PL2291380T3 - Proleki nalmefenu - Google Patents

Proleki nalmefenu

Info

Publication number: PL2291380T3
Authority: PL; Poland
Prior art keywords: compounds; nalmefene; disorders; alcohol; prodrugs
Prior art date: 2008-04-24

Application number

PL09733923T

Other languages

English (en)

Inventor

Michel Joseph Maurice André Guillaume

Tim Gaekens

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-24

Filing date

2009-04-23

Publication date

2012-02-29

2009-04-23 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2012-02-29 Publication of PL2291380T3 publication Critical patent/PL2291380T3/pl

Links

WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 title abstract 2
229960005297 nalmefene Drugs 0.000 title abstract 2
239000000651 prodrug Substances 0.000 title abstract 2
229940002612 prodrug Drugs 0.000 title abstract 2
208000007848 Alcoholism Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
206010012335 Dependence Diseases 0.000 abstract 1
208000026331 Disruptive, Impulse Control, and Conduct disease Diseases 0.000 abstract 1
208000001613 Gambling Diseases 0.000 abstract 1
208000030990 Impulse-control disease Diseases 0.000 abstract 1
206010034158 Pathological gambling Diseases 0.000 abstract 1
206010001584 alcohol abuse Diseases 0.000 abstract 1
201000007930 alcohol dependence Diseases 0.000 abstract 1
208000025746 alcohol use disease Diseases 0.000 abstract 1
238000001311 chemical methods and process Methods 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
201000009032 substance abuse Diseases 0.000 abstract 1
231100000736 substance abuse Toxicity 0.000 abstract 1
208000011117 substance-related disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL09733923T 2008-04-24 2009-04-23 Proleki nalmefenu PL2291380T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08155094		2008-04-24
PCT/EP2009/054882 WO2009130272A1 (en)	2008-04-24	2009-04-23	Nalmefene prodrugs
EP09733923A EP2291380B1 (en)	2008-04-24	2009-04-23	Nalmefene prodrugs

Publications (1)

Publication Number	Publication Date
PL2291380T3 true PL2291380T3 (pl)	2012-02-29

Family

ID=39816976

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL09733923T PL2291380T3 (pl)	2008-04-24	2009-04-23	Proleki nalmefenu

Country Status (19)

Country	Link
US (1)	US8440686B2 (pl)
EP (1)	EP2291380B1 (pl)
JP (1)	JP6009764B2 (pl)
KR (1)	KR101598137B1 (pl)
CN (1)	CN102066381A (pl)
AT (1)	ATE523512T1 (pl)
AU (1)	AU2009239929B2 (pl)
CA (1)	CA2722246C (pl)
CY (1)	CY1112295T1 (pl)
DK (1)	DK2291380T3 (pl)
ES (1)	ES2373364T3 (pl)
HR (1)	HRP20110824T1 (pl)
ME (1)	ME01319B (pl)
PL (1)	PL2291380T3 (pl)
PT (1)	PT2291380E (pl)
RS (1)	RS52041B (pl)
RU (1)	RU2495042C2 (pl)
SI (1)	SI2291380T1 (pl)
WO (1)	WO2009130272A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2019086017A1 (en)	2017-11-03	2019-05-09	Nirsum Laboratories, Inc.	Opioid receptor antagonist prodrugs
TW202015684A (zh)	2018-06-21	2020-05-01	景凱生物科技股份有限公司	那曲酮、納美芬及其衍生物之前藥
CA3139168A1 (en) *	2019-05-07	2020-11-12	Nirsum Laboratories, Inc.	Opioid receptor antagonist prodrugs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4673679A (en) *	1986-05-14	1987-06-16	E. I. Du Pont De Nemours And Company	Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US5086058A (en) *	1990-06-04	1992-02-04	Alko Ltd.	Method for treating alcoholism with nalmefene
JPH06271578A (ja) *	1993-03-15	1994-09-27	Natl Sci Council	鎮痛剤ナルブフィン前薬の誘導体
DE69427551T2 (de) *	1993-03-15	2002-05-16	National Science Council, Taipeh/T'ai-Pei	Nalbuphinester und diese enthaltende Arzneimittel mit verzögerter Wirkstoffabgabe
US5869669A (en) *	1996-07-26	1999-02-09	Penick Corporation	Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
HUP0401022A3 (en) *	2001-08-14	2006-11-28	Biotie Therapies Corp	Method for the preparation of pharmaceutical compositions containing opioid antagonist for treating alcoholism or alcohol abuse
US20040033253A1 (en) *	2002-02-19	2004-02-19	Ihor Shevchuk	Acyl opioid antagonists
US7759358B2 (en) *	2003-07-23	2010-07-20	Crooks Peter A	Oral bioavailable prodrugs
WO2008101187A2 (en) *	2007-02-16	2008-08-21	Pharmacofore, Inc.	Pro-drugs of peripheral phenolic opioid antagonists
ATE535528T1 (de) *	2008-04-24	2011-12-15	Janssen Pharmaceutica Nv	Nalmefendiesterprodrugs

2009
- 2009-04-23 AU AU2009239929A patent/AU2009239929B2/en not_active Ceased
- 2009-04-23 RS RS20110534A patent/RS52041B/sr unknown
- 2009-04-23 US US12/937,744 patent/US8440686B2/en not_active Expired - Fee Related
- 2009-04-23 RU RU2010147833/04A patent/RU2495042C2/ru active
- 2009-04-23 CA CA2722246A patent/CA2722246C/en active Active
- 2009-04-23 DK DK09733923.8T patent/DK2291380T3/da active
- 2009-04-23 KR KR1020107025887A patent/KR101598137B1/ko not_active Expired - Fee Related
- 2009-04-23 ME MEP-2011-200A patent/ME01319B/me unknown
- 2009-04-23 JP JP2011505510A patent/JP6009764B2/ja not_active Expired - Fee Related
- 2009-04-23 HR HR20110824T patent/HRP20110824T1/hr unknown
- 2009-04-23 SI SI200930109T patent/SI2291380T1/sl unknown
- 2009-04-23 PT PT09733923T patent/PT2291380E/pt unknown
- 2009-04-23 ES ES09733923T patent/ES2373364T3/es active Active
- 2009-04-23 AT AT09733923T patent/ATE523512T1/de active
- 2009-04-23 CN CN2009801142933A patent/CN102066381A/zh active Pending
- 2009-04-23 PL PL09733923T patent/PL2291380T3/pl unknown
- 2009-04-23 WO PCT/EP2009/054882 patent/WO2009130272A1/en not_active Ceased
- 2009-04-23 EP EP09733923A patent/EP2291380B1/en active Active
2011
- 2011-12-06 CY CY20111101207T patent/CY1112295T1/el unknown

Also Published As

Publication number	Publication date
KR20110004877A (ko)	2011-01-14
CY1112295T1 (el)	2015-12-09
JP2011518805A (ja)	2011-06-30
JP6009764B2 (ja)	2016-10-19
DK2291380T3 (da)	2011-12-05
AU2009239929B2 (en)	2014-02-13
RU2010147833A (ru)	2012-05-27
RU2495042C2 (ru)	2013-10-10
AU2009239929A1 (en)	2009-10-29
CN102066381A (zh)	2011-05-18
WO2009130272A1 (en)	2009-10-29
US20110034502A1 (en)	2011-02-10
RS52041B (sr)	2012-04-30
ES2373364T3 (es)	2012-02-02
CA2722246A1 (en)	2009-10-29
HRP20110824T1 (hr)	2012-01-31
ME01319B (me)	2013-12-20
EP2291380B1 (en)	2011-09-07
ATE523512T1 (de)	2011-09-15
PT2291380E (pt)	2011-12-22
CA2722246C (en)	2016-06-21
US8440686B2 (en)	2013-05-14
KR101598137B1 (ko)	2016-02-29
EP2291380A1 (en)	2011-03-09
SI2291380T1 (sl)	2012-01-31

Publication	Publication Date	Title
PL2307420T3 (pl)	2012-04-30	Proleki diestrowe nalmefenu
WO2013163190A8 (en)	2014-11-27	Dna-pk inhibitors
MY191669A (en)	2022-07-06	Pyrazolyl quinoxaline kinase inihibitors
SG179120A1 (en)	2012-05-30	Novel compounds
WO2011082270A3 (en)	2011-11-17	Substituted imidazopyridinyl-aminopyridine compounds
WO2011082273A3 (en)	2011-10-20	Substituted pyrrolo-aminopyrimidine compounds
WO2010147898A3 (en)	2011-05-12	Small molecule inhibitors of spleen tyrosine kinase (syk)
WO2011082267A3 (en)	2011-11-24	Substituted triazolo-pyrazine compounds
WO2011082266A3 (en)	2011-10-13	Substituted heterocyclic compounds
IN2012DN02081A (pl)	2015-08-21
MX349004B (es)	2017-07-06	Nuevos compuestos.
NZ590650A (en)	2013-01-25	Buprenorphine analogs
PH12013502674A1 (en)	2014-02-10	Compounds for the treatment of addiction
MX2014013090A (es)	2014-12-08	Derivados de pirrolotriazinona.
TNSN08370A1 (en)	2009-12-29	Tetrahydropyridothienopyrimidine compounds and methods of use thereof
WO2010027424A3 (en)	2010-06-03	9-substituted phenanthrene based tylophorine derivatives
MX2009005938A (es)	2009-06-17	6-oxo-1,6-dihidro-pirimidin-2-ilos en el tratamiento de enfermedades proliferativas.
WO2011082268A3 (en)	2011-10-20	Substituted naphthalenyl-pyrimidine compounds
PL2291380T3 (pl)	2012-02-29	Proleki nalmefenu
WO2010027458A3 (en)	2010-06-17	Pdk inhibitor compounds and methods of use thereof
UA103197C2 (uk)	2013-09-25	Застосування ніфуртимоксу для лікування хвороб, спричинених трихомонадами
WO2011082271A3 (en)	2011-11-17	Substituted triazolo-pyrimidine compounds
WO2009126335A3 (en)	2010-01-14	Ant2 inhibitor compounds and methods of use thereof
WO2009151495A3 (en)	2010-08-26	Oxazole compounds, compositions and methods of use
WO2011082269A3 (en)	2011-11-10	Substituted benzo-pyrimido-tetrazolo-diazepine compounds