	2003-06-03	2013-09-23	노보 노르디스크 에이/에스	안정화된 약학적 펩티드 조성물
RS53890B1 (sr) *	2004-11-10	2015-08-31	Tolmar Therapeutics, Inc.	Stabilizovan polimerni sistem za isporuku
US20060281669A1 (en) *	2005-06-13	2006-12-14	Yue Samuel K	Method and compositions for the treatment of diabetes and related complications
WO2007047834A2 (en) *	2005-10-18	2007-04-26	Biocon Limited	Oral peptide conjugates for metabolic diseases
WO2007067597A2 (en) *	2005-12-05	2007-06-14	Trinity Biosystems, Inc.	Methods and compositions for needleless delivery of binding partners
US8440214B2 (en) *	2006-01-31	2013-05-14	Boston Scientific Scimed, Inc.	Medical devices for therapeutic agent delivery with polymeric regions that contain copolymers having both soft segments and uniform length hard segments
AU2007339280B2 (en) *	2006-12-21	2013-12-05	Stryker Corporation	Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents

2008
- 2008-10-13 JP JP2011503551A patent/JP2011516541A/ja active Pending
- 2008-10-13 AU AU2008354530A patent/AU2008354530B2/en not_active Ceased
- 2008-10-13 CN CN2008801296299A patent/CN102088997A/zh active Pending
- 2008-10-13 EP EP08873840.6A patent/EP2282763B1/en not_active Not-in-force
- 2008-10-13 WO PCT/IN2008/000664 patent/WO2009125423A2/en not_active Ceased
- 2008-10-13 CA CA2720864A patent/CA2720864C/en not_active Expired - Fee Related
- 2008-10-13 US US12/936,709 patent/US20110034385A1/en not_active Abandoned
2009
- 2009-03-06 AU AU2009200906A patent/AU2009200906B2/en not_active Ceased
- 2009-03-20 PT PT91557751T patent/PT2133091E/pt unknown
- 2009-03-20 EP EP09155775.1A patent/EP2133091B1/en not_active Not-in-force
- 2009-03-20 PL PL09155775T patent/PL2133091T3/pl unknown
- 2009-03-20 ES ES09155775T patent/ES2425491T3/es active Active
- 2009-04-02 JP JP2009090219A patent/JP5592077B2/ja not_active Expired - Fee Related
- 2009-04-06 ZA ZA200902374A patent/ZA200902374B/xx unknown
- 2009-04-07 US US12/419,669 patent/US8426362B2/en not_active Expired - Fee Related
2010
- 2010-10-06 ZA ZA2010/07114A patent/ZA201007114B/en unknown
2013
- 2013-03-18 US US13/845,209 patent/US8940691B2/en not_active Expired - Fee Related
- 2013-08-16 HR HRP20130772AT patent/HRP20130772T1/hr unknown
2014
- 2014-08-28 JP JP2014173649A patent/JP5964373B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20110034385A1 (en)	2011-02-10
ZA201007114B (en)	2011-06-29
HRP20130772T1 (hr)	2013-12-06
JP5592077B2 (ja)	2014-09-17
CA2720864A1 (en)	2009-10-15
EP2282763A2 (en)	2011-02-16
AU2009200906B2 (en)	2014-04-03
WO2009125423A3 (en)	2010-03-04
ZA200902374B (en)	2009-12-30
US20130217621A1 (en)	2013-08-22
AU2008354530A1 (en)	2009-10-15
EP2133091B1 (en)	2013-05-22
AU2009200906A1 (en)	2010-03-25
US20090258818A1 (en)	2009-10-15
JP5964373B2 (ja)	2016-08-03
EP2133091A3 (en)	2010-07-14
AU2008354530B2 (en)	2014-02-27
PT2133091E (pt)	2013-08-28
EP2282763B1 (en)	2013-12-11
CA2720864C (en)	2017-07-04
CN102088997A (zh)	2011-06-08
EP2133091A2 (en)	2009-12-16
JP2009249382A (ja)	2009-10-29
US8940691B2 (en)	2015-01-27
JP2011516541A (ja)	2011-05-26
US8426362B2 (en)	2013-04-23
WO2009125423A2 (en)	2009-10-15
ES2425491T3 (es)	2013-10-15
JP2014231520A (ja)	2014-12-11

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