PL2222643T3 - Pochodne synomeniny i sposób ich wytwarzania - Google Patents

Pochodne synomeniny i sposób ich wytwarzania

Info

Publication number: PL2222643T3
Authority: PL; Poland
Prior art keywords: synthesis; processes; sinomenine derivatives; sinomenine; derivatives
Prior art date: 2007-12-17

Application number

PL08862724T

Other languages

English (en)

Inventor

Peter X. Wang

Tao Jiang

Gary L. Cantrell

David W. Berberich

Bobby N. Trawick

Subo Liao

John Brandt

Original Assignee

SpecGx LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-17

Filing date

2008-12-17

Publication date

2019-12-31

2008-12-17 Application filed by SpecGx LLC filed Critical SpecGx LLC

2019-12-31 Publication of PL2222643T3 publication Critical patent/PL2222643T3/pl

Links

INYYVPJSBIVGPH-QHRIQVFBSA-N Sinomenine Chemical class C([C@@H]1N(CC2)C)C3=CC=C(OC)C(O)=C3[C@@]32[C@@H]1C=C(OC)C(=O)C3 INYYVPJSBIVGPH-QHRIQVFBSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL08862724T 2007-12-17 2008-12-17 Pochodne synomeniny i sposób ich wytwarzania PL2222643T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1409907P	2007-12-17	2007-12-17
EP08862724.5A EP2222643B1 (en)	2007-12-17	2008-12-17	Sinomenine derivatives and processes for their synthesis
PCT/US2008/013777 WO2009078988A1 (en)	2007-12-17	2008-12-17	Sinomenine derivatives and processes for their synthesis

Publications (1)

Publication Number	Publication Date
PL2222643T3 true PL2222643T3 (pl)	2019-12-31

Family

ID=40428096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL08862724T PL2222643T3 (pl)	2007-12-17	2008-12-17	Pochodne synomeniny i sposób ich wytwarzania

Country Status (9)

Country	Link
US (2)	US8461337B2 (pl)
EP (1)	EP2222643B1 (pl)
JP (2)	JP5579076B2 (pl)
CN (1)	CN101896464B (pl)
AU (1)	AU2008338970B2 (pl)
CA (1)	CA2709862C (pl)
NZ (2)	NZ611651A (pl)
PL (1)	PL2222643T3 (pl)
WO (1)	WO2009078988A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8252808B2 (en) *	2007-12-17	2012-08-28	Mallinckrodt Llc	Process and compounds for the production of (+)opiates
CN102300848B (zh) *	2008-12-02	2014-07-02	马林克罗特公司	使用超酸制备氢可酮的方法
US8829020B2 (en)	2009-07-16	2014-09-09	Mallinckrodt Llc	Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101899004A (zh) *	2010-06-24	2010-12-01	江苏大学	青藤碱衍生物、制备方法及其医药用途
CN102250003A (zh) *	2011-05-13	2011-11-23	湖南省药品检验所	一种青藤碱磺酸化物及其制备和应用
US20130125231A1 (en) *	2011-11-14	2013-05-16	Utc Fire & Security Corporation	Method and system for managing a multiplicity of credentials
CN102617470A (zh) *	2012-03-07	2012-08-01	江苏大学	青藤碱4-羟基醚化和酯化衍生物、制备方法及用途
US10118890B2 (en)	2014-10-10	2018-11-06	The Research Foundation For The State University Of New York	Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
KR101659659B1 (ko) *	2014-10-30	2016-10-04	한국화학연구원	방기 추출물을 포함하는 골질환 예방 또는 치료용 약학적 조성물
CN109096190B (zh) *	2017-06-21	2021-07-02	中国医学科学院药物研究所	一种青藤碱衍生物及其制备方法、用途和药物组合物
CN114409597B (zh) *	2022-01-04	2023-10-03	广东克冠达医药科技有限公司	一种青藤碱衍生物及其制备方法与应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE289274C (pl) *
CA1012144A (en) *	1973-10-05	1977-06-14	Bristol-Myers Canada Limited	Synthesis for the preparation of 3-hydroxy-n-alkylisomorphinans
US4272541A (en) *	1978-06-02	1981-06-09	Miles Laboratories, Inc.	7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4543256A (en) *	1982-03-17	1985-09-24	Northeastern University	(-)-10,1L Methylenedioxy-N-N-propylnoraporphine and methods employing it for inhibiting the effects of epileptic seizures and for prevention and treatment of duodenal ulcers
US4613668A (en) *	1983-12-22	1986-09-23	The United States Of America As Represented By The Department Of Health And Human Services	Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
IT1199871B (it) *	1984-03-27	1989-01-05	Mallinckrodt Inc	Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento
HU197750B (en) *	1984-07-17	1989-05-29	Alkaloida Vegyeszeti Gyar	Process for n-demethylation of morphine alkaloids
CA2067200C (en) *	1989-10-16	1998-06-30	Kenner C. Rice	Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates
US5366979A (en) *	1990-06-07	1994-11-22	Pharmaco Development Partners	Orally active nonaddicting analgesics
US5869669A (en) *	1996-07-26	1999-02-09	Penick Corporation	Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
PL368732A1 (pl) *	2001-08-23	2005-04-04	Akzo Nobel N.V.	Utlenianie pochodnych morfiny przy C-14
CN1328280C (zh) *	2002-11-28	2007-07-25	中国科学院上海药物研究所	汉防己碱和汉防己碱化合物,合成和应用
MX2007010851A (es) *	2005-03-10	2007-11-12	Mallinckrodt Inc	Procesos para preparar compuestos morfinicos y productos intermedios de los mismos.
CN1785976A (zh) *	2005-12-15	2006-06-14	南京大学	一类n－烃基青藤碱及其制备方法
JP2009519960A (ja) *	2005-12-15	2009-05-21	ナチュアメッドグループコーポレーション	シノメニン派生物の調合と使用
EP2099764B1 (en) *	2006-09-20	2011-07-27	Mallinckrodt Inc.	Preparation of substituted morphinan-6-ones and salts and intermediates thereof
US8252808B2 (en) *	2007-12-17	2012-08-28	Mallinckrodt Llc	Process and compounds for the production of (+)opiates
NO2453895T3 (pl) *	2009-07-16	2018-10-20

2008
- 2008-12-17 US US12/316,846 patent/US8461337B2/en active Active
- 2008-12-17 JP JP2010539460A patent/JP5579076B2/ja active Active
- 2008-12-17 CN CN200880120817.5A patent/CN101896464B/zh active Active
- 2008-12-17 WO PCT/US2008/013777 patent/WO2009078988A1/en not_active Ceased
- 2008-12-17 EP EP08862724.5A patent/EP2222643B1/en active Active
- 2008-12-17 CA CA2709862A patent/CA2709862C/en active Active
- 2008-12-17 PL PL08862724T patent/PL2222643T3/pl unknown
- 2008-12-17 AU AU2008338970A patent/AU2008338970B2/en active Active
- 2008-12-17 NZ NZ611651A patent/NZ611651A/en unknown
- 2008-12-17 NZ NZ586187A patent/NZ586187A/xx unknown
2012
- 2012-01-18 US US13/352,668 patent/US8614224B2/en active Active
2014
- 2014-05-23 JP JP2014106670A patent/JP2014148548A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
NZ586187A (en)	2013-07-26
US20090156816A1 (en)	2009-06-18
WO2009078988A1 (en)	2009-06-25
EP2222643B1 (en)	2019-03-20
US8461337B2 (en)	2013-06-11
US8614224B2 (en)	2013-12-24
JP2014148548A (ja)	2014-08-21
JP2011506603A (ja)	2011-03-03
EP2222643A1 (en)	2010-09-01
AU2008338970B2 (en)	2013-08-22
AU2008338970A1 (en)	2009-06-25
CN101896464B (zh)	2014-12-10
NZ611651A (en)	2014-11-28
US20120116086A1 (en)	2012-05-10
CN101896464A (zh)	2010-11-24
CA2709862A1 (en)	2009-06-25
CA2709862C (en)	2016-03-15
JP5579076B2 (ja)	2014-08-27

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