PL2300489T3 - Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych - Google Patents

Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych

Info

Publication number
PL2300489T3
PL2300489T3 PL09759550.8T PL09759550T PL2300489T3 PL 2300489 T3 PL2300489 T3 PL 2300489T3 PL 09759550 T PL09759550 T PL 09759550T PL 2300489 T3 PL2300489 T3 PL 2300489T3
Authority
PL
Poland
Prior art keywords
alkynyl
preparing
methods
related compounds
hydroxy steroids
Prior art date
Application number
PL09759550.8T
Other languages
English (en)
Inventor
Steven K. White
Yu Ge
Yujin Huang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2300489T3 publication Critical patent/PL2300489T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL09759550.8T 2008-06-06 2009-06-05 Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych PL2300489T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5965808P 2008-06-06 2008-06-06

Publications (1)

Publication Number Publication Date
PL2300489T3 true PL2300489T3 (pl) 2016-11-30

Family

ID=41398563

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09759550.8T PL2300489T3 (pl) 2008-06-06 2009-06-05 Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych

Country Status (12)

Country Link
US (4) US8309746B2 (pl)
EP (1) EP2300489B1 (pl)
JP (2) JP5709743B2 (pl)
CN (1) CN102046647A (pl)
AU (1) AU2009256009B2 (pl)
CA (1) CA2724130C (pl)
DK (1) DK2300489T3 (pl)
ES (1) ES2562083T3 (pl)
HU (1) HUE028327T2 (pl)
IL (1) IL209693A (pl)
PL (1) PL2300489T3 (pl)
WO (1) WO2009149392A1 (pl)

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DK2273994T3 (en) * 2008-04-03 2016-02-01 Neurmedix Inc PHARMACEUTICAL FORMS OF A MEDICINE
HUE028327T2 (en) 2008-06-06 2017-02-28 Neurmedix Inc A process for the preparation of 17-alkynyl-7-hydroxy steroids and related compounds
GB2480632A (en) 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
CN103347525A (zh) * 2010-12-15 2013-10-09 哈博生物科学公司 制备3α-氧取代的甾族化合物的方法及化合物
US20120252774A1 (en) * 2010-12-17 2012-10-04 White Steven K Steroid tetrol solid state forms - 2
WO2013092668A1 (en) * 2011-12-23 2013-06-27 Crystal Pharma, S.A.U. Process for alkynylating 16-substituted-17-keto steroids
CN102603839A (zh) * 2012-01-13 2012-07-25 宜城市共同药业有限公司 去氢表雄酮的制备方法
CN103360458B (zh) * 2012-03-26 2015-05-20 信泰制药（苏州）有限公司 一种阿比特龙的合成方法
CN104292287A (zh) * 2013-07-16 2015-01-21 天津金耀集团有限公司 一种17-乙炔基-16-烯甾体衍生物的合成方法
CN104292288A (zh) * 2013-07-16 2015-01-21 天津金耀集团有限公司 一种17-乙炔基-16-烯甾体衍生物的制备方法
CN105622713B (zh) * 2014-10-27 2020-02-18 天津金耀集团有限公司 一种甾体11位酮基还原工艺
WO2019041078A1 (en) * 2017-08-28 2019-03-07 Zhejiang Jiachi Pharmaceutical Development Ltd. ASYMMETRIC SYNTHESIS AND USES OF COMPOUNDS IN TREATMENT OF DISEASES
CN114478672B (zh) * 2022-01-27 2024-06-14 浙江仙居君业药业有限公司 一种he3286的合成方法
CN120829946A (zh) * 2024-04-19 2025-10-24 湖北大学 一种酶法与化学法相结合合成甾体he3286的方法
CN120484042B (zh) * 2025-05-16 2026-01-30 中国人民解放军军事科学院军事医学研究院 一种he3286的合成方法

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ATE171186T1 (de) 1992-01-28 1998-10-15 Schering Corp Neue steroid-zwischenprodukte und verfahren zu ihrer herstellung
US5922701A (en) * 1992-05-01 1999-07-13 University Of Utah Research Foundation Method for enhancing or accelerating re-epithelialization or re-endothelialization of a tissue
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
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US20060079492A1 (en) 1999-10-25 2006-04-13 Ahlem Clarence N Compositions and treatment methods
US20080015174A1 (en) * 1998-11-24 2008-01-17 Reading Christopher L Metabolic Disease Treatments
US20070129282A1 (en) * 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
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CA2550299C (en) * 2003-12-22 2010-03-30 Christopher R. Roberts Process for fluorocytidine derivatives
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US20080221074A1 (en) * 2006-11-17 2008-09-11 Jaime Flores-Riveros Drug Screen and Treatment Method
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DK2273994T3 (en) 2008-04-03 2016-02-01 Neurmedix Inc PHARMACEUTICAL FORMS OF A MEDICINE
HUE028327T2 (en) 2008-06-06 2017-02-28 Neurmedix Inc A process for the preparation of 17-alkynyl-7-hydroxy steroids and related compounds
US20100075937A1 (en) * 2008-09-24 2010-03-25 Hollis-Eden Pharmaceuticals, Inc. Patient populations and treatment methods

Also Published As

Publication number Publication date
DK2300489T3 (en) 2016-02-15
US20090326251A1 (en) 2009-12-31
CN102046647A (zh) 2011-05-04
US20180215778A1 (en) 2018-08-02
US8309746B2 (en) 2012-11-13
IL209693A (en) 2017-04-30
AU2009256009A8 (en) 2011-11-17
US20130066087A1 (en) 2013-03-14
AU2009256009A1 (en) 2009-12-10
JP2011522836A (ja) 2011-08-04
US20180079775A9 (en) 2018-03-22
AU2009256009B2 (en) 2014-02-06
CA2724130A1 (en) 2009-12-10
CA2724130C (en) 2016-04-26
EP2300489A1 (en) 2011-03-30
EP2300489B1 (en) 2015-11-11
JP2014231526A (ja) 2014-12-11
US9163059B2 (en) 2015-10-20
US9994608B2 (en) 2018-06-12
ES2562083T3 (es) 2016-03-02
IL209693A0 (en) 2011-02-28
US20160039863A1 (en) 2016-02-11
HUE028327T2 (en) 2017-02-28
EP2300489A4 (en) 2012-03-21
JP5709743B2 (ja) 2015-04-30
WO2009149392A1 (en) 2009-12-10

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