PL2346823T3 - Związki pośrednie w syntezie związków 8-[{1-(3,5-bis-(trifluorometylo)fenylo)etoksy}metylo]-8-fenylo-1,7-diaza-spiro[4.5]dekan-2-onu - Google Patents
Związki pośrednie w syntezie związków 8-[{1-(3,5-bis-(trifluorometylo)fenylo)etoksy}metylo]-8-fenylo-1,7-diaza-spiro[4.5]dekan-2-onuInfo
- Publication number
- PL2346823T3 PL2346823T3 PL09792268T PL09792268T PL2346823T3 PL 2346823 T3 PL2346823 T3 PL 2346823T3 PL 09792268 T PL09792268 T PL 09792268T PL 09792268 T PL09792268 T PL 09792268T PL 2346823 T3 PL2346823 T3 PL 2346823T3
- Authority
- PL
- Poland
- Prior art keywords
- phenyl
- decan
- diaza
- spiro
- intermediates
- Prior art date
Links
- FIVSJYGQAIEMOC-UHFFFAOYSA-N 8-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxymethyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one Chemical class C=1C(C(F)(F)F)=CC(C(F)(F)F)=CC=1C(C)OCC(NC1)(C=2C=CC=CC=2)CCC21CCC(=O)N2 FIVSJYGQAIEMOC-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/46—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9447408P | 2008-09-05 | 2008-09-05 | |
| EP09792268.6A EP2346823B1 (en) | 2008-09-05 | 2009-09-04 | Intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds |
| PCT/US2009/056020 WO2010028232A1 (en) | 2008-09-05 | 2009-09-04 | Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2346823T3 true PL2346823T3 (pl) | 2016-01-29 |
Family
ID=41402490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09792268T PL2346823T3 (pl) | 2008-09-05 | 2009-09-04 | Związki pośrednie w syntezie związków 8-[{1-(3,5-bis-(trifluorometylo)fenylo)etoksy}metylo]-8-fenylo-1,7-diaza-spiro[4.5]dekan-2-onu |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9249144B2 (pl) |
| EP (2) | EP3034493A1 (pl) |
| JP (2) | JP5736313B2 (pl) |
| KR (1) | KR101719004B1 (pl) |
| CN (2) | CN102203062B (pl) |
| AU (1) | AU2009289598B2 (pl) |
| CA (1) | CA2736195C (pl) |
| ES (1) | ES2552322T3 (pl) |
| HU (1) | HUE026148T2 (pl) |
| MX (1) | MX2011002475A (pl) |
| PL (1) | PL2346823T3 (pl) |
| PT (1) | PT2346823E (pl) |
| WO (1) | WO2010028232A1 (pl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0710577A2 (pt) | 2006-04-05 | 2011-08-16 | Schering Corp | formulações farmacêuticas: sais de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etóxi-metil]-8-fenil- 1,7-diaza-espiro[4.5]decan-2-ona e métodos de tratamento usando-se as mesmas |
| SG170838A1 (en) | 2006-04-05 | 2011-05-30 | Opko Health Inc | Hydrochloride salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl) -ethoxy}- methyl] -8-phenyl-1,7-diaza-spiro[4.5] decan-2-one and preparation process therefor |
| AR066191A1 (es) | 2007-03-22 | 2009-08-05 | Schering Corp | Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona |
| ES2552322T3 (es) | 2008-09-05 | 2015-11-27 | Opko Health, Inc. | Productos intermedios para la síntesis de compuestos de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4,5]decán-2-ona |
| SG178403A1 (en) | 2009-08-14 | 2012-03-29 | Opko Health Inc | Intravenous formulations of neurokinin-1 antagonists |
| CN105017251B (zh) * | 2015-06-30 | 2018-06-29 | 齐鲁制药有限公司 | 一种nk-1受体拮抗剂的制备方法及其中间体 |
| EA201792513A1 (ru) * | 2015-07-15 | 2018-06-29 | Опко Хелс, Инк. | Гетероарильные карбонитрилы для лечения заболевания |
| CN106866669A (zh) * | 2017-04-19 | 2017-06-20 | 成都百特万合医药科技有限公司 | 一种合成罗拉吡坦中间体的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2146767A1 (en) | 1992-10-28 | 1994-05-11 | Timothy Harrison | 4-arylmethyloxymethyl piperidines as tachykinin antagonists |
| US5661162A (en) | 1992-12-14 | 1997-08-26 | Merck Sharp & Dohme Limited | 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperdines as tachykinin receptor antagonists |
| WO1995019344A1 (en) | 1994-01-13 | 1995-07-20 | Merck Sharp & Dohme Limited | Gem-disubstituted azacyclic tachykinin antagonists |
| GB9626746D0 (en) | 1996-12-23 | 1997-02-12 | Knoll Ag | Process |
| CA2287397A1 (en) | 1997-04-24 | 1998-10-29 | Merck Sharp & Dohme Limited | Use of an nk-1 receptor antagonist and an ssri for treating obesity |
| DE19815275B4 (de) | 1998-04-06 | 2009-06-25 | Evonik Degussa Gmbh | Alkylidenkomplexe des Rutheniums mit N-heterozyklischen Carbenliganden und deren Verwendung als hochaktive, selektive Katalysatoren für die Olefin-Metathese |
| US6215019B1 (en) | 1998-09-01 | 2001-04-10 | Tilliechem, Inc. | Synthesis of 5-decenyl acetate and other pheromone components |
| CN1213032C (zh) | 1999-05-24 | 2005-08-03 | 加州理工学院 | 咪唑烷基金属卡宾易位催化剂 |
| CN1434805A (zh) | 1999-12-17 | 2003-08-06 | 先灵公司 | 选择性神经激肽拮抗剂 |
| GB0004699D0 (en) * | 2000-02-28 | 2000-04-19 | Merck Sharp & Dohme | Chemical synthesis |
| ATE448019T1 (de) | 2000-08-10 | 2009-11-15 | Trustees Boston College | Wiederverwendbare methathese-katalysatoren |
| MXPA04004477A (es) | 2001-11-13 | 2004-08-11 | Schering Corp | Antagonistas del neuropeptido neuroquinina-1(nk1). |
| GB0129525D0 (en) | 2001-12-10 | 2002-01-30 | Floor Image Internat Ltd | Improvements to floor posters |
| PE20030762A1 (es) * | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
| PL199412B1 (pl) | 2002-10-15 | 2008-09-30 | Boehringer Ingelheim Int | Nowe kompleksy rutenu jako (pre)katalizatory reakcji metatezy, pochodne 2-alkoksy-5-nitrostyrenu jako związki pośrednie i sposób ich wytwarzania |
| CN1964969A (zh) * | 2004-04-07 | 2007-05-16 | 先灵公司 | 稠环nk1拮抗剂 |
| KR101228282B1 (ko) | 2004-07-01 | 2013-01-31 | 옵코 헬스, 인크. | Ｎｋ1 길항제로서의 피페리딘 유도체 |
| JP4444745B2 (ja) | 2004-07-08 | 2010-03-31 | キヤノン株式会社 | 偏光分離素子および画像投射装置 |
| US7354922B2 (en) * | 2004-12-14 | 2008-04-08 | Schering Corporation | Bridged ring NK1 antagonists |
| TW200630380A (en) | 2005-02-18 | 2006-09-01 | Nat Univ Chung Hsing | N-acylamino acid racemase of Deinococcus radiodurans and producing method thereof, and L-amino acid production method therefrom |
| EP1905777B2 (en) | 2005-07-04 | 2018-06-27 | Zannan Scitech Co., Ltd. | Ruthenium complex ligand, ruthenium complex, carried ruthenium complex catalyst and the preparing methods and the use thereof |
| TW200806666A (en) * | 2006-04-05 | 2008-02-01 | Schering Corp | Salts of 8-[(1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor |
| SG170838A1 (en) | 2006-04-05 | 2011-05-30 | Opko Health Inc | Hydrochloride salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl) -ethoxy}- methyl] -8-phenyl-1,7-diaza-spiro[4.5] decan-2-one and preparation process therefor |
| BRPI0710577A2 (pt) | 2006-04-05 | 2011-08-16 | Schering Corp | formulações farmacêuticas: sais de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etóxi-metil]-8-fenil- 1,7-diaza-espiro[4.5]decan-2-ona e métodos de tratamento usando-se as mesmas |
| AR066191A1 (es) * | 2007-03-22 | 2009-08-05 | Schering Corp | Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona |
| PE20081891A1 (es) | 2007-03-22 | 2008-12-27 | Opko Health Inc | Formulaciones de comprimidos que contienen sales de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-spiro[4.5]decan-2-ona y comprimidos elaborados a partir de estas |
| ES2552322T3 (es) | 2008-09-05 | 2015-11-27 | Opko Health, Inc. | Productos intermedios para la síntesis de compuestos de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4,5]decán-2-ona |
| SG178403A1 (en) | 2009-08-14 | 2012-03-29 | Opko Health Inc | Intravenous formulations of neurokinin-1 antagonists |
-
2009
- 2009-09-04 ES ES09792268.6T patent/ES2552322T3/es active Active
- 2009-09-04 WO PCT/US2009/056020 patent/WO2010028232A1/en not_active Ceased
- 2009-09-04 HU HUE09792268A patent/HUE026148T2/en unknown
- 2009-09-04 PL PL09792268T patent/PL2346823T3/pl unknown
- 2009-09-04 MX MX2011002475A patent/MX2011002475A/es active IP Right Grant
- 2009-09-04 EP EP15181326.8A patent/EP3034493A1/en not_active Withdrawn
- 2009-09-04 CN CN200980144713.2A patent/CN102203062B/zh not_active Expired - Fee Related
- 2009-09-04 JP JP2011526223A patent/JP5736313B2/ja not_active Expired - Fee Related
- 2009-09-04 CA CA2736195A patent/CA2736195C/en active Active
- 2009-09-04 EP EP09792268.6A patent/EP2346823B1/en not_active Not-in-force
- 2009-09-04 KR KR1020117007788A patent/KR101719004B1/ko not_active Expired - Fee Related
- 2009-09-04 PT PT97922686T patent/PT2346823E/pt unknown
- 2009-09-04 AU AU2009289598A patent/AU2009289598B2/en not_active Ceased
- 2009-09-04 CN CN201410652644.9A patent/CN104496988B/zh not_active Expired - Fee Related
-
2013
- 2013-10-01 US US14/043,210 patent/US9249144B2/en active Active
-
2015
- 2015-04-20 JP JP2015085814A patent/JP2015143265A/ja active Pending
-
2016
- 2016-02-01 US US15/012,422 patent/US9822116B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2011002475A (es) | 2011-08-03 |
| US9822116B2 (en) | 2017-11-21 |
| KR20110067117A (ko) | 2011-06-21 |
| CA2736195A1 (en) | 2010-03-11 |
| CN104496988B (zh) | 2017-04-12 |
| JP2015143265A (ja) | 2015-08-06 |
| CN102203062B (zh) | 2014-12-17 |
| ES2552322T3 (es) | 2015-11-27 |
| JP5736313B2 (ja) | 2015-06-17 |
| AU2009289598A1 (en) | 2010-03-11 |
| HUE026148T2 (en) | 2016-05-30 |
| HK1158623A1 (en) | 2012-07-20 |
| EP2346823A1 (en) | 2011-07-27 |
| WO2010028232A1 (en) | 2010-03-11 |
| PT2346823E (pt) | 2015-11-26 |
| CN102203062A (zh) | 2011-09-28 |
| EP3034493A1 (en) | 2016-06-22 |
| CN104496988A (zh) | 2015-04-08 |
| US9249144B2 (en) | 2016-02-02 |
| US20160145256A1 (en) | 2016-05-26 |
| CA2736195C (en) | 2017-05-16 |
| EP2346823B1 (en) | 2015-08-19 |
| KR101719004B1 (ko) | 2017-03-22 |
| JP2012502053A (ja) | 2012-01-26 |
| US20140031549A1 (en) | 2014-01-30 |
| AU2009289598B2 (en) | 2014-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL2346823T3 (pl) | Związki pośrednie w syntezie związków 8-[{1-(3,5-bis-(trifluorometylo)fenylo)etoksy}metylo]-8-fenylo-1,7-diaza-spiro[4.5]dekan-2-onu | |
| AP2011005706A0 (en) | New compounds. | |
| AU2008229327A8 (en) | Amino-5-[substituted-4-(difluoromethoxy)phenyl]-5- phenylimidazolone compounds as beta-secretase inhibitors | |
| HUS1700037I1 (hu) | A 8-[{1-(3,5-bisz-(trifluor-metil)-fenil)-etoxi}-metil]-8-fenil-1,7-diazaspiro[4.5]dekan-2-on hidroklorid sója, és eljárás elõállítására | |
| IL211744A0 (en) | New chemical compounds | |
| SI2384326T1 (sl) | Pirolo(2,3-d)pirimidinske spojine | |
| ZA201008486B (en) | 5-substituted isoindoline compounds | |
| ZA201005097B (en) | Herbicidal compounds | |
| GB0800856D0 (en) | Herbicidal compounds | |
| IL212186A0 (en) | Fungicidal heterocyclic compounds | |
| IL213690A0 (en) | Novel bicyclic heterocyclic compound | |
| EP2344337A4 (en) | FLUID EJECTION CARTRIDGE | |
| PL2767366T3 (pl) | Wkład paliwowy | |
| IL201730A0 (en) | Bridged six-membered ring compounds | |
| SI2266990T1 (sl) | Spojina 3-fenilpirazolo(5,1-b)tiazola | |
| IL211292A0 (en) | Thiazolyl-pyrazolopyrimidine compounds as synthetic intermediates | |
| IL205181A0 (en) | Compounds for inhibiting ksp kinesin activity | |
| IL213328A0 (en) | Regeneration of 2,2'-cyclopropylidene-bis (oxazolines) | |
| SI2280961T1 (sl) | Spojine difenil pirolidin ona kot ligandi cb | |
| GB0715206D0 (en) | Catalyst compounds | |
| GB0817604D0 (en) | Low molecular weight, non-polar compound depleted media | |
| HK1155152A (en) | Di-substituted phenyl compounds as phosphodiesterase 10 inhibitors | |
| GB0805553D0 (en) | Muz-v single shot cartridge converter | |
| AP2007000277S (en) | Cartridge for multidose inhaler | |
| HK1136297A1 (zh) | 合成8-[{1-(3，5-二(三氟甲基)苯基)-乙氧基}-甲基]-8-苯基-1，7-二氮雜螺[4．5]癸-2-酮化合物的製備過程及中間體 |