PL2398808T3 - Sposób redukcyjnego alkilowania normorfinanów - Google Patents

Sposób redukcyjnego alkilowania normorfinanów

Info

Publication number
PL2398808T3
PL2398808T3 PL10704301T PL10704301T PL2398808T3 PL 2398808 T3 PL2398808 T3 PL 2398808T3 PL 10704301 T PL10704301 T PL 10704301T PL 10704301 T PL10704301 T PL 10704301T PL 2398808 T3 PL2398808 T3 PL 2398808T3
Authority
PL
Poland
Prior art keywords
normorphinans
reductive alkylation
reductive
alkylation
Prior art date
Application number
PL10704301T
Other languages
English (en)
Inventor
Edmund C Hudson
Sharon Woods
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of PL2398808T3 publication Critical patent/PL2398808T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL10704301T 2009-02-17 2010-02-17 Sposób redukcyjnego alkilowania normorfinanów PL2398808T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15302109P 2009-02-17 2009-02-17
EP10704301.0A EP2398808B1 (en) 2009-02-17 2010-02-17 Process for the reductive alkylation of normorphinans
PCT/US2010/024372 WO2010096416A1 (en) 2009-02-17 2010-02-17 Process for the reductive alkylation of normorphinans

Publications (1)

Publication Number Publication Date
PL2398808T3 true PL2398808T3 (pl) 2014-04-30

Family

ID=42115354

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10704301T PL2398808T3 (pl) 2009-02-17 2010-02-17 Sposób redukcyjnego alkilowania normorfinanów

Country Status (8)

Country Link
US (1) US8431701B2 (pl)
EP (1) EP2398808B1 (pl)
JP (2) JP5778042B2 (pl)
AU (1) AU2010216150B2 (pl)
CA (1) CA2752744A1 (pl)
ES (1) ES2440595T3 (pl)
PL (1) PL2398808T3 (pl)
WO (1) WO2010096416A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8962841B2 (en) * 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
PH12012502083A1 (en) 2010-05-10 2017-07-26 Euro Celtique Sa Manufacturing of active-free granules and tablets comprising the same
EP2568965A1 (en) 2010-05-10 2013-03-20 Euro-Celtique S.A. Combination of active loaded granules with additional actives
US9700508B2 (en) 2010-05-10 2017-07-11 Euro-Celtique S.A. Pharmaceutical compositions comprising hydromorphone and naloxone
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN103387579A (zh) * 2012-05-08 2013-11-13 长沙理工大学 4-苄氧基-17-苯磺酰吗啡喃-6-酮的合成
CN103387539A (zh) * 2012-05-08 2013-11-13 长沙理工大学 4-苄氧基-17-乙酰基吗啡喃-6-酮的合成
CA2922723C (en) * 2013-09-25 2022-04-19 Mallinckrodt Llc Improved process for the preparation of radioiodinated 3-fluoropropyl-nor-b-cit
WO2015071380A1 (en) 2013-11-13 2015-05-21 Euro-Celtique S.A. Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
US9701688B2 (en) 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds
US9701687B2 (en) 2014-05-05 2017-07-11 Noramco, Inc. Process for the preparation of opioid compounds
CN109096190B (zh) * 2017-06-21 2021-07-02 中国医学科学院药物研究所 一种青藤碱衍生物及其制备方法、用途和药物组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2578787A (en) 1949-04-09 1951-12-18 Rohm & Haas Reduction of enamines
GB0421687D0 (en) 2004-09-30 2004-11-03 Johnson Matthey Plc Preparation of opiate analgesics
JP4994246B2 (ja) 2006-01-18 2012-08-08 大塚化学株式会社 第３級アミンの製造方法
CA2652849A1 (en) * 2006-05-25 2007-12-06 Alpharma (Bermuda) Investments Ltd. Process useful in the preparation of morphinan antagonists
JP2010533719A (ja) 2007-07-17 2010-10-28 マリンクロッド・インコーポレイテッド 還元的アミノ化によるｎ−アルキル化オピエートの調製
NZ607842A (en) * 2008-09-30 2013-12-20 Mallinckrodt Llc Processes for the selective amination of ketomorphinans

Also Published As

Publication number Publication date
WO2010096416A1 (en) 2010-08-26
EP2398808A1 (en) 2011-12-28
ES2440595T3 (es) 2014-01-29
JP2012518013A (ja) 2012-08-09
US8431701B2 (en) 2013-04-30
AU2010216150B2 (en) 2015-05-14
JP2015180661A (ja) 2015-10-15
EP2398808B1 (en) 2013-11-20
JP5778042B2 (ja) 2015-09-16
AU2010216150A1 (en) 2011-09-08
CA2752744A1 (en) 2010-08-26
US20100210843A1 (en) 2010-08-19

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