PL2146944T3 - Sposób otrzymywania folianów znakowanych fluorem-18 - Google Patents

Sposób otrzymywania folianów znakowanych fluorem-18

Info

Publication number
PL2146944T3
PL2146944T3 PL08736117T PL08736117T PL2146944T3 PL 2146944 T3 PL2146944 T3 PL 2146944T3 PL 08736117 T PL08736117 T PL 08736117T PL 08736117 T PL08736117 T PL 08736117T PL 2146944 T3 PL2146944 T3 PL 2146944T3
Authority
PL
Poland
Prior art keywords
obtaining fluorine
folates
labeled
labeled folates
fluorine
Prior art date
Application number
PL08736117T
Other languages
English (en)
Inventor
Simon Mensah Ametamey
Rudolf Moser
Tobias Ludwig Ross
Phoebe Lam
Viola Groehn
Original Assignee
Merck & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Cie filed Critical Merck & Cie
Publication of PL2146944T3 publication Critical patent/PL2146944T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL08736117T 2007-04-11 2008-04-11 Sposób otrzymywania folianów znakowanych fluorem-18 PL2146944T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07105976 2007-04-11
PCT/EP2008/054404 WO2008125613A1 (en) 2007-04-11 2008-04-11 18f-labelled folates
EP08736117.6A EP2146944B1 (en) 2007-04-11 2008-04-11 A method for the preparation of 18f-labelled folates

Publications (1)

Publication Number Publication Date
PL2146944T3 true PL2146944T3 (pl) 2014-05-30

Family

ID=39620260

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08736117T PL2146944T3 (pl) 2007-04-11 2008-04-11 Sposób otrzymywania folianów znakowanych fluorem-18

Country Status (15)

Country Link
US (2) US20100111864A1 (pl)
EP (1) EP2146944B1 (pl)
JP (1) JP2010523624A (pl)
KR (2) KR101781461B1 (pl)
CN (2) CN107573347A (pl)
AU (1) AU2008237930B2 (pl)
CA (1) CA2670363C (pl)
DK (1) DK2146944T3 (pl)
EA (1) EA200901347A1 (pl)
ES (1) ES2449774T3 (pl)
IL (1) IL201248A (pl)
PL (1) PL2146944T3 (pl)
PT (1) PT2146944E (pl)
WO (1) WO2008125613A1 (pl)
ZA (1) ZA200903486B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG195545A1 (en) 2008-10-10 2013-12-30 Merck & Cie 18f-labelled folates as pet radiotracers
WO2012157900A2 (ko) * 2011-05-13 2012-11-22 서강대학교산학협력단 18f-표지 pet 방사성의약품의 전구체 및 그 제조방법
DK2776382T3 (en) 2011-08-22 2019-01-14 Merck & Cie 18F saccharide-folates
AU2013258027B2 (en) 2012-05-08 2017-11-30 Merck & Cie 18F-labelled follate/antifolate analogues
JP6159803B2 (ja) 2012-09-04 2017-07-05 株式会社Ｎｔｔドコモ 内部相対的送受信機キャリブレーションのための方法および装置
WO2016044645A1 (en) * 2014-09-17 2016-03-24 Elmaleh David R Anticoagulant derivatives for cardiovascular imaging
US10484059B2 (en) 2016-08-12 2019-11-19 Telefonaktiebolaget Lm Ericsson (Publ) Multi-beam codebooks with further optimized overhead
US11071095B2 (en) 2016-08-12 2021-07-20 Telefonaktiebolaget Lm Ericsson (Publ) Layer 1 and layer 2 channel state information rich reporting mechanisms
MY199492A (en) 2016-08-12 2023-11-01 Ericsson Telefon Ab L M Configurable codebook for advanced csi feedback overhead reduction
US11025322B2 (en) 2016-08-12 2021-06-01 Telefonaktiebolaget Lm Ericsson (Publ) Progressive advanced CSI feedback
KR102031652B1 (ko) 2018-01-19 2019-10-14 서울대학교산학협력단 전이체 단백질 과발현 관련 질환의 양성자방출단층촬영 방사성추적자, 형광영상 진단 및 광역학 치료를 위한 전이체 단백질 표적 리간드 및 이의 제조방법

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1458978A (en) * 1973-12-11 1976-12-22 Radiochemical Centre Ltd Saturation analysis
US4202976A (en) * 1973-09-11 1980-05-13 Bayly Russell J Selenium-75 labelled derivatives of folates
US3989812A (en) * 1974-08-09 1976-11-02 Smithkline Instruments, Inc. Folic acid derivatives and use in radio-assay
GB1501119A (en) 1974-12-20 1978-02-15 Radiochemical Centre Ltd Folate compounds
US4276280A (en) * 1976-09-29 1981-06-30 Becton, Dickinson And Company Radiolabeled derivatives of folic acid
US4298735A (en) * 1979-04-30 1981-11-03 Union Carbide Corporation Folic acid derivatives
US4337339A (en) * 1979-04-30 1982-06-29 Baker Instruments Corp. Process for preparation of folic acid derivatives
US4314988A (en) * 1979-10-31 1982-02-09 Baker Instruments Corp. Folic acid derivatives and process for preparation
JPS6144890A (ja) 1984-08-08 1986-03-04 Shionogi & Co Ltd 含フツ素メトトレキサ−ト誘導体
US4628090A (en) * 1984-08-21 1986-12-09 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutanayte formation related compounds
US4584375A (en) * 1984-08-21 1986-04-22 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutamate formation
US5286726A (en) 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
US5066828A (en) 1990-04-12 1991-11-19 Merrell Dow Pharmaceuticals Inc. Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
CA2156657C (en) 1994-11-02 1999-06-15 Richard G. Beauclerc Gravity wedge for a slackless railcar connector assembly
US6291673B1 (en) 1997-10-17 2001-09-18 Purdue Research Foundation Folic acid derivatives
US6093382A (en) * 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
EP1389209B1 (en) * 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
DK2260875T3 (da) 2002-05-06 2014-06-30 Endocyte Inc Folatreceptor-targetede billeddannelsesmidler
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
RU2007128036A (ru) * 2004-12-23 2009-01-27 Пердью Рисерч Фаундейшн (Us) Способ получения изображения позитронно-эмиссионной томографией
EP1863816B1 (en) 2005-03-16 2014-06-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
JP2008540338A (ja) * 2005-04-27 2008-11-20 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド 分子画像化プローブのクリックケミストリー合成法
US20070009434A1 (en) 2005-07-05 2007-01-11 Low Philip S Imaging and therapeutic method using monocytes
EP2382995A3 (en) 2005-08-19 2013-09-25 Endocyte, Inc. Ligand conjugates of Vinca alkaloids, analogs and derivatives
AU2006279304A1 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Multi-drug ligand conjugates
US8795633B2 (en) 2005-09-23 2014-08-05 Purdue Research Foundation Multiphoton in vivo flow cytometry method and device
US20070119258A1 (en) 2005-11-15 2007-05-31 California Institute Of Technology Resonant vibratory device having high quality factor and methods of fabricating same
WO2007139815A2 (en) 2006-05-23 2007-12-06 Purdue Research Foundation Imaging and therapeutic method using progenitor cells
US8586595B2 (en) * 2007-02-07 2013-11-19 Purdue Research Foundation Positron emission tomography imaging method
DK2150514T3 (en) * 2007-04-11 2019-02-18 Merck & Cie 18F-LABELED FOLATES
WO2008125615A1 (en) * 2007-04-11 2008-10-23 Merck Eprova Ag 18 f-labelled folates
SG195545A1 (en) * 2008-10-10 2013-12-30 Merck & Cie 18f-labelled folates as pet radiotracers

Also Published As

Publication number Publication date
DK2146944T3 (da) 2014-02-03
JP2010523624A (ja) 2010-07-15
KR20160074683A (ko) 2016-06-28
EP2146944B1 (en) 2014-01-22
EA200901347A1 (ru) 2010-04-30
CA2670363C (en) 2015-07-21
US20100111864A1 (en) 2010-05-06
PT2146944E (pt) 2014-03-11
CA2670363A1 (en) 2008-10-23
ZA200903486B (en) 2010-01-27
WO2008125613A1 (en) 2008-10-23
ES2449774T3 (es) 2014-03-21
US10377756B2 (en) 2019-08-13
KR101781461B1 (ko) 2017-10-23
AU2008237930B2 (en) 2014-03-27
CN101646639A (zh) 2010-02-10
IL201248A0 (en) 2010-05-31
EP2146944A1 (en) 2010-01-27
AU2008237930A1 (en) 2008-10-23
US20150315189A1 (en) 2015-11-05
KR20090130111A (ko) 2009-12-17
CN107573347A (zh) 2018-01-12
IL201248A (en) 2016-02-29

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