PL2320740T3 - Kompozycje farmaceutyczne klewidypiny oraz sposoby ich wytwarzania z niskim stężeniem zanieczyszczeń - Google Patents

Kompozycje farmaceutyczne klewidypiny oraz sposoby ich wytwarzania z niskim stężeniem zanieczyszczeń

Info

Publication number: PL2320740T3
Authority: PL; Poland
Prior art keywords: clevidipine; methods; same; pharmaceutical compositions; low impurity
Prior art date: 2008-08-01

Application number

PL09803550T

Other languages

English (en)

Inventor

Rajeshwar Motheram

Gopal Krishna

Min Ding

Keith Flood

Kornepati Ramakrishna

Original Assignee

The Medicines Co

Hospira Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-08-01

Filing date

2009-07-29

Publication date

2014-09-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41610719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2320740(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-07-29 Application filed by The Medicines Co, Hospira Inc filed Critical The Medicines Co

2014-09-30 Publication of PL2320740T3 publication Critical patent/PL2320740T3/pl

Links

KPBZROQVTHLCDU-GOSISDBHSA-N clevidipine Chemical group CCCC(=O)OCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@H]1C1=CC=CC(Cl)=C1Cl KPBZROQVTHLCDU-GOSISDBHSA-N 0.000 title 1
229960003597 clevidipine Drugs 0.000 title 1
239000012535 impurity Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Physics & Mathematics (AREA)
Physics & Mathematics (AREA)
Immunology (AREA)
Pathology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL09803550T 2008-08-01 2009-07-29 Kompozycje farmaceutyczne klewidypiny oraz sposoby ich wytwarzania z niskim stężeniem zanieczyszczeń PL2320740T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US8559708P	2008-08-01	2008-08-01
US9377208P	2008-09-03	2008-09-03
PCT/US2009/052127 WO2010014727A1 (en)	2008-08-01	2009-07-29	Pharmaceutical compositions and methods for producing low impurity concentrations of the same
EP09803550.4A EP2320740B1 (en)	2008-08-01	2009-07-29	Pharmaceutical compositions of clevidipine and methods for producing low impurity concentrations of the same

Publications (1)

Publication Number	Publication Date
PL2320740T3 true PL2320740T3 (pl)	2014-09-30

Family

ID=41610719

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL09803550T PL2320740T3 (pl)	2008-08-01	2009-07-29	Kompozycje farmaceutyczne klewidypiny oraz sposoby ich wytwarzania z niskim stężeniem zanieczyszczeń

Country Status (20)

Country	Link
US (6)	US20100113534A1 (pl)
EP (2)	EP2719386A1 (pl)
JP (1)	JP5674660B2 (pl)
KR (1)	KR101772602B1 (pl)
CN (1)	CN102170786B (pl)
AU (1)	AU2009276560B2 (pl)
BR (1)	BRPI0916936B8 (pl)
CA (2)	CA3108961C (pl)
CY (1)	CY1116490T1 (pl)
DK (1)	DK2320740T3 (pl)
EA (1)	EA021336B1 (pl)
ES (1)	ES2468837T3 (pl)
HR (1)	HRP20140434T1 (pl)
MX (1)	MX2011001240A (pl)
NZ (1)	NZ591205A (pl)
PL (1)	PL2320740T3 (pl)
PT (1)	PT2320740E (pl)
SI (1)	SI2320740T1 (pl)
SM (1)	SMT201400081B (pl)
WO (1)	WO2010014727A1 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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CA3108961C (en)	2008-08-01	2024-07-02	Hospira, Inc.	Pharmaceutical compositions comprising clevidipine and methods for producing low concentrations of impurities thereof
WO2012051116A1 (en) *	2010-10-12	2012-04-19	The Medicines Company	Clevidipine emulsion formulations containing antimicrobial agents
US8658676B2 (en)	2010-10-12	2014-02-25	The Medicines Company	Clevidipine emulsion formulations containing antimicrobial agents
CN103134891A (zh) *	2011-11-30	2013-06-05	天津金耀集团有限公司	一种丁酸氯维地平含量和有关物质的测定方法
CN110840890A (zh)	2012-10-26	2020-02-28	凯西制药公司	用于在心力衰竭中控制血压和减轻呼吸困难的方法
CN103417539B (zh) *	2013-08-22	2015-11-25	北京蓝丹医药科技有限公司	一种丁酸氯维地平药物组合物
CN104974042A (zh) *	2014-04-09	2015-10-14	上海信谊金朱药业有限公司	化合物的制备方法
CN104974043A (zh) *	2014-04-09	2015-10-14	上海信谊金朱药业有限公司	丁酸氯维地平的杂质化合物的制备方法
MX385243B (es) *	2014-05-19	2025-03-14	The Medicines Co	Nanoparticulas de clevidipina y composiciones farmaceuticas que las contienen.
CN104458937B (zh) *	2014-11-20	2017-02-22	北京京科泰来科技有限公司	一种丁酸氯维地平脂肪乳有关物质检测方法
CN104597192B (zh) *	2014-12-31	2016-08-24	武汉科福新药有限责任公司	一种丁酸氯维地平及其制剂中有关物质的检测方法
CN105853353A (zh) *	2015-01-20	2016-08-17	江苏正大丰海制药有限公司	一种氯维地平脂肪乳注射液的制备方法
CN107362139B (zh) *	2017-08-29	2020-11-03	辅必成（上海）医药科技有限公司	一种丁酸氯维地平的乳剂注射液
US20200316043A1 (en) *	2017-12-20	2020-10-08	Aurobindo Pharma Ltd.	Pharmaceutical composition comprising clevidipine and process for preparation thereof
CN109956943B (zh) *	2019-04-18	2021-07-20	合肥合源药业有限公司	一种二氢吡啶类药物中脱羧缩合杂质及其制备、控制方法

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US4150744A (en) *	1976-02-27	1979-04-24	Smith & Nephew Pharmaceuticals Ltd.	Packaging
DE3532129A1 (de) *	1985-09-10	1987-03-12	Bayer Ag	Ss-carotin enthaltende gelatine
SE9303657D0 (sv) *	1993-11-05	1993-11-05	Astra Ab	Short-acting dihydropyridines
SE9303744D0 (sv) *	1993-11-12	1993-11-12	Astra Ab	Pharmaceutical emulsion
GB9405593D0 (en)	1994-03-22	1994-05-11	Zeneca Ltd	Pharmaceutical compositions
SE9804002D0 (sv)	1998-11-23	1998-11-23	Astra Ab	New manufacturing process
EP1165091B1 (en)	1999-03-31	2005-01-26	PHARMACIA & UPJOHN COMPANY	Pharmaceutical emulsions for retroviral protease inhibitors
US6956048B2 (en) *	1999-03-31	2005-10-18	Pharmacia & Upjohn Company	Pharmaceutical emulsions for retroviral protease inhibitors
US6680334B2 (en) *	2001-08-28	2004-01-20	Pfizer Inc	Crystalline material
JP2003104888A (ja)	2001-09-28	2003-04-09	Taiyo Yakuhin Kogyo Kk	ジヒドロピリジン誘導体の錠剤
ATE375349T1 (de) *	2002-08-02	2007-10-15	Merck & Co Inc	Substituierte furo(2,3-b)pyridin derivate
US20060160834A1 (en) *	2003-06-06	2006-07-20	Fong Tung M	Combination therapy for the treatment of hypertension
US20050186230A1 (en)	2004-01-23	2005-08-25	Sd Pharmaceuticals, Inc.	Elemene compositions containing liquid oil
TW200613275A (en) *	2004-08-24	2006-05-01	Recordati Ireland Ltd	Lercanidipine salts
US20080095841A1 (en)	2004-10-06	2008-04-24	Eisai R&D Management Co., Ltd.	Pharmaceutical Composition, Method for Producing the Same, and Method for Stabilizing Dihydropyridine Compound in the Pharmaceutical Composition
US20100016378A1 (en) *	2005-04-28	2010-01-21	Toshio Suzuki	Method of preventing dihydropyridine compound from degradation
US7737155B2 (en) *	2005-05-17	2010-06-15	Schering Corporation	Nitrogen-containing heterocyclic compounds and methods of use thereof
AU2006275784A1 (en) *	2005-07-28	2007-02-08	Reliant Pharmaceuticals, Inc.	Treatment with dihydropyridine calcium channel blockers and omega-3 fatty acids and a combination product thereof
CA3108961C (en)	2008-08-01	2024-07-02	Hospira, Inc.	Pharmaceutical compositions comprising clevidipine and methods for producing low concentrations of impurities thereof
CA2734780C (en)	2008-08-22	2016-07-05	Milestone Pharmaceuticals Inc.	Short acting benzothiazepine calcium channel blockers and uses thereof
CN101766568A (zh)	2008-12-31	2010-07-07	北京利乐生制药科技有限公司	一种含有氯维地平的乳剂及其制备工艺和用途
CN101780036B (zh)	2010-03-30	2011-11-16	武汉武药科技有限公司	丁酸氯维地平脂微球注射液及其制备方法
WO2012051116A1 (en)	2010-10-12	2012-04-19	The Medicines Company	Clevidipine emulsion formulations containing antimicrobial agents
US8658676B2 (en)	2010-10-12	2014-02-25	The Medicines Company	Clevidipine emulsion formulations containing antimicrobial agents

2009
- 2009-07-29 CA CA3108961A patent/CA3108961C/en active Active
- 2009-07-29 MX MX2011001240A patent/MX2011001240A/es active IP Right Grant
- 2009-07-29 JP JP2011521291A patent/JP5674660B2/ja active Active
- 2009-07-29 NZ NZ591205A patent/NZ591205A/xx unknown
- 2009-07-29 EP EP14150954.7A patent/EP2719386A1/en not_active Withdrawn
- 2009-07-29 EP EP09803550.4A patent/EP2320740B1/en active Active
- 2009-07-29 WO PCT/US2009/052127 patent/WO2010014727A1/en not_active Ceased
- 2009-07-29 HR HRP20140434AT patent/HRP20140434T1/hr unknown
- 2009-07-29 SI SI200930923T patent/SI2320740T1/sl unknown
- 2009-07-29 PT PT98035504T patent/PT2320740E/pt unknown
- 2009-07-29 AU AU2009276560A patent/AU2009276560B2/en active Active
- 2009-07-29 BR BRPI0916936A patent/BRPI0916936B8/pt active IP Right Grant
- 2009-07-29 ES ES09803550.4T patent/ES2468837T3/es active Active
- 2009-07-29 PL PL09803550T patent/PL2320740T3/pl unknown
- 2009-07-29 CA CA2732760A patent/CA2732760A1/en not_active Abandoned
- 2009-07-29 KR KR1020117004358A patent/KR101772602B1/ko active Active
- 2009-07-29 US US12/511,631 patent/US20100113534A1/en not_active Abandoned
- 2009-07-29 EA EA201170289A patent/EA021336B1/ru not_active IP Right Cessation
- 2009-07-29 DK DK09803550.4T patent/DK2320740T3/da active
- 2009-07-29 CN CN200980139203.6A patent/CN102170786B/zh active Active
2012
- 2012-08-30 US US13/600,056 patent/US20120322835A1/en not_active Abandoned
2013
- 2013-06-17 US US13/919,893 patent/US20140005233A1/en not_active Abandoned
2014
- 2014-05-30 CY CY20141100388T patent/CY1116490T1/el unknown
- 2014-06-25 SM SM201400081T patent/SMT201400081B/xx unknown
2018
- 2018-11-21 US US16/197,647 patent/US11058672B2/en active Active
2021
- 2021-06-16 US US17/304,216 patent/US20220000849A1/en not_active Abandoned
2024
- 2024-09-16 US US18/885,921 patent/US20250213540A1/en active Pending

Also Published As

Publication number	Publication date
BRPI0916936B1 (pt)	2020-08-04
EA021336B1 (ru)	2015-05-29
JP5674660B2 (ja)	2015-02-25
CA3108961C (en)	2024-07-02
CY1116490T1 (el)	2017-03-15
BRPI0916936A2 (pt)	2017-05-23
CA2732760A1 (en)	2010-02-04
EP2320740A1 (en)	2011-05-18
US20250213540A1 (en)	2025-07-03
AU2009276560A1 (en)	2010-02-04
US20120322835A1 (en)	2012-12-20
ES2468837T3 (es)	2014-06-17
CN102170786B (zh)	2015-05-27
EP2719386A1 (en)	2014-04-16
EP2320740A4 (en)	2011-11-30
US20190091212A1 (en)	2019-03-28
DK2320740T3 (da)	2014-06-30
HRP20140434T1 (hr)	2014-08-01
US20100113534A1 (en)	2010-05-06
BRPI0916936B8 (pt)	2021-05-25
CA3108961A1 (en)	2010-02-04
KR20110060889A (ko)	2011-06-08
KR101772602B1 (ko)	2017-08-29
PT2320740E (pt)	2014-06-12
NZ591205A (en)	2012-11-30
AU2009276560B2 (en)	2015-04-16
SI2320740T1 (sl)	2014-08-29
US11058672B2 (en)	2021-07-13
CN102170786A (zh)	2011-08-31
JP2011529900A (ja)	2011-12-15
MX2011001240A (es)	2011-08-12
EA201170289A1 (ru)	2011-10-31
EP2320740B1 (en)	2014-03-26
US20140005233A1 (en)	2014-01-02
BRPI0916936A8 (pt)	2017-12-05
US20220000849A1 (en)	2022-01-06
WO2010014727A1 (en)	2010-02-04
SMT201400081B (it)	2014-09-08

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EP2345416A4 (en)	2012-04-18	PHARMACEUTICAL COMPOSITION FOR CLEANING VENES AND MANUFACTURING METHOD THEREFOR
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