PL2300614T3 - Sposoby i kompozycje do leczenia zaburzeń mitochondrialnych - Google Patents

Sposoby i kompozycje do leczenia zaburzeń mitochondrialnych

Info

Publication number
PL2300614T3
PL2300614T3 PL09707233T PL09707233T PL2300614T3 PL 2300614 T3 PL2300614 T3 PL 2300614T3 PL 09707233 T PL09707233 T PL 09707233T PL 09707233 T PL09707233 T PL 09707233T PL 2300614 T3 PL2300614 T3 PL 2300614T3
Authority
PL
Poland
Prior art keywords
compositions
treatment
methods
mitochondrial disorders
mitochondrial
Prior art date
Application number
PL09707233T
Other languages
English (en)
Inventor
Haya Galski-Lorberboum
Matan Rapoport
Oriy Elpeleg
Ann Saada
Original Assignee
Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd
Hadasit Med Res Service
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd, Hadasit Med Res Service filed Critical Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd
Publication of PL2300614T3 publication Critical patent/PL2300614T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y108/00—Oxidoreductases acting on sulfur groups as donors (1.8)
    • C12Y108/01—Oxidoreductases acting on sulfur groups as donors (1.8) with NAD+ or NADP+ as acceptor (1.8.1)
    • C12Y108/01004—Dihydrolipoyl dehydrogenase (1.8.1.4), i.e. lipoamide-dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
PL09707233T 2008-02-04 2009-02-03 Sposoby i kompozycje do leczenia zaburzeń mitochondrialnych PL2300614T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2593108P 2008-02-04 2008-02-04
PCT/IL2009/000126 WO2009098682A2 (en) 2008-02-04 2009-02-03 Methods and compositions for treatment of mitochondrial disorders
EP09707233.4A EP2300614B1 (en) 2008-02-04 2009-02-03 Methods and compositions for treatment of mitochondrial disorders

Publications (1)

Publication Number Publication Date
PL2300614T3 true PL2300614T3 (pl) 2016-04-29

Family

ID=40723152

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09707233T PL2300614T3 (pl) 2008-02-04 2009-02-03 Sposoby i kompozycje do leczenia zaburzeń mitochondrialnych

Country Status (10)

Country Link
US (3) US20110177051A1 (pl)
EP (1) EP2300614B1 (pl)
DK (1) DK2300614T3 (pl)
ES (1) ES2560097T3 (pl)
HR (1) HRP20160024T1 (pl)
HU (1) HUE026750T2 (pl)
PL (1) PL2300614T3 (pl)
PT (1) PT2300614E (pl)
SI (1) SI2300614T1 (pl)
WO (1) WO2009098682A2 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865160B2 (en) 2008-02-08 2014-10-21 University Of South Alabama Treatment of disease conditions via administration of DNA repair enzyme
EP2369000A1 (en) * 2010-03-16 2011-09-28 3T-Science, S.L. Production of peptides and proteins by accumulation in mitochondria
EP2750686B1 (en) 2011-06-17 2017-06-14 Shire Human Genetic Therapies, Inc. Polypeptide comprising frataxin and a c-terminal mitochondria penetrating peptide for use in the treatment of friedreich's ataxia
US10226507B2 (en) * 2012-09-05 2019-03-12 A1M Pharma Ab Alpha-1-microglobulin for use in the treatment of mitochondria-related diseases
US8912147B2 (en) 2013-04-15 2014-12-16 BioBlast Pharma Ltd. Mitochondrial proteins constructs and uses thereof
US10287331B2 (en) 2013-04-15 2019-05-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Mitochondrial proteins constructs and uses thereof
CN111879948A (zh) 2013-10-17 2020-11-03 综合医院公司 鉴定响应于用于自身免疫性疾病的治疗的受试者的方法以及用于治疗该疾病的组合物
US9550981B2 (en) 2014-01-22 2017-01-24 University Of Washington Modified tafazzin proteins and methods of making and using the same
KR101557101B1 (ko) 2014-03-28 2015-10-06 인제대학교 산학협력단 미토콘드리아 타겟팅 시퀀스와 양이온성 올리고펩타이드를 유효성분으로 함유하는 미토콘드리아 약물전달용 담체
CN106536056B (zh) 2014-06-13 2021-07-16 儿童医学中心公司 分离线粒体的产品和方法
EP2992892A1 (en) * 2014-09-05 2016-03-09 Universität zu Köln Fusion protein for use in the treatment of mitochondrial diseases
WO2016094791A1 (en) 2014-12-12 2016-06-16 University Of Washington Methods for treating and preventing cardiomyopathy
EP3355914B1 (en) * 2015-09-29 2024-03-06 The General Hospital Corporation A composition comprising bcg for reducing cholesterol.
US11903974B2 (en) 2015-11-30 2024-02-20 Flagship Pioneering Innovations V, Inc. Methods and compositions relating to chondrisomes from cultured cells
WO2017124037A1 (en) 2016-01-15 2017-07-20 The Children's Medical Center Corporation Therapeutic use of mitochondria and combined mitochondrial agents
WO2017178885A2 (en) 2016-04-12 2017-10-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methylmalonyl coenzyme a mutase (mcm) fusion constructs for the treatment of disorders associated with mcm deficiency

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2530248A1 (en) * 2003-06-25 2005-01-06 Gencia Corporation Modified vectors for organelle transfection
US8507277B2 (en) * 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
WO2005042560A2 (en) * 2003-10-24 2005-05-12 Wake Forest University Health Sciences Non-viral delivery of compounds to mitochondria

Also Published As

Publication number Publication date
EP2300614B1 (en) 2015-10-28
HUE026750T2 (en) 2016-07-28
WO2009098682A3 (en) 2009-10-01
PT2300614E (pt) 2016-03-02
US20170224783A1 (en) 2017-08-10
EP2300614A2 (en) 2011-03-30
US20110177051A1 (en) 2011-07-21
US20180311318A1 (en) 2018-11-01
ES2560097T3 (es) 2016-02-17
SI2300614T1 (sl) 2016-02-29
DK2300614T3 (en) 2016-02-08
WO2009098682A2 (en) 2009-08-13
HRP20160024T1 (hr) 2016-02-12

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