PL2300459T3 - Nowe fenylopirazynony jako inhibitory kinazy - Google Patents

Nowe fenylopirazynony jako inhibitory kinazy

Info

Publication number: PL2300459T3
Authority: PL; Poland
Prior art keywords: phenylpyrazinones; novel; kinase inhibitors; kinase; inhibitors
Prior art date: 2008-07-02

Application number

PL09772333T

Other languages

English (en)

Inventor

Nolan James Dewdney

Yan Lou

Eric Brian Sjogren

Michael Soth

Zachary Kevin Sweeney

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-02

Filing date

2009-06-22

Publication date

2013-10-31

2009-06-22 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2013-10-31 Publication of PL2300459T3 publication Critical patent/PL2300459T3/pl

Links

SYPKOIOSVWYKHO-UHFFFAOYSA-N 3-phenyl-1h-pyrazin-2-one Chemical class O=C1NC=CN=C1C1=CC=CC=C1 SYPKOIOSVWYKHO-UHFFFAOYSA-N 0.000 title 1
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Hematology (AREA)
Neurology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL09772333T 2008-07-02 2009-06-22 Nowe fenylopirazynony jako inhibitory kinazy PL2300459T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US7751008P	2008-07-02	2008-07-02
PCT/EP2009/057707 WO2010000633A1 (en)	2008-07-02	2009-06-22	Novel phenylpyrazinones as kinase inhibitors
EP09772333.2A EP2300459B1 (en)	2008-07-02	2009-06-22	Novel phenylpyrazinones as kinase inhibitors

Publications (1)

Publication Number	Publication Date
PL2300459T3 true PL2300459T3 (pl)	2013-10-31

Family

ID=40940244

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL09772333T PL2300459T3 (pl)	2008-07-02	2009-06-22	Nowe fenylopirazynony jako inhibitory kinazy

Country Status (24)

Country	Link
US (1)	US8536166B2 (pl)
EP (1)	EP2300459B1 (pl)
JP (1)	JP5490789B2 (pl)
KR (2)	KR101523451B1 (pl)
CN (1)	CN102083819B (pl)
AR (1)	AR072545A1 (pl)
AU (1)	AU2009265813B2 (pl)
BR (1)	BRPI0913879A2 (pl)
CA (1)	CA2728683C (pl)
CL (1)	CL2010001608A1 (pl)
CY (1)	CY1114223T1 (pl)
DK (1)	DK2300459T3 (pl)
ES (1)	ES2420854T3 (pl)
HR (1)	HRP20130698T1 (pl)
IL (1)	IL209729A0 (pl)
MX (1)	MX2010013478A (pl)
PE (1)	PE20110164A1 (pl)
PL (1)	PL2300459T3 (pl)
PT (1)	PT2300459E (pl)
RU (1)	RU2507202C2 (pl)
SI (1)	SI2300459T1 (pl)
TW (1)	TWI401083B (pl)
WO (1)	WO2010000633A1 (pl)
ZA (1)	ZA201008808B (pl)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8299077B2 (en) *	2009-03-02	2012-10-30	Roche Palo Alto Llc	Inhibitors of Bruton's tyrosine kinase
ES2513915T3 (es) *	2009-04-24	2014-10-27	F. Hoffmann-La Roche Ag	Inhibidores de la tirosina quinasa de Bruton
CA3034600C (en) *	2010-05-07	2020-11-10	Genentech, Inc.	Pyridone and aza-pyridone compounds and methods of use
AR082590A1 (es) *	2010-08-12	2012-12-19	Hoffmann La Roche	Inhibidores de la tirosina-quinasa de bruton
CA2809836C (en)	2010-09-01	2019-01-15	Gilead Connecticut, Inc.	Pyridinones/pyrazinones, method of making, and method of use thereof for the treatment of disorders mediated by bruton's tyrosine kinase
ES2548414T3 (es)	2011-07-08	2015-10-16	Novartis Ag	Novedosos derivados de pirrolo pirimidina
TW201326171A (zh)	2011-11-03	2013-07-01	Genentech Inc	烷基化哌□化合物
CA2852964A1 (en)	2011-11-03	2013-05-10	F. Hoffmann-La Roche Ag	Bicyclic piperazine compounds
UA111756C2 (uk)	2011-11-03	2016-06-10	Ф. Хоффманн-Ля Рош Аг	Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
US8669251B2 (en)	2011-11-03	2014-03-11	Genentech, Inc.	8-fluorophthalazin-1(2H)-one compounds
WO2013148603A1 (en)	2012-03-27	2013-10-03	Takeda Pharmaceutical Company Limited	Cinnoline derivatives as as btk inhibitors
CN104662018B (zh)	2012-04-20	2017-10-24	阿迪维纳斯治疗有限公司	取代的杂双环化合物、组合物及其医疗应用
US9499548B2 (en) *	2012-09-13	2016-11-22	Hoffmann-La Roche Inc.	Inhibitors of bruton's tyrosine kinase
WO2014108820A1 (en) *	2013-01-08	2014-07-17	Aurigene Discovery Technologies Limited	Substituted 2-pyrazinone derivatives as kinase inhibitors
WO2014125410A1 (en) *	2013-02-12	2014-08-21	Aurigene Discovery Technologies Limited	N-substituted heterocyclic derivatives as kinase inhibitors
EP2964627B1 (en)	2013-03-05	2017-03-01	F. Hoffmann-La Roche AG	Inhibitors of bruton's tyrosine kinase
JO3377B1 (ar)	2013-03-11	2019-03-13	Takeda Pharmaceuticals Co	مشتقات بيريدينيل وبيريدينيل مندمج
PL2989106T3 (pl)	2013-04-25	2017-08-31	Beigene, Ltd.	Połączone związki heterocykliczne jako inhibitory kinazy białkowej
CN104177338B (zh) *	2013-05-22	2018-04-03	南京勇山生物科技有限公司	一类布鲁顿激酶抑制剂
CN104211703B (zh) *	2013-05-30	2018-04-03	南京勇山生物科技有限公司	一类作为布鲁顿激酶抑制剂的稠杂环化合物
HK1214820A1 (zh) *	2013-07-03	2016-08-05	豪夫迈．罗氏有限公司	杂芳基吡啶酮和氮杂-吡啶酮酰胺化合物
WO2015012149A1 (ja)	2013-07-26	2015-01-29	カルナバイオサイエンス株式会社	新規トリアジン誘導体
PL3027171T3 (pl)	2013-07-30	2020-08-24	Gilead Connecticut, Inc.	Formulacja inhibitorów syk
EA029281B1 (ru)	2013-07-30	2018-03-30	Джилид Коннектикут, Инк.	Полиморф ингибиторов syk
SMT202300039T1 (it)	2013-09-13	2023-03-17	Beigene Switzerland Gmbh	Anticorpi anti-pd1 e loro uso come terapia e per diagnostica
US9512084B2 (en)	2013-11-29	2016-12-06	Novartis Ag	Amino pyrimidine derivatives
CN105793251B (zh)	2013-12-05	2018-10-12	豪夫迈·罗氏有限公司	具有亲电子官能性的杂芳基吡啶酮和氮杂-吡啶酮化合物
TWI662037B (zh)	2013-12-23	2019-06-11	美商基利科學股份有限公司	脾酪胺酸激酶抑制劑
TWI726608B (zh)	2014-07-03	2021-05-01	英屬開曼群島商百濟神州有限公司	抗pd-l1抗體及其作為治療及診斷之用途
EP3042903B1 (en) *	2015-01-06	2019-08-14	Impetis Biosciences Ltd.	Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof
US20180140602A1 (en)	2015-04-07	2018-05-24	Novartis Ag	Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives
JP7305352B2 (ja)	2016-03-31	2023-07-10	武田薬品工業株式会社	イソキノリニルトリアゾロン錯体
WO2018007885A1 (en)	2016-07-05	2018-01-11	Beigene, Ltd.	COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER
IL293319B1 (en)	2016-08-16	2026-01-01	Beone Medicines Ltd	Crystal structure of s)–7–(1–acryloylpiperidin–4–yl)–2–(4–)phenoxyphenyl)–4,5,6,7–tetra–hydropyrazolo(1,5–a)pyrimidine–3–carboxamide, methods of preparation and uses thereof
CN110087680B (zh)	2016-08-19	2024-03-19	百济神州有限公司	使用包含btk抑制剂的组合产品治疗癌症
CN109982687A (zh)	2016-09-19	2019-07-05	梅制药公司	联合疗法
US10842878B2 (en)	2016-11-22	2020-11-24	Dana-Farber Cancer Institute, Inc.	Degradation of Bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use
EP3573989A4 (en)	2017-01-25	2020-11-18	Beigene, Ltd.	CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) PIPERIDIN-4-YL) -2- (4-PHENOXYPHENYL) -4, 5, 6, 7-TETRAHY DROPYRAZOLO [1, 5-A ] PYRIMIDINE-3-CARBOXAMIDE, PREPARATION AND ASSOCIATED USES
EP3645569A4 (en)	2017-06-26	2021-03-24	BeiGene, Ltd.	IMMUNOTHERAPY FOR LIVER CELL CARCINOMA
WO2019034009A1 (en)	2017-08-12	2019-02-21	Beigene, Ltd.	BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY
KR20220070056A (ko)	2017-08-25	2022-05-27	길리애드 사이언시즈, 인코포레이티드	Syk 억제제의 다형체
US11786529B2 (en)	2017-11-29	2023-10-17	Beigene Switzerland Gmbh	Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
AU2020225455A1 (en)	2019-02-22	2021-09-09	Kronos Bio, Inc.	Solid forms of condensed pyrazines as Syk inhibitors
EP3981399A4 (en)	2019-06-10	2023-05-31	BeiGene Switzerland GmbH	ORAL SOLID TABLET WITH A TYROSINE KINAS INHIBITOR AND METHOD OF MANUFACTURE THEREOF
US11786531B1 (en)	2022-06-08	2023-10-17	Beigene Switzerland Gmbh	Methods of treating B-cell proliferative disorder

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1070056T1 (en) *	1998-03-14	2004-12-31	Altana Pharma Ag	Phthalazinone pde iii/iv inhibitors
RU2289581C2 (ru) *	2000-09-15	2006-12-20	Анормед, Инк.	Гетероциклические соединения, содержащая их фармацевтическая композиция и их применение
CA2541667A1 (en) *	2003-10-14	2005-04-21	Pharmacia Corporation	Substituted pyrazinone compounds for the treatment of inflammation
AU2006223409B2 (en) *	2005-03-10	2011-07-21	Gilead Connecticut, Inc.	Certain substituted amides, method of making, and method of use thereof
WO2006124731A2 (en)	2005-05-12	2006-11-23	Irm Llc	Compounds and compositions as protein kinase inhibitors
AU2006279992A1 (en)	2005-08-09	2007-02-22	Irm Llc	Compounds and compositions as protein kinase inhibitors
WO2007027729A1 (en)	2005-08-29	2007-03-08	Vertex Pharmaceuticals Incorporated	3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
JP5112317B2 (ja)	2005-08-29	2013-01-09	バーテックスファーマシューティカルズインコーポレイテッド	非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
AU2006285038A1 (en)	2005-08-29	2007-03-08	Vertex Pharmaceuticals Incorporated	3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
ZA200802977B (en) *	2005-09-09	2009-08-26	Vertex Pharma	Bicyclic derivatives as modulators of voltage gated ion channels
WO2007107469A1 (en) *	2006-03-20	2007-09-27	F. Hoffmann-La Roche Ag	Methods of inhibiting btk and syk protein kinases
JP2009537520A (ja)	2006-05-15	2009-10-29	アイアールエム・リミテッド・ライアビリティ・カンパニー	Ｆｇｆ受容体キナーゼ阻害剤のための組成物および方法
US7838523B2 (en)	2006-09-11	2010-11-23	Cgi Pharmaceuticals, Inc.	Certain substituted amides, method of making, and method of use thereof
JP2010502751A (ja) *	2006-09-11	2010-01-28	シージーアイファーマシューティカルズ，インコーポレイティド	キナーゼ阻害物質、およびキナーゼ阻害物質の使用および同定方法
AR063706A1 (es) *	2006-09-11	2009-02-11	Cgi Pharmaceuticals Inc	Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
PE20081370A1 (es)	2006-09-11	2008-11-28	Cgi Pharmaceuticals Inc	Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas
CL2008002793A1 (es)	2007-09-20	2009-09-04	Cgi Pharmaceuticals Inc	Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras
JP5587193B2 (ja)	2007-10-23	2014-09-10	エフ．ホフマン−ラロシュアーゲー	新規なキナーゼ阻害剤
PE20100851A1 (es) *	2008-06-24	2011-01-31	Hoffmann La Roche	PIRIDIN-2-ONAS Y PIRIDAZIN-3-ONAS SUSTITUIDAS COMO INHIBIDORES DE Btk
ES2542835T3 (es) *	2009-01-08	2015-08-12	Resverlogix Corporation	Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
US8299077B2 (en) *	2009-03-02	2012-10-30	Roche Palo Alto Llc	Inhibitors of Bruton's tyrosine kinase

2009
- 2009-06-22 PL PL09772333T patent/PL2300459T3/pl unknown
- 2009-06-22 PE PE2010001208A patent/PE20110164A1/es not_active Application Discontinuation
- 2009-06-22 KR KR1020137016860A patent/KR101523451B1/ko not_active Expired - Fee Related
- 2009-06-22 EP EP09772333.2A patent/EP2300459B1/en not_active Not-in-force
- 2009-06-22 DK DK09772333.2T patent/DK2300459T3/da active
- 2009-06-22 AU AU2009265813A patent/AU2009265813B2/en not_active Expired - Fee Related
- 2009-06-22 KR KR1020107029738A patent/KR101320763B1/ko not_active Expired - Fee Related
- 2009-06-22 JP JP2011515329A patent/JP5490789B2/ja not_active Expired - Fee Related
- 2009-06-22 MX MX2010013478A patent/MX2010013478A/es active IP Right Grant
- 2009-06-22 SI SI200930631T patent/SI2300459T1/sl unknown
- 2009-06-22 BR BRPI0913879A patent/BRPI0913879A2/pt not_active IP Right Cessation
- 2009-06-22 HR HRP20130698AT patent/HRP20130698T1/hr unknown
- 2009-06-22 PT PT97723332T patent/PT2300459E/pt unknown
- 2009-06-22 ES ES09772333T patent/ES2420854T3/es active Active
- 2009-06-22 CN CN200980125623.9A patent/CN102083819B/zh not_active Expired - Fee Related
- 2009-06-22 WO PCT/EP2009/057707 patent/WO2010000633A1/en not_active Ceased
- 2009-06-22 CA CA2728683A patent/CA2728683C/en not_active Expired - Fee Related
- 2009-06-22 RU RU2011103234/04A patent/RU2507202C2/ru not_active IP Right Cessation
- 2009-06-30 TW TW098122087A patent/TWI401083B/zh not_active IP Right Cessation
- 2009-07-01 AR ARP090102453A patent/AR072545A1/es not_active Application Discontinuation
- 2009-07-01 US US12/459,595 patent/US8536166B2/en not_active Expired - Fee Related
2010
- 2010-12-02 IL IL209729A patent/IL209729A0/en unknown
- 2010-12-07 ZA ZA2010/08808A patent/ZA201008808B/en unknown
- 2010-12-29 CL CL2010001608A patent/CL2010001608A1/es unknown
2013
- 2013-08-01 CY CY20131100661T patent/CY1114223T1/el unknown

Also Published As

Publication number	Publication date
ES2420854T3 (es)	2013-08-27
MX2010013478A (es)	2010-12-20
CA2728683A1 (en)	2010-01-07
CA2728683C (en)	2017-05-02
US8536166B2 (en)	2013-09-17
RU2011103234A (ru)	2012-08-10
BRPI0913879A2 (pt)	2019-09-24
US20100004231A1 (en)	2010-01-07
KR101320763B1 (ko)	2013-10-21
CY1114223T1 (el)	2016-08-31
AU2009265813B2 (en)	2014-04-10
JP2011526279A (ja)	2011-10-06
IL209729A0 (en)	2011-02-28
SI2300459T1 (sl)	2013-07-31
JP5490789B2 (ja)	2014-05-14
KR101523451B1 (ko)	2015-05-27
PE20110164A1 (es)	2011-03-28
EP2300459A1 (en)	2011-03-30
TW201004938A (en)	2010-02-01
CN102083819B (zh)	2014-07-09
PT2300459E (pt)	2013-07-04
AR072545A1 (es)	2010-09-08
KR20110020872A (ko)	2011-03-03
HRP20130698T1 (en)	2013-10-11
DK2300459T3 (da)	2013-09-02
KR20130093156A (ko)	2013-08-21
ZA201008808B (en)	2011-10-26
AU2009265813A1 (en)	2010-01-07
RU2507202C2 (ru)	2014-02-20
EP2300459B1 (en)	2013-05-29
WO2010000633A1 (en)	2010-01-07
CN102083819A (zh)	2011-06-01
CL2010001608A1 (es)	2011-05-13
TWI401083B (zh)	2013-07-11

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