PL2203444T3 - Stałe postacie (s)-2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(O-metylo-1H-pirazol-1-ilo)fenylo)-2,2,2-trifluoroetoksy)pirymidyn-4-ylo)fenylo)propionianu etylu - Google Patents

Stałe postacie (s)-2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(O-metylo-1H-pirazol-1-ilo)fenylo)-2,2,2-trifluoroetoksy)pirymidyn-4-ylo)fenylo)propionianu etylu

Info

Publication number: PL2203444T3
Authority: PL; Poland
Prior art keywords: phenyl; chl0r0; trifluorethoxy; amin0; propanoate
Prior art date: 2007-09-28

Application number

PL08834252T

Other languages

English (en)

Inventor

Mark S Bednarz

Paul Susan De

Ramanaiah C Kanamarlapudi

Anett Perlberg

Haiming Zhang

Original Assignee

Lexicon Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-28

Filing date

2008-09-25

Publication date

2013-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39944300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2203444(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-09-25 Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc

2013-12-31 Publication of PL2203444T3 publication Critical patent/PL2203444T3/pl

Links

125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
239000007787 solid Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL08834252T 2007-09-28 2008-09-25 Stałe postacie (s)-2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(O-metylo-1H-pirazol-1-ilo)fenylo)-2,2,2-trifluoroetoksy)pirymidyn-4-ylo)fenylo)propionianu etylu PL2203444T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US97584607P	2007-09-28	2007-09-28
PCT/US2008/077594 WO2009042733A1 (en)	2007-09-28	2008-09-25	Solids forms of ( s) -ethyl 2-amin0-3- (4- (2 -amino- 6- ( (r) -1- (4-chl0r0-2- o-methyl-ih-pyrazol- 1-yl) phenyl) -2, 2, 2-trifluorethoxy) -pyrimidin-4-yl) phenyl) propanoate
EP08834252.2A EP2203444B1 (en)	2007-09-28	2008-09-25	Solids forms of ( s) -ethyl 2-amin0-3- (4- (2 -amino- 6- ( (r) -1- (4-chl0r0-2- o-methyl-ih-pyrazol- 1-yl) phenyl) -2, 2, 2-trifluorethoxy) -pyrimidin-4-yl) phenyl) propanoate

Publications (1)

Publication Number	Publication Date
PL2203444T3 true PL2203444T3 (pl)	2013-12-31

Family

ID=39944300

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL08834252T PL2203444T3 (pl)	2007-09-28	2008-09-25	Stałe postacie (s)-2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(O-metylo-1H-pirazol-1-ilo)fenylo)-2,2,2-trifluoroetoksy)pirymidyn-4-ylo)fenylo)propionianu etylu

Country Status (25)

Country	Link
US (2)	US8193204B2 (pl)
EP (1)	EP2203444B1 (pl)
JP (1)	JP5717445B2 (pl)
KR (1)	KR101644657B1 (pl)
CN (1)	CN101809018B (pl)
AR (1)	AR068558A1 (pl)
AU (1)	AU2008304439B2 (pl)
BR (1)	BRPI0817270B1 (pl)
CA (1)	CA2700835C (pl)
CL (1)	CL2008002880A1 (pl)
CO (1)	CO6270325A2 (pl)
DK (1)	DK2203444T3 (pl)
EA (1)	EA017275B1 (pl)
EC (1)	ECSP10010076A (pl)
ES (1)	ES2431928T3 (pl)
IL (1)	IL204373A (pl)
MX (1)	MX2010003326A (pl)
NZ (1)	NZ583808A (pl)
PE (1)	PE20090742A1 (pl)
PL (1)	PL2203444T3 (pl)
PT (1)	PT2203444E (pl)
TW (1)	TWI439457B (pl)
UA (1)	UA102079C2 (pl)
UY (1)	UY31364A1 (pl)
WO (1)	WO2009042733A1 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7897763B2 (en)	2005-12-29	2011-03-01	Lexicon Pharmaceuticals, Inc.	Process for the preparation of substituted phenylalanines
CN103265495B (zh) *	2005-12-29	2016-11-16	莱西肯医药有限公司	多环氨基酸衍生物及其使用方法
US7855291B2 (en) *	2005-12-29	2010-12-21	Lexicon Pharmaceuticals, Inc.	Process for the preparation of substituted phenylalanines
UA99270C2 (en) *	2006-12-12	2012-08-10	Лексикон Фармасьютикалз, Инк.	4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
EP2170335A1 (en) *	2007-06-26	2010-04-07	Lexicon Pharmaceuticals, Inc.	Compositions comprising tryptophan hydroxylase inhibitors
RU2493156C2 (ru) *	2007-08-24	2013-09-20	Лексикон Фармасьютикалз, Инк.	Способы получения соединений на основе 4-фенил-6-(2,2,2-трифтор-1-фенилэтокси)пиримидина
JP2011516486A (ja)	2008-03-31	2011-05-26	ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク	骨質量疾患の診断、予防、及び治療方法
US20120316171A1 (en) *	2009-11-05	2012-12-13	Tamas Oravecz	Tryptophan Hydroxylase Inhibitors for the Treatment of Cancer
TW201302754A (zh) *	2010-11-05	2013-01-16	Lexicon Pharmaceuticals Inc	３－（４－（胺甲基）－１－（５－甲基－７ｈ－吡咯［２，３－ｄ］嘧啶－４－基）哌啶－４－甲醯胺基）苯基二甲基胺基甲酸酯之固態形式
EP3763374A1 (en) *	2011-10-17	2021-01-13	Lexicon Pharmaceuticals, Inc.	Solid dosage forms of (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate
EP3061761A1 (en)	2015-02-24	2016-08-31	Max-Delbrück-Centrum für Molekulare Medizin	Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
EP3275885A1 (en)	2016-07-28	2018-01-31	Max-Delbrück-Centrum für Molekulare Medizin	Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
EP3363798A1 (en)	2017-02-20	2018-08-22	Esteve Química, S.A.	Amorphous form of telotristat etiprate
CN109180650A (zh) *	2018-08-28	2019-01-11	湖南华腾制药有限公司	一种氘代色氨酸羟化酶抑制剂的晶型
WO2023192003A1 (en)	2022-04-01	2023-10-05	Tersera Therapeutics Llc	Methods of reducing the likelihood of carcinoid heart disease in patients with neuroendocrine tumors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN103265495B (zh) *	2005-12-29	2016-11-16	莱西肯医药有限公司	多环氨基酸衍生物及其使用方法
UA99270C2 (en) *	2006-12-12	2012-08-10	Лексикон Фармасьютикалз, Инк.	4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
RU2493156C2 (ru) *	2007-08-24	2013-09-20	Лексикон Фармасьютикалз, Инк.	Способы получения соединений на основе 4-фенил-6-(2,2,2-трифтор-1-фенилэтокси)пиримидина
TW200932729A (en)	2007-10-08	2009-08-01	Lexicon Pharmaceuticals Inc	Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and methods of their use

2008
- 2008-09-19 TW TW097136105A patent/TWI439457B/zh active
- 2008-09-25 DK DK08834252.2T patent/DK2203444T3/da active
- 2008-09-25 NZ NZ583808A patent/NZ583808A/en unknown
- 2008-09-25 WO PCT/US2008/077594 patent/WO2009042733A1/en not_active Ceased
- 2008-09-25 AU AU2008304439A patent/AU2008304439B2/en active Active
- 2008-09-25 EP EP08834252.2A patent/EP2203444B1/en active Active
- 2008-09-25 AR ARP080104181A patent/AR068558A1/es not_active Application Discontinuation
- 2008-09-25 PL PL08834252T patent/PL2203444T3/pl unknown
- 2008-09-25 BR BRPI0817270-6A patent/BRPI0817270B1/pt active IP Right Grant
- 2008-09-25 UY UY31364A patent/UY31364A1/es not_active Application Discontinuation
- 2008-09-25 US US12/237,455 patent/US8193204B2/en active Active
- 2008-09-25 JP JP2010527125A patent/JP5717445B2/ja active Active
- 2008-09-25 EA EA201070410A patent/EA017275B1/ru not_active IP Right Cessation
- 2008-09-25 MX MX2010003326A patent/MX2010003326A/es active IP Right Grant
- 2008-09-25 UA UAA201005125A patent/UA102079C2/uk unknown
- 2008-09-25 KR KR1020107006616A patent/KR101644657B1/ko active Active
- 2008-09-25 CA CA2700835A patent/CA2700835C/en active Active
- 2008-09-25 CN CN200880108684XA patent/CN101809018B/zh active Active
- 2008-09-25 PT PT88342522T patent/PT2203444E/pt unknown
- 2008-09-25 ES ES08834252T patent/ES2431928T3/es active Active
- 2008-09-26 CL CL2008002880A patent/CL2008002880A1/es unknown
- 2008-09-26 PE PE2008001677A patent/PE20090742A1/es not_active Application Discontinuation
2010
- 2010-03-09 IL IL204373A patent/IL204373A/en active IP Right Grant
- 2010-03-31 EC EC2010010076A patent/ECSP10010076A/es unknown
- 2010-04-28 CO CO10050287A patent/CO6270325A2/es not_active Application Discontinuation
2012
- 2012-06-01 US US13/486,103 patent/US8653094B2/en active Active

Also Published As

Publication number	Publication date
AU2008304439B2 (en)	2013-10-17
EP2203444A1 (en)	2010-07-07
NZ583808A (en)	2012-01-12
WO2009042733A1 (en)	2009-04-02
JP2010540551A (ja)	2010-12-24
DK2203444T3 (da)	2013-10-28
PT2203444E (pt)	2013-09-12
MX2010003326A (es)	2010-04-09
ES2431928T3 (es)	2013-11-28
CN101809018B (zh)	2013-02-06
UY31364A1 (es)	2009-03-02
CL2008002880A1 (es)	2009-03-27
HK1145023A1 (en)	2011-03-25
PE20090742A1 (es)	2009-07-08
KR101644657B1 (ko)	2016-08-01
TWI439457B (zh)	2014-06-01
CA2700835C (en)	2018-01-09
US20130005754A1 (en)	2013-01-03
US8193204B2 (en)	2012-06-05
ECSP10010076A (es)	2010-04-30
CN101809018A (zh)	2010-08-18
JP5717445B2 (ja)	2015-05-13
KR20100063736A (ko)	2010-06-11
US8653094B2 (en)	2014-02-18
TW200922934A (en)	2009-06-01
AU2008304439A1 (en)	2009-04-02
UA102079C2 (en)	2013-06-10
EP2203444B1 (en)	2013-07-24
EA017275B1 (ru)	2012-11-30
US20090088447A1 (en)	2009-04-02
IL204373A (en)	2013-12-31
BRPI0817270B1 (pt)	2022-02-08
CA2700835A1 (en)	2009-04-02
BRPI0817270A2 (pt)	2017-06-06
CO6270325A2 (es)	2011-04-20
EA201070410A1 (ru)	2010-10-29
AR068558A1 (es)	2009-11-18

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