PL2321295T3 - Pochodne 4-(pirydyn-4-ylo)-1H-[1,3,5]triazyn -2-onu jako inhibitory GSK2-beta do leczenia chorób degeneracyjnych - Google Patents

Pochodne 4-(pirydyn-4-ylo)-1H-[1,3,5]triazyn -2-onu jako inhibitory GSK2-beta do leczenia chorób degeneracyjnych

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Publication number
PL2321295T3
PL2321295T3 PL09769671T PL09769671T PL2321295T3 PL 2321295 T3 PL2321295 T3 PL 2321295T3 PL 09769671 T PL09769671 T PL 09769671T PL 09769671 T PL09769671 T PL 09769671T PL 2321295 T3 PL2321295 T3 PL 2321295T3
Authority
PL
Poland
Prior art keywords
gsk3
triazin
pyridin
derivatives
treatment
Prior art date
Application number
PL09769671T
Other languages
English (en)
Inventor
Alistair Lochead
Mourad Saady
Philippe Yaiche
Original Assignee
Mitsubishi Tanabe Pharma Corp
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp, Sanofi Sa filed Critical Mitsubishi Tanabe Pharma Corp
Publication of PL2321295T3 publication Critical patent/PL2321295T3/pl

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P33/00—Antiparasitic agents
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Dermatology (AREA)
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  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
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  • Cardiology (AREA)
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  • Emergency Medicine (AREA)
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PL09769671T 2008-06-26 2009-06-25 Pochodne 4-(pirydyn-4-ylo)-1H-[1,3,5]triazyn -2-onu jako inhibitory GSK2-beta do leczenia chorób degeneracyjnych PL2321295T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08290617A EP2138488A1 (en) 2008-06-26 2008-06-26 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
EP09769671A EP2321295B1 (en) 2008-06-26 2009-06-25 4-(pyridin-4-yl)-1h-[1,3,5]triazin-2-one derivatives as gsk3-beta inhibitors for the treatment of neurodegenerative diseases
PCT/IB2009/006463 WO2009156860A2 (en) 2008-06-26 2009-06-25 Substituted triazinone derivatives

Publications (1)

Publication Number Publication Date
PL2321295T3 true PL2321295T3 (pl) 2012-06-29

Family

ID=39832570

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09769671T PL2321295T3 (pl) 2008-06-26 2009-06-25 Pochodne 4-(pirydyn-4-ylo)-1H-[1,3,5]triazyn -2-onu jako inhibitory GSK2-beta do leczenia chorób degeneracyjnych

Country Status (23)

Country Link
US (1) US8592580B2 (pl)
EP (2) EP2138488A1 (pl)
JP (1) JP5581318B2 (pl)
KR (1) KR20110025219A (pl)
CN (1) CN102137854A (pl)
AR (1) AR072227A1 (pl)
AT (1) ATE538114T1 (pl)
AU (1) AU2009263846A1 (pl)
BR (1) BRPI0914662A2 (pl)
CA (1) CA2729115A1 (pl)
CY (1) CY1112642T1 (pl)
DK (1) DK2321295T3 (pl)
EA (1) EA201170095A1 (pl)
ES (1) ES2379220T3 (pl)
IL (1) IL210174A0 (pl)
MX (1) MX2010014235A (pl)
NZ (1) NZ590116A (pl)
PL (1) PL2321295T3 (pl)
PT (1) PT2321295E (pl)
SI (1) SI2321295T1 (pl)
TW (1) TW201004935A (pl)
WO (1) WO2009156860A2 (pl)
ZA (1) ZA201100026B (pl)

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EP2138495A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138485A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted N-Oxide pyrazine derivatives
EP2138494A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
EP2138492A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidin-4-one derivatives
EP2138493A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidone derivatives
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
MX353470B (es) * 2012-03-30 2018-01-15 Nissan Chemical Ind Ltd Compuesto de triazinona e inhibidor de canal de calcio tipo t.
JP6378171B2 (ja) 2012-04-24 2018-08-22 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ｄｎａ−ｐｋ阻害剤
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RU2675270C2 (ru) 2013-10-17 2018-12-18 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы и содержащие их фармацевтические композиции
TWI651310B (zh) * 2014-02-20 2019-02-21 日商日本煙草產業股份有限公司 三化合物及其醫藥用途
EP3154953B1 (en) * 2014-06-13 2018-04-04 Fondazione Istituto Italiano di Tecnologia Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer's disease
PE20180951A1 (es) * 2015-08-17 2018-06-11 Japan Tobacco Inc Compuestos de hidroxitriazina y usos medicos de los mismos
RU2758669C2 (ru) 2016-09-27 2021-11-01 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с применением сочетания днк-поражающих агентов и ингибиторов днк-пк
CN115087643B (zh) * 2021-01-15 2023-10-27 中国医药研究开发中心有限公司 稠和杂环类化合物及其制备方法和医药用途

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EP2138485A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted N-Oxide pyrazine derivatives
EP2138492A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidin-4-one derivatives
EP2138495A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138494A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives

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US20110144114A1 (en) 2011-06-16
KR20110025219A (ko) 2011-03-09
EP2321295A2 (en) 2011-05-18
ES2379220T3 (es) 2012-04-23
SI2321295T1 (sl) 2012-04-30
CY1112642T1 (el) 2016-02-10
AU2009263846A1 (en) 2009-12-30
JP2011525905A (ja) 2011-09-29
EA201170095A1 (ru) 2011-08-30
ATE538114T1 (de) 2012-01-15
EP2138488A1 (en) 2009-12-30
DK2321295T3 (da) 2012-04-10
CN102137854A (zh) 2011-07-27
BRPI0914662A2 (pt) 2015-10-20
IL210174A0 (en) 2011-03-31
MX2010014235A (es) 2011-06-24
AR072227A1 (es) 2010-08-11
WO2009156860A3 (en) 2010-03-04
PT2321295E (pt) 2012-03-23
CA2729115A1 (en) 2009-12-30
ZA201100026B (en) 2012-04-25
US8592580B2 (en) 2013-11-26
TW201004935A (en) 2010-02-01
WO2009156860A2 (en) 2009-12-30
JP5581318B2 (ja) 2014-08-27
EP2321295B1 (en) 2011-12-21
NZ590116A (en) 2011-10-28

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