PL2414380T3 - Method for purifying recombinant fsh - Google Patents

Method for purifying recombinant fsh

Info

Publication number
PL2414380T3
PL2414380T3 PL10713424T PL10713424T PL2414380T3 PL 2414380 T3 PL2414380 T3 PL 2414380T3 PL 10713424 T PL10713424 T PL 10713424T PL 10713424 T PL10713424 T PL 10713424T PL 2414380 T3 PL2414380 T3 PL 2414380T3
Authority
PL
Poland
Prior art keywords
recombinant fsh
purifying recombinant
purifying
fsh
recombinant
Prior art date
Application number
PL10713424T
Other languages
Polish (pl)
Inventor
Christian Scheckermann
Dietmar Eichinger
Stefan Arnold
Original Assignee
Theramex Hq Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramex Hq Uk Ltd filed Critical Theramex Hq Uk Ltd
Publication of PL2414380T3 publication Critical patent/PL2414380T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL10713424T 2009-04-01 2010-04-01 Method for purifying recombinant fsh PL2414380T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09157133 2009-04-01
PCT/EP2010/002111 WO2010115586A2 (en) 2009-04-01 2010-04-01 Method for purifying recombinant fsh
EP10713424.9A EP2414380B1 (en) 2009-04-01 2010-04-01 Method for purifying recombinant fsh

Publications (1)

Publication Number Publication Date
PL2414380T3 true PL2414380T3 (en) 2016-01-29

Family

ID=42153744

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10713424T PL2414380T3 (en) 2009-04-01 2010-04-01 Method for purifying recombinant fsh

Country Status (26)

Country Link
US (3) US9096683B2 (en)
EP (1) EP2414380B1 (en)
JP (2) JP5845170B2 (en)
KR (1) KR101761168B1 (en)
CN (1) CN102448979B (en)
AU (1) AU2010234028B2 (en)
BR (1) BRPI1012647B1 (en)
CA (1) CA2755927A1 (en)
CY (1) CY1116963T1 (en)
DK (1) DK2414380T3 (en)
EA (1) EA028065B1 (en)
ES (1) ES2552055T3 (en)
HR (1) HRP20151086T1 (en)
HU (1) HUE025959T2 (en)
IL (1) IL215234A (en)
ME (1) ME02277B (en)
MX (1) MX2011010480A (en)
NZ (1) NZ595661A (en)
PL (1) PL2414380T3 (en)
PT (1) PT2414380E (en)
RS (1) RS54318B1 (en)
SI (1) SI2414380T1 (en)
SM (1) SMT201500276B (en)
UA (1) UA106369C2 (en)
WO (1) WO2010115586A2 (en)
ZA (1) ZA201106800B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5845170B2 (en) * 2009-04-01 2016-01-20 ラティオファーム ゲーエムベーハー Method for purifying recombinant FSH
CN103570820B (en) * 2012-08-06 2015-11-18 齐鲁制药有限公司 The purification process of a kind of Gonal-F
KR101516054B1 (en) * 2012-11-21 2015-05-06 씨제이헬스케어 주식회사 A novel method for preparing long-acting human growth hormone monomers
CN103059125B (en) * 2012-12-27 2015-08-12 浙江海正药业股份有限公司 The purification process of Gonal-F
EP2968391A1 (en) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN103539860B (en) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 Long-acting recombinant human follicle-stimulating hormone-Fc fusion protein (hFSH-Fc)
CN103539861B (en) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 Long-acting recombinant human follicle-stimulating hormone-Fc fusion protein (hFSH-Fc)
KR20160131113A (en) * 2014-04-18 2016-11-15 카딜라 핼쓰캐어 리미티드 Novel purification process of gonadotropin
CN104479005B (en) * 2014-09-05 2017-10-31 上海丽珠制药有限公司 A kind of method of promoting sexual gland hormone purifying
CN105461799A (en) * 2015-12-31 2016-04-06 哈药集团技术中心 Purifying method for human recombinant follicle-stimulating hormone
CN106117342B (en) * 2016-07-07 2020-01-03 江西浩然生物医药有限公司 Preparation method of high-purity urofollitropin
RU2694598C1 (en) * 2018-08-07 2019-07-16 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Cell line hufshkkc6, producer of recombinant human follicle stimulating hormone (fsh) and method for producing fsh using said line
CN114867741A (en) * 2019-12-26 2022-08-05 株式会社Lg化学 Method for purifying follicle stimulating hormone
KR102283871B1 (en) * 2021-03-02 2021-08-02 한국원자력연구원 Method of separating carrier-free holmium-166 using chromatography, apparatus therefor, and carrier-free holmium-166 separated thereby
CN113372433B (en) * 2021-03-12 2022-10-11 上海景泽生物技术有限公司 Method for purifying FSH
CN114591414A (en) * 2022-03-24 2022-06-07 江西浩然生物制药有限公司 Preparation method of human chorionic gonadotropin

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4840896A (en) 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
US6455282B1 (en) * 1983-11-02 2002-09-24 Genzyme Corporation Cells, vectors and methods for producing biologically active TSH
IT1206302B (en) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca URINARY FOLLICLE-STIMULATING HORMONE
CA2018676C (en) 1989-06-20 2003-05-06 Christie A. Kelton Novel heteropolymeric protein production methods
US5021160A (en) * 1990-01-09 1991-06-04 Gelman Sciences, Inc. Strongly acidic microporous membranes for cation exchange
DE4440587A1 (en) 1994-11-14 1996-05-15 Fliether Karl Gmbh & Co Basquill castle
US6261823B1 (en) * 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
ES2332931T3 (en) 1997-06-25 2010-02-15 Merck Serono Sa ANALOGS OF GLICOPROTEINIC HORMONES INTERRELVED BY DISULFURE, ITS PREPARATION AND USE.
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
BRPI0010677B8 (en) * 1999-04-16 2021-05-25 Inst Massone S A purification process of human urinary gonadotropins from crude gonadotropins.
WO2001058493A1 (en) 2000-02-11 2001-08-16 Maxygen Aps Conjugates of follicle stimulating hormones
US7157277B2 (en) * 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
CA2483650A1 (en) 2002-05-31 2003-12-11 E.I. Du Pont De Nemours And Company Copolymers having tunable energy levels and color of emission
DK1610822T4 (en) 2003-04-02 2019-01-14 Ares Trading Sa Liquid pharmaceutical FSH and LH formulations together with a nonionic surfactant
EP1697412B1 (en) * 2003-12-22 2009-10-21 Ares Trading S.A. Method for purifying fsh
DE602005009856D1 (en) * 2004-11-09 2008-10-30 Ares Trading Sa PROCESS FOR CLEANING FSH
ES2572629T3 (en) * 2005-12-09 2016-06-01 Ares Trading S.A. Method for purifying FSH or an FSH mutant
EP1960419B1 (en) 2005-12-09 2016-03-16 Ares Trading S.A. Method for purifying fsh or a fsh mutant
DK2170942T3 (en) * 2007-06-28 2013-11-04 Biogenerix Ag FSH PRODUCING CELL CLEON
AR067536A1 (en) * 2007-07-17 2009-10-14 Hoffmann La Roche METHOD FOR OBTAINING A MONO-PEGILATED ERYTHROPOYETIN IN A SUBSTANTIALLY HOMOGENOUS FORM
JP5845170B2 (en) * 2009-04-01 2016-01-20 ラティオファーム ゲーエムベーハー Method for purifying recombinant FSH

Also Published As

Publication number Publication date
JP2016027050A (en) 2016-02-18
BRPI1012647A2 (en) 2020-08-11
JP5845170B2 (en) 2016-01-20
EP2414380B1 (en) 2015-08-26
KR101761168B1 (en) 2017-07-25
AU2010234028A1 (en) 2011-10-27
SI2414380T1 (en) 2015-12-31
EP2414380A2 (en) 2012-02-08
ME02277B (en) 2016-02-20
AU2010234028B2 (en) 2013-11-14
NZ595661A (en) 2013-07-26
KR20120013359A (en) 2012-02-14
US20120135928A1 (en) 2012-05-31
US20150353599A1 (en) 2015-12-10
RS54318B1 (en) 2016-02-29
UA106369C2 (en) 2014-08-26
JP6231056B2 (en) 2017-11-15
CA2755927A1 (en) 2010-10-14
HRP20151086T1 (en) 2015-12-04
IL215234A0 (en) 2011-12-29
JP2012522736A (en) 2012-09-27
ES2552055T3 (en) 2015-11-25
WO2010115586A3 (en) 2010-11-25
CY1116963T1 (en) 2017-04-05
HUE025959T2 (en) 2016-05-30
EA201171199A1 (en) 2012-05-30
US20160304575A1 (en) 2016-10-20
IL215234A (en) 2016-09-29
DK2414380T3 (en) 2015-10-19
MX2011010480A (en) 2012-09-07
CN102448979A (en) 2012-05-09
SMT201500276B (en) 2016-01-08
PT2414380E (en) 2015-11-13
ZA201106800B (en) 2012-08-28
CN102448979B (en) 2015-03-04
EA028065B1 (en) 2017-10-31
WO2010115586A2 (en) 2010-10-14
US9096683B2 (en) 2015-08-04
BRPI1012647B1 (en) 2022-05-17

Similar Documents

Publication Publication Date Title
IL215234A0 (en) Method for purifying recombinant fsh
SI2522724T1 (en) Polypeptide modification method for purifying polypeptide multimers
ZA201202299B (en) Method for decreasing immunigenicity
ZA201109440B (en) System for gas processing
ZA201107543B (en) Method for on-demand constraception
GB0902476D0 (en) Method
GB0906698D0 (en) Method for quantifying modified peptides
IL214374A0 (en) Process for purifying lipopeptides
IL243248A0 (en) Purification method
GB0901444D0 (en) Method
GB0903316D0 (en) Method
ZA201203155B (en) Method for isolating methylglycinenitrile-n,n-diacetonitrile
ZA201105048B (en) Process for purifying guar
PL2396410T3 (en) Method for producing protein
GB0902034D0 (en) Method
GB0900560D0 (en) Method
IL205807A0 (en) Method for object recognition
ZA201201436B (en) Method and system for polypeptide purification
GB0903026D0 (en) Novel method
HU0900503D0 (en) Process for recognition homofag
GB0908889D0 (en) Method for filtering
GB0922292D0 (en) Novel Method
GB0903580D0 (en) Method
GB0903946D0 (en) Method
EP2448457A4 (en) Method