PL2233156T3 - Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych - Google Patents

Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych

Info

Publication number: PL2233156T3
Authority: PL; Poland
Prior art keywords: carriers; pharmaceutical conjugates; aprotinin polypeptides; aprotinin; polypeptides
Prior art date: 2005-07-15

Application number

PL10006638T

Other languages

English (en)

Inventor

Richard Beliveau

Michel Demeule

Christian Che

Anthony Regina

Original Assignee

Angiochem Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-15

Filing date

2006-07-14

Publication date

2013-09-30

2006-07-14 Application filed by Angiochem Inc filed Critical Angiochem Inc

2013-09-30 Publication of PL2233156T3 publication Critical patent/PL2233156T3/pl

Links

108010039627 Aprotinin Proteins 0.000 title 1
229960004405 aprotinin Drugs 0.000 title 1
239000000969 carrier Substances 0.000 title 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Zoology (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

PL10006638T 2005-07-15 2006-07-14 Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych PL2233156T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US69937505P	2005-07-15	2005-07-15
US75853206P	2006-01-13	2006-01-13
EP10006638.0A EP2233156B1 (en)	2005-07-15	2006-07-14	Use of aprotinin polypeptides as carriers in pharmaceutical conjugates
EP06761127A EP1907009A4 (en)	2005-07-15	2006-07-14	USE OF APROTININ POLYPEPTIDES AS CARRIER IN PHARMACEUTICAL CONJUGATES

Publications (1)

Publication Number	Publication Date
PL2233156T3 true PL2233156T3 (pl)	2013-09-30

Family

ID=37668389

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL10006638T PL2233156T3 (pl)	2005-07-15	2006-07-14	Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych

Country Status (15)

Country	Link
US (3)	US8969310B2 (pl)
EP (4)	EP2471555A3 (pl)
JP (3)	JP5436856B2 (pl)
CN (1)	CN101262890B (pl)
AU (1)	AU2006272405B2 (pl)
BR (1)	BRPI0613005A8 (pl)
CA (1)	CA2614687C (pl)
DK (2)	DK2233156T3 (pl)
ES (2)	ES2424242T3 (pl)
HR (1)	HRP20130720T1 (pl)
PL (1)	PL2233156T3 (pl)
PT (1)	PT2233156E (pl)
RU (2)	RU2422143C2 (pl)
SI (1)	SI2233156T1 (pl)
WO (1)	WO2007009229A1 (pl)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE512674T1 (de)	2003-01-06	2011-07-15	Angiochem Inc	Angiopep-1, verwandte verbindungen, und deren verwnedungen
WO2006081171A1 (en)	2005-01-24	2006-08-03	Amgen Inc.	Humanized anti-amyloid antibody
US7811572B2 (en)	2005-08-24	2010-10-12	Immunogen, Inc.	Process for preparing purified drug conjugates
US20090016959A1 (en) *	2005-02-18	2009-01-15	Richard Beliveau	Delivery of antibodies to the central nervous system
MX2007010113A (es)	2005-02-18	2007-12-07	Angiochem Inc	Polipeptidos de aprotinina para transportar un compuesto a traves de la barrera hematoencefalica.
PL2233156T3 (pl)	2005-07-15	2013-09-30	Angiochem Inc	Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych
JP2010506860A (ja)	2006-10-19	2010-03-04	アンジオケム，インコーポレーテッド	Ｐ−糖タンパク質機能を刺激するための化合物およびその使用
JP5844971B2 (ja) *	2007-05-29	2016-01-20	アンジオケム，インコーポレーテッド	コンジュゲートされた物質を組織に送達するためのアプロチニン様ポリペプチド
CA2688344C (en)	2007-05-29	2019-09-03	Angiochem, Inc.	Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US9365634B2 (en)	2007-05-29	2016-06-14	Angiochem Inc.	Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
EP2235175A4 (en) *	2007-12-20	2012-04-25	Angiochem Inc	POLYPEPTIDE NUCLEIC ACID CONJUGATES AND USES THEREOF
WO2009085200A2 (en)	2007-12-21	2009-07-09	Amgen Inc.	Anti-amyloid antibodies and uses thereof
CN102026667B (zh) *	2008-04-18	2014-06-25	安吉奥开米公司	紫杉醇、紫杉醇类似物或紫杉醇结合物的药物组合物及相关制备方法和用途
WO2010043047A1 (en)	2008-10-15	2010-04-22	Angiochem Inc.	Conjugates of glp-1 agonists and uses thereof
US8828925B2 (en) *	2008-10-15	2014-09-09	Angiochem Inc.	Etoposide and doxorubicin conjugates for drug delivery
WO2010063122A1 (en)	2008-12-05	2010-06-10	Angiochem Inc.	Conjugates of neurotensin or neurotensin analogs and uses thereof
EP2373789A4 (en)	2008-12-17	2012-08-29	Angiochem Inc	MEMBRANTYP-1 MATRIX METALLOPROTEINASE INHIBITORS AND THEIR USE
DE102009006228A1 (de)	2009-01-27	2010-07-29	Epo Experimentelle Pharmakologie & Onkologie Berlin-Buch Gmbh	Liposomale Zusammensetzung zur Behandlung von Hirnmetastasen
JP2010229122A (ja) *	2009-03-06	2010-10-14	Kumamoto Univ	抗癌剤、医薬、及び癌疾患の検査薬
RU2011146654A (ru) *	2009-04-20	2013-05-27	Ангиокем Инк.	Способы лечения рака яичников с применением конъюгированного средства
JP5784592B2 (ja)	2009-06-03	2015-09-24	イミュノジェン・インコーポレーテッド	抱合方法
WO2011000095A1 (en)	2009-07-02	2011-01-06	Angiochem Inc.	Multimeric peptide conjugates and uses thereof
EP2588490B1 (en)	2010-07-02	2017-02-22	Angiochem Inc.	Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
WO2012037687A1 (en) *	2010-09-23	2012-03-29	Angiochem Inc.	Therapeutic polypeptides and uses thereof
CN102085157B (zh) *	2011-01-27	2012-02-01	中国水产科学研究院黄海水产研究所	扇贝抗氧化肽纳米脂质体及其制备方法
CN102614524A (zh) *	2011-02-01	2012-08-01	复旦大学	低密度脂蛋白受体相关蛋白配体多肽修饰的脑肿瘤靶向基因递释复合物
EA033468B1 (ru)	2011-03-29	2019-10-31	Immunogen Inc	Способы получения конъюгата "антитело-майтансиноид"
CN104781276A (zh)	2012-08-14	2015-07-15	安吉奥开米公司	肽-树枝状聚合物结合物及其用途
EP2904089A4 (en) *	2012-10-04	2016-05-25	Immunogen Inc	USE OF A PVDF MEMBRANE FOR PURIFYING CELL BINDING AGENT-CYTOTOXIC AGENT CONJUGATES
CA2891190C (en) *	2012-11-12	2021-08-31	Angiochem Inc.	Aprotinin-derived polypeptide-antibody conjugates
AU2014284496A1 (en) *	2013-07-03	2016-01-21	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Method for treating cognitive dysfunction
WO2015002486A1 (ko)	2013-07-03	2015-01-08	서울대학교산학협력단	시스테인으로 변형된 닭의 항체 및 이를 이용한 부위-특이적 접합
US10183055B2 (en)	2014-07-21	2019-01-22	Arizona Board Of Regents On Behalf Of The University Of Arizona	Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
CN106535920B (zh)	2014-07-21	2020-10-30	代表亚利桑那大学的亚利桑那校董会	Ang-(1-7)衍生物寡肽及其使用和生产方法
GB201502447D0 (en)	2015-02-13	2015-04-01	Univ Liverpool	Method and apparatus for sample analysis
EP3307326B9 (en)	2015-06-15	2021-02-24	Angiochem Inc.	Methods for the treatment of leptomeningeal carcinomatosis
JP2021512165A (ja)	2018-01-29	2021-05-13	コグノス・セラピューティクス・インコーポレイテッド	ボルテゾミブの腫瘍内送達
CN111529716B (zh) *	2020-06-02	2021-05-28	南方医科大学	一种多肽-紫杉醇偶联物及其应用

Family Cites Families (140)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US508697A (en) *		1893-11-14		Jar or bottle receiver
US4671958A (en)	1982-03-09	1987-06-09	Cytogen Corporation	Antibody conjugates for the delivery of compounds to target sites
ES8407536A1 (es) *	1983-10-07	1984-10-01	Jumberca Sa	Mejoras en los alimentadores de hilo para telares circulares de genero de punto dotados de dispositivos listadores.
NZ219609A (en)	1986-03-13	1990-09-26	Univ Monash	Assay methods for inhibin
US4902505A (en) *	1986-07-30	1990-02-20	Alkermes	Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4801575A (en) *	1986-07-30	1989-01-31	The Regents Of The University Of California	Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4904768A (en)	1987-08-04	1990-02-27	Bristol-Myers Company	Epipodophyllotoxin glucoside 4'-phosphate derivatives
GB2208511A (en)	1987-08-07	1989-04-05	Bayer Ag	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US4942184A (en)	1988-03-07	1990-07-17	The United States Of America As Represented By The Department Of Health And Human Services	Water soluble, antineoplastic derivatives of taxol
US5632990A (en)	1988-04-22	1997-05-27	Cancer Research Campaign Tech. Ltd.	Treatment for tumors comprising conjugated antibody A5B7 and a prodrug
US5258499A (en) *	1988-05-16	1993-11-02	Vestar, Inc.	Liposome targeting using receptor specific ligands
US5028697A (en)	1988-08-08	1991-07-02	Eli Lilly And Company	Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers
US5169933A (en) *	1988-08-15	1992-12-08	Neorx Corporation	Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
US5223409A (en) *	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
US5948634A (en) *	1988-12-21	1999-09-07	The General Hospital Coporation	Neural thread protein gene expression and detection of alzheimer's disease
DE3912638A1 (de)	1989-04-18	1990-10-31	Bayer Ag	Gentechnologisch hergestellte homologe des alzheimer protease inhibitors, wirtstaemme sowie expressionsvektoren fuer ihre herstellung und ihre verwendung als arzneimittel
US6020145A (en) *	1989-06-30	2000-02-01	Bristol-Myers Squibb Company	Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
US6475781B1 (en)	1990-05-17	2002-11-05	Dana-Farber Cancer Institute, Inc.	Trans-dominant suppressor genes for oligomeric proteins
US5714167A (en) *	1992-06-15	1998-02-03	Emisphere Technologies, Inc.	Active agent transport systems
US6495513B1 (en)	1991-03-11	2002-12-17	Curis, Inc.	Morphogen-enhanced survival and repair of neural cells
US5955444A (en)	1991-08-09	1999-09-21	Massachusetts Institute Of Technology	Method of inhibiting abnormal tau hyper phosphorylation in a cell
US5627270A (en) *	1991-12-13	1997-05-06	Trustees Of Princeton University	Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
GB9213077D0 (en) *	1992-06-19	1992-08-05	Erba Carlo Spa	Polymerbound taxol derivatives
CA2145517A1 (en)	1992-09-25	1994-04-14	Ignace Lasters	Bovine pancreatic trypsin inhibitor derived inhibitors of factor viia - tissue factor complex
EP0599303A3 (en) *	1992-11-27	1998-07-29	Takeda Chemical Industries, Ltd.	Peptide conjugate
IL107950A (en)	1992-12-15	2001-04-30	Upjohn Co	7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1994019692A1 (en) *	1993-02-18	1994-09-01	The General Hospital Corporation	Alzheimer's disease therapeutics
EP0820466A2 (en)	1995-04-04	1998-01-28	Advanced Bioconcept Inc.	Fluorescent peptides
ZA963619B (en)	1995-05-08	1996-11-22	Scios Inc	Protease inhibitor peptides
JPH11504938A (ja)	1995-05-08	1999-05-11	サイオスインク．	クニッツ型プロテアーゼ阻害因子
WO1996039183A1 (en)	1995-05-31	1996-12-12	Fred Hutchinson Cancer Research Center	Compositions and methods for targeted delivery of effector molecules
US5780265A (en)	1995-06-05	1998-07-14	Genentech, Inc.	Kunitz type plasma kallikrein inhibitors
US5665702A (en)	1995-06-06	1997-09-09	Biomeasure Incorporated	Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
CA2222231A1 (en)	1995-06-07	1996-12-19	Imclone Systems Incorporated	Antibody and antibody fragments for inhibiting the growth of tumors
WO1997033996A2 (en)	1996-03-11	1997-09-18	Bayer Corporation	Human bikunin
AU2409397A (en)	1996-04-24	1997-11-12	Rijksuniversiteit Te Groningen	A prokaryotic protein having functional and structural homology with the uman p-glycoprotein encoded by the mdr-1 gene, nucleic acids encoding and cells expressing said protein
AU729643B2 (en)	1996-05-01	2001-02-08	Antivirals Inc.	Polypeptide conjugates for transporting substances across cell membranes
WO1998016201A1 (en)	1996-10-11	1998-04-23	Sequus Pharmaceuticals, Inc.	Therapeutic liposome composition and method
US6056973A (en) *	1996-10-11	2000-05-02	Sequus Pharmaceuticals, Inc.	Therapeutic liposome composition and method of preparation
US5948750A (en)	1996-10-30	1999-09-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
JP4116683B2 (ja)	1997-02-28	2008-07-09	ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー	徐放性局所送達製剤
WO1998039469A1 (en) *	1997-03-04	1998-09-11	Bio-Technology General Corp.	Isolation of tissue specific peptide ligands and their use for targeting pharmaceuticals to organs
US6126965A (en) *	1997-03-21	2000-10-03	Georgetown University School Of Medicine	Liposomes containing oligonucleotides
ES2210761T3 (es) *	1997-05-21	2004-07-01	The Board Of Trustees Of The Leland Stanford Junior University	Composicion y procedimiento para mejorar el transporte a traves de las membranas biologicas.
US6391305B1 (en)	1997-09-10	2002-05-21	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6093692A (en) *	1997-09-25	2000-07-25	The University Of Southern California	Method and compositions for lipidization of hydrophilic molecules
US6475481B2 (en)	1997-11-18	2002-11-05	Canji Inc	Purging of stem cell products
WO1999026657A1 (en)	1997-11-25	1999-06-03	Musc Foundation For Research Development	Inhibitors of nitric oxide synthase
US5981564A (en) *	1998-07-01	1999-11-09	Universite Laval	Water-soluble derivatives of paclitaxel, method for producing same and uses thereof
GB9814527D0 (en) *	1998-07-03	1998-09-02	Cyclacel Ltd	Delivery system
US6703381B1 (en) *	1998-08-14	2004-03-09	Nobex Corporation	Methods for delivery therapeutic compounds across the blood-brain barrier
US5922754A (en) *	1998-10-02	1999-07-13	Abbott Laboratories	Pharmaceutical compositions containing paclitaxel
EP1154782A4 (en) *	1999-02-24	2002-09-25	Uab Research Foundation	TAXAN DERIVATIVES FOR TARGETED CANCER THERAPY
US6713454B1 (en)	1999-09-13	2004-03-30	Nobex Corporation	Prodrugs of etoposide and etoposide analogs
US6136846A (en)	1999-10-25	2000-10-24	Supergen, Inc.	Formulation for paclitaxel
DE19953696A1 (de) *	1999-11-09	2001-05-10	Alexander Cherkasky	Selektive proteolytische Synzyme (SPS)
CA2307393A1 (en) *	2000-05-01	2001-11-01	The University Of British Columbia	Ginsenoside chemotherapy
CA2355334A1 (en)	2000-10-16	2002-04-16	Procyon Biopharma Inc.	Pharmaceutical preparations and methods for inhibiting tumors
JP2004536026A (ja)	2000-11-28	2004-12-02	トランスフォームファーマシューティカルズ，インコーポレーティッド．	パクリタキセル、その誘導体、および薬剤として許容される塩を含む医薬品製剤
US7115565B2 (en) *	2001-01-18	2006-10-03	Pharmacia & Upjohn Company	Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
WO2002076448A1 (en) *	2001-03-23	2002-10-03	Napro Biotherapeutics, Inc.	Molecular conjugates for use in treatment of cancer
ES2464532T3 (es)	2001-04-19	2014-06-03	The Scripps Research Institute	Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa
CA2450073C (en) *	2001-07-25	2017-08-29	Biomarin Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
US20040161776A1 (en)	2001-10-23	2004-08-19	Maddon Paul J.	PSMA formulations and uses thereof
US7192921B2 (en)	2001-11-08	2007-03-20	The Burnham Institute	Peptides that home to tumor lymphatic vasculature and methods of using same
EP1465618A2 (en) *	2001-12-20	2004-10-13	Bristol-Myers Squibb Company	Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability
RU2196604C1 (ru) *	2001-12-21	2003-01-20	Северин Евгений Сергеевич	Полипептид, являющийся аналогом рецепторсвязывающего фрагмента эпидермального фактора роста с 21-й по 31-ю аминокислоту, его конъюгат с доксорубицином и фармацевтическая композиция на его основе
WO2003066859A2 (en) *	2002-02-07	2003-08-14	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Amino acid sequences capable of facilitating penetration across a biological barrier
US6881829B2 (en)	2002-04-26	2005-04-19	Chimeracom, L.L.C.	Chimeric hybrid analgesics
JP2005537244A (ja)	2002-06-28	2005-12-08	ナステック・ファーマシューティカル・カンパニー・インコーポレーテッド	療法化合物の粘膜搬送を増進させるための、上皮接合部接着分子の生理機能を調節する組成物および方法
US7829694B2 (en)	2002-11-26	2010-11-09	Medtronic, Inc.	Treatment of neurodegenerative disease through intracranial delivery of siRNA
US20040102369A1 (en) *	2002-11-27	2004-05-27	The Regents Of The University Of California	Transport of basic fibroblast growth factor across the blood brain barrier
US7388079B2 (en) *	2002-11-27	2008-06-17	The Regents Of The University Of California	Delivery of pharmaceutical agents via the human insulin receptor
ATE512674T1 (de)	2003-01-06	2011-07-15	Angiochem Inc	Angiopep-1, verwandte verbindungen, und deren verwnedungen
CA2520655A1 (en) *	2003-04-08	2004-11-04	Biotempt, B.V.	Compositions for mucosal and oral administration comprising hcg fragments
KR20060080535A (ko) *	2003-05-14	2006-07-10	이뮤노젠 아이엔씨	약물 콘쥬게이트 조성물
AU2003286870A1 (en)	2003-06-05	2005-01-04	Salk Institute For Biological Studies	Targeting polypeptides to the central nervous system
WO2005002515A2 (en)	2003-06-20	2005-01-13	Biomarin Pharmaceutical Inc.	Delivery of therapeutic compounds to the brain and other tissues
US20050026823A1 (en) *	2003-06-20	2005-02-03	Biomarin Pharmaceutical Inc.	Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
AU2004263458B2 (en)	2003-08-08	2010-06-24	Actgen, Inc.	Polypeptides having brain-localizing activity and uses thereof
JP2007512001A (ja) *	2003-08-28	2007-05-17	バイオレクシスファーマシューティカルコーポレイション	Ｅｐｏミメティックペプチドおよび融合タンパク質
US20050058702A1 (en)	2003-09-17	2005-03-17	Ben-Sasson Shmuel A.	Compositions capable of facilitating penetration across a biological barrier
US20050208095A1 (en)	2003-11-20	2005-09-22	Angiotech International Ag	Polymer compositions and methods for their use
US7208174B2 (en)	2003-12-18	2007-04-24	Hoffmann-La Roche Inc.	Liposome compositions
JP2008507280A (ja) *	2004-07-21	2008-03-13	アンブレツクス・インコーポレイテツド	非天然コードアミノ酸を用いた生合成ポリペプチド
MX2007001180A (es)	2004-07-26	2007-04-13	Asterion Ltd	Enlazantes.
EP1799826B1 (en)	2004-09-29	2009-08-12	Children's Memorial Hospital	siRNA-MEDIATED GENE SILENCING OF ALPHA SYNUCLEIN
CN103169729A (zh)	2005-02-18	2013-06-26	阿布拉科斯生物科学有限公司	治疗剂的组合和给予方式以及联合治疗
MX2007010113A (es) *	2005-02-18	2007-12-07	Angiochem Inc	Polipeptidos de aprotinina para transportar un compuesto a traves de la barrera hematoencefalica.
US20090016959A1 (en)	2005-02-18	2009-01-15	Richard Beliveau	Delivery of antibodies to the central nervous system
CA2616906A1 (en) *	2005-05-12	2006-11-23	Tapestry Pharmaceuticals, Inc.	Molecular constructs suitable for targeted conjugates
US8877714B2 (en)	2005-06-14	2014-11-04	Raptor Pharmaceutical Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for LRP2 and uses thereof
PL2233156T3 (pl)	2005-07-15	2013-09-30	Angiochem Inc	Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych
EP1904642A4 (en) *	2005-07-19	2008-11-26	Univ Illinois	TRANSPORT AGENTS FOR CROSS-BREAKING BLOOD-BRAIN DISEASE AND INTRUSION IN BRAIN CANCER CELLS AND METHOD OF USE THEREOF
GB0517092D0 (en)	2005-08-19	2005-09-28	Novartis Ag	New compositions containing taxane derivatives
JP2009507852A (ja)	2005-09-08	2009-02-26	エムディーアールエヌエー，インコーポレイテッド	リボ核酸の細胞への送達用医薬組成物
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
US8053569B2 (en)	2005-10-07	2011-11-08	Armagen Technologies, Inc.	Nucleic acids encoding and methods of producing fusion proteins
EP2202239A1 (en)	2005-11-01	2010-06-30	Alnylam Pharmaceuticals Inc.	RNAI inhibition of influenza virus replication
AR054215A1 (es)	2006-01-20	2007-06-13	Eriochem Sa	Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit
DK2046826T3 (da)	2006-07-24	2011-10-24	Biorexis Pharmaceutical Corp	Exendin-fusionsproteiner
JP2010503710A (ja)	2006-09-18	2010-02-04	ラプトールファーマシューティカルインコーポレイテッド	受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
JP2010506860A (ja)	2006-10-19	2010-03-04	アンジオケム，インコーポレーテッド	Ｐ−糖タンパク質機能を刺激するための化合物およびその使用
US9365634B2 (en)	2007-05-29	2016-06-14	Angiochem Inc.	Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
CA2688344C (en)	2007-05-29	2019-09-03	Angiochem, Inc.	Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
WO2009039188A1 (en)	2007-09-17	2009-03-26	Ludwig Institute For Cancer Research Ltd	Peptides and methods for the treatment of gliomas and other cancers
WO2009070597A2 (en)	2007-11-26	2009-06-04	Armagen Technologies, Inc.	Fusion proteins for delivery of gdnf to the cns
EP2235175A4 (en)	2007-12-20	2012-04-25	Angiochem Inc	POLYPEPTIDE NUCLEIC ACID CONJUGATES AND USES THEREOF
US8193182B2 (en)	2008-01-04	2012-06-05	Intellikine, Inc.	Substituted isoquinolin-1(2H)-ones, and methods of use thereof
ES2951646T3 (es)	2008-02-21	2023-10-24	Burnham Institute For Medical Res	Métodos y composiciones relacionados con péptidos y proteínas con elementos C-terminales
CN102026667B (zh)	2008-04-18	2014-06-25	安吉奥开米公司	紫杉醇、紫杉醇类似物或紫杉醇结合物的药物组合物及相关制备方法和用途
WO2010043047A1 (en)	2008-10-15	2010-04-22	Angiochem Inc.	Conjugates of glp-1 agonists and uses thereof
US8828925B2 (en)	2008-10-15	2014-09-09	Angiochem Inc.	Etoposide and doxorubicin conjugates for drug delivery
US20110288011A1 (en)	2008-12-05	2011-11-24	Jean-Paul Castaigne	Peptide therapeutic conjugates and uses thereof
WO2010063122A1 (en)	2008-12-05	2010-06-10	Angiochem Inc.	Conjugates of neurotensin or neurotensin analogs and uses thereof
CA2745527A1 (en)	2008-12-05	2010-06-10	Angiochem Inc.	Leptin and leptin analog conjugates and uses thereof
EP2373789A4 (en)	2008-12-17	2012-08-29	Angiochem Inc	MEMBRANTYP-1 MATRIX METALLOPROTEINASE INHIBITORS AND THEIR USE
RU2011146654A (ru)	2009-04-20	2013-05-27	Ангиокем Инк.	Способы лечения рака яичников с применением конъюгированного средства
US20100284921A1 (en)	2009-05-08	2010-11-11	Temple University - Of The Commonwealth System Of Higher Education	Targeted nanoparticles for intracellular cancer therapy
CN103819564A (zh)	2009-06-11	2014-05-28	安吉奥开米公司	用于将gdnf和bdnf递送至中枢神经系统的融合蛋白
WO2011000095A1 (en)	2009-07-02	2011-01-06	Angiochem Inc.	Multimeric peptide conjugates and uses thereof
SI2453923T1 (sl)	2009-07-14	2016-04-29	Mayo Foundation For Medical Education And Research	S peptidi posredovana ne-kovalentna dostava aktivnih učinkovin preko krvno možganske bariere
WO2011041897A1 (en)	2009-10-06	2011-04-14	Angiochem Inc.	Compositions and methods for the transport of therapeutic agents
US8530429B2 (en)	2009-11-24	2013-09-10	Arch Cancer Therapeutics, Inc.	Brain tumor targeting peptides and methods
WO2011153642A1 (en)	2010-06-10	2011-12-15	Angiochem Inc.	Leptin and leptin analog conjugates and fusion proteins and uses thereof
EP2588490B1 (en)	2010-07-02	2017-02-22	Angiochem Inc.	Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
WO2012037687A1 (en)	2010-09-23	2012-03-29	Angiochem Inc.	Therapeutic polypeptides and uses thereof
JP2014505666A (ja)	2010-11-18	2014-03-06	ザジェネラルホスピタルコーポレイション	癌治療のための降圧剤の組成物および使用
WO2013056096A1 (en)	2011-10-13	2013-04-18	Angiochem Inc.	Polypeptide-opioid conjugates and uses thereof
US20140335163A1 (en)	2011-12-01	2014-11-13	Angiochem Inc.	Targeted iduronate-2-sulfatase compounds
CN104145015A (zh)	2011-12-01	2014-11-12	安吉奥开米公司	靶向的溶酶体酶化合物
WO2013185235A1 (en)	2012-06-15	2013-12-19	Angiochem Inc.	Targeted iduronidase compounds
US20160106856A1 (en)	2012-08-14	2016-04-21	Angiochem Inc.	Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
CN104781276A (zh)	2012-08-14	2015-07-15	安吉奥开米公司	肽-树枝状聚合物结合物及其用途
CA2891190C (en)	2012-11-12	2021-08-31	Angiochem Inc.	Aprotinin-derived polypeptide-antibody conjugates
GB201220474D0 (en)	2012-11-14	2012-12-26	Sagetis Biotech Sl	Polypeptides
CN104955946A (zh)	2012-11-30	2015-09-30	安吉奥开米公司	靶向的艾杜糖醛酸-2-硫酸酯酶化合物
HK1179821A2 (en)	2013-05-28	2013-10-04	捷迅视讯器材有限公司	High voltage discharge protection device and radio frequency transmission apparatus using the same
US20160367691A1 (en)	2013-06-06	2016-12-22	Angiochem Inc.	Targeted enzyme compounds and uses thereof
WO2014194428A1 (en)	2013-06-06	2014-12-11	Angiochem Inc.	Targeted heparan sulfatase compounds

2006
- 2006-07-14 PL PL10006638T patent/PL2233156T3/pl unknown
- 2006-07-14 BR BRPI0613005A patent/BRPI0613005A8/pt not_active Application Discontinuation
- 2006-07-14 DK DK10006638.0T patent/DK2233156T3/da active
- 2006-07-14 EP EP11010071A patent/EP2471555A3/en not_active Withdrawn
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- 2006-07-14 AU AU2006272405A patent/AU2006272405B2/en not_active Ceased
- 2006-07-14 RU RU2008105677/15A patent/RU2422143C2/ru active
- 2006-07-14 DK DK11010125.0T patent/DK2433653T3/da active
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- 2007-05-30 US US11/807,917 patent/US8969310B2/en active Active
2011
- 2011-04-19 RU RU2011115418/15A patent/RU2011115418A/ru not_active Application Discontinuation
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- 2012-10-18 JP JP2012230853A patent/JP2013047249A/ja not_active Withdrawn
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- 2013-08-01 HR HRP20130720TT patent/HRP20130720T1/hr unknown
2015
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Publication number	Publication date
RU2011115418A (ru)	2012-10-27
EP2471555A2 (en)	2012-07-04
US20180221497A1 (en)	2018-08-09
RU2422143C2 (ru)	2011-06-27
AU2006272405A1 (en)	2007-01-25
US20090082277A1 (en)	2009-03-26
EP2233156A2 (en)	2010-09-29
RU2008105677A (ru)	2009-08-20
DK2433653T3 (da)	2019-08-19
EP2471555A3 (en)	2012-10-17
EP2433653A1 (en)	2012-03-28
CN101262890A (zh)	2008-09-10
HRP20130720T1 (en)	2013-09-30
WO2007009229A1 (en)	2007-01-25
EP2233156B1 (en)	2013-05-01
AU2006272405B2 (en)	2013-02-07
US8969310B2 (en)	2015-03-03
CA2614687C (en)	2016-03-22
JP2013047249A (ja)	2013-03-07
SI2233156T1 (sl)	2013-09-30
BRPI0613005A8 (pt)	2017-12-26
EP1907009A1 (en)	2008-04-09
HK1148689A1 (en)	2011-09-16
EP2233156A3 (en)	2010-10-13
US9713646B2 (en)	2017-07-25
BRPI0613005A2 (pt)	2010-12-14
JP2009500431A (ja)	2009-01-08
JP2015163641A (ja)	2015-09-10
US20150314010A1 (en)	2015-11-05
CN101262890B (zh)	2015-08-26
PT2233156E (pt)	2013-07-31
ES2424242T3 (es)	2013-09-30
EP2433653B1 (en)	2019-06-05
EP1907009A4 (en)	2009-09-02
DK2233156T3 (da)	2013-08-05
JP5436856B2 (ja)	2014-03-05
CA2614687A1 (en)	2007-01-25
ES2744225T3 (es)	2020-02-24

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