PL2155866T3 - Modyfikowane fosfatazy - Google Patents
Modyfikowane fosfatazyInfo
- Publication number
- PL2155866T3 PL2155866T3 PL08741670T PL08741670T PL2155866T3 PL 2155866 T3 PL2155866 T3 PL 2155866T3 PL 08741670 T PL08741670 T PL 08741670T PL 08741670 T PL08741670 T PL 08741670T PL 2155866 T3 PL2155866 T3 PL 2155866T3
- Authority
- PL
- Poland
- Prior art keywords
- modified phosphatases
- phosphatases
- modified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92669507P | 2007-04-27 | 2007-04-27 | |
| EP07107176A EP1985697A1 (en) | 2007-04-27 | 2007-04-27 | Modified phosphatases |
| EP08741670.7A EP2155866B1 (en) | 2007-04-27 | 2008-04-25 | Modified phosphatases |
| PCT/NL2008/050249 WO2008133511A2 (en) | 2007-04-27 | 2008-04-25 | Modified phosphatases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2155866T3 true PL2155866T3 (pl) | 2018-04-30 |
Family
ID=38521703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08741670T PL2155866T3 (pl) | 2007-04-27 | 2008-04-25 | Modyfikowane fosfatazy |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US8557545B2 (pl) |
| EP (4) | EP1985697A1 (pl) |
| JP (1) | JP5320387B2 (pl) |
| CN (1) | CN101688193B (pl) |
| AU (1) | AU2008244716B2 (pl) |
| CA (1) | CA2685405C (pl) |
| DK (1) | DK2155866T3 (pl) |
| ES (1) | ES2656405T3 (pl) |
| HU (1) | HUE036318T2 (pl) |
| NO (1) | NO2155866T3 (pl) |
| PL (1) | PL2155866T3 (pl) |
| SI (1) | SI2155866T1 (pl) |
| WO (1) | WO2008133511A2 (pl) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005210581B2 (en) | 2004-02-04 | 2010-06-24 | Am-Pharma B.V. | Use of alkaline phosphatase for the detoxification of LPS present at mucosal barriers |
| US20110142817A1 (en) * | 2004-02-04 | 2011-06-16 | Pharmaaware Sepsis B.V. | Means and method for treating and/or preventing necrotizing enterocolitis |
| PL1759001T3 (pl) | 2004-04-21 | 2011-09-30 | Alexion Pharma Inc | Koniugaty dostarczane do kości i sposób ich zastosowania do nakierowywania białek do kości |
| EP1985697A1 (en) | 2007-04-27 | 2008-10-29 | AM-Pharma B.V. | Modified phosphatases |
| MX2011001341A (es) | 2008-08-19 | 2011-03-29 | Xenoport Inc | Prodrogas de metil hidrogeno fumarato, sus composiciones farmaceuticas, y metodos de uso. |
| DK2717906T5 (en) * | 2011-06-08 | 2017-06-19 | Am-Pharma B V | APPLICATION OF ALKALISK PHOSPHATASE FOR THE CONSERVATION OF Kidney Function |
| EP2814331B1 (en) * | 2012-02-16 | 2018-12-05 | Elanco US Inc. | Methods and compositions for reducing the environmental impact of animal waste |
| US9597292B2 (en) | 2012-08-22 | 2017-03-21 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| EP2887934A1 (en) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
| WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
| US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| JP2016534133A (ja) | 2013-09-06 | 2016-11-04 | ゼノポート，インコーポレイティド | （ｎ，ｎ−ジエチルカルバモイル）メチル メチル（２ｅ）ブト−２−エン−１，４−ジオエートの結晶形態、その合成方法及び使用 |
| CN103656637B (zh) * | 2013-11-05 | 2015-02-25 | 范列英 | 抗人葡萄糖-6-磷酸异构酶单克隆抗体的用途 |
| DK3461891T3 (da) * | 2014-01-24 | 2020-08-10 | Am-Pharma Bv | Nedstrømsbehandling af en alkalisk phosphatase |
| WO2015112017A1 (en) | 2014-01-24 | 2015-07-30 | Am-Pharma B.V. | Chimeric alkaline phosphatase-like proteins |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| JP6787894B2 (ja) | 2014-12-05 | 2020-11-18 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 組換えアルカリホスファターゼを用いた発作の処置 |
| CA2973883A1 (en) | 2015-01-28 | 2016-08-04 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| JP6993961B2 (ja) * | 2015-08-17 | 2022-01-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼの製造 |
| EP3355904A4 (en) | 2015-09-28 | 2019-06-12 | Alexion Pharmaceuticals, Inc. | IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA |
| EP3368062A4 (en) | 2015-10-30 | 2019-07-03 | Alexion Pharmaceuticals, Inc. | METHODS OF TREATING CRANIOSYNOSTOSIS IN A PATIENT |
| JP6732368B2 (ja) * | 2016-01-12 | 2020-07-29 | 東ソー株式会社 | アルカリホスファターゼ及びその製造方法 |
| US11065306B2 (en) | 2016-03-08 | 2021-07-20 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| KR20180125979A (ko) | 2016-04-01 | 2018-11-26 | 알렉시온 파마슈티칼스, 인코포레이티드 | 알칼리성 포스파타아제로 근육 약화의 치료 |
| US10898549B2 (en) | 2016-04-01 | 2021-01-26 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| WO2017214130A1 (en) | 2016-06-06 | 2017-12-14 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
| JP7018933B2 (ja) | 2016-08-18 | 2022-02-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 気管気管支軟化症の治療方法 |
| WO2018175413A1 (en) * | 2017-03-21 | 2018-09-27 | Synthetic Biologics, Inc. | Alkaline phosphatase formulations |
| KR20190129058A (ko) | 2017-03-31 | 2019-11-19 | 알렉시온 파마슈티칼스, 인코포레이티드 | 성인 및 청소년에서 저포스파타제증 (hpp)을 치료하는 방법 |
| CN107802642B (zh) * | 2017-12-08 | 2020-07-24 | 惠觅宙 | 一种含有铝碳酸镁的药物组合物及制药用途 |
| AU2019207600B2 (en) | 2018-01-09 | 2025-01-09 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| DK3762018T3 (da) | 2018-03-08 | 2024-05-06 | Am Pharma Bv | Rekombinant alkalisk phosphatase til anvendelse i behandling af sepsis-forbundet akut nyrelæsion |
| EP3768302B1 (en) * | 2018-03-20 | 2025-05-07 | Theriva Biologics, Inc. | Intestinal alkaline phosphatase formulations |
| EP4275761A3 (en) | 2018-03-20 | 2024-02-28 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| WO2019190752A1 (en) | 2018-03-30 | 2019-10-03 | Alexion Pharmaceuticals, Inc. | Manufacturing of glycoproteins |
| EP3807408A4 (en) * | 2018-06-18 | 2022-03-30 | Synthetic Biologics, Inc. | METHODS OF MAKING ALKALINE PHOSPHATASE AGENTS |
| WO2020033867A2 (en) | 2018-08-10 | 2020-02-13 | Alexion Pharmaceuticals, Inc. | Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase |
| KR102795670B1 (ko) * | 2019-03-06 | 2025-04-15 | 감브로 룬디아 아베 | 알칼리성 포스파타제를 포함하는 혈액 처리 장치 |
| WO2020227263A1 (en) | 2019-05-06 | 2020-11-12 | Synthetic Biologics, Inc. | Alkaline phosphate-based oncology treatments |
| GB2599573A (en) | 2019-05-31 | 2022-04-06 | Rhogen Biotech Llc | Compositions and methods for detoxifying bacterial endotoxins |
| EP3975999A4 (en) * | 2019-06-03 | 2023-07-19 | Theriva Biologics, Inc. | ALKALINE PHOSPHATASE FORMULATIONS AND THEIR USES |
| CN114891765B (zh) * | 2019-11-21 | 2023-12-19 | 天津科技大学 | 一种磷脂酶及其应用 |
| CA3161266A1 (en) | 2019-12-09 | 2021-06-17 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| US12611447B2 (en) | 2020-09-04 | 2026-04-28 | Alexion Pharmaceuticals, Inc. | Methods for treating bone mineralization disorders |
| EP4210731A1 (en) | 2020-09-09 | 2023-07-19 | AM-Pharma B.V. | Recombinant alkaline phosphatase for use in treating acute respiratory distress syndrome |
| AU2022218782B2 (en) | 2021-02-12 | 2026-06-25 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| WO2025244531A1 (en) | 2024-05-22 | 2025-11-27 | Am-Pharma B.V. | High concentration phosphatase compositions |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69127482T2 (de) * | 1990-02-07 | 1998-03-19 | Abbott Lab | Alkalische Phosphatase mit verbesserter spezifischer Aktivität zur Verwendung in Indikatorreagenzien |
| AU4835693A (en) * | 1993-08-13 | 1995-03-14 | Rijksuniversiteit Te Groningen | Pharmaceutical composition comprising phosphatase or a derivative thereof |
| FR2736065B1 (fr) * | 1995-06-29 | 1997-09-19 | Commissariat Energie Atomique | Phosphatases alcalines bacteriennes modifiees et leurs applications. |
| JP2000350596A (ja) * | 1999-06-11 | 2000-12-19 | Toyobo Co Ltd | 分泌性アルカリフォスファターゼの選択的活性測定方法 |
| JP2005065564A (ja) * | 2003-08-22 | 2005-03-17 | Hiroshi Ueda | センサー蛋白質 |
| US20110142817A1 (en) * | 2004-02-04 | 2011-06-16 | Pharmaaware Sepsis B.V. | Means and method for treating and/or preventing necrotizing enterocolitis |
| AU2005210581B2 (en) * | 2004-02-04 | 2010-06-24 | Am-Pharma B.V. | Use of alkaline phosphatase for the detoxification of LPS present at mucosal barriers |
| WO2006096527A2 (en) * | 2005-03-04 | 2006-09-14 | Diversa Corporation | Nucleic acids and proteins and methods for making and using them |
| US20070059300A1 (en) * | 2005-09-12 | 2007-03-15 | Zoltan Laboratories Llc | Compounds and compositions to control abnormal cell growth |
| EP1952823A1 (en) * | 2007-01-30 | 2008-08-06 | AM-Pharma B.V. | The use of alkaline phosphatase in the treatment of reduced renal function |
| EP1985697A1 (en) | 2007-04-27 | 2008-10-29 | AM-Pharma B.V. | Modified phosphatases |
-
2007
- 2007-04-27 EP EP07107176A patent/EP1985697A1/en not_active Withdrawn
-
2008
- 2008-04-25 EP EP17202268.3A patent/EP3336182A3/en not_active Withdrawn
- 2008-04-25 HU HUE08741670A patent/HUE036318T2/hu unknown
- 2008-04-25 AU AU2008244716A patent/AU2008244716B2/en active Active
- 2008-04-25 JP JP2010506102A patent/JP5320387B2/ja active Active
- 2008-04-25 EP EP08741670.7A patent/EP2155866B1/en active Active
- 2008-04-25 SI SI200831903T patent/SI2155866T1/en unknown
- 2008-04-25 CA CA2685405A patent/CA2685405C/en active Active
- 2008-04-25 WO PCT/NL2008/050249 patent/WO2008133511A2/en not_active Ceased
- 2008-04-25 CN CN2008800178100A patent/CN101688193B/zh active Active
- 2008-04-25 ES ES08741670.7T patent/ES2656405T3/es active Active
- 2008-04-25 US US12/451,137 patent/US8557545B2/en active Active
- 2008-04-25 EP EP13162182.3A patent/EP2666853A1/en not_active Withdrawn
- 2008-04-25 NO NO08741670A patent/NO2155866T3/no unknown
- 2008-04-25 PL PL08741670T patent/PL2155866T3/pl unknown
- 2008-04-25 DK DK08741670.7T patent/DK2155866T3/da active
-
2013
- 2013-09-06 US US14/020,269 patent/US20140193388A1/en not_active Abandoned
-
2015
- 2015-03-23 US US14/665,846 patent/US20160046913A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUE036318T2 (hu) | 2018-07-30 |
| US8557545B2 (en) | 2013-10-15 |
| WO2008133511A2 (en) | 2008-11-06 |
| DK2155866T3 (da) | 2018-01-29 |
| CN101688193A (zh) | 2010-03-31 |
| AU2008244716A1 (en) | 2008-11-06 |
| JP5320387B2 (ja) | 2013-10-23 |
| EP3336182A3 (en) | 2018-09-19 |
| CA2685405A1 (en) | 2008-11-06 |
| US20100143323A1 (en) | 2010-06-10 |
| US20160046913A1 (en) | 2016-02-18 |
| EP2155866A2 (en) | 2010-02-24 |
| NO2155866T3 (pl) | 2018-04-28 |
| SI2155866T1 (en) | 2018-03-30 |
| CA2685405C (en) | 2016-12-13 |
| EP2155866B1 (en) | 2017-11-29 |
| ES2656405T3 (es) | 2018-02-27 |
| EP1985697A1 (en) | 2008-10-29 |
| US20140193388A1 (en) | 2014-07-10 |
| EP3336182A2 (en) | 2018-06-20 |
| JP2010524496A (ja) | 2010-07-22 |
| EP2666853A1 (en) | 2013-11-27 |
| WO2008133511A3 (en) | 2009-03-12 |
| AU2008244716B2 (en) | 2013-07-11 |
| CN101688193B (zh) | 2012-05-23 |
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