PL2288612T3 - Modulatory receptora GABAA - Google Patents

Modulatory receptora GABAA

Info

Publication number
PL2288612T3
PL2288612T3 PL09726806T PL09726806T PL2288612T3 PL 2288612 T3 PL2288612 T3 PL 2288612T3 PL 09726806 T PL09726806 T PL 09726806T PL 09726806 T PL09726806 T PL 09726806T PL 2288612 T3 PL2288612 T3 PL 2288612T3
Authority
PL
Poland
Prior art keywords
receptor modulators
gabaa receptor
gabaa
modulators
receptor
Prior art date
Application number
PL09726806T
Other languages
English (en)
Inventor
Mogens Nielsen
Tommy Liljefors
Jakob Nilsson
Olov Sterner
Original Assignee
Gabather Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gabather Ab filed Critical Gabather Ab
Publication of PL2288612T3 publication Critical patent/PL2288612T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL09726806T 2008-04-04 2009-04-02 Modulatory receptora GABAA PL2288612T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0800759 2008-04-04
EP09726806.4A EP2288612B1 (en) 2008-04-04 2009-04-02 Gabaa receptor modulators
PCT/SE2009/000176 WO2009123537A1 (en) 2008-04-04 2009-04-02 GABAa RECEPTOR MODULATORS

Publications (1)

Publication Number Publication Date
PL2288612T3 true PL2288612T3 (pl) 2015-12-31

Family

ID=41135804

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09726806T PL2288612T3 (pl) 2008-04-04 2009-04-02 Modulatory receptora GABAA

Country Status (6)

Country Link
US (1) US8809355B2 (pl)
EP (1) EP2288612B1 (pl)
CN (1) CN102046627B (pl)
CA (1) CA2720464C (pl)
PL (1) PL2288612T3 (pl)
WO (1) WO2009123537A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7236458B2 (ja) * 2017-12-19 2023-03-09 ガバテール アクチエボラグ トリアゾロキナゾリノンの合成
CN116806147A (zh) * 2020-10-06 2023-09-26 加巴瑟公司 三唑并喹唑啉酮化合物的脂质制剂
WO2025128933A1 (en) * 2023-12-14 2025-06-19 The Brigham And Women's Hospital, Inc. Gaba-a receptor positive allosteric modulators and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268496B1 (en) * 1990-10-31 2001-07-31 Neurogen Corporation Certain imidazoquinoxalines: a new class of GABA brain receptor ligands
EP0760819B1 (en) * 1994-05-24 2000-07-19 F. Hoffmann-La Roche Ag Tricyclic dicarbonyl derivatives
US5955465A (en) * 1996-03-22 1999-09-21 Neurogen Corporation 1,2,4-triazolo 4,3-c!quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones
KR20000029548A (ko) * 1996-07-25 2000-05-25 더블유. 지. 콜 가바수용체에대한리간드로서의치환된트리아졸로-피리다진유도체
GB9813006D0 (en) * 1998-06-16 1998-08-12 Merck Sharp & Dohme Therapeutic agents
AU2001275014A1 (en) * 2000-05-30 2001-12-11 Neurogen Corporation Imidazoloisoquinolines

Also Published As

Publication number Publication date
US8809355B2 (en) 2014-08-19
CA2720464A1 (en) 2009-10-08
CN102046627A (zh) 2011-05-04
CA2720464C (en) 2017-05-02
EP2288612A4 (en) 2011-04-13
EP2288612B1 (en) 2015-07-29
WO2009123537A1 (en) 2009-10-08
EP2288612A1 (en) 2011-03-02
US20110092525A1 (en) 2011-04-21
CN102046627B (zh) 2013-09-04

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