PL2389204T3 - Rusztowanie warstwowe odpowiednie do naprawy kostno- chrzęstnej - Google Patents

Rusztowanie warstwowe odpowiednie do naprawy kostno- chrzęstnej

Info

Publication number
PL2389204T3
PL2389204T3 PL10706393T PL10706393T PL2389204T3 PL 2389204 T3 PL2389204 T3 PL 2389204T3 PL 10706393 T PL10706393 T PL 10706393T PL 10706393 T PL10706393 T PL 10706393T PL 2389204 T3 PL2389204 T3 PL 2389204T3
Authority
PL
Poland
Prior art keywords
scaffold suitable
layered scaffold
osteochondral repair
osteochondral
repair
Prior art date
Application number
PL10706393T
Other languages
English (en)
Inventor
John P. Gleeson
Tanya J. Levingstone
Fergal J. O'brien
Original Assignee
Royal College Of Surgeons In Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Royal College Of Surgeons In Ireland filed Critical Royal College Of Surgeons In Ireland
Publication of PL2389204T3 publication Critical patent/PL2389204T3/pl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
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    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
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    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61F2002/30766—Scaffolds for cartilage ingrowth and regeneration
    • A—HUMAN NECESSITIES
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    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • C—CHEMISTRY; METALLURGY
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Composite Materials (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
PL10706393T 2009-01-23 2010-01-25 Rusztowanie warstwowe odpowiednie do naprawy kostno- chrzęstnej PL2389204T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14700609P 2009-01-23 2009-01-23
EP09151226 2009-01-23
PCT/IE2010/000005 WO2010084481A1 (en) 2009-01-23 2010-01-25 Layered scaffold suitable for osteochondral repair
EP10706393.5A EP2389204B1 (en) 2009-01-23 2010-01-25 Layered scaffold suitable for osteochondral repair

Publications (1)

Publication Number Publication Date
PL2389204T3 true PL2389204T3 (pl) 2019-12-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL10706393T PL2389204T3 (pl) 2009-01-23 2010-01-25 Rusztowanie warstwowe odpowiednie do naprawy kostno- chrzęstnej

Country Status (6)

Country Link
US (4) US8613943B2 (pl)
EP (1) EP2389204B1 (pl)
AU (1) AU2010207472B2 (pl)
CA (1) CA2750605C (pl)
PL (1) PL2389204T3 (pl)
WO (1) WO2010084481A1 (pl)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6964685B2 (en) 1999-06-22 2005-11-15 The Brigham And Women's Hospital, Inc. Biologic replacement for fibrin clot
AU2007208243B2 (en) 2006-01-25 2013-09-19 Children's Medical Center Corporation Methods and procedures for ligament repair
CA2664866C (en) 2006-09-28 2018-08-14 Children's Medical Center Coporation Methods and collagen products for tissue repair
EP1964583A1 (en) * 2007-02-09 2008-09-03 Royal College of Surgeons in Ireland Process for producing a collagen/hydroxyapatite composite scaffold
US11786636B2 (en) * 2010-06-15 2023-10-17 Versitech Limited Methods for complex tissue engineering
EP2508212A1 (en) 2011-04-05 2012-10-10 Universitätsklinikum Freiburg Biocompatible and biodegradable gradient layer system for regenerative medicine and for tissue support
US11484578B2 (en) 2012-02-01 2022-11-01 Children's Medical Center Corporation Biomaterial for articular cartilage maintenance and treatment of arthritis
US20130345826A1 (en) * 2012-06-22 2013-12-26 Collagen Matrix, Inc. Implants for Bone and Cartilage Repair
CN103920190B (zh) * 2013-01-14 2017-09-29 陕西博鸿生物科技集团有限公司 一种关节软骨移植物及其制备方法
EP2951193A4 (en) 2013-02-01 2017-03-01 Children's Medical Center Corporation Collagen scaffolds
US12599700B2 (en) 2013-02-01 2026-04-14 The Children's Medical Center Corporation System and methods for connective tissue repair using scaffolds
US9616110B2 (en) * 2013-02-28 2017-04-11 Purdue Research Foundation Fabrication method for stratified and layered tissue to repair osteochondral defects
US10940236B2 (en) * 2013-05-17 2021-03-09 Ospedale San Raffaele S.R.L. Composite scaffold for tissue repair
CN105611952B (zh) * 2013-07-16 2018-05-29 岭南大学校产学协力团 通过单步过程制备双层支架的方法以及利用由该制备方法获得的双层支架进行组织再生的方法
EP3180043B1 (en) * 2014-08-15 2018-12-26 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of Holy and Undiv. Trinity of Queen Elizabeth near Dublin A method for making a porous scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal
CA2962223C (en) 2014-09-23 2020-08-25 Cytex Therapeutics, Inc. Articular cartilage repair
CN104307047B (zh) * 2014-10-29 2017-02-01 中国科学院长春应用化学研究所 一种双梯度仿生修复支架及其制备方法
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
AU2016344019B2 (en) 2015-10-30 2021-07-15 New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery Suture sleeve patch and methods of delivery within an existing arthroscopic workflow
US11523812B2 (en) 2016-02-01 2022-12-13 Medos International Sarl Soft tissue fixation repair methods using tissue augmentation constructs
US20170273680A1 (en) 2016-02-01 2017-09-28 DePuy Synthes Products, Inc. Tissue augmentation tacks for use with soft tissue fixation repair systems and methods
US11484401B2 (en) 2016-02-01 2022-11-01 Medos International Sarl Tissue augmentation scaffolds for use in soft tissue fixation repair
EP3785738B1 (en) 2016-07-06 2025-11-05 Children's Medical Center Corporation Indirect method of articular tissue repair
US10537417B2 (en) * 2016-07-07 2020-01-21 Collagen Matrix, Inc. Density gradient biopolymeric matrix implants
US10022231B2 (en) 2016-07-22 2018-07-17 Cytex Therapeutics, Inc. Articular cartilage repair
EP3491122A4 (en) 2016-07-27 2020-04-08 The University of North Carolina at Chapel Hill METHOD FOR PRODUCING POLYMER SCAFFOLDINGS WITH A GRADIENT OF CROSSLINKING DENSITY
CN106110367A (zh) * 2016-07-29 2016-11-16 北京化工大学常州先进材料研究院 基于天然高分子多层复合医用敷料及其制备方法
CN106178120B (zh) * 2016-08-05 2019-05-03 东华大学 一种仿生天然血管三层结构的复合材料血管支架及其制备方法
KR102183048B1 (ko) * 2017-06-19 2020-11-25 주식회사 나이벡 골조직 재생을 위한 일체형 바이오소재 및 그 제조방법
CN107456608A (zh) * 2017-07-27 2017-12-12 中山大学附属第医院 一种三维多孔结构的人工皮肤及制备方法
CN107469149B (zh) * 2017-08-02 2022-05-24 中南大学湘雅医院 一种双相组织工程支架
WO2019070112A2 (en) * 2017-10-06 2019-04-11 Universiti Kebangsaan Malaysia (Ukm) DOUBLE DENSITY SCAFFOLDING
CN107693847A (zh) * 2017-10-10 2018-02-16 东华大学 一种角蛋白/羟基磷灰石复合膜、制备方法及其应用
US12104149B2 (en) 2018-05-15 2024-10-01 The University Of North Carolina At Chapel Hill Devices, systems and apparatuses for generating self-sustaining hypoxic conditions and gaseous and non-gaseous chemical gradients for in vitro cell culture
IT201800005455A1 (it) * 2018-05-17 2019-11-17 Processo per la preparazione di un materiale biocompatibile per l'uso in chirurgia
GB201808106D0 (en) * 2018-05-18 2018-07-04 Cambridge Entpr Ltd Collagen biomaterials and methods for manufacturing collagen biomaterials
JP7451427B2 (ja) 2018-05-25 2024-03-18 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 幹細胞/増殖細胞区画及び分化細胞ゾーンを有する平面腸陰窩のアレイの形成
WO2019232318A1 (en) * 2018-06-01 2019-12-05 Kansas State University Research Foundation Biomimetic 3d printing of hierarchical and interconnected porous hydroxyapatite bone structure
EP3880785A4 (en) 2018-11-16 2022-08-24 The University of North Carolina at Chapel Hill In vitro cell culture mucus systems
WO2020120805A2 (en) 2018-12-14 2020-06-18 Institut Químic De Sarrià Cets Fundació Privada Heterogeneous scaffolds and methods of functionalising surfaces
KR102169924B1 (ko) * 2019-03-26 2020-10-26 연세대학교 산학협력단 연골세포 분화 유도용 조성물 및 이의 용도
WO2020255113A1 (en) * 2019-06-20 2020-12-24 Datum Biotech Ltd. An implantable structure having a collagen membrane
GB201917246D0 (en) 2019-11-27 2020-01-08 Royal College Surgeons Ireland A collagen scaffold
CZ308862B6 (cs) * 2019-12-17 2021-07-21 Všeobecná fakultní nemocnice v Praze Sendvičová kolagenní pěna pro řízené uvolňování aktivních látek a způsob její přípravy
AU2021375535B2 (en) * 2020-11-05 2026-02-05 Datum Dental Ltd. Multi-layered collagen structure
EP4395796A4 (en) 2021-09-01 2024-12-25 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells
EP4422709A1 (en) * 2021-10-29 2024-09-04 Askel Healthcare Ltd. A pla-collagen scaffold for medical use loaded with cells
EP4457266A4 (en) 2021-12-28 2025-10-22 Shanghai Qisheng Biological Preparation Co Ltd HYALURONIC ACID-COLLAGEN COPOLYMER COMPOSITIONS AND THEIR MEDICAL APPLICATIONS
CN114225110B (zh) * 2022-01-05 2023-02-17 奥精医疗科技股份有限公司 一种胶原基硬脑膜及其制备方法
CN114618008A (zh) * 2022-02-24 2022-06-14 跃美生物科技(苏州)有限公司 一种医用丝素蛋白胶原制备方法
CN115721776B (zh) * 2022-11-10 2024-02-20 奥精医疗科技股份有限公司 一种儿童颅骨修复材料的制备方法
SK289409B6 (sk) 2022-12-05 2026-03-11 Ústav materiálového výskumu Slovenskej akadémie vied, verejná výskumná inštitúcia Kompozitný biocementový systém
JP2026514806A (ja) * 2023-04-17 2026-05-13 ヴァスクダイン・インコーポレイテッド 組織インプラント用の外部支持体
WO2024254185A2 (en) * 2023-06-05 2024-12-12 Novabone Products, Llc Methods and compositions for dental care
WO2024254184A2 (en) * 2023-06-05 2024-12-12 Novabone Products, Llc Methods and compositions for wound care
CN116531143B (zh) * 2023-07-07 2023-11-10 天新福(北京)医疗器材股份有限公司 一种改善双层冻干管状物质地均匀度的方法与应用
CN116570770B (zh) * 2023-07-12 2023-11-07 天新福(北京)医疗器材股份有限公司 一种双层冻干管状物及其制备方法与应用
EP4777160A1 (en) * 2023-09-14 2026-07-22 Shu-Tung and Alice Li Foundation Inc. Implants for articular cartilage repair
US12521468B1 (en) * 2024-11-20 2026-01-13 Biogend Therapeutics Co., Ltd. Implants for cartilage and related devices and methods
CN121338116B (zh) * 2025-12-19 2026-05-01 北京邦塞科技有限公司 一种矿化胶原软骨修复支架及其制备方法和应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US113951A (en) 1871-04-18 Improvement in propelling canal-boats
ATE155583T1 (de) 1991-03-06 1997-08-15 Ortho Diagnostic Systems Inc Denaturierte transportproteine zur verbesserung von enzymgebundenen immunoassays (elisa)
US6080194A (en) 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
GB9721585D0 (en) 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
NZ315995A (en) 1995-09-01 1999-09-29 Millenium Biologix Inc Artificial sintered composition comprising stabilised calcium phosphate phases capable of supporting bone cell activity
HUP9903586A3 (en) * 1996-04-04 2003-02-28 Baxter Ag Hemostatic sponge based on collagen
US6214049B1 (en) 1999-01-14 2001-04-10 Comfort Biomedical, Inc. Method and apparatus for augmentating osteointegration of prosthetic implant devices
US5899939A (en) 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6200347B1 (en) 1999-01-05 2001-03-13 Lifenet Composite bone graft, method of making and using same
DE10029520A1 (de) 2000-06-21 2002-01-17 Merck Patent Gmbh Beschichtung für metallische Implantatmaterialien
GB0020610D0 (en) 2000-08-21 2000-10-11 Dytech Corp Ltd Uses of porous carriers
US6599516B1 (en) 2000-09-14 2003-07-29 Etex Corporation Malleable implant containing solid element that resorbs or fractures to provide access channels
US20030003127A1 (en) 2001-06-27 2003-01-02 Ethicon, Inc. Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
DE10135275A1 (de) 2001-07-13 2003-01-30 Jotec Gmbh Implantat und Verfahren zu seiner Herstellung
DE10312144B4 (de) 2003-03-13 2006-12-14 Technische Universität Dresden Trägermaterial für die Gewebe- und Zellkultur und die Herstellung von Implantatmaterialien
WO2004085998A2 (en) 2003-03-28 2004-10-07 The Children's Hospital Of Philadelphia Biomimetic hierarchies using functionalized nanoparticles as building blocks
US8039090B2 (en) 2003-05-26 2011-10-18 Hoya Corporation Porous composite containing calcium phosphate and process for producing the same
US7537617B2 (en) 2003-06-05 2009-05-26 Warsaw Orthopedic, Inc. Bone strip implants and method of making same
DE602004007267T2 (de) 2003-06-11 2008-02-28 Centre National De La Recherche Scientifique (C.N.R.S.) Modelle für ein skelettsystem
US7217294B2 (en) 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
US7375077B2 (en) 2003-09-19 2008-05-20 The Board Of Trustees Of The University Of Illinois In vivo synthesis of connective tissues
GB2407580B (en) 2003-10-28 2009-02-25 Univ Cambridge Tech Biomaterial
US20050100578A1 (en) 2003-11-06 2005-05-12 Schmid Steven R. Bone and tissue scaffolding and method for producing same
ITPD20030286A1 (it) 2003-11-27 2005-05-28 Fidia Advanced Biopolymers Srl Strutture composite multistrato contenenti acido ialuronico
US9427496B2 (en) 2005-02-18 2016-08-30 Drexel University Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering
US20080020049A1 (en) 2005-02-25 2008-01-24 Andrew Darling Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications
ITMI20050343A1 (it) 2005-03-04 2006-09-05 Fin Ceramica Faenza S R L Sostituto cartilagineo e osteocindrale comprendente una struttura multistrato e relativo impiego
GB2424223C (en) * 2005-03-07 2011-02-02 Massachusetts Inst Technology Biomaterial.
CA2606379A1 (en) 2005-04-18 2006-10-26 Duke University Three-dimensional fiber scaffolds for tissue engineering
TWI316860B (en) 2005-12-29 2009-11-11 Ind Tech Res Inst Multi-layered matrix, method of tissue repair using the same and multi-layered implant prepared thereof
US20080026032A1 (en) 2006-07-27 2008-01-31 Zubery Yuval Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use
GB2440721A (en) 2006-08-11 2008-02-13 Univ Cambridge Tech Composite biomaterial formed by cooling a fluid composition on a porous solid and removing solidified crystals of the liquid carrier
EP1964583A1 (en) 2007-02-09 2008-09-03 Royal College of Surgeons in Ireland Process for producing a collagen/hydroxyapatite composite scaffold
EP1961433A1 (en) 2007-02-20 2008-08-27 National University of Ireland Galway Porous substrates for implantation
WO2008157608A1 (en) 2007-06-18 2008-12-24 Cartlix, Inc. Composite scaffolds for tissue regeneration
US9782300B2 (en) 2008-02-01 2017-10-10 Kci Licensing, Inc. Fiber-microsphere bioresorbable composite scaffold for wound healing
US8367148B2 (en) 2008-10-09 2013-02-05 Mimedx Group, Inc. Methods of making biocomposite medical constructs and related constructs including artificial tissues, vessels and patches
JP5945380B2 (ja) 2008-12-09 2016-07-05 Hoya株式会社 吸収置換型人工骨及びその製造方法
FR2940620B1 (fr) 2008-12-26 2012-03-30 Hoya Corp Os artificiel pouvant etre resorbe et remplace par un os autogene, et procede pour sa production
WO2010117389A1 (en) 2009-04-07 2010-10-14 University Of Arkansas Advanced bio-compatible nanocomposite surface coatings for implants and tissue engineering scaffolds
IT1396934B1 (it) 2009-11-25 2012-12-20 Fin Ceramica Faenza Spa Materiali bio-mimetici compositi, relativo processo di preparazione e loro uso per la realizzazione di strutture mono-, bi- o multi-strato per la rigenerazione di tessuto osseo, cartilagineo o osteocartilagineo
US8475824B2 (en) 2010-01-26 2013-07-02 Warsaw Orthopedic, Inc. Resorbable matrix having elongated particles
GB201003656D0 (en) 2010-03-05 2010-04-21 Tigenix Ltd Fabrication process
ITMI20102070A1 (it) 2010-11-08 2012-05-09 Consiglio Nazionale Ricerche Impianti per sostituzioni ossee "load bearing" ad architettura gerarchicamente organizzata derivante dalla trasformazione di strutture vegetali

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