PL2411507T3 - Namnażanie komórek nk - Google Patents

Namnażanie komórek nk

Info

Publication number
PL2411507T3
PL2411507T3 PL10756430T PL10756430T PL2411507T3 PL 2411507 T3 PL2411507 T3 PL 2411507T3 PL 10756430 T PL10756430 T PL 10756430T PL 10756430 T PL10756430 T PL 10756430T PL 2411507 T3 PL2411507 T3 PL 2411507T3
Authority
PL
Poland
Prior art keywords
expansion
cells
Prior art date
Application number
PL10756430T
Other languages
English (en)
Inventor
Evren Alici
Original Assignee
Cellprotect Nordic Pharmaceuticals Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellprotect Nordic Pharmaceuticals Ab filed Critical Cellprotect Nordic Pharmaceuticals Ab
Publication of PL2411507T3 publication Critical patent/PL2411507T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1164—NK cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
PL10756430T 2009-03-26 2010-03-25 Namnażanie komórek nk PL2411507T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16359009P 2009-03-26 2009-03-26
EP10756430.4A EP2411507B1 (en) 2009-03-26 2010-03-25 Expansion of nk cells
PCT/SE2010/050333 WO2010110734A1 (en) 2009-03-26 2010-03-25 Expansion of nk cells

Publications (1)

Publication Number Publication Date
PL2411507T3 true PL2411507T3 (pl) 2020-07-13

Family

ID=42781254

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10756430T PL2411507T3 (pl) 2009-03-26 2010-03-25 Namnażanie komórek nk

Country Status (10)

Country Link
US (1) US8877182B2 (pl)
EP (1) EP2411507B1 (pl)
JP (3) JP2012521215A (pl)
KR (1) KR101881520B1 (pl)
CN (1) CN102428173B (pl)
DK (1) DK2411507T3 (pl)
ES (1) ES2763169T3 (pl)
PL (1) PL2411507T3 (pl)
PT (1) PT2411507T (pl)
WO (1) WO2010110734A1 (pl)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ599825A (en) 2007-09-28 2014-10-31 Anthrogenesis Corp Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
ES2666746T3 (es) 2010-07-13 2018-05-07 Anthrogenesis Corporation Métodos para generar linfocitos citolíticos naturales
JP5572863B2 (ja) * 2011-06-24 2014-08-20 国立大学法人九州大学 Ｎｋ細胞の増幅方法
ES2652666T3 (es) 2011-12-22 2018-02-05 Mogam Biotechnology Institute Procedimiento de producción de linfocitos citolíticos naturales, linfocitos citolíticos naturales producidos de este modo y composición para el tratamiento de cánceres y enfermedades infecciosas que contienen los mismos
US10066207B2 (en) 2012-04-18 2018-09-04 Board Of Trustees Of Michigan State University Natural killer cells with enhanced immune response
KR101525199B1 (ko) * 2012-09-13 2015-06-04 (주)케이셀바이오 100㎖ 이하 말초혈액으로부터 ｎｋ세포의 대량 증식 방법
CN102994449A (zh) * 2012-12-13 2013-03-27 上海柯莱逊生物技术有限公司 一种体外扩增nk细胞的方法
EP2948544A4 (en) 2013-01-28 2016-08-03 St Jude Childrens Res Hospital CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES
CN115137753A (zh) 2013-02-05 2022-10-04 细胞结构公司 来自胎盘的自然杀伤细胞
HK1215860A1 (zh) * 2013-03-27 2016-09-23 Biotherapy Institute Of Japan Nk细胞强化型血液制剂的制造方法
WO2014183066A2 (en) 2013-05-10 2014-11-13 Whitehead Institute For Biomedical Research Protein modification of living cells using sortase
WO2015125113A1 (en) * 2014-02-21 2015-08-27 Dr. Reddy's Laboratories Limited Method of culturing high cell density pbmc's
CN105002139B (zh) * 2014-04-25 2019-02-01 中国医学科学院肿瘤医院 一种cd3+cd8+cd56+t细胞亚型促进nk细胞增殖的方法
DK3143134T3 (da) 2014-05-15 2021-01-04 Nat Univ Singapore Modificerede, naturlige dræberceller og anvendelser deraf
CN104357390B (zh) * 2014-10-15 2017-07-07 恒瑞源正（深圳）生物科技有限公司 同时扩增cd3+cd56+cik细胞和cd3‑cd56+nk细胞的方法
KR101697473B1 (ko) 2014-11-26 2017-01-18 주식회사 녹십자랩셀 T 세포를 이용한 자연살해세포의 배양방법
CN108289909A (zh) 2015-10-19 2018-07-17 巴尔的摩马里兰大学 用于产生工程改造的人原代血液树突细胞系的方法
CN105624109B (zh) * 2016-02-26 2019-07-12 广州赛莱拉干细胞科技股份有限公司 一种使用生物反应器培养nkt细胞的方法
CN107779434A (zh) * 2016-08-30 2018-03-09 天津市康婷生物工程有限公司 高效扩增人外周血nk细胞的实验方法
CN110546265A (zh) 2017-02-09 2019-12-06 因达普塔治疗公司 工程化自然杀伤(nk)细胞及其组合物和方法
BR112019019917A2 (pt) 2017-03-27 2020-04-22 Nat Univ Singapore receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais
CA3056591A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
EP3633029A4 (en) 2017-05-26 2021-06-09 Green Cross Lab Cell Corporation METHOD OF DEVELOPING A NATURAL KILLER CELL USING A T-CELL
CN107541491A (zh) * 2017-10-12 2018-01-05 广州金晟生物科技有限公司 一种nk细胞体外培养方法
KR102265437B1 (ko) * 2017-11-24 2021-06-15 의료법인 성광의료재단 Nk 배양용 조성물 및 이를 이용하여 nk 세포를 배양하는 방법
CN108192868B (zh) * 2017-12-29 2018-12-07 广州沙艾生物科技有限公司 免疫细胞的诱导扩增方法
CN108060130B (zh) * 2017-12-29 2018-12-07 广州沙艾生物科技有限公司 控制培养箱适于免疫细胞的诱导扩增的方法
IL276365B2 (en) 2018-02-01 2023-10-01 Nkmax Co Ltd A method for the production of natural killer cells and a preparation for cancer treatment
EP3749685A4 (en) 2018-02-09 2021-12-22 National University of Singapore ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY
ES2973728T3 (es) * 2018-03-13 2024-06-24 Fundacion Para La Investigacion Biomedica Del Hospital Univ La Paz Anticuerpo anti-CXCR4 combinado con linfocitos citolíticos naturales activados y expandidos para inmunoterapia contra el cáncer
KR102232321B1 (ko) * 2018-03-23 2021-03-26 주식회사 녹십자랩셀 자연살해세포의 제조방법
WO2019182392A1 (ko) * 2018-03-23 2019-09-26 주식회사 녹십자랩셀 자연살해세포의 제조방법
JP7334985B2 (ja) 2018-04-02 2023-08-29 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和
GB201807050D0 (en) 2018-04-30 2018-06-13 Cellprotect Nordic Pharmaceuticals Ab Medical uses
KR102069704B1 (ko) * 2018-05-16 2020-01-23 고려대학교 산학협력단 Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법
US20210207097A1 (en) * 2018-05-31 2021-07-08 Korea University Research And Business Foundation Expansion and culture of human-derived natural killer cells by using igfbp2
CN110628715B (zh) * 2018-06-21 2022-11-25 精准生技股份有限公司 体外扩增自然杀手细胞及自然杀手t细胞的方法及其医药组成物
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
AU2019381526B2 (en) 2018-11-14 2023-02-23 Green Cross Lab Cell Corporation Method for culturing cord blood-derived natural killer cells using transformed T-cells
EP3884041A2 (en) * 2018-11-21 2021-09-29 Indapta Therapeutics, Inc. Methods for expansion of natural killer (nk) cell subset and related compositions and methods
CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
IL286482B2 (en) * 2019-03-21 2025-01-01 Gamida Cell Ltd Cultured NK cell fractions for use in combination therapy
US11453862B2 (en) 2019-07-08 2022-09-27 Immunitybio, Inc. Mononuclear cell derived NK cells
AU2019456283B2 (en) * 2019-07-08 2023-06-08 Immunitybio, Inc. Mononuclear cell derived NK cells
WO2021154886A1 (en) 2020-01-28 2021-08-05 Sorrento Therapeutics, Inc. Natural killer cells for treatment of coronavirus infection
AR124414A1 (es) 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
JP2024502170A (ja) * 2021-01-12 2024-01-17 ハダシット メディカル リサーチ サービシーズ アンド ディベロップメント リミテッド 癌のための改良された養子細胞移植療法
GB202115389D0 (en) 2021-10-26 2021-12-08 XNK Therapeutics AB Methods
US20250346649A1 (en) 2021-11-05 2025-11-13 St. Jude Children's Research Hospital, Inc. Zip cytokine receptors
US20250312450A1 (en) 2022-06-08 2025-10-09 St. Jude Children's Research Hospital, Inc. Disruption of kdm4a in t cells to enhance immunotherapy
US20260091115A1 (en) 2022-09-16 2026-04-02 St. Jude Children's Research Hospital, Inc. Disruption of asxl1 in t cells to enhance immunotherapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60042606D1 (de) * 1999-11-24 2009-09-03 Ernest G Hope Anti-angiogener zellulärer wirkstoff zur krebsbehanldung
US20030119185A1 (en) * 2000-02-24 2003-06-26 Xcyte Therapies, Inc. Activation and expansion of cells
EP1288291A4 (en) * 2000-06-06 2004-05-12 Kirin Brewery METHOD FOR REPLACING NATURAL KILLER T CELLS
US20030068306A1 (en) * 2001-09-14 2003-04-10 Dilber Mehmet Sirac Medium
US20080199423A1 (en) * 2004-06-18 2008-08-21 Genentech, Inc. Methods of Using Apo2l Receptor Agonists and Ink Cell Activators
US20090196850A1 (en) 2005-01-06 2009-08-06 Novo Nordisk A/S Anti-Kir Combination Treatments and Methods
WO2009060865A1 (ja) * 2007-11-05 2009-05-14 Tsuneo Kuramochi 医薬組成物及び医薬組成物の製造方法
US20090123442A1 (en) * 2007-11-09 2009-05-14 Avaris Ab Expanded nk cells
KR20090127974A (ko) * 2008-06-10 2009-12-15 주식회사 엔케이바이오 자기활성화 림프구 배양용 배지 조성물

Also Published As

Publication number Publication date
PT2411507T (pt) 2020-01-09
JP6574823B2 (ja) 2019-09-11
CN102428173B (zh) 2014-07-30
CN102428173A (zh) 2012-04-25
HK1170258A1 (en) 2013-02-22
JP2016105713A (ja) 2016-06-16
US20120258085A1 (en) 2012-10-11
EP2411507A1 (en) 2012-02-01
JP2018046840A (ja) 2018-03-29
EP2411507A4 (en) 2013-06-19
US8877182B2 (en) 2014-11-04
DK2411507T3 (da) 2020-01-06
KR101881520B1 (ko) 2018-07-24
KR20110132618A (ko) 2011-12-08
JP2012521215A (ja) 2012-09-13
EP2411507B1 (en) 2019-09-25
WO2010110734A1 (en) 2010-09-30
ES2763169T3 (es) 2020-05-27

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