PL2262778T3 - Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CXCR1 i p40 - Google Patents

Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CXCR1 i p40

Info

Publication number: PL2262778T3
Authority: PL; Poland
Prior art keywords: cxcr1; mcp; benzyl; expression; treatment
Prior art date: 2008-03-07

Application number

PL09718483T

Other languages

English (en)

Inventor

Angelo Guglielmotti

Guido Furlotti

Giorgina Mangano

Nicola Cazzolla

Original Assignee

Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-07

Filing date

2009-03-05

Publication date

2020-02-28

2009-03-05 Application filed by Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.

2020-02-28 Publication of PL2262778T3 publication Critical patent/PL2262778T3/pl

Links

AKQDXNFPEFHRLS-UHFFFAOYSA-N (1-benzylindazol-3-yl)methanol Chemical class C12=CC=CC=C2C(CO)=NN1CC1=CC=CC=C1 AKQDXNFPEFHRLS-UHFFFAOYSA-N 0.000 title 1
101100504320 Caenorhabditis elegans mcp-1 gene Proteins 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Hematology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Surgery (AREA)
Otolaryngology (AREA)

PL09718483T 2008-03-07 2009-03-05 Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CXCR1 i p40 PL2262778T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08425140		2008-03-07
EP09718483.2A EP2262778B8 (en)	2008-03-07	2009-03-05	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
PCT/EP2009/052588 WO2009109616A2 (en)	2008-03-07	2009-03-05	Novel 1-benzil-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40

Publications (1)

Publication Number	Publication Date
PL2262778T3 true PL2262778T3 (pl)	2020-02-28

Family

ID=39672136

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL09718483T PL2262778T3 (pl)	2008-03-07	2009-03-05	Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CXCR1 i p40

Country Status (25)

Country	Link
US (2)	US8461194B2 (pl)
EP (1)	EP2262778B8 (pl)
JP (1)	JP5509100B2 (pl)
KR (1)	KR101640844B1 (pl)
CN (1)	CN101965337B (pl)
AR (1)	AR070812A1 (pl)
AU (1)	AU2009221087B2 (pl)
BR (1)	BRPI0907974A2 (pl)
CA (1)	CA2714436C (pl)
CY (1)	CY1122349T1 (pl)
DK (1)	DK2262778T5 (pl)
EA (1)	EA018976B1 (pl)
ES (1)	ES2753149T3 (pl)
GE (1)	GEP20135927B (pl)
HR (1)	HRP20191953T8 (pl)
HU (1)	HUE047318T2 (pl)
IL (1)	IL207277A (pl)
LT (1)	LT2262778T (pl)
MX (1)	MX2010009625A (pl)
PL (1)	PL2262778T3 (pl)
PT (1)	PT2262778T (pl)
SG (1)	SG188178A1 (pl)
SI (1)	SI2262778T1 (pl)
UA (1)	UA103609C2 (pl)
WO (1)	WO2009109616A2 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2262777B8 (en)	2008-03-07	2016-05-04	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1 and cx3cr1
WO2009109613A2 (en) *	2008-03-07	2009-09-11	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
HRP20191953T8 (hr) *	2008-03-07	2021-06-25	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	DERIVATI 1-BENZIL-3-HIDROKSIMETILINDAZOLA I NJIHOVA UPORABA U LIJEČENJU BOLESTI KOJE SE BAZIRAJU NA EKSPRESIJI MCP-1, CX3CR1 i P40
UA108742C2 (uk)	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
US8435993B2 (en)	2010-12-07	2013-05-07	Philadelphia Health And Education Corporation	Methods of inhibiting metastasis from cancer
JP2015521183A (ja)	2012-05-18	2015-07-27	サノフイ	ピリジン誘導体および病理学的血栓形成に関連する状態の治療へのその使用
PL2882715T3 (pl)	2012-05-18	2017-04-28	Sanofi	Pochodne pirazolowe i ich zastosowanie jako antagonistów LPAR5
JP6478908B2 (ja)	2012-05-25	2019-03-06	バーグエルエルシー	熱ショックタンパク質（ＨＳＰ）９０−βを調節することによる代謝症候群の治療方法
US9013997B2 (en)	2012-06-01	2015-04-21	Broadcom Corporation	System for performing distributed data cut-through
EP2861563B1 (en) *	2012-06-01	2017-07-12	Nogra Pharma Limited	Bicyclic heterocycles capable of modulating t-cell responses, and methods of using same
WO2015188198A2 (en)	2014-06-06	2015-12-10	Berg Llc	Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta
CA2989270A1 (en) *	2015-06-16	2016-12-22	Translatum Medicus, Inc.	Compositions and methods for treating and diagnosing ocular disorders
CN108290881B (zh) *	2015-09-28	2021-12-07	健泰科生物技术公司	治疗性化合物和其使用方法
US11267817B2 (en)	2017-05-02	2022-03-08	Drexel University	Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists
WO2020261158A1 (en)	2019-06-25	2020-12-30	Translatum Medicus Inc.	Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1230441B (it)	1989-02-07	1991-10-23	Acraf	Eteri della serie dell'indazolo
IT1253703B (it)	1991-04-22	1995-08-23	Angelini Francesco Ist Ricerca	Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it)	1997-07-28	1999-03-10	Angelini Ricerche Spa	Farmaco attivo nel ridurre la produzione di proteina mcp-1
EP1185528A4 (en)	1999-06-17	2003-03-26	Shionogi Biores Corp	INHIBITORS OF IL-12 PRODUCTION
EP1188438A1 (en)	2000-09-15	2002-03-20	Warner-Lambert Company	Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
EP1199074A1 (en)	2000-09-15	2002-04-24	Warner-Lambert Company	Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
DE60230388D1 (de)	2001-03-15	2009-01-29	Seikagaku Kogyo Co Ltd	Mittel zur steurung der expression von il-12
WO2003047516A2 (en)	2001-11-30	2003-06-12	Synta Pharmaceuticals Corporation	Pyrimidine compounds
EP1675862A1 (en)	2003-10-07	2006-07-05	AstraZeneca AB	New 2-substituted, 4-amino-thiazolo 4,5-d pyrimidines, useful as chemokine receptor antagonists, esp. cx3cr1
US20070015771A1 (en)	2004-07-29	2007-01-18	Threshold Pharmaceuticals, Inc.	Lonidamine analogs
US20070043057A1 (en)	2005-02-09	2007-02-22	Threshold Pharmaceuticals, Inc.	Lonidamine analogs
US7514463B2 (en) *	2004-08-20	2009-04-07	University Of Kansas	Lonidamine analogues and their use in male contraception and cancer treatment
DE102004043005A1 (de) *	2004-09-02	2006-03-09	Biotronik Vi Patent Ag	Signalverarbeitungsvorrichtung für physiologische Signale
WO2006053227A2 (en)	2004-11-10	2006-05-18	Synta Pharmaceuticals Corp.	Il-12 modulatory compounds
JP2006137718A (ja) *	2004-11-12	2006-06-01	Astellas Pharma Inc	インドール若しくはインダゾール誘導体
US7851466B2 (en)	2004-11-19	2010-12-14	Synta Pharmaceuticals Corp.	Pyrimidine compounds and uses thereof
UA90707C2 (en)	2005-04-06	2010-05-25	Астразенека Аб	Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
AR053347A1 (es)	2005-04-06	2007-05-02	Astrazeneca Ab	Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
US7858645B2 (en) *	2006-11-01	2010-12-28	Hoffmann-La Roche Inc.	Indazole derivatives
CN101074208A (zh) *	2007-06-29	2007-11-21	方炳良	吲哚衍生物的制备方法
WO2009109613A2 (en) *	2008-03-07	2009-09-11	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
EP2262777B8 (en) *	2008-03-07	2016-05-04	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1 and cx3cr1
HRP20191953T8 (hr) *	2008-03-07	2021-06-25	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	DERIVATI 1-BENZIL-3-HIDROKSIMETILINDAZOLA I NJIHOVA UPORABA U LIJEČENJU BOLESTI KOJE SE BAZIRAJU NA EKSPRESIJI MCP-1, CX3CR1 i P40
WO2010148050A2 (en) *	2009-06-16	2010-12-23	Curna, Inc.	Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
EA019060B1 (ru) *	2009-08-03	2013-12-30	Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.	Способ получения 1-бензил-3-гидроксиметил-1н-индазола и его производных и необходимые промежуточные соединения с магнием
UA108742C2 (uk)	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1

2009
- 2009-03-05 HR HRP20191953TT patent/HRP20191953T8/hr unknown
- 2009-03-05 MX MX2010009625A patent/MX2010009625A/es active IP Right Grant
- 2009-03-05 BR BRPI0907974-2A patent/BRPI0907974A2/pt not_active IP Right Cessation
- 2009-03-05 ES ES09718483T patent/ES2753149T3/es active Active
- 2009-03-05 LT LT09718483T patent/LT2262778T/lt unknown
- 2009-03-05 EP EP09718483.2A patent/EP2262778B8/en active Active
- 2009-03-05 JP JP2010549145A patent/JP5509100B2/ja active Active
- 2009-03-05 DK DK09718483.2T patent/DK2262778T5/da active
- 2009-03-05 CN CN2009801068437A patent/CN101965337B/zh not_active Expired - Fee Related
- 2009-03-05 US US12/865,792 patent/US8461194B2/en not_active Expired - Fee Related
- 2009-03-05 PT PT97184832T patent/PT2262778T/pt unknown
- 2009-03-05 GE GEAP200911964A patent/GEP20135927B/en unknown
- 2009-03-05 KR KR1020107019965A patent/KR101640844B1/ko not_active Expired - Fee Related
- 2009-03-05 SI SI200932007T patent/SI2262778T1/sl unknown
- 2009-03-05 PL PL09718483T patent/PL2262778T3/pl unknown
- 2009-03-05 WO PCT/EP2009/052588 patent/WO2009109616A2/en not_active Ceased
- 2009-03-05 EA EA201071039A patent/EA018976B1/ru not_active IP Right Cessation
- 2009-03-05 SG SG2013013131A patent/SG188178A1/en unknown
- 2009-03-05 HU HUE09718483A patent/HUE047318T2/hu unknown
- 2009-03-05 CA CA2714436A patent/CA2714436C/en not_active Expired - Fee Related
- 2009-03-05 AU AU2009221087A patent/AU2009221087B2/en not_active Ceased
- 2009-03-06 AR ARP090100802A patent/AR070812A1/es unknown
- 2009-05-03 UA UAA201009901A patent/UA103609C2/uk unknown
2010
- 2010-07-29 IL IL207277A patent/IL207277A/en not_active IP Right Cessation
2013
- 2013-05-21 US US13/898,950 patent/US9255073B2/en not_active Expired - Fee Related
2019
- 2019-11-18 CY CY20191101210T patent/CY1122349T1/el unknown

Also Published As

Publication number	Publication date
WO2009109616A3 (en)	2009-12-10
MX2010009625A (es)	2010-09-28
DK2262778T5 (da)	2020-06-08
HRP20191953T1 (hr)	2020-01-24
PT2262778T (pt)	2019-11-19
CA2714436A1 (en)	2009-09-11
LT2262778T (lt)	2019-11-11
CA2714436C (en)	2017-06-27
IL207277A (en)	2015-03-31
WO2009109616A8 (en)	2010-08-12
SI2262778T1 (sl)	2019-12-31
JP5509100B2 (ja)	2014-06-04
BRPI0907974A2 (pt)	2015-08-04
IL207277A0 (en)	2010-12-30
AU2009221087B2 (en)	2013-12-05
EP2262778A2 (en)	2010-12-22
AU2009221087A1 (en)	2009-09-11
HUE047318T2 (hu)	2020-04-28
DK2262778T3 (da)	2019-11-18
US20110082141A1 (en)	2011-04-07
EA201071039A1 (ru)	2011-02-28
SG188178A1 (en)	2013-03-28
KR101640844B1 (ko)	2016-07-19
CN101965337B (zh)	2013-11-06
CN101965337A (zh)	2011-02-02
ES2753149T3 (es)	2020-04-07
GEP20135927B (en)	2013-10-10
EP2262778B8 (en)	2020-01-01
AR070812A1 (es)	2010-05-05
EA018976B1 (ru)	2013-12-30
JP2011513366A (ja)	2011-04-28
US8461194B2 (en)	2013-06-11
WO2009109616A2 (en)	2009-09-11
US20130267704A1 (en)	2013-10-10
CY1122349T1 (el)	2020-11-25
EP2262778B1 (en)	2019-08-21
KR20100133970A (ko)	2010-12-22
UA103609C2 (en)	2013-11-11
HRP20191953T8 (hr)	2021-06-25
US9255073B2 (en)	2016-02-09

Publication	Publication Date	Title
SI2262778T1 (sl)	2019-12-31	1-benzil-3-hidroksimetilindazolni derivati in njihova uporaba pri zdravljenju bolezni, na osnovi izražanja MCP-1, CXCR1 in P40
IL215579A0 (en)	2011-11-30	Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
IL207278A0 (en)	2010-12-30	1 - benzyl - 3 - hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp - 1, and cx3cr1
IL212856A (en)	2016-09-29	Human antibodies against human tissue factor, conjugates and uses thereof
IL207080A0 (en)	2010-12-30	Azabicyclic carboxamide derivatives, preparation thereof and therapeutic use thereof
IL207078A0 (en)	2010-12-30	Azabicyclic carboxamide derivatives, preparation thereof and therapeutic use thereof
IL213168A0 (en)	2011-07-31	1,2,4-oxadiazole derivatives and their therapeutic use
IL216723A0 (en)	2012-03-01	1,2,4-thiazolidin-3-one derivatives and their use in the treatment of cancer
ZA201100210B (en)	2012-03-28	Pyridino-pyridinone derivatives,preparation thereof,and therapeutic use thereof
IL216967B (en)	2018-06-28	The history of 17-hydroxy-17-pentafluoroethyl-astra-9,4 (10)-diene-11-aryl and their use for the treatment of diseases
PL2148667T3 (pl)	2013-11-29	Stosowanie pochodnych cycloheksanoheksolu w leczeniu chorób oczu
IL217300A0 (en)	2012-02-29	Pyrazole derivatives' prepartion thereof, and therapeutic use thereof
ZA201108106B (en)	2013-07-31	Use of phthalimide derivatives in the treatment of diseases
IL207647A0 (en)	2010-12-30	Use of interleukin-1 conjugates in the treatment of diabetes
IL201426A0 (en)	2010-05-31	Drug combination and its use in the treatment of muscle loss
DK2310383T3 (da)	2012-03-26	2-oxo-alkyl-1-piperazin-2-onderivater, fremstilling deraf og terapeutisk anvendelse deraf
GB0710277D0 (en)	2007-07-11	Use of antivirals in the treatment of medical disorders
IL202474A0 (en)	2010-06-30	1-benzylpyrazole derivatives, preparation thereof and therapeutic use thereof
HK1145323A (en)	2011-04-15	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1