PL2146946T3 - (-)- stereoisomer of 2,6-di-sec-butylphenol and analogs thereof - Google Patents

(-)- stereoisomer of 2,6-di-sec-butylphenol and analogs thereof

Info

Publication number
PL2146946T3
PL2146946T3 PL08769338T PL08769338T PL2146946T3 PL 2146946 T3 PL2146946 T3 PL 2146946T3 PL 08769338 T PL08769338 T PL 08769338T PL 08769338 T PL08769338 T PL 08769338T PL 2146946 T3 PL2146946 T3 PL 2146946T3
Authority
PL
Poland
Prior art keywords
stereoisomer
butylphenol
analogs
sec
anesthetic
Prior art date
Application number
PL08769338T
Other languages
Polish (pl)
Inventor
Thomas E Jenkins
Original Assignee
Pharmacofore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacofore Inc filed Critical Pharmacofore Inc
Publication of PL2146946T3 publication Critical patent/PL2146946T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/06—Alkylated phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
    • C07C39/27—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms all halogen atoms being bound to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A (-)-stereoisomer of formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic:
PL08769338T 2007-05-09 2008-05-08 (-)- stereoisomer of 2,6-di-sec-butylphenol and analogs thereof PL2146946T3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92829607P 2007-05-09 2007-05-09
US92832707P 2007-05-09 2007-05-09
US92842907P 2007-05-09 2007-05-09
PCT/US2008/063082 WO2008141097A2 (en) 2007-05-09 2008-05-08 Stereoisomers propofol therapeutic compounds
EP08769338A EP2146946B1 (en) 2007-05-09 2008-05-08 (-)- stereoisomer of 2,6-di-sec-butylphenol and analogs thereof

Publications (1)

Publication Number Publication Date
PL2146946T3 true PL2146946T3 (en) 2011-04-29

Family

ID=39798084

Family Applications (2)

Application Number Title Priority Date Filing Date
PL08769338T PL2146946T3 (en) 2007-05-09 2008-05-08 (-)- stereoisomer of 2,6-di-sec-butylphenol and analogs thereof
PL10014318T PL2301908T3 (en) 2007-05-09 2008-05-08 (-)-stereoisomer of 2,6-di-sec-butylphenol and analogs thereof for promoting antiemetic effect, treatment of nausea and vomiting and treatment of migraine

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL10014318T PL2301908T3 (en) 2007-05-09 2008-05-08 (-)-stereoisomer of 2,6-di-sec-butylphenol and analogs thereof for promoting antiemetic effect, treatment of nausea and vomiting and treatment of migraine

Country Status (22)

Country Link
US (4) US8071818B2 (en)
EP (4) EP2146946B1 (en)
JP (1) JP5651009B2 (en)
KR (1) KR20100017436A (en)
CN (1) CN101715437B (en)
AT (1) ATE487685T1 (en)
AU (1) AU2008251482C1 (en)
BR (1) BRPI0811220A2 (en)
CA (1) CA2685570A1 (en)
DE (1) DE602008003431D1 (en)
DK (2) DK2301908T3 (en)
ES (1) ES2501592T3 (en)
HR (1) HRP20140896T1 (en)
IL (1) IL201795A0 (en)
MX (1) MX2009012124A (en)
NZ (1) NZ580752A (en)
PL (2) PL2146946T3 (en)
PT (1) PT2146946E (en)
RU (1) RU2470908C2 (en)
SI (1) SI2301908T1 (en)
WO (1) WO2008141097A2 (en)
ZA (1) ZA201007603B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0811220A2 (en) 2007-05-09 2014-10-29 Pharmacofore Inc THERAPEUTIC COMPOUNDS
WO2012017950A1 (en) * 2010-08-03 2012-02-09 学校法人 久留米大学 Electroencephalographic electrode device for small laboratory animal and electroencephalographic method
CN102731265B (en) * 2012-06-12 2014-12-10 四川百利药业有限责任公司 Preparation method of high-purity propofol
US11331271B2 (en) * 2016-05-27 2022-05-17 The Johns Hopkins University Buccal, sublingual and intranasal delivery of fospropofol
RU2635532C1 (en) * 2016-09-06 2017-11-13 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Method for prevention of agitation syndrome in children with oncological pathology
CN115708819A (en) * 2022-11-24 2023-02-24 中国科学院深圳先进技术研究院 Anxiolytic pharmaceutical application of propofol and anxiolytic pharmaceutical preparation

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US237213A (en) 1881-02-01 William j
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GB1472793A (en) 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
US4798846A (en) 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions
SU1525139A1 (en) * 1987-11-10 1989-11-30 Куйбышевский политехнический институт им.В.В.Куйбышева Method of obtaining o-sec-butylphenol
ES2087019B1 (en) * 1994-02-08 1997-03-16 Bobel246 S L USE OF DERIVATIVES OF PHENOLS 2,4-DISUBSTITUTED AS INHIBITORS OF 5-LIPOXIGENASE.
GB9405593D0 (en) 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US5731356A (en) 1994-03-22 1998-03-24 Zeneca Limited Pharmaceutical compositions of propofol and edetate
US6254853B1 (en) 1998-05-08 2001-07-03 Vyrex Corporation Water soluble pro-drugs of propofol
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US6140374A (en) 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
US7060290B1 (en) 1999-02-18 2006-06-13 Supergen, Inc. Phosphocholine linked prodrug derivatives
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6362234B1 (en) 2000-08-15 2002-03-26 Vyrex Corporation Water-soluble prodrugs of propofol for treatment of migrane
US20020099013A1 (en) 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
WO2002028411A1 (en) 2000-10-06 2002-04-11 Xenoport, Inc. Compounds for sustained release of orally delivered drugs
JP4334229B2 (en) * 2001-03-20 2009-09-30 サイデックス・ファーマシューティカルズ・インコーポレイテッド Formulation containing propofol and sulfoalkyl ether cyclodextrin
PL205271B1 (en) 2001-12-28 2010-03-31 Mgi Gp Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
WO2003077902A1 (en) 2002-02-19 2003-09-25 Xenoport, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
CA2480881C (en) 2002-04-08 2012-09-11 Guilford Pharmaceuticals, Inc. Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same
DE20215415U1 (en) 2002-10-08 2004-02-26 Biotechnologie Gesellschaft Mittelhessen Mbh Water soluble precursors of propofol
ATE409048T1 (en) 2002-10-08 2008-10-15 Fresenius Kabi De Gmbh PHARMACEUTICALLY ACTIVE OLIGOSACCHARIDE CONJUGATES
ZA200504940B (en) 2003-01-28 2006-09-27 Xenoport Inc Amino acid derived prodrugs of propofol, compositions and uses thereof
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WO2005033279A2 (en) * 2003-09-29 2005-04-14 University Of Virginia Patent Foundation Discovery of novel soluble crystalline anesthetics
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Also Published As

Publication number Publication date
CN101715437B (en) 2013-06-12
HRP20140896T1 (en) 2015-01-02
WO2008141097A3 (en) 2008-12-31
US8071818B2 (en) 2011-12-06
PT2146946E (en) 2011-02-14
BRPI0811220A2 (en) 2014-10-29
EP2301908A1 (en) 2011-03-30
PL2301908T3 (en) 2015-02-27
JP2010526826A (en) 2010-08-05
EP2146946A2 (en) 2010-01-27
US8242315B2 (en) 2012-08-14
WO2008141097A2 (en) 2008-11-20
US20100292346A1 (en) 2010-11-18
ZA201007603B (en) 2012-08-29
US8575400B2 (en) 2013-11-05
AU2008251482B2 (en) 2013-09-26
US20120035271A1 (en) 2012-02-09
EP2301908B8 (en) 2014-09-03
AU2008251482C1 (en) 2014-04-03
EP2810927A1 (en) 2014-12-10
US20140206773A1 (en) 2014-07-24
KR20100017436A (en) 2010-02-16
ES2501592T3 (en) 2014-10-02
IL201795A0 (en) 2010-06-16
US8871815B2 (en) 2014-10-28
RU2009145537A (en) 2011-06-20
EP2146946B1 (en) 2010-11-10
JP5651009B2 (en) 2015-01-07
DK2301908T3 (en) 2014-09-15
EP2292577A1 (en) 2011-03-09
WO2008141097A9 (en) 2009-04-02
CN101715437A (en) 2010-05-26
AU2008251482A1 (en) 2008-11-20
EP2301908B1 (en) 2014-06-25
HK1138829A1 (en) 2010-09-03
US20130059919A1 (en) 2013-03-07
ATE487685T1 (en) 2010-11-15
DK2146946T3 (en) 2011-02-14
CA2685570A1 (en) 2008-11-20
SI2301908T1 (en) 2014-10-30
DE602008003431D1 (en) 2010-12-23
MX2009012124A (en) 2010-02-18
RU2470908C2 (en) 2012-12-27
NZ580752A (en) 2012-03-30
HK1156019A1 (en) 2012-06-01

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