PL2421849T3 - Związki diamidowe wykazujące aktywność antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta2 - Google Patents

Związki diamidowe wykazujące aktywność antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta2

Info

Publication number: PL2421849T3
Authority: PL; Poland
Prior art keywords: agonist activity; diamide compounds; beta2 adrenergic; receptor antagonist; receptor agonist
Prior art date: 2009-04-23

Application number

PL10715058T

Other languages

English (en)

Inventor

Adam Hughes

Daniel Byun

Yan Chen

Melissa Fleury

John R Jacobsen

Eric L Stangeland

Richard D Wilson

Rose Yen

Original Assignee

Theravance Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-04-23

Filing date

2010-04-16

Publication date

2013-08-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42272140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2421849(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-04-16 Application filed by Theravance Inc filed Critical Theravance Inc

2013-08-30 Publication of PL2421849T3 publication Critical patent/PL2421849T3/pl

Links

102100039705 Beta-2 adrenergic receptor Human genes 0.000 title 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
239000000048 adrenergic agonist Substances 0.000 title 1
229940126157 adrenergic receptor agonist Drugs 0.000 title 1
108010014499 beta-2 Adrenergic Receptors Proteins 0.000 title 1
150000001470 diamides Chemical class 0.000 title 1
230000000694 effects Effects 0.000 title 1
239000003149 muscarinic antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL10715058T 2009-04-23 2010-04-16 Związki diamidowe wykazujące aktywność antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta2 PL2421849T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17203909P	2009-04-23	2009-04-23
EP10715058A EP2421849B1 (en)	2009-04-23	2010-04-16	Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
PCT/US2010/031356 WO2010123766A1 (en)	2009-04-23	2010-04-16	DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITY

Publications (1)

Publication Number	Publication Date
PL2421849T3 true PL2421849T3 (pl)	2013-08-30

Family

ID=42272140

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL17164740T PL3210981T3 (pl)	2009-04-23	2010-04-16	Związki diamidowe wykazujące działanie jako antagonista receptora muskarynowego i agonista antagonista receptora beta 2 adrenergicznego
PL10715058T PL2421849T3 (pl)	2009-04-23	2010-04-16	Związki diamidowe wykazujące aktywność antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta2
PL13151470T PL2599778T3 (pl)	2009-04-23	2010-04-16	Związki diamidowe mających działanie antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta 2

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL17164740T PL3210981T3 (pl)	2009-04-23	2010-04-16	Związki diamidowe wykazujące działanie jako antagonista receptora muskarynowego i agonista antagonista receptora beta 2 adrenergicznego

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL13151470T PL2599778T3 (pl)	2009-04-23	2010-04-16	Związki diamidowe mających działanie antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta 2

Country Status (31)

Country	Link
US (14)	US8138345B2 (pl)
EP (3)	EP3210981B1 (pl)
JP (3)	JP5671006B2 (pl)
KR (1)	KR101769061B1 (pl)
CN (2)	CN102405218B (pl)
AR (1)	AR076412A1 (pl)
AU (1)	AU2010239522B2 (pl)
BR (1)	BRPI1014877B8 (pl)
CA (1)	CA2758505C (pl)
CL (1)	CL2011002637A1 (pl)
CO (1)	CO6440584A2 (pl)
CY (2)	CY1119008T1 (pl)
DK (3)	DK2599778T3 (pl)
ES (3)	ES2635358T3 (pl)
HR (3)	HRP20130468T1 (pl)
HU (2)	HUE042975T2 (pl)
IL (1)	IL215554A (pl)
LT (2)	LT3210981T (pl)
MX (1)	MX2011011156A (pl)
MY (1)	MY158339A (pl)
NZ (1)	NZ595850A (pl)
PL (3)	PL3210981T3 (pl)
PT (3)	PT2599778T (pl)
RU (2)	RU2676686C2 (pl)
SG (1)	SG175330A1 (pl)
SI (3)	SI2421849T1 (pl)
SM (3)	SMT201900168T1 (pl)
TR (1)	TR201903556T4 (pl)
TW (2)	TWI513693B (pl)
WO (1)	WO2010123766A1 (pl)
ZA (1)	ZA201107743B (pl)

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ES2635358T3 (es)	2009-04-23	2017-10-03	Theravance Respiratory Company, Llc	Compuestos de diamina que tienen actividad antagonista del receptor muscarínico y agonista del receptor beta2 adrenérgico
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BR112013031493B1 (pt)	2011-06-10	2022-04-19	Chiesi Farmaceutici S.P.A	Composto, composição farmacêutica, uso de um composto, combinação de um composto, dispositivo e processo de preparação de um composto
KR20180085068A (ko)	2011-06-10	2018-07-25	키에시 파르마슈티시 엣스. 피. 에이.	무스카린 수용체 길항제 및 베타2 아드레날린 수용체 작용제 효능을 갖는 화합물
EP2592078A1 (en)	2011-11-11	2013-05-15	Almirall, S.A.	New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
SG10201704032RA (en)	2012-12-06	2017-06-29	Chiesi Farm Spa	Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
CN104854105B (zh)	2012-12-06	2017-05-17	奇斯药制品公司	具有毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂活性的化合物
ES2750523T3 (es)	2012-12-18	2020-03-26	Almirall Sa	Derivados de ciclohexil y quinuclidinil carbamato que tienen actividades de agonista beta2 adrenérgicos y antagonistas muscarínicos M3
TWI643853B (zh)	2013-02-27	2018-12-11	阿爾米雷爾有限公司	同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TW201517906A (zh)	2013-07-25	2015-05-16	Almirall Sa	含有ｍａｂａ化合物和皮質類固醇之組合
TWI641373B (zh)	2013-07-25	2018-11-21	阿爾米雷爾有限公司	具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
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TW201617343A (zh)	2014-09-26	2016-05-16	阿爾米雷爾有限公司	具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
TWI703138B (zh)	2015-02-12	2020-09-01	義大利商吉斯藥品公司	具有蕈毒鹼受體拮抗劑及β２腎上腺素受體促效劑活性之化合物
WO2016155573A1 (zh) *	2015-03-27	2016-10-06	四川海思科制药有限公司	一种杂环衍生物及其制备方法和在医药上的用途
CN107108502A (zh) *	2015-05-14	2017-08-29	四川海思科制药有限公司	具有β2受体激动及M受体拮抗活性的联苯衍生物及其在医药上的用途
WO2016180348A1 (zh) *	2015-05-14	2016-11-17	四川海思科制药有限公司	具有β2受体激动及M受体拮抗活性的含氮杂螺环衍生物及其在医药上的用途
AR104828A1 (es)	2015-06-01	2017-08-16	Chiesi Farm Spa	COMPUESTOS CON ACTIVIDAD ANTAGONISTA DE LOS RECEPTORES MUSCARÍNICOS Y ACTIVIDAD AGONISTA DEL RECEPTOR b2 ADRENÉRGICO
WO2017093208A1 (en)	2015-12-03	2017-06-08	Chiesi Farmaceutici S.P.A.	Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
WO2017125060A1 (zh) *	2016-01-22	2017-07-27	四川海思科制药有限公司	一种氮杂环酰胺衍生物及其制备方法和在医药上的用途
WO2018011090A1 (en)	2016-07-13	2018-01-18	Chiesi Farmaceutici S.P.A.	Hydroxyquinolinone compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
KR102278197B1 (ko)	2016-12-14	2021-07-15	베이징 서우바이 파마슈티컬 컴퍼니 리미티드	4차 암모늄염 구조의 이중기능 화합물
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2010
- 2010-04-16 ES ES13151470.5T patent/ES2635358T3/es active Active
- 2010-04-16 RU RU2015101032A patent/RU2676686C2/ru active
- 2010-04-16 CN CN201080017581.XA patent/CN102405218B/zh not_active Expired - Fee Related
- 2010-04-16 EP EP17164740.7A patent/EP3210981B1/en active Active
- 2010-04-16 LT LTEP17164740.7T patent/LT3210981T/lt unknown
- 2010-04-16 SI SI201030228T patent/SI2421849T1/sl unknown
- 2010-04-16 SI SI201031498T patent/SI2599778T1/sl unknown
- 2010-04-16 BR BRPI1014877A patent/BRPI1014877B8/pt not_active IP Right Cessation
- 2010-04-16 EP EP10715058A patent/EP2421849B1/en active Active
- 2010-04-16 PT PT131514705T patent/PT2599778T/pt unknown
- 2010-04-16 ES ES17164740T patent/ES2715965T3/es active Active
- 2010-04-16 EP EP13151470.5A patent/EP2599778B1/en active Active
- 2010-04-16 WO PCT/US2010/031356 patent/WO2010123766A1/en not_active Ceased
- 2010-04-16 RU RU2011147374/04A patent/RU2543716C2/ru active
- 2010-04-16 AU AU2010239522A patent/AU2010239522B2/en not_active Ceased
- 2010-04-16 HU HUE17164740A patent/HUE042975T2/hu unknown
- 2010-04-16 DK DK13151470.5T patent/DK2599778T3/en active
- 2010-04-16 HU HUE13151470A patent/HUE035049T2/en unknown
- 2010-04-16 PL PL17164740T patent/PL3210981T3/pl unknown
- 2010-04-16 SM SM20190168T patent/SMT201900168T1/it unknown
- 2010-04-16 CA CA2758505A patent/CA2758505C/en not_active Expired - Fee Related
- 2010-04-16 MX MX2011011156A patent/MX2011011156A/es active IP Right Grant
- 2010-04-16 HR HRP20130468AT patent/HRP20130468T1/hr unknown
- 2010-04-16 SM SM20170305T patent/SMT201700305T1/it unknown
- 2010-04-16 DK DK10715058.3T patent/DK2421849T3/da active
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Also Published As

Publication number	Publication date
US8138345B2 (en)	2012-03-20
BRPI1014877B1 (pt)	2020-11-10
TWI570115B (zh)	2017-02-11
SMT201300060B (it)	2013-07-09
BRPI1014877A2 (pt)	2016-04-12
US10358433B2 (en)	2019-07-23
RU2011147374A (ru)	2013-05-27
US20210024493A1 (en)	2021-01-28
CN102405218A (zh)	2012-04-04
HUE035049T2 (en)	2018-05-02
US10836744B2 (en)	2020-11-17
CN102405218B (zh)	2014-06-04
US20150274697A1 (en)	2015-10-01
MY158339A (en)	2016-09-30
EP2421849B1 (en)	2013-04-03
HRP20190417T1 (hr)	2019-04-19
JP2012524783A (ja)	2012-10-18
AU2010239522B2 (en)	2015-07-02
SI2599778T1 (sl)	2017-08-31
RU2676686C2 (ru)	2019-01-10
PT2421849E (pt)	2013-05-27
EP2599778A1 (en)	2013-06-05
PL2599778T3 (pl)	2018-01-31
JP2015147807A (ja)	2015-08-20
PT3210981T (pt)	2019-04-01
US8551978B2 (en)	2013-10-08
KR20110138292A (ko)	2011-12-26
HK1165799A1 (en)	2012-10-12
IL215554A (en)	2014-08-31
LT3210981T (lt)	2019-04-10
ES2417339T3 (es)	2013-08-07
US20170096412A1 (en)	2017-04-06
TW201546057A (zh)	2015-12-16
JP5671006B2 (ja)	2015-02-18
ZA201107743B (en)	2012-06-27
CA2758505C (en)	2017-03-07
EP3210981A1 (en)	2017-08-30
CN103936716A (zh)	2014-07-23
RU2015101032A3 (pl)	2018-07-30
MX2011011156A (es)	2011-11-04
US20170226082A1 (en)	2017-08-10
TR201903556T4 (tr)	2019-04-22
US20130137665A1 (en)	2013-05-30
EP2599778B1 (en)	2017-04-12
US10590107B2 (en)	2020-03-17
SG175330A1 (en)	2011-11-28
ES2635358T3 (es)	2017-10-03
US9975875B2 (en)	2018-05-22
ES2715965T3 (es)	2019-06-07
DK3210981T3 (en)	2019-04-01
TW201041866A (en)	2010-12-01
RU2015101032A (ru)	2015-06-27
EP3210981B1 (en)	2019-01-02
HUE042975T2 (hu)	2019-07-29
TWI513693B (zh)	2015-12-21
WO2010123766A1 (en)	2010-10-28
BRPI1014877B8 (pt)	2021-05-25
CL2011002637A1 (es)	2012-04-27
US9682957B2 (en)	2017-06-20
AR076412A1 (es)	2011-06-08
US20200165223A1 (en)	2020-05-28
KR101769061B1 (ko)	2017-08-17
US20140323733A1 (en)	2014-10-30
JP2014210816A (ja)	2014-11-13
DK2599778T3 (en)	2017-06-26
US9394275B2 (en)	2016-07-19
US20170362200A1 (en)	2017-12-21
PT2599778T (pt)	2017-06-06
LT2599778T (lt)	2017-08-25
NZ595850A (en)	2013-05-31
HRP20170960T1 (hr)	2017-09-22
EP2421849A1 (en)	2012-02-29
CO6440584A2 (es)	2012-05-15
US9771350B2 (en)	2017-09-26
CA2758505A1 (en)	2010-10-28
IL215554A0 (en)	2011-12-29
US9000173B2 (en)	2015-04-07
CY1121601T1 (el)	2020-05-29
US20100273755A1 (en)	2010-10-28
BRPI1014877A8 (pt)	2018-03-13
US8816088B2 (en)	2014-08-26
US9572802B2 (en)	2017-02-21
DK2421849T3 (da)	2013-07-01
US20130331364A1 (en)	2013-12-12
CN103936716B (zh)	2016-09-07
US20160361304A1 (en)	2016-12-15
CY1119008T1 (el)	2018-01-10
SI3210981T1 (sl)	2019-05-31
AU2010239522A1 (en)	2011-11-10
SMT201900168T1 (it)	2019-05-10
SI2421849T1 (sl)	2013-07-31
JP5965440B2 (ja)	2016-08-03
US10138220B1 (en)	2018-11-27
PL3210981T3 (pl)	2019-06-28
US20190300504A1 (en)	2019-10-03
HRP20130468T1 (en)	2013-06-30
US20190047984A1 (en)	2019-02-14
SMT201700305T1 (it)	2017-09-07
RU2543716C2 (ru)	2015-03-10

Publication	Publication Date	Title
IL215554A0 (en)	2011-12-29	Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
ZA201309242B (en)	2015-05-27	Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
PL2928890T3 (pl)	2018-07-31	Związki wykazujące aktywność antagonisty receptorów muskarynowych i agonisty receptorów beta 2 adrenergicznych
ZA201503965B (en)	2016-09-28	Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
KR20180085068A (ko)	2018-07-25	무스카린 수용체 길항제 및 베타2 아드레날린 수용체 작용제 효능을 갖는 화합물
IL219893A0 (en)	2012-07-31	Combinations of a muscarinic receptor antagonist and a beta-2 adrenorecptor agonist
LT2569308T (lt)	2017-01-10	Naujieji cikloheksilamino dariniai, turintys beta2 adrenerginio agonisto ir m3 muskarininio antagonisto aktyvumus