PL2262500T3 - Pochodne tienopirydonowe jako aktywatory kinazy białkowej aktywowanej przez amp (ampk) - Google Patents

Pochodne tienopirydonowe jako aktywatory kinazy białkowej aktywowanej przez amp (ampk)

Info

Publication number
PL2262500T3
PL2262500T3 PL09731265.6T PL09731265T PL2262500T3 PL 2262500 T3 PL2262500 T3 PL 2262500T3 PL 09731265 T PL09731265 T PL 09731265T PL 2262500 T3 PL2262500 T3 PL 2262500T3
Authority
PL
Poland
Prior art keywords
ampk
activators
protein kinase
activated protein
thienopyridone derivatives
Prior art date
Application number
PL09731265.6T
Other languages
English (en)
Inventor
Daniel Cravo
Franck Lepifre
Sophie Hallakou-Bozec
Christine Charon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40671017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2262500(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of PL2262500T3 publication Critical patent/PL2262500T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL09731265.6T 2008-04-11 2009-03-17 Pochodne tienopirydonowe jako aktywatory kinazy białkowej aktywowanej przez amp (ampk) PL2262500T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08290364 2008-04-11

Publications (1)

Publication Number Publication Date
PL2262500T3 true PL2262500T3 (pl) 2016-09-30

Family

ID=40671017

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09731265.6T PL2262500T3 (pl) 2008-04-11 2009-03-17 Pochodne tienopirydonowe jako aktywatory kinazy białkowej aktywowanej przez amp (ampk)

Country Status (25)

Country Link
US (1) US8563729B2 (pl)
EP (1) EP2262500B1 (pl)
JP (1) JP5592348B2 (pl)
KR (1) KR101630466B1 (pl)
CN (1) CN101998853B (pl)
AU (1) AU2009235784B2 (pl)
BR (1) BRPI0910439B8 (pl)
CA (1) CA2721025C (pl)
CO (1) CO6300954A2 (pl)
DK (1) DK2262500T3 (pl)
EA (1) EA017756B1 (pl)
EC (1) ECSP10010599A (pl)
ES (1) ES2584278T3 (pl)
HR (1) HRP20160907T1 (pl)
HU (1) HUE027857T2 (pl)
IL (1) IL208067A (pl)
MX (1) MX2010011047A (pl)
MY (1) MY155836A (pl)
NZ (1) NZ589136A (pl)
PL (1) PL2262500T3 (pl)
PT (1) PT2262500T (pl)
SI (1) SI2262500T1 (pl)
UA (1) UA103321C2 (pl)
WO (1) WO2009124636A1 (pl)
ZA (1) ZA201008050B (pl)

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JP5536757B2 (ja) * 2008-05-05 2014-07-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ａｍｐにより活性化されたプロテインキナーゼ（ａｍｐｋ）アクチベーターとしてのチエノピリドン誘導体
EP2519527B1 (en) * 2009-12-29 2013-12-18 Poxel Thieno[2,3-b]pyridinedione activators of ampk and therapeutic uses thereof
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2552435A1 (en) 2010-04-02 2013-02-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1)
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2012028582A1 (de) 2010-09-01 2012-03-08 Bayer Cropscience Ag Herbizid wirksame ketosultame und diketopyridine
KR101624020B1 (ko) * 2011-03-07 2016-05-24 글락소스미스클라인 엘엘씨 퀴놀리논 유도체
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2679591A1 (en) 2012-06-29 2014-01-01 Poxel Thienopyridone derivatives useful as activators of AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
WO2015002818A1 (en) 2013-07-01 2015-01-08 Emory University Treating or preventing nephrogenic diabetes insipidus
WO2015103480A1 (en) 2014-01-02 2015-07-09 Massachusetts Eye & Ear Infirmary Treating ocular neovascularization
CN105037321A (zh) * 2015-06-23 2015-11-11 佛山市赛维斯医药科技有限公司 含六甲基苯环的黄原酸酯类的ampk激活剂、制备方法及用途
CN104945369A (zh) * 2015-06-23 2015-09-30 佛山市赛维斯医药科技有限公司 一种含六甲基苯环和硝基苯结构的黄原酸酯类化合物、其制备方法及用途
CN104892568A (zh) * 2015-06-23 2015-09-09 佛山市赛维斯医药科技有限公司 一种含六甲基苯环和腈基苯结构的黄原酸酯类化合物、其制备方法及用途
CN104892569A (zh) * 2015-06-23 2015-09-09 佛山市赛维斯医药科技有限公司 末端取代的硝苯六甲苯黄原酸酯类的化合物、制备方法及用途
CN104945370A (zh) * 2015-06-23 2015-09-30 佛山市赛维斯医药科技有限公司 含卤代噻吩和硝苯六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN105037322A (zh) * 2015-06-23 2015-11-11 佛山市赛维斯医药科技有限公司 含六甲基苯环和烷氧苯结构的黄原酸酯类化合物、其制备方法及用途
CN104926757A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 含烷氧苯基的双酰基苄胺类ampk激活剂、其制备方法及用途
CN104926755A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 硝苯双酰基苄胺类ampk激活剂、其制备方法及用途
CN104926756A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 一类含腈基苯的双酰基苄胺类化合物、其制备方法及用途
CN105001194A (zh) * 2015-06-24 2015-10-28 佛山市赛维斯医药科技有限公司 一种含氨基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN104945372A (zh) * 2015-06-24 2015-09-30 佛山市赛维斯医药科技有限公司 一种含二硝基以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN105001181A (zh) * 2015-06-24 2015-10-28 佛山市赛维斯医药科技有限公司 一类双酰基苄胺类的ampk激活剂、其制备方法及用途
CN105037296A (zh) * 2015-06-24 2015-11-11 佛山市赛维斯医药科技有限公司 一类卤代苯双酰基苄胺类的ampk激活剂、其制备方法及用途
CN104945371A (zh) * 2015-06-24 2015-09-30 佛山市赛维斯医药科技有限公司 一种含腈基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
JP6898868B2 (ja) 2015-06-25 2021-07-07 ユニバーシティー ヘルス ネットワーク Ｈｐｋ１阻害剤およびそれを用いる方法
US20190054096A1 (en) 2015-09-30 2019-02-21 Instituto De Medicina Molecular Methods for attenuating parasite virulence
US20190350955A1 (en) 2016-06-30 2019-11-21 Inserm (Institut National De La Sante Et De La Recherche Medicale Methods and pharmaceutical compositions for the treatment of cardiomyopathies
IL282444B2 (en) * 2018-11-16 2024-07-01 Poxel Monohydrate potassium salt of a thienopyridone derivative and its preparation process
WO2020201263A1 (en) 2019-04-01 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling
CN115335048B (zh) 2020-03-26 2025-04-04 博希尔公司 噻吩并吡啶酮衍生物在治疗肾上腺脑白质营养不良或肾上腺脊髓神经病中的用途
CA3171422A1 (en) * 2020-04-02 2021-10-07 Sebastien Bolze Use of a thienopyridone derivative in the treatment of autosomal dominant polycystic kidney disease (adpkd)
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂
CN116322663A (zh) 2020-09-30 2023-06-23 比奥维拉迪维治疗股份有限公司 Ampk激活剂及其使用方法
WO2022106892A1 (en) 2020-11-17 2022-05-27 Instituto De Medicina Molecular Anti-malarial compounds
AU2022391025A1 (en) 2021-11-19 2024-06-06 The Brigham And Women's Hospital, Inc. Bifunctional chimeric molecules for labeling of kinases with target binding moieties and methods of use thereof

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Also Published As

Publication number Publication date
HRP20160907T1 (hr) 2016-09-23
US20110034505A1 (en) 2011-02-10
UA103321C2 (ru) 2013-10-10
BRPI0910439B1 (pt) 2020-10-20
ZA201008050B (en) 2011-07-27
JP2011516510A (ja) 2011-05-26
EP2262500B1 (en) 2016-04-27
KR101630466B1 (ko) 2016-06-14
ECSP10010599A (es) 2010-12-30
SI2262500T1 (sl) 2016-09-30
EA017756B1 (ru) 2013-02-28
KR20100137563A (ko) 2010-12-30
CN101998853B (zh) 2015-02-11
ES2584278T3 (es) 2016-09-26
AU2009235784B2 (en) 2013-09-19
AU2009235784A1 (en) 2009-10-15
US8563729B2 (en) 2013-10-22
CN101998853A (zh) 2011-03-30
PT2262500T (pt) 2016-08-16
CO6300954A2 (es) 2011-07-21
JP5592348B2 (ja) 2014-09-17
HUE027857T2 (en) 2016-11-28
MY155836A (en) 2015-12-15
MX2010011047A (es) 2010-10-26
EA201001585A1 (ru) 2011-06-30
CA2721025C (en) 2016-07-26
BRPI0910439B8 (pt) 2021-05-25
DK2262500T3 (en) 2016-08-15
IL208067A0 (en) 2010-12-30
IL208067A (en) 2015-05-31
EP2262500A1 (en) 2010-12-22
WO2009124636A1 (en) 2009-10-15
NZ589136A (en) 2012-06-29
CA2721025A1 (en) 2009-10-15
BRPI0910439A2 (pt) 2015-09-29
HK1155955A1 (en) 2012-06-01

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