PL2403854T3 - Sulfonylowane tetrahydroazolopirazyny i ich zastosowanie jako produktów leczniczych - Google Patents

Sulfonylowane tetrahydroazolopirazyny i ich zastosowanie jako produktów leczniczych

Info

Publication number: PL2403854T3
Authority: PL; Poland
Prior art keywords: medicinal products; tetrahydroazolopyrazines; sulfonylated; sulfonylated tetrahydroazolopyrazines; medicinal
Prior art date: 2009-03-04

Application number

PL10708496T

Other languages

English (en)

Inventor

Beatrix Merla

Stefan Oberbörsch

Melanie Reich

Stefan Schunk

Ruth Jostock

Sabine Hees

Michael Engels

Tieno Germann

Edward Bijsterveld

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-04

Filing date

2010-03-03

Publication date

2014-02-28

2010-03-03 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2014-02-28 Publication of PL2403854T3 publication Critical patent/PL2403854T3/pl

Links

WEXJJSPMIBHSKF-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-pyrrolo[2,3-b]pyrazine Chemical class N1CCNC2=C1C=CN2 WEXJJSPMIBHSKF-UHFFFAOYSA-N 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Pulmonology (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL10708496T 2009-03-04 2010-03-03 Sulfonylowane tetrahydroazolopirazyny i ich zastosowanie jako produktów leczniczych PL2403854T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP09003075		2009-03-04
PCT/EP2010/001299 WO2010099938A1 (en)	2009-03-04	2010-03-03	Sulfonylated tetrahydroazolopyrazines and their use as medicinal products
EP10708496.4A EP2403854B1 (en)	2009-03-04	2010-03-03	Sulfonylated tetrahydroazolopyrazines and their use as medicinal products

Publications (1)

Publication Number	Publication Date
PL2403854T3 true PL2403854T3 (pl)	2014-02-28

Family

ID=40716949

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL10708496T PL2403854T3 (pl)	2009-03-04	2010-03-03	Sulfonylowane tetrahydroazolopirazyny i ich zastosowanie jako produktów leczniczych

Country Status (15)

Country	Link
US (1)	US8158628B2 (pl)
EP (1)	EP2403854B1 (pl)
JP (1)	JP2012519196A (pl)
CN (1)	CN102341398A (pl)
AR (1)	AR075539A1 (pl)
AU (1)	AU2010220561A1 (pl)
BR (1)	BRPI1010533A2 (pl)
CA (1)	CA2754330A1 (pl)
ES (1)	ES2437108T3 (pl)
IL (1)	IL214911A0 (pl)
MX (1)	MX305105B (pl)
PL (1)	PL2403854T3 (pl)
RU (1)	RU2011140061A (pl)
TW (1)	TW201035102A (pl)
WO (1)	WO2010099938A1 (pl)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2013002446A (es) *	2010-09-03	2013-04-08	Gruenenthal Gmbh	Derivados de tetrahidropirrolopirazina sustituidos.
WO2012088266A2 (en)	2010-12-22	2012-06-28	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
DE102011082013A1 (de) *	2011-09-01	2013-03-07	Bayer Pharma AG	6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
TWI633087B (zh) *	2012-06-13	2018-08-21	赫孚孟拉羅股份公司	新穎二氮雜螺環烷及氮雜螺環烷
LT3495367T (lt)	2012-06-13	2021-02-25	Incyte Holdings Corporation	Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai
WO2014026125A1 (en)	2012-08-10	2014-02-13	Incyte Corporation	Pyrazine derivatives as fgfr inhibitors
EP3590940B1 (en)	2012-09-25	2021-06-09	F. Hoffmann-La Roche AG	Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
CN103113324B (zh) *	2013-02-07	2015-08-05	浙江工业大学	一种n-磺酰基取代的四氢吡咯类化合物的制备方法
AR095079A1 (es)	2013-03-12	2015-09-16	Hoffmann La Roche	Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
LT2986610T (lt)	2013-04-19	2018-04-10	Incyte Holdings Corporation	Bicikliniai heterociklai, kaip fgfr inhibitoriai
AR098414A1 (es)	2013-11-14	2016-05-26	Bristol Myers Squibb Co	PIPERAZINAS DE PIRAZOLO SUSTITUIDO COMO INHIBIDORES DE CASEÍNA QUINASA 1 d/e
NO3074400T3 (pl)	2013-11-26	2018-04-14
EP3122751B1 (en)	2014-03-26	2019-10-30	F.Hoffmann-La Roche Ag	Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
MA39792B1 (fr)	2014-03-26	2019-12-31	Hoffmann La Roche	Composés bicycliques en tant qu'inhibiteurs de production d'autotaxine (atx) et d'acide lysophosphatidique (lpa)
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
SG11201706287PA (en)	2015-02-20	2017-09-28	Incyte Corp	Bicyclic heterocycles as fgfr inhibitors
WO2016134294A1 (en)	2015-02-20	2016-08-25	Incyte Corporation	Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
MA41898A (fr)	2015-04-10	2018-02-13	Hoffmann La Roche	Dérivés de quinazolinone bicyclique
MX387736B (es)	2015-09-04	2025-03-18	Hoffmann La Roche	Derivados de fenoximetilo.
KR20180054634A (ko)	2015-09-24	2018-05-24	에프. 호프만-라 로슈 아게	이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물
CN107635995B (zh)	2015-09-24	2022-08-19	豪夫迈·罗氏有限公司	作为atx抑制剂的二环化合物
MX2017015034A (es)	2015-09-24	2018-04-13	Hoffmann La Roche	Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
PE20180451A1 (es)	2015-09-24	2018-03-05	Hoffmann La Roche	Nuevos compuestos biciclicos como inhibidores de atx
JOP20190024A1 (ar)	2016-08-26	2019-02-19	Gilead Sciences Inc	مركبات بيروليزين بها استبدال واستخداماتها
CN110382484B (zh)	2017-03-16	2022-12-06	豪夫迈·罗氏有限公司	新的作为atx抑制剂的二环化合物
MA49879A (fr)	2017-03-16	2020-06-24	Hoffmann La Roche	Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
KR102526964B1 (ko)	2018-02-26	2023-04-28	길리애드 사이언시즈, 인코포레이티드	Hbv 복제 억제제로서의 치환된 피롤리진 화합물
ES3061844T3 (en)	2018-05-04	2026-04-07	Incyte Corp	Salts of an fgfr inhibitor
MX2020011718A (es)	2018-05-04	2021-02-15	Incyte Corp	Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas.
US11628162B2 (en)	2019-03-08	2023-04-18	Incyte Corporation	Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en)	2019-07-09	2023-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en)	2019-10-01	2024-10-22	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
TWI891666B (zh)	2019-10-14	2025-08-01	美商英塞特公司	作為ｆｇｆｒ抑制劑之雙環雜環
US11566028B2 (en)	2019-10-16	2023-01-31	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
CA3163875A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
WO2021113462A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Derivatives of an fgfr inhibitor
US12012409B2 (en)	2020-01-15	2024-06-18	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
TW202304459A (zh)	2021-04-12	2023-02-01	美商英塞特公司	包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法
JP2024522189A (ja)	2021-06-09	2024-06-11	インサイト・コーポレイション	Ｆｇｆｒ阻害剤としての三環式ヘテロ環
EP4352060A1 (en)	2021-06-09	2024-04-17	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
CN121175287A (zh) *	2023-03-29	2025-12-19	安道麦阿甘有限公司	用于制备胺中间体的方法
CN119490446A (zh) *	2024-09-23	2025-02-21	苏州艾缇克药物化学有限公司	一种左旋舒必利的重要中间体(S)-2-Boc-氨甲基吡咯烷的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7563793B2 (en) *	2004-12-20	2009-07-21	Wyeth	Pyrrolo[1,2-a]quinoxalin-5-(4H)-yl)sulfonyls and carbonyls and their use as estrogenic agents
WO2007101007A2 (en)	2006-02-23	2007-09-07	Neurogen Corporation	Aryl sulfonyl heterocycles
US8097626B2 (en) *	2006-04-21	2012-01-17	Glaxosmithkline Llc	IL-8 receptor antagonists
WO2007140383A2 (en)	2006-05-30	2007-12-06	Neurogen Corporation	Spirocyclic sulfonamides and related compounds
MX2009003382A (es)	2006-09-29	2009-04-08	Gruenenthal Gmbh	Derivados de sulfonamidas sustituidos.
EP2086935A1 (de)	2006-10-16	2009-08-12	Grünenthal GmbH	Substituierte sulfonamid-derivate als bradykinin 1 rezeptor modulatoren
BRPI0812504B8 (pt) *	2007-06-21	2021-05-25	Cara Therapeutics Inc	composto para profilaxia ou tratamento de doença ou condição associada a receptor de canabinoides em sujeito mamífero

2010
- 2010-02-26 TW TW099105566A patent/TW201035102A/zh unknown
- 2010-03-03 MX MX2011008864A patent/MX305105B/es active IP Right Grant
- 2010-03-03 AU AU2010220561A patent/AU2010220561A1/en not_active Abandoned
- 2010-03-03 BR BRPI1010533A patent/BRPI1010533A2/pt not_active IP Right Cessation
- 2010-03-03 CA CA2754330A patent/CA2754330A1/en not_active Abandoned
- 2010-03-03 EP EP10708496.4A patent/EP2403854B1/en not_active Not-in-force
- 2010-03-03 CN CN2010800106612A patent/CN102341398A/zh active Pending
- 2010-03-03 JP JP2011552360A patent/JP2012519196A/ja not_active Withdrawn
- 2010-03-03 PL PL10708496T patent/PL2403854T3/pl unknown
- 2010-03-03 RU RU2011140061/04A patent/RU2011140061A/ru not_active Application Discontinuation
- 2010-03-03 ES ES10708496.4T patent/ES2437108T3/es active Active
- 2010-03-03 WO PCT/EP2010/001299 patent/WO2010099938A1/en not_active Ceased
- 2010-03-04 AR ARP100100647A patent/AR075539A1/es not_active Application Discontinuation
- 2010-03-04 US US12/717,625 patent/US8158628B2/en not_active Expired - Fee Related
2011
- 2011-09-01 IL IL214911A patent/IL214911A0/en unknown

Also Published As

Publication number	Publication date
BRPI1010533A2 (pt)	2016-03-15
HK1160450A1 (en)	2012-08-17
MX305105B (es)	2012-11-12
WO2010099938A1 (en)	2010-09-10
MX2011008864A (es)	2011-09-15
US8158628B2 (en)	2012-04-17
CN102341398A (zh)	2012-02-01
US20100234387A1 (en)	2010-09-16
EP2403854B1 (en)	2013-09-11
AR075539A1 (es)	2011-04-20
CA2754330A1 (en)	2010-09-10
IL214911A0 (en)	2011-11-30
TW201035102A (en)	2010-10-01
AU2010220561A1 (en)	2011-10-27
JP2012519196A (ja)	2012-08-23
ES2437108T3 (es)	2014-01-08
RU2011140061A (ru)	2013-04-10
EP2403854A1 (en)	2012-01-11

Publication	Publication Date	Title
MX305105B (es)	2012-11-12	Tetrahidroazolopirazinas sulfoniladas y su uso como productos medicinales.
IL253870B (en)	2018-05-31	Certain amino-pyrimidines and pharmaceutical preparations containing them
ZA201303600B (en)	2014-01-29	Composition i-ii and products and uses thereof
IL221511A (en)	2015-04-30	Arilatriazolones associated with bis aryl and their use
GB201010193D0 (en)	2010-07-21	Medicinal use
GB201005063D0 (en)	2010-05-12	Biological products
IL234628A0 (en)	2014-11-30	Imidazolyl-pyrimidines are converted into amino-indolyl and their use as drugs
ZA201208173B (en)	2013-07-31	Peptices and their use
PL2575493T3 (pl)	2016-06-30	Kompozycja cukiernicza i wyrób
GB201011971D0 (en)	2010-09-01	Methods and product
GB0921001D0 (en)	2010-01-13	Products and uses
SI2605757T1 (sl)	2015-11-30	Formulacije na osnovi nalbufina in njihove uporabe
ZA201301608B (en)	2014-09-25	Compositions comprising oleuropeins and flavanoids and their use
ZA201302854B (en)	2014-07-25	Substituted benzamides and their uses
EP2621435A4 (en)	2014-07-30	ABSORBENT ARTICLE
SI2552440T1 (sl)	2019-03-29	Nove kombinacije in uporaba
IL223254A0 (en)	2013-02-03	Use of diatomaceous earth in the pharmaceutical industry
PL2648715T3 (pl)	2017-09-29	Mieszaniny karnozyny-kwasu hialuronowego i ich zastosowanie
GB201007202D0 (en)	2010-06-16	Product and uses
PL2538955T3 (pl)	2016-04-29	Formulacja farmaceutyczna lub nutraceutyczna
GB2504390B (en)	2015-06-03	Nutraceutical and pharmaceutical composition
GB201301571D0 (en)	2013-03-13	Product and use
IL221501A (en)	2016-11-30	Medicinal product containing miramistine
PL2491021T3 (pl)	2014-10-31	Nowe acylopiperazynony i ich zastosowanie jako środki farmaceutyczne
IL217137A0 (en)	2012-02-29	Medicinal and herbal composition and uses thereof