PL2325181T3 - Inhibitor STAT3 zawierający jako składnik aktywny pochodną chinolinokarboksyamidu - Google Patents
Inhibitor STAT3 zawierający jako składnik aktywny pochodną chinolinokarboksyamiduInfo
- Publication number
- PL2325181T3 PL2325181T3 PL09794208T PL09794208T PL2325181T3 PL 2325181 T3 PL2325181 T3 PL 2325181T3 PL 09794208 T PL09794208 T PL 09794208T PL 09794208 T PL09794208 T PL 09794208T PL 2325181 T3 PL2325181 T3 PL 2325181T3
- Authority
- PL
- Poland
- Prior art keywords
- active ingredient
- inhibitor containing
- stat3 inhibitor
- quinolinecarboxamide derivative
- quinolinecarboxamide
- Prior art date
Links
- 101150099493 STAT3 gene Proteins 0.000 title 1
- 239000004480 active ingredient Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- ZEXKKIXCRDTKBF-UHFFFAOYSA-N quinoline-2-carboxamide Chemical class C1=CC=CC2=NC(C(=O)N)=CC=C21 ZEXKKIXCRDTKBF-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008180433 | 2008-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2325181T3 true PL2325181T3 (pl) | 2017-09-29 |
Family
ID=41506885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09794208T PL2325181T3 (pl) | 2008-07-10 | 2009-07-10 | Inhibitor STAT3 zawierający jako składnik aktywny pochodną chinolinokarboksyamidu |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8466290B2 (pl) |
| EP (1) | EP2325181B1 (pl) |
| JP (1) | JP5650529B2 (pl) |
| KR (1) | KR101696936B1 (pl) |
| CN (1) | CN102099352B (pl) |
| AU (1) | AU2009269410B2 (pl) |
| CA (1) | CA2729988C (pl) |
| EA (1) | EA021306B1 (pl) |
| ES (1) | ES2622575T3 (pl) |
| NZ (2) | NZ590355A (pl) |
| PL (1) | PL2325181T3 (pl) |
| WO (1) | WO2010004761A1 (pl) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5794922B2 (ja) * | 2009-12-28 | 2015-10-14 | 一般社団法人ファルマバレープロジェクト支援機構 | １，３，４−オキサジアゾール−２−カルボキサミド化合物 |
| ES2553771T3 (es) * | 2010-10-08 | 2015-12-11 | Nivalis Therapeutics, Inc. | Nuevos compuestos de quinolina sustituidos como inhibidores de la S-nitrosoglutatión reductasa |
| WO2013074059A2 (en) | 2010-11-05 | 2013-05-23 | Regents Of The University Of Minnesota | Cytosine deaminase modulators for enhancement of dna transfection |
| JPWO2012121168A1 (ja) * | 2011-03-04 | 2014-07-17 | 国立大学法人京都大学 | キナーゼ阻害剤 |
| CN102827142B (zh) * | 2011-06-17 | 2014-11-12 | 中国科学院上海药物研究所 | 一类喹啉-8-甲酰胺类化合物、其制备方法及其医药用途 |
| CN102417479B (zh) * | 2011-08-29 | 2014-02-26 | 南京大学 | Stat3小分子选择性抑制剂及其制备方法和应用 |
| HK1218709A1 (zh) * | 2012-05-25 | 2017-03-10 | 多伦多大学管理委员会 | 新水楊酸衍生物、其藥學上可接受的鹽、其組合物以及其使用方法 |
| US8791067B2 (en) | 2012-07-24 | 2014-07-29 | Morehouse School Of Medicine | Method for treating malaria |
| CN103910727B (zh) * | 2012-12-31 | 2016-06-15 | 北京大学 | STAT3-Hif1α信号通路抑制剂及其在抗肿瘤中的应用 |
| US10562912B2 (en) * | 2013-06-05 | 2020-02-18 | C&C Research Laboratories | Heterocyclic derivatives and use thereof |
| WO2015106272A1 (en) * | 2014-01-13 | 2015-07-16 | Harki Daniel A | Small molecule inhibitors of apobec3g and apobec3b |
| WO2015120436A2 (en) | 2014-02-10 | 2015-08-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Stat3 phosphorylation during graft-versus-host disease |
| KR20160066490A (ko) * | 2014-12-02 | 2016-06-10 | 주식회사 씨앤드씨신약연구소 | 헤테로사이클 유도체 및 그의 용도 |
| WO2016202935A1 (en) * | 2015-06-19 | 2016-12-22 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| AU2017330443B2 (en) * | 2016-09-26 | 2023-08-24 | Dana-Farber Cancer Institute, Inc. | Chromobox protein inhibitors and uses thereof |
| TWI853814B (zh) | 2018-05-31 | 2024-09-01 | 南韓商Ｃ＆Ｃ新藥研究所 | 雜環衍生物及其用途 |
| US20220008409A1 (en) * | 2018-09-18 | 2022-01-13 | Kabushiki Kaisha Yakult Honsha | Cancer combination therapy using quinoline carboxamide derivative |
| CN113613730A (zh) * | 2019-03-22 | 2021-11-05 | 株式会社益力多本社 | 喹啉甲酰胺衍生物和其制造中间物的制造方法 |
| CN113891749A (zh) * | 2019-03-28 | 2022-01-04 | 埃皮齐梅股份有限公司 | 喹啉衍生物及其用于治疗癌症的用途 |
| WO2020219792A1 (en) * | 2019-04-26 | 2020-10-29 | Purdue Research Foundation | Cf3-, ocf3-, scf3- and sf5-containing antibacterial agents |
| WO2020218432A1 (ja) * | 2019-04-26 | 2020-10-29 | 株式会社ヤクルト本社 | キノリンカルボキサミド誘導体を用いる免疫チェックポイント阻害剤併用療法 |
| CN117186086B (zh) * | 2023-09-06 | 2026-03-27 | 中山大学 | 一种苯并吡啶类化合物及其制备方法与应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| MXPA02001498A (es) | 1999-08-12 | 2003-07-21 | Pharmacia & Italia S P A | Derivados de 3(5)-amino-pirazol, procedimiento para la preparacion de los mismos y usos como agentes antitumorales. |
| JP4883862B2 (ja) * | 1999-11-15 | 2012-02-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ファルネシルトランスフェラーゼ阻害剤としてのトリアゾール類 |
| US7049324B1 (en) | 1999-11-15 | 2006-05-23 | Ashis Kumar Saha | Triazoles as farnesyl transferase inhibitors |
| GB0109122D0 (en) | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
| CN1665808A (zh) | 2002-05-06 | 2005-09-07 | 沃泰克斯药物股份有限公司 | 噻二唑或噁二唑及其作为jak蛋白激酶抑制剂的用途 |
| AR042052A1 (es) | 2002-11-15 | 2005-06-08 | Vertex Pharma | Diaminotriazoles utiles como inhibidores de proteinquinasas |
| WO2004078731A1 (en) | 2003-03-06 | 2004-09-16 | 'chemical Diversity Research Institute', Ltd. | Quinoline-carboxylic acids and the derivatives thereof, a focused library |
| EP1820504A1 (en) * | 2004-11-15 | 2007-08-22 | Taisho Pharmaceutical Co., Ltd | Imine compound |
| CA2599992A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Acridine and quinoline dervatives as sirtuin modulators |
| US20090054445A1 (en) | 2006-01-27 | 2009-02-26 | Astrazeneca Ab | Amide Substituted Quinolines |
| US20080033000A1 (en) * | 2006-05-15 | 2008-02-07 | Senex Biotechnology, Inc. | Identification of CDKI pathway inhibitors |
| UA95978C2 (ru) | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Ингибитор активации stat3/5 |
-
2009
- 2009-07-10 NZ NZ590355A patent/NZ590355A/xx not_active IP Right Cessation
- 2009-07-10 US US13/003,441 patent/US8466290B2/en not_active Expired - Fee Related
- 2009-07-10 CA CA2729988A patent/CA2729988C/en active Active
- 2009-07-10 CN CN200980126951.0A patent/CN102099352B/zh not_active Expired - Fee Related
- 2009-07-10 NZ NZ602099A patent/NZ602099A/en not_active IP Right Cessation
- 2009-07-10 WO PCT/JP2009/003235 patent/WO2010004761A1/ja not_active Ceased
- 2009-07-10 ES ES09794208.0T patent/ES2622575T3/es active Active
- 2009-07-10 EP EP09794208.0A patent/EP2325181B1/en active Active
- 2009-07-10 JP JP2010519655A patent/JP5650529B2/ja not_active Expired - Fee Related
- 2009-07-10 EA EA201170176A patent/EA021306B1/ru not_active IP Right Cessation
- 2009-07-10 KR KR1020107029688A patent/KR101696936B1/ko not_active Expired - Fee Related
- 2009-07-10 AU AU2009269410A patent/AU2009269410B2/en not_active Ceased
- 2009-07-10 PL PL09794208T patent/PL2325181T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2325181A1 (en) | 2011-05-25 |
| US8466290B2 (en) | 2013-06-18 |
| JPWO2010004761A1 (ja) | 2011-12-22 |
| KR20110039221A (ko) | 2011-04-15 |
| NZ590355A (en) | 2013-01-25 |
| ES2622575T3 (es) | 2017-07-06 |
| CN102099352B (zh) | 2014-02-26 |
| AU2009269410B2 (en) | 2013-12-05 |
| WO2010004761A1 (ja) | 2010-01-14 |
| US20110172429A1 (en) | 2011-07-14 |
| EA021306B1 (ru) | 2015-05-29 |
| CA2729988A1 (en) | 2010-01-14 |
| EA201170176A1 (ru) | 2011-08-30 |
| JP5650529B2 (ja) | 2015-01-07 |
| CA2729988C (en) | 2016-09-13 |
| EP2325181A4 (en) | 2012-03-07 |
| EP2325181B1 (en) | 2017-03-29 |
| AU2009269410A1 (en) | 2010-01-14 |
| NZ602099A (en) | 2014-06-27 |
| KR101696936B1 (ko) | 2017-01-16 |
| CN102099352A (zh) | 2011-06-15 |
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