PL2390255T3 - Nowe aminoglikozydy i ich zastosowania w leczeniu zaburzeń genetycznych - Google Patents

Nowe aminoglikozydy i ich zastosowania w leczeniu zaburzeń genetycznych

Info

Publication number
PL2390255T3
PL2390255T3 PL11173958T PL11173958T PL2390255T3 PL 2390255 T3 PL2390255 T3 PL 2390255T3 PL 11173958 T PL11173958 T PL 11173958T PL 11173958 T PL11173958 T PL 11173958T PL 2390255 T3 PL2390255 T3 PL 2390255T3
Authority
PL
Poland
Prior art keywords
treatment
genetic disorders
novel aminoglycosides
aminoglycosides
novel
Prior art date
Application number
PL11173958T
Other languages
English (en)
Inventor
Timor Baasov
Tamar Ben-Yosef
Igor Nudelman
Annie Rebibo-Sabbah
Dalia Shallom-Shezifi
Mariana Hainrichson
Original Assignee
Technion Research & Development Foundation Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technion Research & Development Foundation Ltd. filed Critical Technion Research & Development Foundation Ltd.
Publication of PL2390255T3 publication Critical patent/PL2390255T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/20—External fittings
    • B65D25/205—Means for the attachment of labels, cards, coupons or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mechanical Engineering (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL11173958T 2006-04-03 2007-04-10 Nowe aminoglikozydy i ich zastosowania w leczeniu zaburzeń genetycznych PL2390255T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78807006P 2006-04-03 2006-04-03

Publications (1)

Publication Number Publication Date
PL2390255T3 true PL2390255T3 (pl) 2017-01-31

Family

ID=38353813

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11173958T PL2390255T3 (pl) 2006-04-03 2007-04-10 Nowe aminoglikozydy i ich zastosowania w leczeniu zaburzeń genetycznych

Country Status (13)

Country Link
US (4) US9073958B2 (pl)
EP (3) EP2007783B1 (pl)
JP (1) JP5345928B2 (pl)
CA (1) CA2646407C (pl)
CY (1) CY1118065T1 (pl)
DK (1) DK2390255T3 (pl)
ES (2) ES2594343T3 (pl)
HU (1) HUE031643T2 (pl)
LT (1) LT2390255T (pl)
PL (1) PL2390255T3 (pl)
PT (1) PT2390255T (pl)
SI (1) SI2390255T1 (pl)
WO (1) WO2007113841A2 (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE031643T2 (en) 2006-04-03 2017-07-28 Technion Res & Dev Foundation New aminoglycosides and their applications in the treatment of genetic disorders
MX2012009028A (es) 2010-02-03 2012-10-15 Microbial Chem Res Found Inductor de lectura traspasada y agente terapeutico para enfermedades geneticas de tipo mutacion sin sentido.
US8765698B2 (en) * 2010-02-03 2014-07-01 University Of Central Florida Research Foundation, Inc. Methods and products for reawakening retrocyclins
WO2012021707A2 (en) * 2010-08-11 2012-02-16 The Regents Of The University Of California Premature-termination-codons readthrough compounds
SMT201800019T1 (it) 2010-11-18 2018-03-08 Technion Res & Dev Foundation Amminoglicosidi e relativi usi nel trattamento di malattie genetiche
US9181292B2 (en) * 2011-01-05 2015-11-10 Pi-Hui Liang Methods for preparation of glycosphingolipids and uses thereof
JP6076498B2 (ja) 2012-12-13 2017-02-08 ノバルティス アーゲー ナンセンス突然変異抑制剤としてのピリミド［４，５−ｂ］キノリン−４，５（３ｈ，１０ｈ）−ジオン
EP3152207B1 (en) 2014-06-03 2019-05-08 Novartis AG Pyridopyrimidinedione derivatives as suppressors of non-sens mutations
JP6560257B2 (ja) 2014-06-03 2019-08-14 ノバルティス アーゲー ピリミド［４，５−ｂ］キノリン−４，５（３Ｈ，１０Ｈ）−ジオン誘導体
AR100706A1 (es) 2014-06-03 2016-10-26 Novartis Ag Derivados de naftiridinadiona
US20170360817A1 (en) 2014-06-05 2017-12-21 Eloxx Pharmaceuticals Ltd. Use of aminoglycoside analogs in the treatment of rett syndrome
CA2987980A1 (en) * 2015-06-05 2016-12-08 Ptc Therapeutics, Inc. Use of an aminoglycoside for nonsense mutation suppression and the treatment of disease
WO2017037717A1 (en) * 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
EP3350194A4 (en) 2015-09-02 2019-04-24 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
CA2996763A1 (en) * 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
EP3400232A4 (en) * 2016-01-05 2019-10-16 Eloxx Pharmaceuticals Ltd. AMINO-L-KOSIDE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
US20190016745A1 (en) * 2016-01-05 2019-01-17 Technion Research & Development Foundation Limited Aminoglycoside derivatives and uses thereof in treating microbial infections
EP3442512A4 (en) * 2016-04-15 2020-07-22 The UAB Research Foundation METHODS AND COMPOUNDS FOR STIMULATING THE TRANSLECTURE OF PREMATURE TERMINATION CODONS
EP3609902A4 (en) 2017-03-15 2021-01-06 Eloxx Pharmaceuticals Ltd. LARGE-SCALE PREPARATION OF PSEUDO-TRISACCHARIDE AMINOGLYCOSIDES AND INTERMEDIARIES THEREOF
US11485751B2 (en) 2017-05-01 2022-11-01 Wayne State University Apramycin derivatives
CN108358983A (zh) * 2018-04-11 2018-08-03 常州方圆制药有限公司 一种侧链酰胺衍生化合成阿贝卡星的方法
CN108358982A (zh) * 2018-04-11 2018-08-03 常州方圆制药有限公司 一种硫酸阿贝卡星游离碱的分离提纯方法
JPWO2023120658A1 (pl) 2021-12-24 2023-06-29

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US3897412A (en) * 1972-05-04 1975-07-29 Bristol Myers Co Paromomycin antibiotic derivatives
US4024332A (en) * 1973-06-05 1977-05-17 Pfizer Inc. Aminoglycoside antibiotics and intermediates therefor
US4029882A (en) * 1974-03-19 1977-06-14 Schering Corporation Selective acylation of the C-1 amino group of aminoglycoside antibiotics
ES433990A1 (es) * 1974-03-19 1977-03-01 Scherico Ltd Procedimiento para la preparacion de derivados de diaminoci-clitoles.
AR207582A1 (es) 1974-03-19 1976-10-15 Scherico Ltd Procedimiento para preparar derivados de diaminociclitole
US3996205A (en) * 1975-09-08 1976-12-07 The Upjohn Company Aminoglycoside antibiotics and intermediates
FR2427341A1 (fr) * 1978-06-02 1979-12-28 Delalande Sa Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique
JPH0446189A (ja) * 1990-06-08 1992-02-17 Meiji Seika Kaisha Ltd 新規なリボスタマイシン誘導体
US5840702A (en) * 1996-03-22 1998-11-24 Uab Research Foundation Cystic fibrosis treatment
AU5821998A (en) * 1997-01-13 1998-08-03 Scripps Research Institute, The Nucleic acid binders having an hydroxyamine motif
US6403777B1 (en) * 1999-07-06 2002-06-11 The Ohio State University Research Foundation Metalloligands for cleaving nucleic acids
JP4629192B2 (ja) 2000-07-07 2011-02-09 富士通セミコンダクター株式会社 トリミング回路、調整回路及び半導体装置
US7749971B2 (en) * 2001-02-20 2010-07-06 Bedwell David M Aminoglycoside treatment for lysosomal storage diseases
KR100450864B1 (ko) * 2001-11-23 2004-10-01 한국과학기술연구원 Ｒｎａ 표적 분자에 대해 특이성이 향상된네오마이신-클로람페니콜 헤테로 이합체 및 그의 제조방법
US7364905B2 (en) 2001-11-29 2008-04-29 Techelan, Llc Apparatus and method for high throughput analysis of compound-membrane interactions
WO2005000249A2 (en) 2003-06-27 2005-01-06 Smithkline Beecham Corporation Preparation of chemical compounds
WO2005002498A2 (en) * 2003-07-01 2005-01-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of treating disorders caused by formation of transcripts carrying nonsense mutations
US20050004052A1 (en) * 2003-07-03 2005-01-06 Technion Research & Development Foundation Ltd. Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes
US7504381B2 (en) * 2004-09-27 2009-03-17 Technion Research & Development Foundation Ltd. Antimicrobial agents
HUE031643T2 (en) 2006-04-03 2017-07-28 Technion Res & Dev Foundation New aminoglycosides and their applications in the treatment of genetic disorders

Also Published As

Publication number Publication date
JP2009532461A (ja) 2009-09-10
PT2390255T (pt) 2016-10-24
EP2390255A1 (en) 2011-11-30
EP3421481A1 (en) 2019-01-02
WO2007113841A2 (en) 2007-10-11
EP2007783A2 (en) 2008-12-31
US20150352136A1 (en) 2015-12-10
ES2689539T3 (es) 2018-11-14
EP2390255B1 (en) 2016-07-13
US20190060340A1 (en) 2019-02-28
WO2007113841A3 (en) 2007-11-29
LT2390255T (lt) 2016-10-25
US9821001B2 (en) 2017-11-21
ES2594343T3 (es) 2016-12-19
US20090093418A1 (en) 2009-04-09
US10159689B2 (en) 2018-12-25
CA2646407C (en) 2015-08-18
US9073958B2 (en) 2015-07-07
EP2007783B1 (en) 2018-07-11
JP5345928B2 (ja) 2013-11-20
CY1118065T1 (el) 2017-06-28
US20180064743A1 (en) 2018-03-08
SI2390255T1 (sl) 2016-12-30
DK2390255T3 (en) 2016-11-07
HUE031643T2 (en) 2017-07-28
CA2646407A1 (en) 2007-10-11

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